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List of works by Richard Lee

A Fluorescent Probe for Detecting Mycobacterium tuberculosis and Identifying Genes Critical for Cell Entry

scientific article published on 20 December 2016

A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents

scientific article published on 07 August 2008

A newly discovered mycobacterial pathogen isolated from laboratory colonies of Xenopus species with lethal infections produces a novel form of mycolactone, the Mycobacterium ulcerans macrolide toxin

scientific article published in June 2005

A pantothenate kinase from Staphylococcus aureus refractory to feedback regulation by coenzyme A.

scientific article published on 17 November 2004

A screen for and validation of prodrug antimicrobials

scientific article published on 16 December 2013

A simple in vitro PK/PD model system to determine time-kill curves of drugs against Mycobacteria

scientific article published on 11 September 2009

A statistical framework to evaluate virtual screening

scientific article published on 20 July 2009

A therapeutic approach to pantothenate kinase associated neurodegeneration

scientific article published in Nature Communications

Activation of Exogenous Fatty Acids to Acyl-Acyl Carrier Protein Cannot Bypass FabI Inhibition in Neisseria

scientific article

Acyl carrier protein is a cellular target for the antibacterial action of the pantothenamide class of pantothenate antimetabolites

scientific article

Acyl-Phosphates Initiate Membrane Phospholipid Synthesis in Gram-Positive Pathogens

scientific article published on 01 September 2006

Acyl-sulfamates target the essential glycerol-phosphate acyltransferase (PlsY) in Gram-positive bacteria

scientific article

Allosteric Regulation of Mammalian Pantothenate Kinase

scientific article published on 23 August 2016

Aminomethyl spectinomycins as therapeutics for drug-resistant respiratory tract and sexually transmitted bacterial infections

scientific article

Aminomethyl spectinomycins: a novel antibacterial chemotype for biothreat pathogens

scientific article published on 04 June 2019

Analysis of Mycobacterium species for the presence of a macrolide toxin, mycolactone

scientific article published in January 2004

Antibacterial and antitubercular activity of fosmidomycin, FR900098, and their lipophilic analogs ⬇️

scientific article published on October 5, 2011

Antitubercular nitrofuran isoxazolines with improved pharmacokinetic properties

scientific article published on 28 August 2012

Applications of pharmacometrics in the clinical development and pharmacotherapy of anti-infectives

scientific article published on March 2013

Biopharmaceutics, pharmacokinetics and pharmacodynamics of antituberculosis drugs

scientific article published on January 2008

Catalysis and Sulfa Drug Resistance in Dihydropteroate Synthase

scientific article

Characterization of the in vitro synthesized arabinan of mycobacterial cell walls

scientific article published on 01 June 1997

Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis

scientific article published in March 2007

Chemical modulation of the biological activity of reutericyclin: a membrane-active antibiotic from Lactobacillus reuteri

scientific article published on 17 April 2014

Combinatorial lead optimization of [1,2]-diamines based on ethambutol as potential antituberculosis preclinical candidates

scientific article published in March 2003

Comparative pharmacokinetics of spectinamide 1599 after subcutaneous and intrapulmonary aerosol administration in mice

scientific article published on 31 December 2018

Covalent modification of the Mycobacterium tuberculosis FAS-II dehydratase by Isoxyl and Thiacetazone

scientific article

Crystal Structure of the 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase•Dihydropteroate Synthase Bifunctional Enzyme from Francisella tularensis

scientific article

Crystal structure of the anthrax drug target, Bacillus anthracis dihydrofolate reductase

scientific article

Design, synthesis and anti-tuberculosis activity of 1-adamantyl-3-heteroaryl ureas with improved in vitro pharmacokinetic properties

scientific article published on 26 February 2013

Design, synthesis and microbiological evaluation of ampicillin-tetramic acid hybrid antibiotics

scientific article published on 18 May 2016

Design, synthesis, and evaluation of novel ethambutol analogues

scientific article

Detection of Mycolactone A/B in Mycobacterium ulcerans-Infected Human Tissue

scientific article

Development of BODIPY FL Thalidomide As a High-Affinity Fluorescent Probe for Cereblon in a Time-Resolved Fluorescence Resonance Energy Transfer Assay

scientific article published on 18 October 2020

Development of BODIPY FL vindoline as a novel and high-affinity pregnane X receptor fluorescent probe

scientific article

Development of a pterin-based fluorescent probe for screening dihydropteroate synthase

scientific article

Development of an etoposide prodrug for dual prodrug-enzyme antitumor therapy

scientific article

Discovery and Characterization of the Antimetabolite Action of Thioacetamide-Linked 1,2,3-Triazoles as Disruptors of Cysteine Biosynthesis in Gram-Negative Bacteria

scientific article published on 13 January 2020

Discovery of non-carbohydrate inhibitors of aminoglycoside-modifying enzymes

scientific article published in November 2005

Discovery of novel bacterial elongation condensing enzyme inhibitors by virtual screening

scientific article published on 2 April 2014

Discovery of novel isoxazolines as anti-tuberculosis agents

scientific article

Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity

scientific article

Discovery, synthesis, and biological evaluation of piperidinol analogs with anti-tuberculosis activity

scientific article

Evaluation of Flavonoid and Resveratrol Chemical Libraries Reveals Abyssinone II as a Promising Antibacterial Lead ⬇️

scientific article published on July 30, 2012

Evaluation of analogs of reutericyclin as prospective candidates for treatment of staphylococcal skin infections

scientific article

Exposure of Methicillin-Resistant Staphylococcus aureus to Low Levels of the Antibacterial THAM-3ΦG Generates a Small Colony Drug-Resistant Phenotype.

scientific article published on 29 June 2018

First cultivation and characterization of mycobacterium ulcerans from the environment

scientific article published in 2008

Gastrointestinal localization of metronidazole by a lactobacilli-inspired tetramic acid motif improves treatment outcomes in the hamster model of Clostridium difficile infection

scientific article

Genome-wide expression profiling of the response to ciclopirox olamine in Candida albicans

scientific article published on 6 April 2005

Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans ⬇️

scientific article

Globally distributed mycobacterial fish pathogens produce a novel plasmid-encoded toxic macrolide, mycolactone F

scientific article

Heterogeneity of mycolactones produced by clinical isolates of Mycobacterium ulcerans: implications for virulence ⬇️

scientific article

Identification and characterization of an allosteric inhibitory site on dihydropteroate synthase

scientific article

Identification of a gene involved in the biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis

scientific journal article

In vitro and in vivo Evaluation of Synergism between Anti-Tubercular Spectinamides and Non-Classical Tuberculosis Antibiotics

scientific article

In vitro and in vivo activities of HPi1, a selective antimicrobial against Helicobacter pylori

scientific article

In vitro pharmacokinetic/pharmacodynamic models in anti-infective drug development: focus on TB

scientific article

Inhibition of UDP-Gal Mutase and Mycobacterial Galactan Biosynthesis by Pyrrolidine Analogues of Galactofuranose

article

Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane

scientific journal article

Isoniazid affects multiple components of the type II fatty acid synthase system of Mycobacterium tuberculosis.

scientific article published in November 2000

LipE guided discovery of isopropylphenyl pyridazines as pantothenate kinase modulators

scientific article published on 12 November 2021

Mechanisms involved in the intrinsic isoniazid resistance of Mycobacterium avium

scientific article published in March 1998

Mechanisms of Resistance Associated with the Inhibition of the Dehydration Step of Type II Fatty Acid Synthase in Mycobacterium tuberculosis

scientific article published on 11 December 2019

Metabolic activation of CaMKII by coenzyme A.

scientific article published on 03 October 2013

Methods for acquisition and assignment of multidimensional high-resolution magic angle spinning NMR of whole cell bacteria

scientific article published in September 2005

Model-Based Exposure-Response Assessment for Spectinamide 1810 in a Mouse Model of Tuberculosis

scientific article published on 23 August 2021

Mycobacterial arabinan biosynthesis: the use of synthetic arabinoside acceptors in the development of an arabinosyl transfer assay

article

Mycolactone: a polyketide toxin from Mycobacterium ulcerans required for virulence

scientific article

Mycolic acid biosynthesis: definition and targeting of the Claisen condensation step

scientific article published on 01 June 1997

Mycolic acids: structure, biosynthesis and physiological functions

scientific article

N-substituted 3-acetyltetramic acid derivatives as antibacterial agents

scientific article

New agents for the treatment of drug-resistant Mycobacterium tuberculosis

scientific article

Nitrofurans as novel anti-tuberculosis agents: identification, development and evaluation

scientific article

Novel Polyoxyethylene-Containing Glycolipids Are Synthesized in Corynebacterium matruchotii and Mycobacterium smegmatis Cultured in the Presence of Tween 80.

scientific article published on 20 July 2010

Novel acyl phosphate mimics that target PlsY, an essential acyltransferase in gram-positive bacteria

scientific article published on December 2008

Novel inhibitors of an emerging target in Mycobacterium tuberculosis; substituted thiazolidinones as inhibitors of dTDP-rhamnose synthesis

scientific article published on 6 October 2003

Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis

scientific article

Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated

scientific article

Pentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomes

scientific article published on 18 December 2015

Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicating Mycobacterium tuberculosis

scientific article (publication date: 2014)

Pharmacokinetically-guided lead optimization of nitrofuranylamide anti-tuberculosis agents

scientific article published on 14 March 2008

Phase II Metabolic Pathways of Spectinamide Antitubercular Agents: A Comparative Study of the Reactivity of 4-Substituted Pyridines to Glutathione Conjugation

scientific article published on 7 September 2015

Potentiation of azole antifungals by 2-adamantanamine

scientific article published on 20 May 2013

Pterin-sulfa conjugates as dihydropteroate synthase inhibitors and antibacterial agents

scientific article published on 4 July 2016

Quantitative structure-activity relationship studies on nitrofuranyl anti-tubercular agents

scientific article published on 29 July 2008

Rapid structural characterization of the arabinogalactan and lipoarabinomannan in live mycobacterial cells using 2D and 3D HR-MAS NMR: structural changes in the arabinan due to ethambutol treatment and gene mutation are observed

article

RelA Mutant Enterococcus faecium with Multiantibiotic Tolerance Arising in an Immunocompromised Host

scientific article published on 03 January 2017

Replacing sulfa drugs with novel DHPS inhibitors

scientific article

Reutericyclin and related analogues kill stationary phase Clostridium difficile at achievable colonic concentrations

scientific article

SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A

scientific article

Screening a library of 1600 adamantyl ureas for anti-Mycobacterium tuberculosis activity in vitro and for better physical chemical properties for bioavailability

scientific article

Solid-phase synthesis and biological evaluation of a uridinyl branched peptide urea library

scientific article

Solid-phase synthesis of a thymidinyl dipeptide urea library

scientific article

Spectinamides are effective partner agents for the treatment of tuberculosis in multiple mouse infection models

scientific article

Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux

scientific article published on 26 January 2014

Structural Characterization of the Mycobacterium tuberculosis Biotin Biosynthesis Enzymes 7,8-Diaminopelargonic Acid Synthase and Dethiobiotin Synthetase,

scientific article

Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase

scientific article

Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design

scientific article

Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases

scientific article published on 01 October 2020

Structure-Activity Relationships of Spectinamide Antituberculosis Agents: A Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions

scientific article published on 11 November 2016

Structure-Based Design of Novel Pyrimido[4,5-c]pyridazine Derivatives as Dihydropteroate Synthase Inhibitors with Increased Affinity

scientific article

Structure-Based Design, Synthesis, and Evaluation of 2′-(2-Hydroxyethyl)-2′-deoxyadenosine and the 5′-Diphosphate Derivative as Ribonucleotide Reductase Inhibitors

scientific article

Structure-activity relationships and enzyme inhibition of pantothenamide-type pantothenate kinase inhibitors

scientific article

Syntheses and evaluation of macrocyclic engelhardione analogs as antitubercular and antibacterial agents ⬇️

scientific article published on April 3, 2013

Synthesis and Evaluation of Thiazolidine Amide and N-Thiazolyl Amide Fluoroquinolone Derivatives.

scientific article published on 21 April 2017

Synthesis and Structure–Activity Relationship of Thioacetamide-Triazoles against Escherichia coli

scientific article published in 2022

Synthesis and evaluation of cyclic secondary amine substituted phenyl and benzyl nitrofuranyl amides as novel antituberculosis agents

scientific article published on December 2005

Synthesis and evaluation of esters and carbamates to identify critical functional groups for esterase-specific metabolism

scientific article published in July 2003

Synthesis and evaluation of nitrofuranylamides as novel antituberculosis agents

scientific article

Synthesis and evaluation of pretomanid (PA-824) oxazolidinone hybrids

scientific article

Synthesis and structure of mycolactone E isolated from frog mycobacterium

scientific article published on December 2008

Synthesis of beta-D-arabinofuranosyl-1-monophosphoryl polyprenols: examination of their function as mycobacterial arabinosyl transferase donors.

scientific article

Synthesis of bi-substrate state mimics of dihydropteroate synthase as potential inhibitors and molecular probes

scientific article

Synthesis of new and potent analogues of anti-tuberculosis agent 5-nitro-furan-2-carboxylic acid 4-(4-benzyl-piperazin-1-yl)-benzylamide with improved bioavailability

scientific article published on 10 March 2006

Synthesis, optimization and structure-activity relationships of 3,5-disubstituted isoxazolines as new anti-tuberculosis agents

scientific article published on 29 April 2008

Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives

scientific article

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

scientific article

The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase

scientific article

The membrane as a target for controlling hypervirulent Clostridium difficile infections

scientific article published on 21 December 2012

The structure of the pantothenate kinase.ADP.pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites

scientific article

The structure-activity relationship of urea derivatives as anti-tuberculosis agents

scientific article

Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3

scientific article published on 13 June 2016

Topology and Active Site of PlsY

scientific article published on 16 February 2007

Ureadepsipeptides as ClpP Activators

scientific article published on 24 October 2019

Validation of molecular docking programs for virtual screening against dihydropteroate synthase

scientific article published on February 2009

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