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List of works by Thomas Kilduff

A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight.

scientific article published on 29 May 2012

A role for cryptochromes in sleep regulation

scientific article

Activation of cortical interneurons during sleep: an anatomical link to homeostatic sleep regulation?

scientific article

Acute optogenetic silencing of orexin/hypocretin neurons induces slow-wave sleep in mice.

scientific article published on July 2011

Age-related decline in hypocretin (orexin) receptor 2 messenger RNA levels in the mouse brain.

scientific article published in November 2002

Almorexant promotes sleep and exacerbates cataplexy in a murine model of narcolepsy

scientific article published on March 2013

Automated Sleep Stage Scoring Using k-Nearest Neighbors Classifier

scientific article published on 04 September 2020

Autoradiographic patterns of hippocampal metabolism during induced hypothermia.

scientific article published in December 1982

Brain dopamine receptor levels elevated in canine narcolepsy

scientific article published on 01 January 1987

C-fos mRNA increases in the ground squirrel suprachiasmatic nucleus during arousal from hibernation.

scientific article

Challenges in the development of therapeutics for narcolepsy

scientific article published on 22 December 2015

Characterization of the Circadian System of NGFI-A and NGFI-A/NGFI-B Deficient Mice ⬇️

scientific article published on August 1, 1998

Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor.

scientific article

Circadian and light-induced expression of immediate early gene mRNAs in the rat suprachiasmatic nucleus.

scientific article published in October 1992

Cortical nNOS neurons co-express the NK1 receptor and are depolarized by Substance P in multiple mammalian species.

scientific article

Daily variation of CNS gene expression in nocturnal vs. diurnal rodents and in the developing rat brain.

scientific article published in August 1997

Developmental changes in nicotinic receptor mRNAs and responses to nicotine in the suprachiasmatic nucleus and other brain regions.

scientific article published in March 1999

Differential increase in the expression of heat shock protein family members during sleep deprivation and during sleep.

scientific article published on January 2003

Discovery of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (nelotanserin) and related 5-hydroxytryptamine2A inverse agonists for the treatment of insomnia.

scientific article

Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone

scientific article

Dual orexin and MCH neuron-ablated mice display severe sleep attacks and cataplexy

scientific article published on 21 April 2020

Evidence for excessive sleepiness in canine narcoleptics

scientific article published on 01 November 1986

Focal increases of white matter glucose utilization produced by electrical stimulation of rat motor cortex

scientific article published on 01 March 1983

GABA(B) receptor-mediated modulation of hypocretin/orexin neurones in mouse hypothalamus.

scientific article published on 20 April 2006

GABAA, GABAC, and NMDA receptor subunit expression in the suprachiasmatic nucleus and other brain regions

scientific article published on 01 February 1995

Gene expression in the rat brain during prostaglandin D2 and adenosinergically-induced sleep.

scientific article published on 7 March 2008

Gene expression in the rat brain during sleep deprivation and recovery sleep: an Affymetrix GeneChip study.

scientific article published on 28 October 2005

Gene expression in the rat cerebral cortex: comparison of recovery sleep and hypnotic-induced sleep

scientific journal article

H1N1 infection of sleep/wake regions results in narcolepsy-like symptoms.

scientific article

HSP70 expression is increased during the day in a diurnal animal, the golden-mantled ground squirrel Spermophilus lateralis

scientific article published on 01 September 1999

Homeostatic sleep pressure is the primary factor for activation of cortical nNOS/NK1 neurons

scientific article

Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia.

scientific article

Hypocretin/orexin antagonism enhances sleep-related adenosine and GABA neurotransmission in rat basal forebrain

scientific article

Hypocretin/orexin: maintenance of wakefulness and a multiplicity of other roles.

scientific article

Identification of a population of sleep-active cerebral cortex neurons

scientific article

Immune response gene expression increases in the aging murine hippocampus.

scientific article

Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response

scientific article published on 01 December 2004

Light-induced gene expression in the suprachiasmatic nucleus of young and aging rats

scientific article published on 01 September 1993

Locus Coeruleus and Tuberomammillary Nuclei Ablations Attenuate Hypocretin/Orexin Antagonist-Mediated REM Sleep

scientific article

Longitudinal analysis of the electroencephalogram and sleep phenotype in the R6/2 mouse model of Huntington's disease.

scientific article published in July 2013

Mapping of the mRNAs for the hypocretin/orexin and melanin-concentrating hormone receptors: networks of overlapping peptide systems.

scientific article

Metabolic activation of the brachium conjunctivum during induced hypothermia.

scientific article published in June 1983

Narcolepsy without unique MHC class II antigen association: studies in the canine model

scientific article published on 01 May 1989

New developments in sleep research: molecular genetics, gene expression, and systems neurobiology

scientific article

Nicotine administration differentially affects gene expression in the maternal and fetal circadian clock

scientific article published on 01 January 1995

Nicotine and nicotinic receptors in the circadian system.

scientific article published in February 1998

Ontogeny of photic-induced c-fos mRNA expression in rat suprachiasmatic nuclei ⬇️

scientific article published on December 20, 1994

Parallel Arousal Pathways in the Lateral Hypothalamus

scientific article published on 01 July 2018

Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression

scientific article

Prostaglandin E2 levels in cerebrospinal fluid of normal and narcoleptic dogs.

scientific article

Quantitative Electroencephalographic Analysis Provides an Early-Stage Indicator of Disease Onset and Progression in the zQ175 Knock-In Mouse Model of Huntington's Disease

scientific article

REM sleep-active MCH neurons are involved in forgetting hippocampus-dependent memories

scientific article published on 01 September 2019

Region-specific changes in immediate early gene expression in response to sleep deprivation and recovery sleep in the mouse brain.

scientific article published in January 2003

Relative 2-deoxyglucose uptake of the paratrigeminal nucleus increases during hibernation

scientific article published on 01 February 1983

Restriction fragment length polymorphism in canine narcolepsy

scientific article published on 01 January 1989

Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture.

scholarly article

Serotonergic regulation of the orexin/hypocretin neurons through the 5-HT1A receptor.

scientific article

Sleep-Active Neuronal Nitric Oxide Synthase-Positive Cells of the Cerebral Cortex: A Local Regulator of Sleep? ⬇️

scientific article published on January 1, 2011

Sleep-active cells in the cerebral cortex and their role in slow-wave activity

scientific article

Sleepy dogs don't lie: a genetic disorder informative about sleep.

scientific article

The Dual Hypocretin Receptor Antagonist Almorexant is Permissive for Activation of Wake-Promoting Systems.

scientific article

The Neurobiology of Sleep and Wakefulness

scientific article

The hypocretin/orexin antagonist almorexant promotes sleep without impairment of performance in rats

scientific article published on 31 January 2014

The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders.

scientific article published in August 2000

The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity

scientific article published in January 1998

The relationship of local cerebral glucose utilization to optical density ratios.

scientific article published in March 1983

The wake-promoting effects of hypocretin-1 are attenuated in old rats.

scientific article

Trace Amine-Associated Receptor 1 Regulates Wakefulness and EEG Spectral Composition.

scientific article

Trace amine-associated receptor 1 agonism promotes wakefulness without impairment of cognition in Cynomolgus macaques

scientific article published on 06 April 2019

Trace amine-associated receptor 1 partial agonism reveals novel paradigm for neuropsychiatric therapeutics.

scientific article

Transgenic Archaerhodopsin-3 Expression in Hypocretin/Orexin Neurons Engenders Cellular Dysfunction and Features of Type 2 Narcolepsy

scientific article published on 18 October 2019

Understanding the sleep-wake cycle: sleep, insomnia, and the orexin system.

scientific article published on January 2013

What rest in flies can tell us about sleep in mammals.

scientific article

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