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List of works by Nir Barzilai

40 YEARS of IGF1: IGF1: the Jekyll and Hyde of the aging brain

scientific article published on 08 May 2018

A Compendium of Age-Related PheWAS and GWAS Traits for Human Genetic Association Studies, Their Networks and Genetic Correlations

publication published on 01 June 2021

A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF.

scientific article published on July 2016

A Human Variant of Glucose-Regulated Protein 94 That Inefficiently Supports IGF Production

scientific article published on 16 March 2016

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

scientific article published on 24 March 2017

A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup

scientific article published on 27 August 2018

A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci

scientific journal article

A geroscience perspective on immune resilience and infectious diseases: a potential case for metformin

scientific article published on 09 September 2020

A meta-analysis of genome-wide association studies identifies multiple longevity genes

scientific article published on 14 August 2019

APOE Alleles and Extreme Human Longevity

scientific article published on 01 January 2019

ARDD 2020: from aging mechanisms to interventions

scientific article published on 30 December 2020

Accretion of visceral fat and hepatic insulin resistance in pregnant rats

scientific article published on 11 December 2007

Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity

scientific article published on 9 May 2017

Adiponectin levels and genotype: a potential regulator of life span in humans

scientific article

Advanced aging phenotype is revealed by epigenetic modifications in rat liver after in utero malnutrition

scientific article published on 29 July 2016

Ageing, longevity, exceptional longevity and related genetic and non genetics markers: panel statement

scientific article published on 01 January 2014

Aging as a Biological Target for Prevention and Therapy

scientific article published in The Journal of the American Medical Association

Aging is associated with resistance to effects of leptin on fat distribution and insulin action

scientific article published on 01 June 2002

Aging per se increases the susceptibility to free fatty acid-induced insulin resistance

scientific article

Ashkenazi Jewish centenarians do not demonstrate enrichment in mitochondrial haplogroup J

scientific article

Association between Sleep Patterns and Health in Families with Exceptional Longevity

scientific article published on 8 December 2017

Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity

scientific article

Association of Family History of Exceptional Longevity With Decline in Physical Function in Aging

scientific article published in April 2017

Association of a functional polymorphism in the cholesteryl ester transfer protein (CETP) gene with memory decline and incidence of dementia

scientific article

Association of anti-inflammatory cytokine IL10 polymorphisms with motoric cognitive risk syndrome in an Ashkenazi Jewish population

scientific article published on 19 June 2017

Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity

scientific article

Association of exceptional parental longevity and physical function in aging

scientific article

BIOMARKER STRATEGIES FOR GEROSCIENCE-GUIDED CLINICAL TRIALS

article published in 2019

Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms

scientific article published on 16 August 2016

Benefits of Metformin in Attenuating the Hallmarks of Aging

scientific article published on 23 April 2020

Biological approaches to mechanistically understand the healthy life span extension achieved by calorie restriction and modulation of hormones

scientific article

Biological evidence for inheritance of exceptional longevity

scientific article published in February 2005

Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging

scientific article

Cell type-specific expression and coregulation of murine resistin and resistin-like molecule-alpha in adipose tissue

scientific article published on August 2002

Central and opposing effects of IGF-I and IGF-binding protein-3 on systemic insulin action.

scientific article published in October 2006

Central insulin-like growth factor-1 (IGF-1) restores whole-body insulin action in a model of age-related insulin resistance and IGF-1 decline

scientific article

Central resistance to the inhibitory effects of leptin on stimulated insulin secretion with aging

scientific article published on 24 August 2005

Cholesteryl ester transfer protein (CETP) genotype and reduced CETP levels associated with decreased prevalence of hypertension

scientific article

Chronic inflammation in the etiology of disease across the life span

scientific article published on 05 December 2019

Clinical Outcome of Isolated Tricuspid Regurgitation in Patients with Preserved Left Ventricular Ejection Fraction and Pulmonary Hypertension

Clinical Trials Targeting Aging and Age-Related Multimorbidity

scientific article published on March 2017

Comparison between surrogate indexes of insulin sensitivity/resistance and hyperinsulinemic euglycemic clamp estimates in rats.

scientific article published on 25 August 2009

Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing ⬇️

scientific article published on July 31, 2012

Compression of Morbidity Is Observed Across Cohorts with Exceptional Longevity

scientific article published on 5 July 2016

Contribution of adipose tissue to health span and longevity

scientific article published on 10 August 2010

Correction: Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population

correction of a scientific article; published on 30 May 2019

Correction: RNA Editing Genes Associated with Extreme Old Age in Humans and with Lifespan in C. elegans.

scientific article published on 15 December 2009

Creating the Next Generation of Translational Geroscientists

scientific article published on 09 July 2019

Decrease in glucose-stimulated insulin secretion with aging is independent of insulin action.

scientific article published in February 2004

Development of Clinical Trials to Extend Healthy Lifespan

scientific article published on 01 December 2018

Differential responses of visceral and subcutaneous fat depots to nutrients

scientific article published in March 2005

Discovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next-generation sequencing ⬇️

scientific article published on February 1, 2013

Disease drivers of aging

scientific article published on December 2016

Disease variants in genomes of 44 centenarians.

scientific article

Disrupting mitochondrial-nuclear coevolution affects OXPHOS complex I integrity and impacts human health.

scientific article

Dissecting the Mechanisms Underlying Unusually Successful Human Health Span and Life Span

scientific article

Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene

scientific article published on 10 April 2012

Effect of Exceptional Parental Longevity and Lifestyle Factors on Prevalence of Cardiovascular Disease in Offspring

scientific article published on 18 September 2017

Effect of longevity genetic variants on the molecular aging rate

scientific article published on 04 May 2021

Effects of FOXO3 Polymorphisms on Survival to Extreme Longevity in Four Centenarian Studies.

scientific article

Einstein's Institute for Aging Research: collaborative and programmatic approaches in the search for successful aging.

scientific article

Einstein-Nathan Shock Center: translating the hallmarks of aging to extend human health span

scientific article published in October 2021

Enhanced activation of a "nutrient-sensing" pathway with age contributes to insulin resistance

scientific article published on 19 June 2008

Erratum. Mediobasal Hypothalamic SIRT1 Is Essential for Resveratrol's Effects on Insulin Action in Rats. Diabetes 2011;60:2691-2700.

scientific article published in December 2017

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

scientific article published on 23 January 2018

Evaluating Health Span in Preclinical Models of Aging and Disease: Guidelines, Challenges, and Opportunities for Geroscience

scientific article published on 16 August 2016

Evidence against a role for rare ADAM10 mutations in sporadic Alzheimer disease

scientific article

Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians

scientific article

Exceptional longevity is associated with decreased reproduction ⬇️

scientific article published on December 1, 2011

Exceptional parental longevity associated with lower risk of Alzheimer's disease and memory decline

scientific article

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

article by Jason Flannick et al published 22 May 2019 in Nature

Expanded genetic screening panel for the Ashkenazi Jewish population.

scientific article published on 3 September 2015

Exploring the Promise of Resveratrol: Where Do We Go From Here? ⬇️

scientific article published on April 1, 2013

Extreme longevity is associated with increased serum thyrotropin

scientific article published on 21 January 2009

Family History of Exceptional Longevity Is Associated with Lower Serum Uric Acid Levels in Ashkenazi Jews ⬇️

scientific article published on March 16, 2012

Fatty Acid-Induced Production of Plasminogen Activator Inhibitor-1 by Adipose Macrophages Is Greater in Middle-Aged Versus Younger Adult Participants ⬇️

scientific article published on October 22, 2012

Four Genome-Wide Association Studies Identify New Extreme Longevity Variants

scientific article published on 15 March 2017

Frailty and Risk of Incident Motoric Cognitive Risk Syndrome

scientific article published on 01 January 2019

Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes

scientific article published on 16 August 2016

Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease

scientific article published in January 2018

Functionally significant insulin-like growth factor I receptor mutations in centenarians

scholarly article

GWAS identifies an NAT2 acetylator status tag single nucleotide polymorphism to be a major locus for skin fluorescence

scientific article

Gene-gene interactions lead to higher risk for development of type 2 diabetes in an Ashkenazi Jewish population

scientific article

Genetic Insights Into Frailty: Association of 9p21-23 Locus With Frailty.

scientific article

Genetic Studies Reveal the Role of the Endocrine and Metabolic Systems in Aging ⬇️

scientific article published on October 1, 2010

Genetic determinants of human health span and life span: progress and new opportunities

scientific article

Genetic landscape of APOE in human longevity revealed by high-throughput sequencing

scientific article published on 27 February 2016

Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity

scientific article

Genetic signature of human longevity in PKC and NF-κB signaling

scientific article published on 01 July 2021

Genetic variation in Sirtuin 1 (SIRT1) is associated with lipid profiles but not with longevity in Ashkenazi Jews

scientific article published on 22 September 2014

Genetics of extreme human longevity to guide drug discovery for healthy ageing

scientific article published on 27 July 2020

Genetics, lifestyle and longevity: Lessons from centenarians

scientific article

Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity

scientific article published on 17 December 2015

Genome-wide analysis identifies 12 loci influencing human reproductive behavior

scientific article

Genome-wide data from medieval German Jews show that the Ashkenazi founder event pre-dated the 14 century

scholarly article

Genome-wide mapping of IBD segments in an Ashkenazi PD cohort identifies associated haplotypes

scientific article

Geroscience in the Age of COVID-19

scientific article published on 23 July 2020

Geroscience-guided repurposing of FDA-approved drugs to target aging: A proposed process and prioritization

scientific article published in April 2022

Greater effect of polygenic risk score for Alzheimer's disease among younger cases who are apolipoprotein E-ε4 carriers

scientific article published on 30 September 2020

Hepatic insulin resistance precedes the development of diabetes in a model of intrauterine growth retardation.

scientific article published in October 2004

High-depth whole genome sequencing of a large population-specific reference panel: Enhancing sensitivity, accuracy, and imputation

High-depth whole genome sequencing of an Ashkenazi Jewish reference panel: enhancing sensitivity, accuracy, and imputation.

scientific article published on 28 April 2018

Human longevity and common variations in the LMNA gene: a meta-analysis

scientific article

Humanin: a novel central regulator of peripheral insulin action

scientific article

Hyperglycemia induces PAI-1 gene expression in adipose tissue by activation of the hexosamine biosynthetic pathway ⬇️

scientific article published on January 1, 2002

ICC-dementia (International Centenarian Consortium - dementia): an international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups

scientific article

INVESTIGATING DYNAMICS OF AGE-ASSOCIATED TRANSCRIPTIONAL NETWORKS WITH INTERVENTIONS TARGETING AGING

scholarly article in Innovation in Aging, vol. 3, Suppl 1, November 2019

Identification of genes promoting skin youthfulness by genome-wide association study

scientific article published on 13 September 2013

Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles ⬇️

scientific article published on April 12, 2011

Increased intrahepatic triglyceride is associated with peripheral insulin resistance: in vivo MR imaging and spectroscopy studies

scientific article published on 2 October 2007

Individuals with exceptional longevity manifest a delayed association between vitamin D insufficiency and cognitive impairment

scientific article

Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults

scientific article published on 26 February 2009

Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population

preprint published 25 September 2016

Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population.

scientific article

Insulin resistance and aging: a cause or a protective response?

scientific article published on 02 August 2012

Insulin-like Growth Factor-1 and IGF Binding Proteins Predict All-Cause Mortality and Morbidity in Older Adults

scientific article published on 01 June 2020

Insulin-like growth factor binding protein-3 induces insulin resistance in adipocytes in vitro and in rats in vivo

scientific article published on February 2007

Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies

scientific article published on 01 March 2019

Interventions to Slow Aging in Humans: Are We Ready?

scientific article

Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice.

scientific article

Latest advances in aging research and drug discovery

scientific article published on 21 November 2019

Leptin resistance during aging is independent of fat mass

scientific article published in April 2002

Lifestyle Factors of People with Exceptional Longevity ⬇️

scientific article published on August 3, 2011

Lipoprotein genotype and conserved pathway for exceptional longevity in humans

scientific article

Longevity Genes: From Primitive Organisms to Humans

article

Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity

scientific article

Lower circulating insulin-like growth factor-I is associated with better cognition in females with exceptional longevity without compromise to muscle mass and function.

scientific article published on 14 October 2016

Mediobasal Hypothalamic SIRT1 Is Essential for Resveratrol’s Effects on Insulin Action in Rats ⬇️

scientific article published on September 6, 2011

Metformin alters skeletal muscle transcriptome adaptations to resistance training in older adults

scientific article published on 18 October 2020

Metformin as a Tool to Target Aging

scientific article published on June 2016

Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults

scientific article published on 31 January 2018

Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series

scientific article published on 29 January 2019

Motoric Cognitive Risk Syndrome and Falls Risk: A Multi-Center Study

scientific article published on 18 June 2016

Motoric cognitive risk syndrome: Multicenter incidence study

scientific article

Motoric cognitive risk syndrome: multicountry prevalence and dementia risk

scientific article

Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers

scientific article published on 10 April 2016

New Locus for Skin Intrinsic Fluorescence in Type 1 Diabetes Also Associated With Blood and Skin Glycated Proteins.

scientific article published on 12 April 2016

Novel ultra-rare exonic variants identified in a founder population implicate cadherins in schizophrenia

scientific article published on 22 March 2021

Pennington scientific symposium on mechanisms and retardation of aging

scientific article published on 01 October 2003

Personality, self-rated health, and cognition in centenarians: do personality and self-rated health relate to cognitive function in advanced age?

scientific article

Phenotypes and genotypes of high density lipoprotein cholesterol in exceptional longevity

scientific article published on 01 January 2014

Physiologic effect of leptin on insulin secretion is mediated mainly through central mechanisms ⬇️

scientific article published on April 22, 2003

Pilot study of resveratrol in older adults with impaired glucose tolerance.

scientific article published on 4 January 2012

Plasma HDL levels highly correlate with cognitive function in exceptional longevity

scientific article published in November 2002

Plasma proteomic profile of age, health span, and all-cause mortality in older adults

scientific article published on 22 October 2020

Plasma proteomic profile of frailty

scientific article published on 06 August 2020

PopCluster: an algorithm to identify genetic variants with ethnicity-dependent effects

scientific article published on 01 September 2019

Positive attitude toward life, emotional expression, self-rated health, and depressive symptoms among centenarians and near-centenarians

scientific article

Positive attitude towards life and emotional expression as personality phenotypes for centenarians ⬇️

scientific article published on May 1, 2012

Post-challenge hyperglycemia in older adults is associated with increased cardiovascular risk profile

scientific article published on 10 February 2009

Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell.

scientific article published on 30 August 2013

RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans

scientific article

Redox-mediated regulation of aging and healthspan by an evolutionarily conserved transcription factor HLH-2/Tcf3/E2A

scientific article published on 04 February 2020

Relative Trajectories of Gait and Cognitive Decline in Aging

scientific article published on 15 November 2021

Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process?

scientific article

Resistance to leptin action is the major determinant of hepatic triglyceride accumulation in vivo.

scientific article published on 10 November 2006

Resveratrol Improves Vascular Function and Mitochondrial Number but Not Glucose Metabolism in Older Adults.

scientific article published on 16 March 2017

Role of APOE Genotype in Gait Decline and Disability in Aging ⬇️

scientific article published on July 31, 2013

Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans

scientific article published on 01 October 2018

Screening Human Embryos for Polygenic Traits Has Limited Utility

scientific article published on 21 November 2019

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

scientific article published on 19 December 2017

Sequencing an Ashkenazi reference panel supports population-targeted personal genomics and illuminates Jewish and European origins

scientific article

Serum heat shock protein 70 level as a biomarker of exceptional longevity

scientific article published on 6 October 2006

Similar burden of pathogenic coding variants in exceptionally long-lived individuals and individuals without exceptional longevity

scientific article published on 29 August 2020

Statin therapy and risk of developing type 2 diabetes: a meta-analysis

scientific article published on October 2009

Strategies and Challenges in Clinical Trials Targeting Human Aging

scientific article published on 16 August 2016

Surgical removal of visceral adipose tissue: effects on insulin action

scientific article

Symptoms of Apathy Independently Predict Incident Frailty and Disability in Community-Dwelling Older Adults

scientific article published on 11 April 2017

The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature.

scientific article

The Somatotropic Axis in Human Aging: Framework for the Current State of Knowledge and Future Research

scientific article published on June 2016

The challenges in moving from ageing to successful longevity

scientific article published in January 2014

The critical role of metabolic pathways in aging

scientific article

The genetic architecture of type 2 diabetes

scientific article (publication date: 11 July 2016)

The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species

scientific article published on 9 November 2004

The influence of gender on inheritance of exceptional longevity

scientific article published in June 2015

The insulin/IGF-1 signaling in mammals and its relevance to human longevity

scientific article

The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan

scientific article published on 23 June 2020

The paradox of the insulin/IGF-1 signaling pathway in longevity

scientific article

The place of genetics in ageing research.

scientific article published on 10 July 2012

The role of dietary patterns and exceptional parental longevity in healthy aging.

scientific article published on 7 December 2017

The second international conference "genetics of aging and longevity".

scientific article published on May 2012

Tissue-specific dysregulation of DNA methylation in aging

scientific article

Treatment of diabetes mellitus in older people: oral therapy options

scientific article published on 01 February 2003

Undulating changes in human plasma proteome profiles across the lifespan

scientific article published on 05 December 2019

Unique lipoprotein phenotype and genotype associated with exceptional longevity

scientific article (publication date: 15 October 2003)

Varying Effects of APOE Alleles on Extreme Longevity in European Ethnicities

scientific article published on 01 November 2019

Visceral adipose tissue modulates mammalian longevity

scientific article published on 18 March 2008

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