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List of works by Roman Lesyk

2-[7-(3,5-Dibromo-2-hydroxyphenyl)-6-ethoxycarbonyl-2-oxo-5H-2,3,6,7-tetrahydrothiopyrano[2,3-d][1,3]thiazol-6-yl]acetic acid ethanol monosolvate ⬇️

scientific article published on August 15, 2012

2-[N-(2,4-Dimeth-oxy-phen-yl)acetamido]-1,3-thia-zol-4-yl acetate.

scientific article published on 9 February 2013

2-{5-[(,2)-2-Chloro-3-(4-nitrophenyl)-2-propenylidene]-4-oxo-2-thioxothiazolidin-3-yl}-3-methylbutanoic Acid as a Potential Anti-Breast Cancer Molecule

scientific article published on 7 April 2022

3D-MoRSE descriptors explained

scientific article published on 4 November 2014

4-Thiazolidinone derivative Les-3833 effectively inhibits viability of human melanoma cells through activating apoptotic mechanisms.

scientific article

5-Arylidene-2-(4-hydroxyphenyl)aminothiazol-4(5H)-ones with selective inhibitory activity against some leukemia cell lines

scientific article published on 25 November 2020

5-Ene-4-thiazolidinones - An efficient tool in medicinal chemistry

scientific article

5-Ene-4-thiazolidinones induce apoptosis in mammalian leukemia cells.

scientific article

5-Year Trends in QSAR and its Machine Learning Methods.

scientific article published on 9 May 2016

A facile synthesis and anticancer activity evaluation of spiro[thiazolidinone-isatin] conjugates

scientific article published on 3 October 2011

Anticancer properties of 4-thiazolidinone derivatives depend on peroxisome proliferator-activated receptor gamma (PPARγ).

scientific article published on 30 September 2017

Anticancer properties of 5Z-(4-fluorobenzylidene)-2-(4-hydroxyphenylamino)-thiazol-4-one

scientific article published on 23 July 2019

Anticancer thiopyrano[2,3-d][1,3]thiazol-2-ones with norbornane moiety. Synthesis, cytotoxicity, physico-chemical properties, and computational studies.

scientific article published on 2 May 2006

Antifibrotic and anticancer action of 5-ene amino/iminothiazolidinones.

scientific article published on 09 February 2016

Biochemical indicators of nephrotoxicity in blood serum of rats treated with novel 4-thiazolidinone derivatives or their complexes with polyethylene glycol-containing nanoscale polymeric carrier

scientific article

Bradykinin antagonists and thiazolidinone derivatives as new potential anti-cancer compounds.

scientific article

Computational Search for Possible Mechanisms of 4-Thiazolidinones Anticancer Activity: The Power of Visualization

scientific article published on 11 March 2014

Conformational space and vibrational spectra of 2-[(2,4-dimethoxyphenyl)amino]-1,3-thiazolidin-4-one

scientific article

Development of Predictive QSAR Models of 4-Thiazolidinones Antitrypanosomal Activity using Modern Machine Learning Algorithms.

scientific article published on 14 November 2017

Differential pro-apoptotic effects of synthetic 4-thiazolidinone derivative Les-3288, doxorubicin and temozolomide in human glioma U251 cells.

scientific article

Enhanced Proapoptotic Effects of Water Dispersed Complexes of 4-Thiazolidinone-Based Chemotherapeutics with a PEG-Containing Polymeric Nanocarrier

scientific article published on 23 April 2019

Fused Thiopyrano[2,3-d]thiazole Derivatives as Potential Anticancer Agents.

scientific article

Heterocyclic tautomerism: reassignment of two crystal structures of 2-amino-1,3-thiazolidin-4-one derivatives

scientific article published on 31 July 2014

Hydrogen Sulfide Releasing 2-Mercaptoacrylic Acid-Based Derivative Possesses Cytoprotective Activity in a Small Intestine of Rats with Medication-Induced Enteropathy

scientific article published on 24 October 2017

Induction of Cyp450 enzymes by 4-thiazolidinone-based derivatives in 3T3-L1 cells in vitro

scientific article published on 21 November 2020

Isothiocoumarin-3-carboxylic acid derivatives: synthesis, anticancer and antitrypanosomal activity evaluation.

scientific article

New 5-substituted thiazolo[3,2-b][1,2,4]triazol-6-ones: synthesis and anticancer evaluation

scientific article published on 9 January 2007

Putative anticancer potential of novel 4-thiazolidinone derivatives: cytotoxicity toward rat C6 glioma in vitro and correlation of general toxicity with the balance of free radical oxidation in rats

scientific article published on April 2016

Recent developments with rhodanine as a scaffold for drug discovery

scientific article

Study of novel anticancer 4-thiazolidinone derivatives.

scientific article published on 11 December 2016

Synthesis and Anticancer Activity of Isatin‐Based Pyrazolines and Thiazolidines Conjugates ⬇️

scientific article published on June 16, 2011

Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides

scientific article published on 15 September 2014

Synthesis and Biological Activity of New Thiopyrano[2,3-d]thiazoles Containing a Naphthoquinone Moiety

scientific article published on 04 February 2013

Synthesis and anticancer activity evaluation of 4-thiazolidinones containing benzothiazole moiety.

scientific article published on 12 August 2010

Synthesis and anticancer activity of 6-heteroarylcoumarins.

scientific article published on 19 October 2015

Synthesis and antitrypanosomal activity of new 6,6,7-trisubstituted thiopyrano[2,3-d][1,3]thiazoles

scientific article published on 02 October 2012

Synthesis and evaluation of anticancer activity of 5-ylidene-4- aminothiazol-2(5H)-one derivatives.

scientific article

Synthesis and evaluation of anticancer activity of 6-pyrazolinylcoumarin derivatives

scientific article published on 03 June 2016

Synthesis and in vitro anticancer activity of 2,4-azolidinedione-acetic acids derivatives

scientific article published on 27 February 2009

Synthesis of 5-arylidene-2-amino-4-azolones and evaluation of their anticancer activity.

scientific article published on 9 June 2010

Synthesis of 5-enamine-4-thiazolidinone derivatives with trypanocidal and anticancer activity

scientific article published on 22 January 2019

Synthesis of new 4-thiazolidinone-, pyrazoline-, and isatin-based conjugates with promising antitumor activity

scientific article

Synthesis of novel thiazolone-based compounds containing pyrazoline moiety and evaluation of their anticancer activity.

scientific article

Synthesis of pyrazoline-thiazolidinone hybrids with trypanocidal activity.

scientific article

Synthesis of some N-substituted nitroimidazole derivatives as potential antioxidant and antifungal agents.

scientific article published on 28 May 2008

Synthesis, antioxidant and antimicrobial activities of novel thiopyrano[2,3-d]thiazoles based on aroylacrylic acids

scientific article published on 19 April 2017

Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline-thiazolidine-based hybrids.

scientific article published on 16 February 2016

Thiazolidinone/thiazole based hybrids - New class of antitrypanosomal agents

scientific article published on 24 April 2019

Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry.

scientific article

Trends in research of antitrypanosomal agents among synthetic heterocycles.

scientific article

rel-2-[4-Chloro-2-[(5R,6R,7S)-6-[5-(4-methoxyphenyl)-3-(2-naphthyl)-3,4-dihydropyrazole-2-carbonyl]-5-methyl-2-oxo-3,5,6,7-tetrahydrothiopyrano[2,3-d]thiazol-7-yl]phenoxy]acetic Acid

scientific article published in 2022

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