List of works by Luigi Naldini

'Advanced' generation lentiviruses as efficient vectors for cardiomyocyte gene transduction in vitro and in vivo.

scientific article published on April 2003

42. Correction of SCID-X1 by Targeted Genome Editing of Hematopoietic Stem/Progenitor Cells (HSPC) in the Mouse Model

scholarly article by Giulia Schiroli published in May 2016

481. Targeted Genome Editing in Mouse Hematopoietic Stem/Progenitor Cells (HSPC) To Model Gene Correction of SCID-X1

article

5 INVITED Role of haematopoietic cells in tumour angiogenesis: from discovery to targeted cancer gene therapy

article

79. Systemic Administration of Lentiviral Vectors Triggers Innate Host Responses

article

A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood "resident" monocytes, and embryonic macrophages suggests common functions and developmental relationships

scientific article published on 21 April 2009

A double-switch vector system positively regulates transgene expression by endogenous microRNA expression (miR-ON vector).

scientific article published on 26 February 2013

A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR.

scientific article

A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis ⬇️

scientific article published on December 1, 1992

A human immunodeficiency virus type 1 pol gene-derived sequence (cPPT/CTS) increases the efficiency of transduction of human nondividing monocytes and T lymphocytes by lentiviral vectors

scientific article published in October 2002

A microRNA-based system for selecting and maintaining the pluripotent state in human induced pluripotent stem cells

scientific article

A microRNA-regulated and GP64-pseudotyped lentiviral vector mediates stable expression of FVIII in a murine model of Hemophilia A.

scientific article published on February 2011

A microRNA-regulated lentiviral vector mediates stable correction of hemophilia B mice

scientific article published on 28 August 2007

A new-generation stable inducible packaging cell line for lentiviral vectors

scientific article

A role for miR-155 in enabling tumor-infiltrating innate immune cells to mount effective antitumor responses in mice.

scientific article published on 13 March 2013

Activation of the protein-tyrosine kinase associated with the bombesin receptor complex in small cell lung carcinomas

scientific article

An unbiased genome-wide analysis of zinc-finger nuclease specificity

scientific article

An uncleavable form of pro-scatter factor suppresses tumor growth and dissemination in mice

scientific article

An uncleavable form of pro–scatter factor suppresses tumor growth and dissemination in mice

Angiopoietin 2 expression in the cornea and its control of corneal neovascularisation

scientific article

Angiopoietin-2 TIEs up macrophages in tumor angiogenesis.

scientific article

Antagonizing metastasis

scientific article published in April 2010

Assessing the impact of lentiviral vector integration on splicing of cellular genes at the genome-wide level.

scientific article published on 3 October 2011

Attenuation of miR-126 activity expands HSC in vivo without exhaustion.

scientific article

Axons mediate the distribution of arylsulfatase A within the mouse hippocampus upon gene delivery.

scientific article

B-cell reconstitution after lentiviral vector-mediated gene therapy in patients with Wiskott-Aldrich syndrome.

scientific article published on 16 March 2015

Biological Activation of pro-HGF (Hepatocyte Growth Factor) by Urokinase Is Controlled by a Stoichiometric Reaction

scientific article published in Journal of Biological Chemistry

Brain conditioning is instrumental for successful microglia reconstitution following hematopoietic stem cell transplantation

scientific article

CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma

scientific article published on 9 September 2013

CD4⁺ T cells from IPEX patients convert into functional and stable regulatory T cells by FOXP3 gene transfer

scientific article published on December 2013

CRISPR germline engineering--the community speaks

scientific article published on May 2015

Cardiomyocytes induce endothelial cells to trans-differentiate into cardiac muscle: implications for myocardium regeneration

scientific article

Cell-substratum interaction of cultured avian osteoclasts is mediated by specific adhesion structures

scientific article

Cellular innate immunity and restriction of viral infection: implications for lentiviral gene therapy in human hematopoietic cells

scientific article published on 13 April 2015

Challenges in vector and trial design using retroviral vectors for long-term gene correction in hematopoietic stem cell gene therapy

scientific article published in June 2012

Characterization of new arylsulfatase A gene mutations reinforces genotype-phenotype correlation in metachromatic leukodystrophy.

scientific article

Characterization of the detergent solubilized receptor for gastrin-releasing peptide

scientific article published on July 1990

Charting a clear path: the ASGCT Standardized Pathways Conference

scientific article

Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity

scientific article

Comprehensive genomic access to vector integration in clinical gene therapy

scientific article published on 22 November 2009

Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters.

scientific article

Correction of metachromatic leukodystrophy in the mouse model by transplantation of genetically modified hematopoietic stem cells

scientific article

Correction of mucopolysaccharidosis type IIIb fibroblasts by lentiviral vector-mediated gene transfer

scientific article

Corrigendum to "Evidence for Long-term Efficacy and Safety of Gene Therapy for Wiskott-Aldrich Syndrome in Preclinical Models".

scientific article published on July 2009

Cyclosporin a and rapamycin relieve distinct lentiviral restriction blocks in hematopoietic stem and progenitor cells

scientific article published on October 2014

Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells

article

Debate on Germline Gene Editing.

scientific article published in August 2016

Deletion in a (T)8 microsatellite abrogates expression regulation by 3'-UTR.

scientific article

Design and optimization of lentiviral vectors for transfer of GALC expression in Twitcher brain.

scientific article published in August 2006

Design of a regulated lentiviral vector for hematopoietic stem cell gene therapy of globoid cell leukodystrophy

scientific article

Development and maturation of invariant NKT cells in the presence of lysosomal engulfment

scientific article

Distribution of nerve growth factor in chick embryo sympathetic neurons in vitro

scientific article published on 01 February 1981

Dual-regulated lentiviral vector for gene therapy of X-linked chronic granulomatosis.

scientific article published on 29 May 2014

Dynamic Activity of miR-125b and miR-93 during Murine Neural Stem Cell Differentiation In Vitro and in the Subventricular Zone Neurogenic Niche.

scientific article

Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming

scientific article published on 02 October 2019

ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially.

scientific article published on January 2006

Ectopic FOXP3 Expression Preserves Primitive Features Of Human Hematopoietic Stem Cells While Impairing Functional T Cell Differentiation.

scientific article published on 17 November 2017

Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer

scientific article

Effects of phosphorylation and neuronal activity on the control of synapse formation by synapsin I

scientific article published on 01 November 2011

Efficacy of gene therapy for Wiskott-Aldrich syndrome using a WAS promoter/cDNA-containing lentiviral vector and nonlethal irradiation.

scientific article published in March 2006

Efficiency of onco-retroviral and lentiviral gene transfer into primary mouse and human B-lymphocytes is pseudotype dependent

scientific article published in February 2003

Efficient Ex Vivo Engineering and Expansion of Highly Purified Human Hematopoietic Stem and Progenitor Cell Populations for Gene Therapy

scientific article published on 13 March 2017

Efficient Tet-dependent expression of human factor IX in vivo by a new self-regulating lentiviral vector

scientific article

Efficient gene delivery and targeted expression to hepatocytes in vivo by improved lentiviral vectors

scientific article published in January 2002

Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking

scientific article published on 29 June 2020

Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector

scientific article published on October 1996

Elusive identities and overlapping phenotypes of proangiogenic myeloid cells in tumors

scientific article published on 18 February 2010

Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state

scientific article published on 16 November 2007

Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer

scientific article

Engineered tumor-infiltrating macrophages as gene delivery vehicles for interferon-α activates immunity and inhibits breast cancer progression.

scientific article published on 29 April 2014

Erratum to “Lentiviral Vector-Mediated Gene Transfer in T Cells from Wiskott–Aldrich Syndrome Patients Leads to Functional Correction”

article

Evidence for long-term efficacy and safety of gene therapy for Wiskott-Aldrich syndrome in preclinical models

scientific article

Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defects

scientific article published on 11 July 2006

Ex vivo gene transfer and correction for cell-based therapies

scientific article published on 29 March 2011

Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications

scientific article published on August 2009

FcRgamma activation regulates inflammation-associated squamous carcinogenesis.

scientific article

Fighting Rare Diseases: The Model of the Telethon Research Institutes in Italy

article

Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke

scientific article

Forkhead box protein 3 (FOXP3) mutations lead to increased TH17 cell numbers and regulatory T-cell instability

scientific article published on 13 October 2011

Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery

scientific article (publication date: 28 October 2007)

Gene therapy augments the efficacy of hematopoietic cell transplantation and fully corrects mucopolysaccharidosis type I phenotype in the mouse model.

scientific article

Gene therapy for ADA-SCID, the first marketing approval of an ex vivo gene therapy in Europe: paving the road for the next generation of advanced therapy medicinal products

scientific article

Gene therapy for a mucopolysaccharidosis type I murine model with lentiviral-IDUA vector.

scientific article

Gene therapy of metachromatic leukodystrophy reverses neurological damage and deficits in mice

scientific article

Gene therapy of storage disorders by retroviral and lentiviral vectors

scientific article

Gene therapy returns to centre stage

scientific article published on October 2015

Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences

scientific article

Generation of potent and stable human CD4+ T regulatory cells by activation-independent expression of FOXP3.

scientific article published on 6 November 2007

Genetic engineering of hematopoiesis for targeted IFN-α delivery inhibits breast cancer progression

scientific article

Genetic engineering of hematopoiesis: current stage of clinical translation and future perspectives

scientific article published on 01 March 2019

Genome editing for scalable production of alloantigen-free lentiviral vectors for in vivo gene therapy

scientific article

Genome editing: a tool for research and therapy: targeted genome editing hits the clinic

scientific article published on October 2014

Genomic instability in induced stem cells

scientific article

Good news on the clinical gene transfer front

scientific article published on 01 May 2008

HIV-1-derived lentiviral vectors directly activate plasmacytoid dendritic cells, which in turn induce the maturation of myeloid dendritic cells.

scientific article

HIV-based vectors. Preparation and use.

scientific article

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

scientific article (publication date: June 2006)

Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth

scientific article published on November 1992

Hepatocyte growth factor is a regulator of monocyte-macrophage function

scientific article published on 01 January 2001

Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk

scientific article

Human T lymphocytes transduced by lentiviral vectors in the absence of TCR activation maintain an intact immune competence

scientific article published on 20 March 2003

Hyperfunctional coagulation factor IX improves the efficacy of gene therapy in hemophilic mice

scientific article

IFNα gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment

scientific article published on 14 January 2016

Identification of hematopoietic stem cell-specific miRNAs enables gene therapy of globoid cell leukodystrophy

scientific article published in November 2010

Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer.

scientific article published on 27 February 2007

Immune responses in liver-directed lentiviral gene therapy.

scientific article published on 26 January 2013

Immunological detection of proteins phosphorylated at tyrosine in cells stimulated by growth factors or transformed by retroviral-oncogene-coded tyrosine kinases.

scientific article published in July 1986

In vitro gene therapy of mucopolysaccharidosis type I by lentiviral vectors

scientific article published in June 2002

In vivo administration of lentiviral vectors triggers a type I interferon response that restricts hepatocyte gene transfer and promotes vector clearance.

scientific article published in April 2007

In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance

scientific article published on December 2009

In vivo gene therapy of metachromatic leukodystrophy by lentiviral vectors: correction of neuropathology and protection against learning impairments in affected mice

scientific article published in March 2001

In vivo targeting of tumor endothelial cells by systemic delivery of lentiviral vectors.

scientific article published in August 2003

Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing

scientific article published on September 2016

Inserting optimism into gene therapy.

scientific article published in April 2006

Insulin B chain 9-23 gene transfer to hepatocytes protects from type 1 diabetes by inducing Ag-specific FoxP3+ Tregs.

scientific article

Integration of retroviral vectors induces minor changes in the transcriptional activity of T cells from ADA-SCID patients treated with gene therapy.

scientific article

Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens

scientific article published in Nature Communications

Intracellular distribution of nerve growth factor in rat pheochromocytoma PC12 cells: evidence for a perinuclear and intranuclear location

scientific article

In Vivo Tracking of Human Hematopoiesis Reveals Patterns of Clonal Dynamics during Early and Steady-State Reconstitution Phases

scientific article published on 25 May 2016

Large-scale manufacture and characterization of a lentiviral vector produced for clinical ex vivo gene therapy application

scientific article

Lentiviral gene transfer ameliorates disease progression in Long-Evans cinnamon rats: an animal model for Wilson disease

scientific article published on 01 August 2006

Lentiviral gene transfer and ex vivo expansion of human primitive stem cells capable of primary, secondary, and tertiary multilineage repopulation in NOD/SCID mice. Nonobese diabetic/severe combined immunodeficient

scientific article published on 01 December 2002

Lentiviral haemopoietic stem-cell gene therapy in early-onset metachromatic leukodystrophy: an ad-hoc analysis of a non-randomised, open-label, phase 1/2 trial.

scientific article published on 8 June 2016

Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy

scientific article

Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome.

scientific article

Lentiviral transduction of primary myeloma cells with CD80 and CD154 generates antimyeloma effector T cells

scientific article

Lentiviral vector common integration sites in preclinical models and a clinical trial reflect a benign integration bias and not oncogenic selection

scientific article published on 14 March 2011

Lentiviral vector gene transfer is limited by the proteasome at postentry steps in various types of stem cells

scientific article

Lentiviral vector integration profiles differ in rodent postmitotic tissues

scientific article

Lentiviral vector-based insertional mutagenesis identifies genes associated with liver cancer

scientific article published on 13 January 2013

Lentiviral vector-based insertional mutagenesis identifies genes involved in the resistance to targeted anticancer therapies

scientific article published on 8 September 2014

Lentiviral vector-mediated gene transfer in T cells from Wiskott-Aldrich syndrome patients leads to functional correction.

scientific article

Lentiviral vectors containing the human immunodeficiency virus type-1 central polypurine tract can efficiently transduce nondividing hepatocytes and antigen-presenting cells in vivo

scientific article published in August 2002

Lentiviral vectors escape innate sensing but trigger p53 in human hematopoietic stem and progenitor cells.

scientific article published on 30 June 2017

Lentiviral vectors, two decades later

scientific article

Lentiviral-mediated gene therapy leads to improvement of B-cell functionality in a murine model of Wiskott-Aldrich syndrome

scientific article

Lentivirus-mediated gene transfer into hematopoietic repopulating cells in baboons.

scientific article published in November 2002

Leukocytes recruited by tumor-derived HMGB1 sustain peritoneal carcinomatosis

scientific article published on 08 January 2016

Limited transgene immune response and long-term expression of human alpha-L-iduronidase in young adult mice with mucopolysaccharidosis type I by liver-directed gene therapy

scientific article

Liver gene therapy by lentiviral vectors reverses anti-factor IX pre-existing immunity in haemophilic mice

scientific article published on 16 September 2013

Liver-directed lentiviral gene therapy in a dog model of hemophilia B.

scientific article

Loss of transcriptional control over endogenous retroelements during reprogramming to pluripotency

scientific article

MET overexpression turns human primary osteoblasts into osteosarcomas.

scientific article published on May 2006

Manipulating Immune Tolerance with Micro-RNA Regulated Gene Therapy.

scientific article

Medicine. A comeback for gene therapy

scientific article

MicroRNA-223 dose levels fine tune proliferation and differentiation in human cord blood progenitors and acute myeloid leukemia.

scientific article published on 8 July 2015

Microtubules and microfilaments in fixed and permeabilized cells are selectively decorated by nerve growth factor

scientific article

Minicircle DNA-based gene therapy coupled with immune modulation permits long-term expression of α-L-iduronidase in mice with mucopolysaccharidosis type I

scientific article

Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome

scientific article published on 21 January 2021

Modulation of immune responses in lentiviral vector-mediated gene transfer

scientific article published on 27 April 2018

Molecular evidence of inefficient transduction of proliferating human B lymphocytes by VSV-pseudotyped HIV-1-derived lentivectors

scientific article published in August 2004

Molecular evidence of lentiviral vector-mediated gene transfer into human self-renewing, multi-potent, long-term NOD/SCID repopulating hematopoietic cells

scientific article published on November 2002

Monitoring disease evolution and treatment response in lysosomal disorders by the peripheral benzodiazepine receptor ligand PK11195.

scientific article

Multiple Integrated Non-clinical Studies Predict the Safety of Lentivirus-Mediated Gene Therapy for β-Thalassemia

article

NY-ESO-1 TCR single edited stem and central memory T cells to treat multiple myeloma without graft-versus-host disease.

scientific article

Neural stem cell gene therapy ameliorates pathology and function in a mouse model of globoid cell leukodystrophy.

scientific article published on October 2011

Novel candidate disease for gene therapy: metachromatic leukodystrophy

scientific article published on August 2007

Oncoretroviral and lentiviral vector-mediated gene therapy

scientific article published on January 2002

Pervasive supply of therapeutic lysosomal enzymes in the CNS of normal and Krabbe-affected non-human primates by intracerebral lentiviral gene therapy

scientific article published on 29 March 2016

Phagocytosis-shielded lentiviral vectors improve liver gene therapy in nonhuman primates

scientific article published on 01 May 2019

Phosphotyrosine antibodies identify the p210c-abl tyrosine kinase and proteins phosphorylated on tyrosine in human chronic myelogenous leukemia cells

scientific article published on May 1986

Post-natal cardiomyocytes can generate iPS cells with an enhanced capacity toward cardiomyogenic re-differentation

scientific article

Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1.

scientific article published in October 2017

Preclinical safety and efficacy of human CD34(+) cells transduced with lentiviral vector for the treatment of Wiskott-Aldrich syndrome

scientific article

Preclinical testing of the safety and tolerability of LV-mediated above normal alpha-L-iduronidase expression in murine and human hematopoietic cells using toxicology and biodistribution GLP studies

scientific article published on 18 July 2016

Promoter trapping reveals significant differences in integration site selection between MLV and HIV vectors in primary hematopoietic cells

scientific article published on 12 November 2004

Proteasome activity restricts lentiviral gene transfer into hematopoietic stem cells and is down-regulated by cytokines that enhance transduction.

scientific article published on 9 February 2006

Protein phosphorylation at tyrosine residues in v-abl transformed mouse lymphocytes and fibroblasts.

scientific article published in April 1986

Proteins phosphorylated on tyrosine as markers of human tumor cell lines

scientific article published on 01 April 1987

Pseudotyped human lentiviral vector-mediated gene transfer to airway epithelia in vivo.

scientific article published on April 2000

Quantitative proteomic analysis of lentiviral vectors using 2-DE.

scientific article published in July 2009

RNAi technology and lentiviral delivery as a powerful tool to suppress Tpr-Met-mediated tumorigenesis.

scientific article published on May 2005

Receptor for bombesin with associated tyrosine kinase activity.

scientific article published on December 1986

Regulated and multiple miRNA and siRNA delivery into primary cells by a lentiviral platform

scientific article published on 17 March 2009

Reprogramming T lymphocytes for melanoma adoptive immunotherapy by T-cell receptor gene transfer with lentiviral vectors.

scientific article published in December 2009

Retroviral vectors containing Tet-controlled bidirectional transcription units for simultaneous regulation of two gene activities

scientific article published on 17 July 2006

Reversible immortalisation enables genetic correction of human muscle progenitors and engineering of next-generation human artificial chromosomes for Duchenne muscular dystrophy.

scientific article published on 14 December 2017

Robust and efficient regulation of transgene expression in vivo by improved tetracycline-dependent lentiviral vectors

scientific article published on March 2002

Robust in vivo gene transfer into adult mammalian neural stem cells by lentiviral vectors

scholarly article

Role of haematopoietic cells and endothelial progenitors in tumour angiogenesis

scientific article published on 27 June 2006

SUMF1 enhances sulfatase activities in vivo in five sulfatase deficiencies

scientific article

Safer conditioning for blood stem cell transplants.

scientific article published in July 2016

Safety of arylsulfatase A overexpression for gene therapy of metachromatic leukodystrophy.

scientific article published in September 2007

Shedding of clinical-grade lentiviral vectors is not detected in a gene therapy setting.

scientific article

Site-specific integration and tailoring of cassette design for sustainable gene transfer.

scientific article published on 21 August 2011

Solubilization of the receptor for the neuropeptide gastrin-releasing peptide (bombesin) with functional ligand binding properties

scientific article published on May 1990

Stability of lentiviral vector-mediated transgene expression in the brain in the presence of systemic antivector immune responses

scientific article published on June 2005

Stable knockdown of microRNA in vivo by lentiviral vectors

scientific article

Stable transduction of quiescent CD34(+)CD38(-) human hematopoietic cells by HIV-1-based lentiviral vectors

scientific article

Stem cell gene therapy for fanconi anemia: report from the 1st international Fanconi anemia gene therapy working group meeting.

scientific article

Su.98. Defining a Role for FOXP3 in Human Cd4+ T-Cells

Systemic and targeted delivery of semaphorin 3A inhibits tumor angiogenesis and progression in mouse tumor models

scientific article published on 4 January 2011

TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice

scientific article

TIE2-expressing monocytes/macrophages regulate revascularization of the ischemic limb ⬇️

scientific article published on 07 May 2013

Targeted Gene Correction in Osteopetrotic-Induced Pluripotent Stem Cells for the Generation of Functional Osteoclasts

scientific article

Targeted gene addition in human epithelial stem cells by zinc-finger nuclease-mediated homologous recombination

scientific article published on 13 June 2013

Targeted gene therapy and cell reprogramming in Fanconi anemia

scientific article published on 23 May 2014

Targeted genome editing in human repopulating haematopoietic stem cells

scientific article published on 28 May 2014

Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells

scientific article published on 12 May 2003

Targeting lentiviral vector expression to hepatocytes limits transgene-specific immune response and establishes long-term expression of human antihemophilic factor IX in mice

scientific article

Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells.

scientific article

Targeting the tumor and its microenvironment by a dual-function decoy Met receptor

scientific article

The MET oncogene drives a genetic programme linking cancer to haemostasis

scientific article published in Nature

The Renaissance of Gene and Cell Therapy: Florence 2016.

scientific article published in October 2016

The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity

scientific article

The galactocerebrosidase enzyme contributes to the maintenance of a functional hematopoietic stem cell niche

scientific article

The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy

scientific article published on 23 March 2009

The immune response to lentiviral-delivered transgene is modulated in vivo by transgene-expressing antigen-presenting cells but not by CD4+CD25+ regulatory T cells.

scientific article published on 10 May 2007

The impact of amino acid variability on alloreactivity defines a functional distance predictive of permissive HLA-DPB1 mismatches in hematopoietic stem cell transplantation

scientific article

Therapeutic benefit of lentiviral-mediated neonatal intracerebral gene therapy in a mouse model of globoid cell leukodystrophy

scientific article

Therapeutic gene editing in CD34+ hematopoietic progenitors from Fanconi anemia patients.

scientific article published on 12 September 2017

Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors.

scientific article published in September 2005

Tie2-expressing monocytes (TEMs): novel targets and vehicles of anticancer therapy?

scientific article published on 10 April 2009

Tie2-expressing monocytes and tumor angiogenesis: regulation by hypoxia and angiopoietin-2.

scientific article published on September 2007

Tie2-expressing monocytes: regulation of tumor angiogenesis and therapeutic implications

scientific article

Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors

scientific article

Transcriptional targeting of lentiviral vectors by long terminal repeat enhancer replacement

scientific article published on April 2002

Transduction of Human CD34+CD38- Bone Marrow and Cord Blood-Derived SCID-Repopulating Cells with Third-Generation Lentiviral Vectors

scientific article published on 01 June 2000

Transduction of a gene expression cassette using advanced generation lentiviral vectors

scientific article published on 01 January 2002

Treatment of the mouse model of mucopolysaccharidosis type IIIB with lentiviral-NAGLU vector

scientific article published on June 2005

Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis

scientific article published on October 2008

Uncovering and dissecting the genotoxicity of self-inactivating lentiviral vectors in vivo

scientific article

Use of Defibrotide to help prevent post-transplant endothelial injury in a genetically predisposed infant with metachromatic leukodystrophy undergoing hematopoietic stem cell gene therapy

scientific article

Visualization of phosphotyrosine containing molecules within the detergent insoluble cell matrix of v-src transformed fibroblasts

scientific article published on November 1984

WFH State-of-the-art paper 2020: In vivo lentiviral vector gene therapy for haemophilia

scientific article published on 14 June 2020

Whole transcriptome characterization of aberrant splicing events induced by lentiviral vector integrations.

scientific article published on 23 April 2012

Widespread enzymatic correction of CNS tissues by a single intracerebral injection of therapeutic lentiviral vector in leukodystrophy mouse models

scientific article published on 4 March 2010

[26] Generation of HIV-1 derived lentiviral vectors

article

miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells

scientific article published on 20 January 2016

miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells.

scientific article published on April 2016

miR-142-3p prevents macrophage differentiation during cancer-induced myelopoiesis

scientific article published on June 2013

miR-511-3p modulates genetic programs of tumor-associated macrophages

scientific journal article

miRNA-126 Orchestrates an Oncogenic Program in B Cell Precursor Acute Lymphoblastic Leukemia

scientific article published in June 2016

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