List of works by Alysson Muotri

A human neurodevelopmental model for Williams syndrome

scientific journal article

A phenotypic spectrum of autism is attributable to the combined effects of rare variants, polygenic risk and sex

scientific article published in 2022

A quantitative framework to evaluate modeling of cortical development by neural stem cells

scientific article

A quantitative proteomic and transcriptomic comparison of human mesenchymal stem cells from bone marrow and umbilical cord vein.

scientific article published on 7 August 2012

Activity of Retrotransposons in Stem Cells and Differentiated Cells

article

Altered Gene Expression of Thyroid Hormone Transporters and Deiodinases in iPS MeCP2-Knockout Cells-Derived Neurons

scientific article published on 18 June 2019

Altered network and rescue of human neurons derived from individuals with early-onset genetic epilepsy

scientific article published on 22 April 2021

Altered proliferation and networks in neural cells derived from idiopathic autistic individuals

scientific article published on 05 July 2016

Alternative splicing events identified in human embryonic stem cells and neural progenitors

scientific article published on 24 August 2007

Analysis of LINE-1 Retrotransposition in Neural Progenitor Cells and Neurons

article

Astroglial cells regulate the developmental timeline of human neurons differentiated from induced pluripotent stem cells

scientific article published on 16 May 2013

Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells

scientific article published on 9 December 2011

Author Correction: Blocking Zika virus vertical transmission.

scientific article published on 5 June 2018

Author Correction: L1-associated genomic regions are deleted in somatic cells of the healthy human brain

scientific article published on 01 July 2018

Autism Spectrum Disorders: Challenges and perspectives

scientific article published on 8 March 2018

Autism spectrum disorders and disease modeling using stem cells

scientific article published on 16 September 2017

Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling

scientific article published on 16 March 2021

Autophagy in stem cell maintenance and differentiation

scientific article published on 04 January 2012

Blocking Zika virus vertical transmission

scientific article published on 19 January 2018

Bradykinin promotes neuron-generating division of neural progenitor cells through ERK activation.

scientific article

Brain Organoids and the Study of Neurodevelopment

scholarly article by Cleber A Trujillo published in October 2018

Brain Organoids as Tools for Modeling Human Neurodevelopmental Disorders

scientific article published on 01 September 2019

Brain organoids and insights on human evolution

scientific article published in 2019

Brain organoids as a model system for human neurodevelopment and disease

scientific article published on 23 March 2019

Brainstem Organoids From Human Pluripotent Stem Cells

scientific article published on 26 June 2020

Cellular and Animal Models of Neurologic Disease

scientific article published in 2017

Chemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics

scientific article published on 14 December 2018

Cockayne syndrome-derived neurons display reduced synapse density and altered neural network synchrony

scientific article published on 10 January 2016

Comment on “Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals”

scientific article published on 29 March 2023

Complementation of the DNA repair deficiency in human xeroderma pigmentosum group a and C cells by recombinant adenovirus-mediated gene transfer.

scientific article published in October 2002

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development

scientific article published on 29 August 2019

Contributors

article

Coordination of centrosome homeostasis and DNA repair is intact in MCF-7 and disrupted in MDA-MB 231 breast cancer cells

scientific article published on 13 April 2010

Corrigendum: L1-associated genomic regions are deleted in somatic cells of the healthy human brain.

scientific article

Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism

scientific article published on 26 August 2021

Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders

scientific article

DNA repair proteins affect the lifecycle of herpes simplex virus 1.

scientific article

Development of functional human embryonic stem cell-derived neurons in mouse brain

scientific article

Differential L1 regulation in pluripotent stem cells of humans and apes.

scientific article published on 23 October 2013

Direct Generation of Human Cortical Organoids from Primary Cells

scientific article published on 22 September 2018

Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients

scientific article

Editorial: Brain Organoids: Modeling in Neuroscience

scientific article published on 21 October 2020

Efficient generation of human iPSCs by a synthetic self-replicative RNA.

scientific article

Engineered LINE-1 retrotransposition in nondividing human neurons

scientific article published on 13 December 2016

Environmental influence on L1 retrotransposons in the adult hippocampus

scientific article published on October 2009

Evidence for premature aging due to oxidative stress in iPSCs from Cockayne syndrome

scientific article

Evidence of nuclei-encoded spliceosome mediating splicing of mitochondrial RNA.

scientific article published in July 2017

Evidence of nuclei-encoded spliceosome mediating splicing of mitochondrial RNA.

scientific article

Evolution, development, and plasticity of the human brain: from molecules to bones

scientific article (publication date: 30 October 2013)

Exercise induces age-dependent changes on epigenetic parameters in rat hippocampus: a preliminary study

scientific journal article

Exosomes regulate neurogenesis and circuit assembly

scientific article published on 18 July 2019

Exploring DNA damage responses in human cells with recombinant adenoviral vectors.

scientific article

Feeder-free derivation of induced pluripotent stem cells from human immature dental pulp stem cells

scientific article

Frequency and Complexity of De Novo Structural Mutation in Autism

scientific article

Frequency and association of mitochondrial genetic variants with neurological disorders

scientific article published on 13 September 2018

Functional lentiviral vectors for xeroderma pigmentosum gene therapy.

scientific article

Gene expression profile of mesenchymal stem cells from paired umbilical cord units: cord is different from blood

scientific article

Gene transduction in skin cells: preventing cancer in xeroderma pigmentosum mice

scientific article

Generation of neuronal variability and complexity

scientific article published on June 2006

Genetic variations on SETD5 underlying autistic conditions

scientific article published on 26 February 2018

Getting to the Cores of Autism

scientific article published on 01 September 2019

Hematopoietic stem cell transplantation protects mice from lethal stroke

scientific article

Human embryonic stem cells express an immunogenic nonhuman sialic acid

scientific article

IGF1 neuronal response in the absence of MECP2 is dependent on TRalpha 3.

scientific article published on 22 December 2016

Identification of XP complementation groups by recombinant adenovirus carrying DNA repair genes

article

Identification of a neuronal gene expression signature: role of cell cycle arrest in murine neuronal differentiation in vitro

scientific article

Identification of small molecules from human embryonic stem cells using metabolomics

scientific article published on December 2007

Intact piRNA pathway prevents L1 mobilization in male meiosis

scientific article

Interactome analysis illustrates diverse gene regulatory processes associated with LIN28A in human iPS cell-derived neural progenitor cells

scientific article published on 23 October 2021

KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome

scientific article

Kinin-B2 receptor activity determines the differentiation fate of neural stem cells

scientific article

L1 Retrotransposition in Neural Progenitor Cells.

scientific article published in January 2016

L1 retrotransposition in neurons is modulated by MeCP2 ⬇️

scientific article published on November 18, 2010

L1-associated genomic regions are deleted in somatic cells of the healthy human brain.

scientific article published on 12 September 2016

LINE-1 Retrotransposons in Healthy and Diseased Human Brain

scientific article published on 14 December 2017

LINE-1 retrotransposition in human embryonic stem cells

scientific article published on 27 April 2007

LINE-1 retrotransposition in the nervous system

scientific article published on January 2012

LINE-1: creators of neuronal diversity

scientific article

Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction

scientific article published on 4 March 2016

Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research

scientific article

Low amounts of the DNA repair XPA protein are sufficient to recover UV-resistance.

scientific article

Maintenance and differentiation of neural stem cells ⬇️

scientific article published on January 1, 2011

Mesenchymal stem cells from umbilical cord: Do not discard the cord!

scientific article published on 21 December 2007

Metabolic and Organelle Morphology Defects in Mice and Human Patients Define Spinocerebellar Ataxia Type 7 as a Mitochondrial Disease

Methadone Suppresses Neuronal Function and Maturation in Human Cortical Organoids

scientific article published on 23 November 2020

Methadone interrupts neural growth and function in human cortical organoids

scientific article published on 27 October 2020

Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function ⬇️

scientific article published on May 14, 2003

Micro RNA detection in long-term fixed tissue of cortical glutamatergic pyramidal neurons after targeted laser-capture neuroanatomical microdissection

scientific article

Modeling Rett Syndrome With Human Patient-Specific Forebrain Organoids

scientific article published on 10 December 2020

Modeling Williams syndrome with induced pluripotent stem cells

scientific article published on 6 February 2017

Modeling autism spectrum disorders with human neurons

scientific article published on 4 February 2016

Modeling epilepsy with pluripotent human cells

scientific article published on 19 October 2008

Modeling neuro-immune interactions during Zika virus infection

scientific article published on 17 October 2017

Modeling neurodevelopmental disorders using human neurons

scientific article

Modeling of TREX1-Dependent Autoimmune Disease using Human Stem Cells Highlights L1 Accumulation as a Source of Neuroinflammation

scientific article published on 2 August 2017

Modeling the Interplay Between Neurons and Astrocytes in Autism Using Human Induced Pluripotent Stem Cells

scientific article

Molecular neuroanatomy of anorexia nervosa

scientific article published on 10 July 2020

Multiple layers of molecular controls modulate self-renewal and neuronal lineage specification of embryonic stem cells

scientific article published on April 2008

Multipotent Stem Cells from Umbilical Cord: Cord Is Richer than Blood!

scientific article published on 11 October 2007

Neurotoxic Methamphetamine Doses Increase LINE-1 Expression in the Neurogenic Zones of the Adult Rat Brain

scientific article

Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells

scientific article

Noncoding RNAs in the mammalian central nervous system.

scientific article published on January 2006

Novel tools, classic techniques: evolutionary studies using primate pluripotent stem cells

scientific article

Overexpression of KLC2 due to a homozygous deletion in the non-coding region causes SPOAN syndrome.

scientific article published on 18 September 2015

Parkinson's disease patient-specific neuronal networks carrying the LRRK2 G2019S mutation unveil early functional alterations that predate neurodegeneration

scientific article published on 02 July 2021

Paternally inherited cis-regulatory structural variants are associated with autism.

scientific article published in April 2018

Pharmacological Bypass of Cockayne Syndrome B Function in Neuronal Differentiation

scientific article published on 09 March 2016

Pharmacological reversal of synaptic and network pathology in human MECP2-KO neurons and cortical organoids

scientific article published on 08 December 2020

Pig models of neurodegenerative disorders: Utilization in cell replacement-based preclinical safety and efficacy studies.

scientific article published on 12 April 2014

Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA.

scientific article

Proteomic analyses reveal misregulation of LIN28 expression and delayed timing of glial differentiation in human iPS cells with MECP2 loss-of-function

scientific article published on 21 February 2019

Publisher Correction: A phenotypic spectrum of autism is attributable to the combined effects of rare variants, polygenic risk and sex

correction of a scholarly article

Repurposing of the anti-malaria drug chloroquine for Zika Virus treatment and prophylaxis

scientific article published on 17 November 2017

Restoring DNA repair capacity of cells from three distinct diseases by XPD gene-recombinant adenovirus.

scientific article

Setd5 haploinsufficiency alters neuronal network connectivity and leads to autistic-like behaviors in mice

scientific article published on 17 January 2019

Severe Hypoxia: Consequences to Neural Stem Cells and Neurons

scientific article published on January 2011

Skeletal muscle cells expressing VEGF induce capillary formation and reduce cardiac injury in rats.

scientific article published on 3 May 2006

Species-specific maturation profiles of human, chimpanzee and bonobo neural cells

scientific article published on 07 February 2019

Stem cell contributions to neurological disease modeling and personalized medicine

scientific article published on 30 May 2017

Stem cells and modeling of autism spectrum disorders

scientific article

Survival of syngeneic and allogeneic iPSC-derived neural precursors after spinal grafting in minipigs

scientific article published on 01 May 2018

Systematic optimization of human pluripotent stem cells media using Design of Experiments

scientific article published on 5 May 2015

TRPC Channels and Mental Disorders

scientific article published in January 2017

The Brazilian Zika virus strain causes birth defects in experimental models

scientific article

The Human Model: Changing Focus on Autism Research

scientific article

The L1 adhesion molecule normalizes neuritogenesis in Rett syndrome-derived neural precursor cells

scientific article

The Na+/HCO3- co-transporter is protective during ischemia in astrocytes

scientific article

The Use of Induced Pluripotent Stem Cell Technology to Advance Autism Research and Treatment

scientific article

The contribution of GTF2I haploinsufficiency to Williams syndrome.

scientific article published on 3 January 2018

The necessary junk: new functions for transposable elements

scientific article published on October 2007

Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions

scientific article published on 04 June 2020

Tissue-type plasminogen activator-primed human iPSC-derived neural progenitor cells promote motor recovery after severe spinal cord injury

scientific article published on 17 December 2019

Towards a 21st-century roadmap for biomedical research and drug discovery: consensus report and recommendations.

scientific article published on 28 October 2016

Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content

scientific article published on 02 May 2022

Transcription factor 4 and its association with psychiatric disorders

scientific article published on 05 January 2021

Transcriptional signature and memory retention of human-induced pluripotent stem cells

scientific article

Transposable Elements, Inflammation, and Neurological Disease

scientific article published on 20 August 2019

Treadmill exercise induces age-related changes in aversive memory, neuroinflammatory and epigenetic processes in the rat hippocampus

scientific article

UV-mediated NF-kappaB activation is abolished in deficient XPC/D primary fibroblasts.

scientific article

Unconventional translation of mammalian LINE-1 retrotransposons.

scientific article

Vibrating in the background ⬇️

scientific article published on 01 November 2003

What makes each brain unique

scientific article published in March 2012

Wide spectrum of neuronal and network phenotypes in human stem cell-derived excitatory neurons with Rett syndrome-associated MECP2 mutations

scientific article published in 2022

Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis.

scientific article published on 23 August 2009

XPC deficiency is related to APE1 and OGG1 expression and function.

scientific article published on 16 January 2016

Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis

scientific article published on 16 January 2020

Paulina is supported by:

About Paulina

Help