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List of works by Aleksander S. Popel

A Computational Model of Neoadjuvant PD-1 Inhibition in Non-Small Cell Lung Cancer

scientific article published on 24 June 2019

A Mathematical Model of Countercurrent Exchange of Oxygen Between Paired Arterioles and Venules.

scientific article published in September 1988

A QSP Model for Predicting Clinical Responses to Monotherapy, Combination and Sequential Therapy Following CTLA-4, PD-1, and PD-L1 Checkpoint Blockade

scientific article published on 02 August 2019

A biochemical model of matrix metalloproteinase 9 activation and inhibition

scientific article published on 11 September 2007

A bioimage informatics based reconstruction of breast tumor microvasculature with computational blood flow predictions.

scientific article published on 14 December 2013

A biomimetic collagen derived peptide exhibits anti-angiogenic activity in triple negative breast cancer

scientific article

A compartment model of VEGF distribution in blood, healthy and diseased tissues.

scientific article

A compartment model of VEGF distribution in humans in the presence of soluble VEGF receptor-1 acting as a ligand trap

scientific article

A compartmental model for oxygen transport in brain microcirculation

scientific article published in January 1989

A compartmental model for oxygen transport in brain microcirculation in the presence of blood substitutes

scientific article published in June 2002

A computational model of intracellular oxygen sensing by hypoxia-inducible factor HIF1 alpha

scientific article published on August 2006

A computational model of oxygen delivery by hemoglobin-based oxygen carriers in three-dimensional microvascular networks.

scientific article published on 16 June 2007

A computational model of oxygen transport in skeletal muscle for sprouting and splitting modes of angiogenesis

scientific article published on 4 January 2006

A computational study of the effect of capillary network anastomoses and tortuosity on oxygen transport

scientific article published on 01 September 2000

A computational study of the effect of vasomotion on oxygen transport from capillary networks

scientific article published on 01 March 2001

A computer-based method for determination of the cell-free layer width in microcirculation

scientific article published in April 2006

A model for cochlear outer hair cell deformations in micropipette aspiration experiments: an analytical solution

scientific article published in July 1996

A model of nitric oxide capillary exchange.

scientific article published in December 2003

A multiscale computational model predicts distribution of anti-angiogenic isoform VEGF165b in peripheral arterial disease in human and mouse

scientific article

A peptide derived from type 1 thrombospondin repeat-containing protein WISP-1 inhibits corneal and choroidal neovascularization

scientific article

A reaction-diffusion model of basic fibroblast growth factor interactions with cell surface receptors

scientific article published on May 2004

A systematic methodology for proteome-wide identification of peptides inhibiting the proliferation and migration of endothelial cells

scholarly article

A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use.

scientific article published on 16 October 2009

A systems biology view of blood vessel growth and remodelling

scientific article

A theoretical analysis of intracellular oxygen diffusion

scientific article published on 01 October 1995

A theoretical analysis of the effect of the particulate nature of blood on oxygen release in capillaries

scientific article

A theoretical model of type I collagen proteolysis by matrix metalloproteinase (MMP) 2 and membrane type 1 MMP in the presence of tissue inhibitor of metalloproteinase 2.

scientific article published on 12 July 2004

A two-compartment model of VEGF distribution in the mouse

scientific article

Aggregate formation of erythrocytes in postcapillary venules

scientific article published on 30 September 2004

Algorithm for computing oxygen dissociation curve with pH, PCO2, and CO in sheep blood

scientific article published in January 1989

An agent-based model of cancer stem cell initiated avascular tumour growth and metastasis: the effect of seeding frequency and location

scientific article

An analytical solution for steady flow of a Quemada fluid in a circular tube

scientific article published on July 1993

An experimental and theoretical study on the dissolution of mural fibrin clots by tissue-type plasminogen activator

scientific article published on 01 February 2002

An immersed boundary lattice Boltzmann approach to simulate deformable liquid capsules and its application to microscopic blood flows

scientific article published on 21 November 2007

Analysis of Capillary-Tissue Diffusion in Multicapillary Systems.

scientific article published on June 1978

Analysis of VEGF--a regulated gene expression in endothelial cells to identify genes linked to angiogenesis

scientific article published in 2011

Analysis of gene expression of secreted factors associated with breast cancer metastases in breast cancer subtypes

scientific article

Analysis of the micropipet experiment with the anisotropic outer hair cell wall

scientific article published in February 1998

Analysis of vascular pattern and dimensions in arteriolar networks of the retractor muscle in young hamsters

scientific article published in September 1987

Angiogenesis interactome and time course microarray data reveal the distinct activation patterns in endothelial cells

scientific article

Angiogenesis-associated crosstalk between collagens, CXC chemokines, and thrombospondin domain-containing proteins

scientific article published on 18 May 2011

Anisotropic poly(lactic-co-glycolic acid) microparticles enable sustained release of a peptide for long-term inhibition of ocular neovascularization

scientific article published on 30 July 2019

Anti-angiogenic peptides for cancer therapeutics

scientific article

Anti-angiogenic peptides identified in thrombospondin type I domains

scientific article published on 14 May 2007

Antiangiogenic cancer drug sunitinib exhibits unexpected proangiogenic effects on endothelial cells

scientific article

Application of Chimera grid to modelling cell motion and aggregation in a narrow tube.

scientific article published on 19 June 2006

Assessment and impact of heterogeneities of convective oxygen transport parameters in capillaries of striated muscle: experimental and theoretical

scientific article published in May 1988

Blood flow and cell-free layer in microvessels

scientific article published on November 2010

Blood-plasma separation in Y-shaped bifurcating microfluidic channels: a dissipative particle dynamics simulation study

scientific article

Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis

scientific article

Calculations of intracapillary oxygen tension distributions in muscle

scientific article published in October 2000

Calculations of oxygen transport by red blood cells and hemoglobin solutions in capillaries

scientific article published in May 2002

Canine sternal force-displacement relationship during cardiopulmonary resuscitation

scientific article published on 01 July 1999

Collagen IV and CXC chemokine-derived antiangiogenic peptides suppress glioma xenograft growth.

scientific article

Compartment model predicts VEGF secretion and investigates the effects of VEGF trap in tumor-bearing mice

scientific article published on 30 July 2013

Computational Model of Gab1/2-Dependent VEGFR2 Pathway to Akt Activation.

scientific article

Computational Model of MicroRNA Control of HIF-VEGF Pathway: Insights into the Pathophysiology of Ischemic Vascular Disease and Cancer

scientific article published on 20 November 2015

Computational analysis of the tether-pulling experiment to probe plasma membrane-cytoskeleton interaction in cells.

scientific article published on 06 October 2009

Computational drug repositioning for peripheral arterial disease: prediction of anti-inflammatory and pro-angiogenic therapeutics

scientific article

Computational fluid dynamic simulation of aggregation of deformable cells in a shear flow

scientific article published in December 2005

Computational fluid dynamics of aggregating red blood cells in postcapillary venules

scientific article published on August 2009

Computational investigation of sphingosine kinase 1 (SphK1) and calcium dependent ERK1/2 activation downstream of VEGFR2 in endothelial cells

scientific article

Computational model of VEGFR2 pathway to ERK activation and modulation through receptor trafficking.

scientific article published on 29 August 2013

Computational model of vascular endothelial growth factor spatial distribution in muscle and pro-angiogenic cell therapy

scientific article

Computational models of VEGF-associated angiogenic processes in cancer

scientific article published on 25 January 2011

Computational systems biology approaches to anti-angiogenic cancer therapeutics.

scientific article

Constructing the angiome: a global angiogenesis protein interaction network

scientific article

Contribution of nNOS- and eNOS-derived NO to microvascular smooth muscle NO exposure

scientific article published on 19 March 2004

Contributions of collision rate and collision efficiency to erythrocyte aggregation in postcapillary venules at low flow rates

scientific article published on 6 July 2007

Converging three-dimensional Stokes flow of two fluids in a T-type bifurcation.

scientific article published on July 1994

Corrigendum: Inhibition of VEGFR2 Activation and Its Downstream Signaling to ERK1/2 and Calcium by Thrombospondin-1 (TSP1): In silico Investigation

scientific article published on 7 March 2017

Crosstalk between cancer cells and blood endothelial and lymphatic endothelial cells in tumour and organ microenvironment

scientific article

Development of a biomimetic peptide derived from collagen IV with anti-angiogenic activity in breast cancer ⬇️

scientific article published on November 1, 2011

Diffusion in tissue slices with metabolism obeying Michaelis-Menten kinetics ⬇️

scientific article published on October 7, 1979

Dimerization of VEGF receptors and implications for signal transduction: a computational study

scientific article

Distinct modes of collagen type I proteolysis by matrix metalloproteinase (MMP) 2 and membrane type I MMP during the migration of a tip endothelial cell: insights from a computational model.

scientific article published on 6 July 2005

Effect of Heterogeneous Oxygen Delivery on the Oxygen Distribution in Skeletal Muscle

scientific article published on September 1986

Effect of convection in capillaries on oxygen removal from arterioles in striated muscle

scientific article published on 01 November 1990

Effect of dispersion of vessel diameters and lengths in stochastic networks. I. Modeling of microcirculatory flow

scientific article published in March 1986

Effect of dispersion of vessel diameters and lengths in stochastic networks. II. Modeling of microvascular hematocrit distribution

scientific article published in March 1986

Effect of erythrocyte aggregation at normal human levels on functional capillary density in rat spinotrapezius muscle.

scientific article

Effect of intracapillary resistance to oxygen transport on the diffusional shunting between capillaries

scientific article published in October 1988

Effect of nonaxisymmetric hematocrit distribution on non-Newtonian blood flow in small tubes

scientific article published on 01 January 1998

Effect of outer hair cell piezoelectricity on high-frequency receptor potentials

scientific article published on 01 January 2003

Effect of red blood cell shape on oxygen transport in capillaries.

scientific article published in July 1993

Effect of tumor microenvironment on tumor VEGF during anti-VEGF treatment: systems biology predictions

scientific article published on 13 May 2013

Effect of voltage-dependent membrane properties on active force generation in cochlear outer hair cell

scientific article published in December 2005

Effects of chlorpromazine on mechanical properties of the outer hair cell plasma membrane.

scientific article

Effects of endothelial cell proliferation and migration rates in a computational model of sprouting angiogenesis

scientific article

Effects of erythrocyte deformability and aggregation on the cell free layer and apparent viscosity of microscopic blood flows

scientific article

Elastic properties of the composite outer hair cell wall.

scientific article published on January 1998

Elongation, proliferation & migration differentiate endothelial cell phenotypes and determine capillary sprouting

scientific article

Endothelial cell-by-cell profiling reveals the temporal dynamics of VEGFR1 and VEGFR2 membrane localization after murine hindlimb ischemia.

scientific article

Endothelial cells decode VEGF-mediated Ca2+ signaling patterns to produce distinct functional responses

scientific article

Estimation of elastic moduli and bending stiffness of the anisotropic outer hair cell wall

scientific article published in February 1998

Expression of VEGF receptors on endothelial cells in mouse skeletal muscle.

scientific article

Extracellular regulation of VEGF: isoforms, proteolysis, and vascular patterning.

scientific article

Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysis ⬇️

scientific article

Gene delivery nanoparticles to modulate angiogenesis

scientific article published on 29 November 2016

Hemorrhagic shock and nitric oxide release from erythrocytic nitric oxide synthase: a quantitative analysis.

scientific article published on 10 March 2009

High-frequency force generation in the constrained cochlear outer hair cell: a model study

scientific article

Hypotonic swelling of salicylate-treated cochlear outer hair cells

scientific article published on March 2007

Identification of dynamic mechanical parameters of the human chest during manual cardiopulmonary resuscitation

scientific article published on 01 February 1990

Identification of novel short peptides derived from the alpha 4, alpha 5, and alpha 6 fibrils of type IV collagen with anti-angiogenic properties

scientific article published on 16 January 2007

Immunoactivating the tumor microenvironment enhances immunotherapy as predicted by integrative computational model

scientific article published on 26 February 2020

Impaired angiogenesis after hindlimb ischemia in type 2 diabetes mellitus: differential regulation of vascular endothelial growth factor receptor 1 and soluble vascular endothelial growth factor receptor 1

scientific article published on 06 September 2007

In silico simulation of a clinical trial with anti-CTLA-4 and anti-PD-L1 immunotherapies in metastatic breast cancer using a systems pharmacology model.

scientific article published on 22 May 2019

Increase of plasma VEGF after intravenous administration of bevacizumab is predicted by a pharmacokinetic model

scientific article published on 30 November 2010

Inhibition of VEGFR2 Activation and Its Downstream Signaling to ERK1/2 and Calcium by Thrombospondin-1 (TSP1): In silico Investigation

scientific article published on 06 February 2017

Inhibition of breast cancer growth and metastasis by a biomimetic peptide

scientific article

Inhibition of lymphangiogenesis and angiogenesis in breast tumor xenografts and lymph nodes by a peptide derived from transmembrane protein 45A

scientific article published on February 2013

Interactions of VEGF isoforms with VEGFR-1, VEGFR-2, and neuropilin in vivo: a computational model of human skeletal muscle

scientific article published on 15 September 2006

Long-term suppression of ocular neovascularization by intraocular injection of biodegradable polymeric particles containing a serpin-derived peptide

scientific article

Lymphatic endothelial cells support tumor growth in breast cancer

scientific article published on 28 July 2014

MASS TRANSFER IN THE ENTRANCE REGION OF A CIRCULAR TUBE.

scientific article published in August 1978

MOTION OF A RIGID CYLINDER BETWEEN PARALLEL PLATES IN STOKES FLOW: PART 2: POISEUILLE AND COUETTE FLOW.

scientific article published on January 1987

Mathematical Modeling of Oxygen Transport Near a Tissue Surface: Effect of the Surface PO2.

scientific article published on August 1981

Measurements and a model of the outer hair cell hydraulic conductivity

scientific article published in July 1996

Mechanistic Computational Models of MicroRNA-Mediated Signaling Networks in Human Diseases

scientific article published on 19 January 2019

Mechanosensitive channels in the lateral wall can enhance the cochlear outer hair cell frequency response

scientific article published in August 2005

Micro- and nanomechanics of the cochlear outer hair cell.

scientific article

Microcirculation Physiome Project

scientific article published on 01 May 1999

Microcirculation and Hemorheology

scientific article published on January 2005

Modeling high-frequency electromotility of cochlear outer hair cell in microchamber experiment

scientific article published in April 2005

Modeling of growth factor-receptor systems from molecular-level protein interaction networks to whole-body compartment models

scientific article published on January 2009

Modeling the circulation with three-terminal electrical networks containing special nonlinear capacitors

scientific article published on January 1, 1992

Modeling the mechanics of tethers pulled from the cochlear outer hair cell membrane

scientific article published in June 2008

Module-based multiscale simulation of angiogenesis in skeletal muscle

scientific article

Monte Carlo simulations of VEGF binding to cell surface receptors in vitro

scientific article published on 5 October 2005

Motion of a Rigid Cylinder Between Parallel Plates in Stokes Flow: Part 1: Motion in A Quiescent Fluid and Sedimentation

scientific article published on January 1987

Multi-scale Modeling in Clinical Oncology: Opportunities and Barriers to Success.

scientific article

Multi-scale computational models of pro-angiogenic treatments in peripheral arterial disease

scientific article published on 10 April 2007

Multiscale Agent-Based and Hybrid Modeling of the Tumor Immune Microenvironment

Multiscale Modeling in the Clinic: Drug Design and Development

scientific article published on 17 February 2016

Multiscale imaging and computational modeling of blood flow in the tumor vasculature.

scientific article published on 08 May 2012

Multiscale models of angiogenesis

scientific article

Nanostructure, effective properties, and deformation pattern of the cochlear outer hair cell cytoskeleton

scientific article published on 01 April 2002

Nitric oxide from nitrite reduction by hemoglobin in the plasma and erythrocytes.

scientific article published on 09 October 2007

Nitric oxide production pathways in erythrocytes and plasma.

scientific article published on January 2009

Nonlinear active force generation by cochlear outer hair cell

scientific article published on 01 April 1999

Novel anti-angiogenic peptides derived from ELR-containing CXC chemokines.

scientific article published in July 2008

Novel peptide-specific quantitative structure-activity relationship (QSAR) analysis applied to collagen IV peptides with antiangiogenic activity

scientific article published on 13 September 2011

Numerical Solution of Two-Dimensional Stokes Equations for Flow with Particles in a Channel of Arbitrary Shape Using Boundary-Conforming Coordinates

scientific article published on November 1986

Outer hair cell active force generation in the cochlear environment

scientific article

Outer hair cell length changes in an external electric field. I. The role of intracellular electro-osmotically generated pressure gradients

scientific article published in October 1995

Outer hair cell length changes in an external electric field. II. The role of electrokinetic forces on the cell surface

scientific article published on 01 October 1995

Oxygen diffusive shunts under conditions of heterogeneous oxygen delivery

scientific article published on 01 June 1982

Oxygen tension profiles in isolated hamster retractor muscle at different temperatures

scientific article published in May 1996

PADPIN: protein-protein interaction networks of angiogenesis, arteriogenesis, and inflammation in peripheral arterial disease

scientific article

Parametric analysis of the relationship between end-capillary and mean tissue PO2 as predicted by a mathematical model

scientific article published in December 1998

Pentastatin-1, a collagen IV derived 20-mer peptide, suppresses tumor growth in a small cell lung cancer xenograft model

scientific article

Peptides derived from type I thrombospondin repeat-containing proteins of the CCN family inhibit proliferation and migration of endothelial cells

scientific article published on 30 July 2007

Pharmacokinetics and pharmacodynamics of VEGF-neutralizing antibodies

scientific article

Pharmacokinetics of Anti-VEGF Agent Aflibercept in Cancer Predicted by Data-Driven, Molecular-Detailed Model

scientific article

Potential distribution for a spheroidal cell having a conductive membrane in an electric field

scientific article published in September 1996

Pre-treatment of mice with tumor-conditioned media accelerates metastasis to lymph nodes and lungs: a new spontaneous breast cancer metastasis model.

scientific article published on 21 August 2013

Predicting the effects of anti-angiogenic agents targeting specific VEGF isoforms.

scientific article

Protein transport to choroid and retina following periocular injection: theoretical and experimental study

scientific article published on 3 February 2007

Quantification and cell-to-cell variation of vascular endothelial growth factor receptors ⬇️

scientific article published on December 23, 2010

Quantifying the proteolytic release of extracellular matrix-sequestered VEGF with a computational model

scientific article

Quantitative fluorescent profiling of VEGFRs reveals tumor cell and endothelial cell heterogeneity in breast cancer xenografts.

scientific article published on 22 January 2014

Reactive oxygen species regulate hypoxia-inducible factor 1alpha differentially in cancer and ischemia

scientific article published on 16 June 2008

Regulation of the tumor immune microenvironment and vascular normalization in TNBC murine models by a novel peptide

scientific article published on 14 May 2020

Skeletal muscle VEGF gradients in peripheral arterial disease: simulations of rest and exercise

scientific article published on 21 September 2007

Small peptides derived from somatotropin domain-containing proteins inhibit blood and lymphatic endothelial cell proliferation, migration, adhesion and tube formation

scientific article published on 6 September 2011

Structure–Activity Relationship Study of Collagen‐Derived Anti‐Angiogenic Biomimetic Peptides ⬇️

scientific article published on April 27, 2012

Suppression of Ocular Vascular Inflammation through Peptide-Mediated Activation of Angiopoietin-Tie2 Signaling

scientific article published on 21 July 2020

Synergy between a collagen IV mimetic peptide and a somatotropin-domain derived peptide as angiogenesis and lymphangiogenesis inhibitors.

scientific article published on 29 September 2012

Systems Biology and Physiome Projects ⬇️

scientific article published on September 1, 2009

Systems biology of pro-angiogenic therapies targeting the VEGF system

scientific article

Systems biology of vascular endothelial growth factors

scientific article

Targeting neuropilin-1 to inhibit VEGF signaling in cancer: Comparison of therapeutic approaches

scientific article

Temporal and spatial variations of cell-free layer width in arterioles

scientific article

The Angiogenic Secretome in VEGF overexpressing Breast Cancer Xenografts

scientific article published on 20 December 2016

The cost of departure from optimal radii in microvascular networks

scientific article published in February 1989

The presence of VEGF receptors on the luminal surface of endothelial cells affects VEGF distribution and VEGF signaling

scientific article

The ratio of elastic moduli of cochlear outer hair cells derived from osmotic experiments

scientific article published in February 1996

Theoretical analysis of biochemical pathways of nitric oxide release from vascular endothelial cells

scientific article published on 19 May 2006

Theoretical models for coronary vascular biomechanics: progress & challenges

scientific article (publication date: 2011)

Three autocrine feedback loops determine HIF1 alpha expression in chronic hypoxia.

scientific article published on 20 July 2007

Trans-scleral delivery of antiangiogenic proteins

scientific article published in February 2008

Transcriptional and Post-Transcriptional Regulation of Thrombospondin-1 Expression: A Computational Model.

scientific article

Tumor Ensemble-Based Modeling and Visualization of Emergent Angiogenic Heterogeneity in Breast Cancer ⬇️

scientific article published on 27 March 2019

Tyrosine kinase blocking collagen IV-derived peptide suppresses ocular neovascularization and vascular leakage

scientific article published in January 2017

VEGF and soluble VEGF receptor-1 (sFlt-1) distributions in peripheral arterial disease: an in silico model

scientific article

VEGF gradients, receptor activation, and sprout guidance in resting and exercising skeletal muscle

scientific article published on 12 October 2006

Vascular and perivascular nitric oxide release and transport: biochemical pathways of neuronal nitric oxide synthase (NOS1) and endothelial nitric oxide synthase (NOS3).

scientific article

Vascular smooth muscle NO exposure from intraerythrocytic SNOHb: a mathematical model

scientific article published in August 2007

Vasculature-specific MRI reveals differential anti-angiogenic effects of a biomimetic peptide in an orthotopic breast cancer model

scientific article

Venular endothelium-derived NO can affect paired arteriole: a computational model

scientific article

Wall shear stress differentially affects NO level in arterioles for volume expanders and Hb-based O2 carriers

scientific article

Where is VEGF in the body? A meta-analysis of VEGF distribution in cancer.

scientific article published on 2 October 2007

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