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List of works by Irja Lutsar

A CCL5 Haplotype Is Associated with Low Seropositivity Rate of HCV Infection in People Who Inject Drugs

scientific article

A highly sensitive method for the simultaneous UHPLC-MS/MS analysis of clonidine, morphine, midazolam and their metabolites in blood plasma using HFIP as the eluent additive

scientific article published on 10 March 2017

Absence of genotypic drug resistance and presence of several naturally occurring polymorphisms of human immunodeficiency virus-1 CRF06_cpx in treatment-naive patients in Estonia

scientific article

Acute gastroenteritis hospitalizations after implementation of universal mass vaccination against rotavirus

scientific article published on 14 February 2020

Age-appropriate formulations including pharmaceutical excipients in neonatal medicines

scientific article published on 26 September 2017

Ampicillin versus penicillin in the empiric therapy of extremely low-birthweight neonates at risk of early onset sepsis

scientific article published on 01 December 2011

An optimised dosing regimen versus a standard dosing regimen of vancomycin for the treatment of late onset sepsis due to Gram-positive microorganisms in neonates and infants aged less than 90 days (NeoVanc): study protocol for a randomised controlle

scientific article published on 15 April 2020

Antibiotic prescription preferences in paediatric outpatient setting in Estonia and Sweden ⬇️

scientific article published on March 21, 2013

Antibiotic therapy for pediatric community-acquired pneumonia: do we know when, what and for how long to treat?

scientific article published on June 2012

Antiretroviral drug resistance and viral tropism in HIV-1 CRF06_cpx infected patients failing antiretroviral (ARV) therapy

scientific article published on 29 May 2014

Association between HIV-1 tropism and CCR5 human haplotype E in a Caucasian population

scientific article

Association between TLR3 rs3775291 and resistance to HIV among highly exposed Caucasian intravenous drug users

scientific article published on 17 August 2013

Association of IFNλ4 rs12979860 polymorphism with the acquisition of HCV and HIV infections among people who inject drugs

article

Blood loss related to participation in pharmacokinetic study in preterm neonates

scientific article published on 2 March 2011

CCL3L1 copy number is a strong genetic determinant of HIV seropositivity in Caucasian intravenous drug users

scientific article (publication date: March 2010)

CCR5 haplotypes influence HCV serostatus in Caucasian intravenous drug users

scientific article (publication date: 2013)

Central European Vaccination Advisory Group (CEVAG) guidance statement on recommendations for the introduction of HPV vaccines

scientific article published on 20 March 2009

Characteristics of Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae and Contact to Animals in Estonia

scientific article published on 27 July 2020

Characterization of integrase region polymorphisms in HIV type 1 CRF06_cpx viruses in treatment-naive patients in Estonia

scientific article published on 19 September 2010

Clinical and pathological findings of fatal 2009-2010 pandemic influenza A (H1N1) infection in Estonia

scientific article

Clinical parameters predicting failure of empirical antibacterial therapy in early onset neonatal sepsis, identified by classification and regression tree analysis

scientific article

Clinical trials in neonatal sepsis

scientific article published on 30 July 2013

Co-infection with hepatitis C virus (HCV) in Estonian intravenous drug users HIV epidemic

scientific article published on 29 May 2014

Coagulase negative staphylococcal sepsis in neonates: do we need to adapt vancomycin dose or target?

scientific article

Coagulase-Negative Staphylococci in Human Milk From Mothers of Preterm Compared With Term Neonates

scientific article published on 10 March 2017

Comment on Pharmacokinetic Studies in Neonates: The Utility of an Opportunistic Sampling Design

scientific article published on 01 December 2015

Comparison of two alternative study designs in assessment of medicines utilisation in neonates

scientific article

Correction: Geographic and Temporal Trends in the Molecular Epidemiology and Genetic Mechanisms of Transmitted HIV-1 Drug Resistance: An Individual-Patient- and Sequence-Level Meta-Analysis

scientific article

Current management of late onset neonatal bacterial sepsis in five European countries

scientific article published on 13 February 2014

Design and structure of the Estonian HIV Cohort Study (E-HIV).

scientific article

Development and Evaluation of a Gentamicin Pharmacokinetic Model That Facilitates Opportunistic Gentamicin Therapeutic Drug Monitoring in Neonates and Infants

scientific article published on 06 June 2016

Differences in T cell distribution and CCR5 expression in HIV-positive and HIV-exposed seronegative persons who inject drugs

scientific article published on 22 December 2015

Discovery and development of safe-in-man broad-spectrum antiviral agents

scientific article published on 17 February 2020

DosOpt: A Tool for Personalized Bayesian Dose Adjustment of Vancomycin in Neonates

scientific article published on 27 October 2017

Drug utilisation pattern and off-label use of medicines in Estonian neonatal units

scientific article published on 11 June 2011

Dynamics of pertussis toxin IgG after symptomatic pertussis in children and adults

scientific article published on 11 March 2020

Emerging transmitted drug resistance in treatment-naïve human immunodeficiency virus-1 CRF06_cpx-infected patients in Estonia

scientific article

Epidemiological characteristics of pertussis in Estonia, Lithuania, Romania, the Czech Republic, Poland and Turkey-1945 to 2005.

scientific article

Estimated and reported incidence of pertussis in Estonian adults: A seroepidemiological study

scientific article published on 12 August 2015

Evaluating Safety Reporting in Paediatric Antibiotic Trials, 2000-2016: A Systematic Review and Meta-Analysis

scientific article published on 7 December 2017

First report of Wohlfahrtiimonas chitiniclastica from soft tissue and bone infection at an unusually high northern latitude

scientific article

Framework conditions facilitating paediatric clinical research ⬇️

scientific article published on February 23, 2011

Full-length genome sequences of Estonian HIV-1 CRF06 and Eastern-European subtype A1 recombinant forms

article

GAPPS (Grading and Assessment of Pharmacokinetic-Pharmacodynamic Studies) a critical appraisal system for antimicrobial PKPD studies - development and application in pediatric antibiotic studies

scientific article published on 30 November 2019

Genetic Relatedness of Staphylococcus haemolyticus in Gut and Skin of Preterm Neonates and Breast Milk of Their Mothers

scientific article published on 2 April 2018

Genetic relatedness of Gram-negative bacteria colonizing gut and skin of neonates and mother's own milk

Genetic relatedness of coagulase-negative Staphylococci from gastrointestinal tract and blood of preterm neonates with late-onset sepsis

scientific article published in April 2013

Geographic and temporal trends in the molecular epidemiology and genetic mechanisms of transmitted HIV-1 drug resistance: an individual-patient- and sequence-level meta-analysis

scientific article

Global shortage of neonatal and paediatric antibiotic trials: rapid review

scientific article

Gut colonization by aerobic microorganisms is associated with route and type of nutrition in premature neonates

scientific article published on 16 April 2015

HTLV-1/2 is rare among Eastern-European intravenous drug users (IDUs).

scientific article published on 28 August 2015

Harmonisation in study design and outcomes in paediatric antibiotic clinical trials: a systematic review

scientific article

High variability in the dosing of commonly used antibiotics revealed by a Europe-wide point prevalence study: implications for research and dissemination

scientific article published on 16 April 2015

Higher intake of coagulase-negative staphylococci from maternal milk promotes gut colonization with mecA-negative Staphylococcus epidermidis in preterm neonates

scientific article published on 03 August 2018

Hospitalised neonates in Estonia commonly receive potentially harmful excipients

scientific article

Human T-lymphotropic virus types 1 and 2 are rare among intravenous drug users in Eastern Europe

scientific article

Immunologic response to Hib tetanus toxoid conjugated vaccine coadministered with DTPa either mixed or in two separate injections in toddlers not primed with Hib vaccine

scientific article published on 14 August 2007

Improved outcome in central nervous system aspergillosis, using voriconazole treatment

scientific article published on 5 July 2005

In vitrosynergy of oxacillin and gentamicin against coagulase-negative staphylococci from blood cultures of neonates with late-onset sepsis

article

Infections due to Aspergillus terreus: a multicenter retrospective analysis of 83 cases

scientific article

Influence of interleukin 10 polymorphisms -592 and -1082 to the HIV, HBV and HCV serostatus among intravenous drug users

scientific article published on 24 December 2014

Laboratory markers to determine clinical significance of coagulase-negative staphylococci in blood cultures.

scientific article published on 26 September 2007

Low Temperature and Low UV Indexes Correlated with Peaks of Influenza Virus Activity in Northern Europe during 2010⁻2018

scientific article published on 01 March 2019

Medicines prescription patterns in European neonatal units

scientific article published on 17 October 2019

Meropenem vs standard of care for treatment of late onset sepsis in children of less than 90 days of age: study protocol for a randomised controlled trial

scientific article

Meropenem vs standard of care for treatment of neonatal late onset sepsis (NeoMero1): A randomised controlled trial

scientific article published on 04 March 2020

Molecular epidemiology of Staphylococcus epidermidis in neonatal intensive care units

scientific article

Multidrug resistant Pseudomonas aeruginosa in Estonian hospitals

scholarly article by Kaidi Telling et al published 11 October 2018 in BMC Infectious Diseases

New antibiotics for paediatric use: a review of a decade of regulatory trials submitted to the European Medicines Agency from 2000--why aren't we doing better?

scientific article published on July 2013

Novel activities of safe-in-human broad-spectrum antiviral agents

scientific article published on 23 April 2018

Off label use of prescription medicines in children in outpatient setting in Estonia is common ⬇️

scientific article published on May 1, 2011

People living with HIV in Estonia: engagement in HIV care in 2013.

scientific article published on October 2016

Peripheral blood RNA gene expression profiling in patients with bacterial meningitis

scientific article published on 18 March 2013

Pertussis and parapertussis in children and adults with a persistent cough: an observational study

scientific article published in November 2017

Pharmacokinetics and Pharmacodynamics of Oseltamivir in Neonates, Infants and Children ⬇️

scientific article published on February 1, 2013

Pharmacokinetics and safety of intravenous voriconazole in children after single- or multiple-dose administration

scientific article

Pharmacokinetics of penicillin G in preterm and term neonates

scientific article published on 20 February 2018

Pharmacokinetics of penicillin g in very-low-birth-weight neonates

scientific article published on 19 March 2007

Pharmacokinetics, safety, and tolerability of voriconazole in immunocompromised children

scientific article

Plasma and CSF pharmacokinetics of meropenem in neonates and young infants: results from the NeoMero studies

scholarly article by Eva Germovsek et al published 19 April 2018 in Journal of Antimicrobial Chemotherapy

Plasmid with Colistin Resistance Gene mcr-1 in Extended-Spectrum-β-Lactamase-Producing Escherichia coli Strains Isolated from Pig Slurry in Estonia

scientific article

Population pharmacokinetic analysis of voriconazole plasma concentration data from pediatric studies

scientific article

Population pharmacokinetic meta-analysis of individual data to design the first randomized efficacy trial of vancomycin in neonates and young infants

scientific article published on 01 August 2019

Potentially harmful excipients in neonatal medicines: a pan-European observational study

scientific article published on 8 April 2015

Prevalence and genotypes of GBV-C and its associations with HIV infection among persons who inject drugs in Eastern Europe

scientific article published on 7 September 2016

Prevalence of drug resistance mutations in HAART patients infected with HIV-1 CRF06_cpx in Estonia

scientific article published on 20 August 2015

Product Substitution as a Way Forward in Avoiding Potentially Harmful Excipients in Neonates

scientific article

Rate of CD4 Decline and HIV-RNA Change Following HIV Seroconversion in Men Who Have Sex With Men ⬇️

scientific article published on April 1, 2013

Risk factors associated with gut and nasopharyngeal colonization by common Gram-negative species and yeasts in neonatal intensive care units patients

scientific article published on 21 March 2011

Safety and immunogenicity of a primary course and booster dose of a combined diphtheria, tetanus, acellular pertussis, hepatitis B and inactivated poliovirus vaccine.

scientific article

Safety of voriconazole and dose individualization

scientific article published in April 2003

Seroprevalence of IgG antibodies to pertussis toxin in children and adolescents in Estonia

scientific article published on 3 August 2014

Short versus long infusion of meropenem in very-low-birth-weight neonates

scientific article

Stable level of HIV transmitted drug resistance in Estonia despite significant scale-up of antiretroviral therapy

scientific article published on 28 May 2019

Standardising neonatal and paediatric antibiotic clinical trial design and conduct: the PENTA-ID network view

scientific article published on 31 December 2019

T Cell Distribution in Relation to HIV/HBV/HCV Coinfections and Intravenous Drug Use.

scientific article published on 26 August 2016

The concordance of the limiting antigen and the Bio-Rad avidity assays in persons from Estonia infected mainly with HIV-1 CRF06_cpx.

scientific article published on 24 May 2019

The development of gut microbiota in critically ill extremely low birth weight infants assessed with 16S rRNA gene based sequencing

scientific article

The impact of transient combination antiretroviral treatment in early HIV infection on viral suppression and immunologic response in later treatment

scientific article published on 3 December 2015

The role of breast milk in the colonization of neonatal gut and skin with coagulase-negative staphylococci

scientific article published on 02 August 2017

Transmitted drug resistance is still low in newly diagnosed human immunodeficiency virus type 1 CRF06_cpx-infected patients in Estonia in 2010

scientific article published on 05 October 2013

Treatment of scedosporiosis with voriconazole: clinical experience with 107 patients

scientific article published on 22 January 2008

Treatment option for sepsis in children in the era of antibiotic resistance

scientific article published on 04 September 2014

Understanding pharmacokinetics/pharmacodynamics in managing neonatal sepsis

scientific article published on June 2010

Use of oral fluid to examine the molecular epidemiology of varicella zoster virus in the United Kingdom and continental Europe

scientific article published on 19 October 2012

Using incidence assays within the context of the recent infections testing algorithm

scientific article published in September 2014

Voriconazole Treatment for Less‐Common, Emerging, or Refractory Fungal Infections ⬇️

scientific article published on April 22, 2003

Voriconazole concentrations in the cerebrospinal fluid and brain tissue of guinea pigs and immunocompromised patients

scientific article published on 7 August 2003

Voriconazole for invasive bone aspergillosis: a worldwide experience of 20 cases

scientific article published on 14 March 2005

Voriconazole in the treatment of aspergillosis, scedosporiosis and other invasive fungal infections in children

scientific article

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