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List of works by Kai Kaila

A Prestabilized Harmony

scientific article published on 01 July 2011

A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2.

scientific article

A novel prodrug-based strategy to increase effects of bumetanide in epilepsy

scientific article published on 2 April 2014

A physiologically validated rat model of term birth asphyxia with seizure generation after, not during, brain hypoxia

scientific article published on 18 December 2020

A single seizure episode leads to rapid functional activation of KCC2 in the neonatal rat hippocampus

scientific article published on September 2010

A variant of KCC2 from patients with febrile seizures impairs neuronal Cl- extrusion and dendritic spine formation

scientific journal article

Acetazolamide and midazolam act synergistically to inhibit neuropathic pain

scientific article

Acid extrusion via blood-brain barrier causes brain alkalosis and seizures after neonatal asphyxia

scientific article

Acidosis of hippocampal neurones mediated by a plasmalemmal Ca2+/H+ pump

scientific article published in August 1996

Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain.

scientific article

An Ion Transport-Independent Role for the Cation-Chloride Cotransporter KCC2 in Dendritic Spinogenesis In Vivo ⬇️

scientific article published on February 17, 2012

Aquaporin-4 regulates extracellular space volume dynamics during high-frequency synaptic stimulation: a gene deletion study in mouse hippocampus

scientific article published on 14 March 2012

BDNF is required for seizure-induced but not developmental up-regulation of KCC2 in the neonatal hippocampus

scientific article published on 16 September 2014

Brain alkalosis causes birth asphyxia seizures, suggesting therapeutic strategy.

scientific article published on 18 February 2011

Brain interstitial pH changes in the subacute phase of hypoxic-ischemic encephalopathy in newborn pigs

scientific article published on 29 May 2020

Bumepamine, a brain-permeant benzylamine derivative of bumetanide, does not inhibit NKCC1 but is more potent to enhance phenobarbital's anti-seizure efficacy

scientific article published on 21 September 2018

CO2-evoked release of PGE2 modulates sighs and inspiration as demonstrated in brainstem organotypic culture.

scientific article published on 05 July 2016

Calcium-dependent increase in the potassium permeability of human red blood cells by pentachlorophenol and 2,4,6-trinitrophenol

scientific article published in October 1982

Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines

scientific article

Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides

scientific article

Carbonic anhydrase inhibitors: Inhibition of the cytosolic human isozyme VII with anions

scientific article published on 18 April 2006

Carbonic anhydrase isoform VII acts as a molecular switch in the development of synchronous gamma-frequency firing of hippocampal CA1 pyramidal cells.

scientific article published in March 2004

Carbonic anhydrases and brain pH in the control of neuronal excitability

scientific article published on January 2014

Cation-chloride co-transporters in neuronal communication, development and trauma

scientific article

Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments

scientific article

Cation-chloride cotransporters and neuronal function

scientific article

Cation-chloride cotransporters in neuronal development, plasticity and disease

scientific article

Cell type-specific differences in chloride-regulatory mechanisms and GABA(A) receptor-mediated inhibition in rat substantia nigra

scientific journal article

Cellular neurophysiological effects of phenol derivatives ⬇️

scientific article published on January 1, 1982

Changes in [Ca2+]0 during anoxia in CNS white matter.

scientific article published in June 1998

Chloride homeostasis and GABA signaling in temporal lobe epilepsy

Cold-adapted protease enables quantitation of surface proteins in the absence of membrane trafficking

scientific article published on 01 April 2011

Comment on "Local impermeant anions establish the neuronal chloride concentration"

scientific article published in Science

Comparison of Umbilical Serum Copeptin Relative to Erythropoietin and S100B as Asphyxia Biomarkers at Birth

scientific article published on 29 March 2017

Compensatory enhancement of intrinsic spiking upon NKCC1 disruption in neonatal hippocampus.

scientific article published in May 2009

Contributions of the Na⁺/K⁺-ATPase, NKCC1, and Kir4.1 to hippocampal K⁺ clearance and volume responses

scientific article

Corrigendum to "Bumepamine, a brain-permeant benzylamine derivative of bumetanide, does not inhibit NKCC1 but is more potent to enhance phenobarbital's antiseizure efficacy" [Neuropharmacology 143 (2018) 186-204]

scientific article published on 19 October 2018

Cortical inhibition, pH and cell excitability in epilepsy: what are optimal targets for antiepileptic interventions?

scientific article published on 13 August 2012

DC-EEG discloses prominent, very slow activity patterns during sleep in preterm infants

scientific article published in November 2002

Dependence of cytoplasmic calcium transients on the membrane potential in isolated nerve endings of the guinea pig.

scientific article published in May 1985

Dependence of intracellular free calcium and tension on membrane potential and intracellular pH in single crayfish muscle fibres

scientific article published on 01 July 1990

Depolarization of the mitochondrial membrane potential increases free cytosolic calcium in synaptosomes

scientific article published in August 1984

Depolarizing GABA acts on intrinsically bursting pyramidal neurons to drive giant depolarizing potentials in the immature hippocampus.

scientific article published in June 2005

Development of a neural phenotype in differentiating ganglion cell-derived human neuroblastoma cells

article

Development of hemodynamic responses and functional connectivity in rat somatosensory cortex

article

Development of neonatal EEG activity: from phenomenology to physiology

scientific article published on 2 October 2006

Developmental Expression Patterns of KCC2 and Functionally Associated Molecules in the Human Brain.

scientific article

Developmental up-regulation of KCC2 in the absence of GABAergic and glutamatergic transmission

scientific article published in December 2003

Different sensitivities of human and rat rho(1) GABA receptors to extracellular pH.

scientific article

Distinct gamma-band evoked responses to speech and non-speech sounds in humans.

scientific article

Distinct properties of functional KCC2 expression in immature mouse hippocampal neurons in culture and in acute slices

scientific article published in February 2005

Effect of gamma-aminobutyric acid on intracellular pH in the crayfish stretch-receptor neurone

scientific article published in March 1991

Effect of heparin-binding growth-associated molecule (HB-GAM) on synaptic transmission and early LTP in rat hippocampal slices

scientific journal article

Effect of repetitive activity upon intracellular pH, sodium and contraction in sheep cardiac Purkinje fibres

scientific article published on 01 April 1988

Effects of CO2 on excitatory transmission apparently caused by changes in intracellular pH in the rat hippocampal slice

scientific article published in January 1996

Effects of two chlorinated phenols on the spontaneous impulse activity of the abdominal tonic motor system in the crayfish (Astacus fluviatilis L.).

scientific article published on January 1977

Effects of voluntary hyperventilation on cortical sensory responses. Electroencephalographic and magnetoencephalographic studies.

scientific article published in April 1999

Endogenous brain-sparing responses in brain pH and PO2 in a rodent model of birth asphyxia

scientific article published on 16 March 2020

Enhanced expression of potassium-chloride cotransporter KCC2 in human temporal lobe epilepsy.

scientific article

Enhanced temporal stability of cholinergic hippocampal gamma oscillations following respiratory alkalosis in vitro.

scientific article

Evaluation of commercially available electrodes and gels for recording of slow EEG potentials

scientific article published on 23 November 2004

Experimental febrile seizures are precipitated by a hyperthermia-induced respiratory alkalosis

scientific article

Extracellular alkaline transients mediated by glutamate receptors in the rat hippocampal slice are not due to a proton conductance.

scientific article

Facilitation of transmission at the crayfish neuromuscular synapse by a convulsant phenol.

scientific article

Fall in intracellular pH and increase in resting tension induced by a mitochondrial uncoupling agent in crayfish muscle

scientific article published on 01 January 1989

Fall in intracellular pH mediated by GABAA receptors in cultured rat astrocytes

scientific article published on 01 May 1991

Fast network oscillations in the newborn rat hippocampus in vitro

scientific article published on 01 February 2000

Five percent CO₂ is a potent, fast-acting inhalation anticonvulsant.

scientific article

Forebrain-independent generation of hyperthermic convulsions in infant rats

scientific article published on 7 November 2015

Free extracellular [Ca2+] at photoreceptor level equals that in vitreous in frog and carp eyes.

scientific article

Full-band EEG (FbEEG): an emerging standard in electroencephalography

scientific article

Full-band EEG (fbEEG): a new standard for clinical electroencephalography.

scientific article

GABA actions and ionic plasticity in epilepsy.

scientific article

GABA uptake via GABA transporter-1 modulates GABAergic transmission in the immature hippocampus.

scientific article

GABA-gated anion channels in intact crayfish opener muscle fibres and stretch-receptor neurons are neither activated nor desensitized by glutamate

scientific article published on 01 April 1992

GABAergic control of CA3-driven network events in the developing hippocampus

scientific article published on January 2008

GABAergic depolarization of the axon initial segment in cortical principal neurons is caused by the Na-K-2Cl cotransporter NKCC1.

scientific article published in April 2008

GABAergic excitation and K(+)-mediated volume transmission in the hippocampus.

scientific article

GAT-1 acts to limit a tonic GABA(A) current in rat CA3 pyramidal neurons at birth

scientific article published on 12 February 2007

Gap Junctions Link Regular-Spiking and Fast-Spiking Interneurons in Layer 5 Somatosensory Cortex.

scientific article published on 17 July 2017

General anaesthetics do not impair developmental expression of the KCC2 potassium-chloride cotransporter in neonatal rats during the brain growth spurt

scientific article published on 26 March 2013

Generation of ‘positive slow waves’ in the preterm EEG: By the brain or by the EEG setup?

scientific article published on 10 April 2008

Glycine transporter-1 controls nonsynaptic inhibitory actions of glycine receptors in the neonatal rat hippocampus.

scientific article published in July 2014

Heterogeneous expression of the potassium-chloride cotransporter KCC2 in gonadotropin-releasing hormone neurons of the adult mouse

scientific article

Influence of GABA-gated bicarbonate conductance on potential, current and intracellular chloride in crayfish muscle fibres

scientific article published on 01 September 1989

Influence of Hepes- and CO2/HCO(3-)-buffer on Ca2+ transients induced by TRH and elevated K+ in rat pituitary GH4C1 cells

scientific article

Influence of extracellular and intracellular pH on GABA-gated chloride conductance in crayfish muscle fibres

scientific article published on 01 January 1992

Influence of sodium-hydrogen exchange on intracellular pH, sodium and tension in sheep cardiac Purkinje fibres

scientific article published in September 1987

Infraslow oscillations modulate excitability and interictal epileptic activity in the human cortex during sleep

scientific article

Inhibition and brain work

scientific article

Inhibition of carbonic anhydrase augments GABAA receptor-mediated analgesia via a spinal mechanism of action

scientific article published on 09 January 2014

Inhibition of voltage-dependent potassium conductance by convulsant phenols in the medial giant axon of the crayfish

scientific article published on 01 January 1980

Interstimulus interval dependence of the auditory vertex response and its magnetic counterpart: implications for their neural generation

scientific article

Interstitial PCO2 and pH in rat hippocampal slices measured by means of a novel fast CO2/H(+)-sensitive microelectrode based on a PVC-gelled membrane.

scientific article

Intracellular carbonic anhydrase activity and its role in GABA-induced acidosis in isolated rat hippocampal pyramidal neurones

scientific article published in June 1993

Intrinsic bursting of immature CA3 pyramidal neurons and consequent giant depolarizing potentials are driven by a persistent Na+ current and terminated by a slow Ca2+ -activated K+ current

scientific article published in May 2006

Intrinsic proton modulation of excitatory transmission in rat hippocampal slices.

scientific article published in January 1993

Inward current caused by sodium-dependent uptake of GABA in the crayfish stretch receptor neurone

scientific article published on 01 January 1992

Ionic Mechanisms of Spontaneous GABAergic Events in Rat Hippocampal Slices Exposed to 4-Aminopyridine ⬇️

scientific article published on November 1, 1997

Ionic basis of GABAA receptor channel function in the nervous system ⬇️

scientific article published on March 1, 1994

K-Cl Cotransporter 2-mediated Cl- Extrusion Determines Developmental Stage-dependent Impact of Propofol Anesthesia on Dendritic Spines

scientific article published on 16 March 2017

KCC2 interacts with the dendritic cytoskeleton to promote spine development

scientific article

KCC2-Mediated Cl Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice

scientific article published on 01 January 2019

Long-lasting GABA-mediated depolarization evoked by high-frequency stimulation in pyramidal neurons of rat hippocampal slice is attributable to a network-driven, bicarbonate-dependent K+ transient.

scientific article published in October 1997

Loss of non-canonical KCC2 functions promotes developmental apoptosis of cortical projection neurons

scientific article published on 17 February 2020

Mechanism of action of GABA on intracellular pH and on surface pH in crayfish muscle fibres

scientific article published in August 1990

Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2.

scientific article

Mechanism of rate-dependent pH changes in the sheep cardiac Purkinje fibre

scientific article published on 01 December 1988

Membrane-potential changes caused by 2,4-DNP and related phenols in resting crayfish axons are not due to uncoupling of mitochondria

scientific article published on 01 January 1981

Millivolt-scale DC shifts in the human scalp EEG: evidence for a nonneuronal generator

scientific article

Modulation of neuronal activity by phosphorylation of the K-Cl cotransporter KCC2

scientific article

Modulation of pH by neuronal activity

scientific article

Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice

scientific article

Nest Carbon Dioxide Masks GABA-Dependent Seizure Susceptibility in the Naked Mole-Rat

scientific article published on 28 April 2020

Neurobiological and physiological mechanisms of fever-related epileptiform syndromes

scientific article published on 07 February 2009

Nonneuronal origin of CO2-related DC EEG shifts: an in vivo study in the cat.

scientific article published on 31 March 2004

Opposite effect of membrane raft perturbation on transport activity of KCC2 and NKCC1.

scientific article

Optimal resource allocation for novelty detection in a human auditory memory

scientific article

Patterns of cation-chloride cotransporter expression during embryonic rodent CNS development

scientific article

Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy.

scientific article

Pharmacological characterization of extracellular pH transients evoked by selective synaptic and exogenous activation of AMPA, NMDA, and GABAA receptors in the rat hippocampal slice

scientific article published on 01 August 1995

Pharmacological isolation of the synaptic and nonsynaptic components of the GABA-mediated biphasic response in rat CA1 hippocampal pyramidal cells

scientific article published in November 1999

Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures

scientific article

Phase synchrony among neuronal oscillations in the human cortex.

scientific article published in April 2005

Post-insult activity is a major cause of delayed neuronal death in organotypic hippocampal slices exposed to glutamate

scientific article published in January 2001

Post-traumatic hyperexcitability is not caused by impaired buffering of extracellular potassium.

scientific article published on July 2003

Postnatal development of rat hippocampal gamma rhythm in vivo

scientific article published in September 2002

Postsynaptic fall in intracellular pH and increase in surface ph caused by efflux of formate and acetate anions through GABA-gated channels in crayfish muscle fibres

scientific article published on 01 January 1990

Postsynaptic fall in intracellular pH induced by GABA-activated bicarbonate conductance.

scientific article

Posttetanic excitation mediated by GABA(A) receptors in rat CA1 pyramidal neurons

scientific article published in April 1997

Posttraumatic GABA(A)-mediated [Ca2+]i increase is essential for the induction of brain-derived neurotrophic factor-dependent survival of mature central neurons

scientific article published in July 2008

Premature expression of KCC2 in embryonic mice perturbs neural development by an ion transport-independent mechanism

scientific article

Preterm EEG: a multimodal neurophysiological protocol

scientific article published on 18 February 2012

Pronounced increase in breathing rate in the "hair dryer model" of experimental febrile seizures.

scientific article published on 04 March 2008

Proton Modulation of Functionally Distinct GABA A Receptors in Acutely Isolated Pyramidal Neurons of Rat Hippocampus

scientific article published on 01 January 1996

Quantitative Changes in the Mitochondrial Proteome of Cerebellar Synaptosomes From Preclinical Cystatin B-Deficient Mice

scientific article published on 13 November 2020

Quantitative analysis of surface expression of membrane proteins using cold-adapted proteases.

scientific article published on 24 September 2013

Quantitative measurements of the cytosolic Ca2+ activity within isolated guinea pig nerve-endings using entrapped arsenazo III and quin2.

scientific article published in June 1986

Redox modulation of calcium entry and release of intracellular calcium by thimerosal in GH4C1 pituitary cells

scientific article published in December 1996

Reg1ulatory role and molecular interactions of a cell-surface heparan sulfate proteoglycan (N-syndecan) in hippocampal long-term potentiation.

scientific article published in February 1999

Relationship between neuronal vulnerability and potassium-chloride cotransporter 2 immunoreactivity in hippocampus following transient forebrain ischemia

scientific article published on 7 April 2008

Relative contributions of excitatory and inhibitory neuronal activity to alkaline transients evoked by stimulation of Schaffer collaterals in the rat hippocampal slice

scientific article published on 01 August 1995

Respiratory alkalosis in children with febrile seizures

scientific article published on 12 September 2011

RhoGEF9 splice isoforms influence neuronal maturation and synapse formation downstream of α2 GABAA receptors.

scientific article published on 25 October 2017

Role of voltage-gated calcium channels in the generation of activity-induced extracellular pH transients in the rat hippocampal slice

scientific article published in June 1996

Scalp-recorded slow EEG responses generated in response to hemodynamic changes in the human brain

scientific article published in September 2003

Serum copeptin and neuron specific enolase are markers of neonatal distress and long-term neurodevelopmental outcome

scientific article published on 20 September 2017

Simultaneous measurement of intracellular and extracellular carbonic anhydrase activity in intact muscle fibres

scientific article published on 01 July 1992

Simultaneous two-photon imaging of intracellular chloride concentration and pH in mouse pyramidal neurons in vivo.

scientific article

Slow endogenous activity transients and developmental expression of K+-Cl- cotransporter 2 in the immature human cortex.

scientific article

Sphingosine derivatives inhibit depolarization-evoked calcium entry in rat GH4C1 cells

scientific article published on November 1995

Sphingosine inhibits voltage-operated calcium channels in GH4C1 cells

scientific article

Spontaneous epileptiform activity mediated by GABA(A) receptors and gap junctions in the rat hippocampal slice following long-term exposure to GABA(B) antagonists

scientific article published in September 2002

Spontaneous network events driven by depolarizing GABA action in neonatal hippocampal slices are not attributable to deficient mitochondrial energy metabolism

scientific article

Stimulation-induced changes in the intracellular sodium activity of the crayfish stretch receptor.

scientific article published in February 1987

Stimulus-induced change in long-range temporal correlations and scaling behaviour of sensorimotor oscillations.

scientific article published in January 2004

Studies on the role of metabotropic glutamate receptors in long-term potentiation: some methodological considerations

scientific article published on 01 June 1995

Subplate neurons promote spindle bursts and thalamocortical patterning in the neonatal rat somatosensory cortex

scientific article

Surge of Peripheral Arginine Vasopressin in a Rat Model of Birth Asphyxia

scientific article published on 19 January 2018

Synaptic activation of GABAA receptors induces neuronal uptake of Ca2+ in adult rat hippocampal slices

scientific article published in February 1999

The K+-Cl cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus

scientific article published on 8 March 2010

The KCl cotransporter, KCC2, is highly expressed in the vicinity of excitatory synapses in the rat hippocampus.

scientific article

The NKCC1 ion transporter modulates microglial phenotype and inflammatory response to brain injury in a cell-autonomous manner

scientific article published on 27 January 2022

The cation-chloride cotransporter NKCC1 promotes sharp waves in the neonatal rat hippocampus

scientific article published on 27 April 2006

The cellular, molecular and ionic basis of GABA(A) receptor signalling

scientific article published on January 2007

The role of bicarbonate in GABAA receptor-mediated IPSPs of rat neocortical neurones.

scientific article

The sensitivity of liquid sensor, ion-selective microelectrodes to changes in temperature and solution level

scientific article published in June 1986

Treatment of acute migraine by a partial rebreathing device: A randomized controlled pilot study

scientific article published on 22 August 2018

Use-dependent block of GABA-activated chloride channels in crayfish muscle fibers by picrate

scientific article

Vagal nerve stimulation induces intermittent hypocapnia

scientific article published in December 2003

Vasopressin excites interneurons to suppress hippocampal network activity across a broad span of brain maturity at birth

scientific article published on 28 November 2017

Very slow EEG responses lateralize temporal lobe seizures: An evaluation of non-invasive DC-EEG

article

Visually evoked gamma responses in the human brain are enhanced during voluntary hyperventilation

scientific article published in March 2002

[Neurobiology in the next millennium:challenges and dreams]

scientific article published on 01 January 1999

pH transients due to monosynaptic activation of GABAA receptors in rat hippocampal slices

scientific article published in January 1992

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