List of works by Heikki Joensuu

2-Weekly versus 3-weekly docetaxel to treat castration-resistant advanced prostate cancer: a randomised, phase 3 trial

scientific article published on 4 January 2013

A Novel Anti-HER2 Antibody-Drug Conjugate XMT-1522 for HER2-Positive Breast and Gastric Cancers Resistant to Trastuzumab Emtansine

scientific article published on 10 July 2019

A dosimetric study on the use of bolus materials for treatment of superficial tumors with BNCT.

scientific article published in November 2004

A patient-centered methodology that improves the accuracy of prognostic predictions in cancer

scientific article

A phase II trial of pemetrexed plus gemcitabine in locally advanced and/or metastatic transitional cell carcinoma of the urothelium.

scientific article

A short communication course for physicians improves the quality of patient information in a clinical trial

scientific article published on 01 January 2007

ARX788, a novel anti-HER2 antibody-drug conjugate, shows anti-tumor effects in preclinical models of trastuzumab emtansine-resistant HER2-positive breast cancer and gastric cancer

scientific article published on 02 January 2020

Acute Myeloid Leukemia Following Hodgkin Lymphoma: A Population-Based Study of 35 511 Patients

article by Sara J. Schonfeld et al published 1 February 2006 in Journal of the National Cancer Institute

Adjuvant Capecitabine in Combination With Docetaxel, Epirubicin, and Cyclophosphamide for Early Breast Cancer: The Randomized Clinical FinXX Trial

scientific article published on 02 March 2017

Adjuvant Capecitabine, Docetaxel, Cyclophosphamide, and Epirubicin for Early Breast Cancer: Final Analysis of the Randomized FinXX Trial

article

Adjuvant Imatinib for High-Risk GI Stromal Tumor: Analysis of a Randomized Trial

scientific article published on 2 November 2015

Adjuvant capecitabine in combination with docetaxel and cyclophosphamide plus epirubicin for breast cancer: an open-label, randomised controlled trial

scientific article published on 10 November 2009

Afatinib alone or afatinib plus vinorelbine versus investigator's choice of treatment for HER2-positive breast cancer with progressive brain metastases after trastuzumab, lapatinib, or both (LUX-Breast 3): ...

scientific article (publication date: December 2015)

Allelic imbalance of HER2 variant in sporadic breast and ovarian cancer.

scientific article

Amplification of KIT, PDGFRA, VEGFR2, and EGFR in gliomas

scientific article published in December 2006

Anagrelide for Gastrointestinal Stromal Tumor

scientific article published on 07 December 2018

Association of Angiopoietin-2 and Ki-67 Expression with Vascular Density and Sunitinib Response in Metastatic Renal Cell Carcinoma

scientific article

Association of Merkel cell polyomavirus infection with tumor p53, KIT, stem cell factor, PDGFR-alpha and survival in Merkel cell carcinoma.

scientific article

Association of Wwox with ErbB4 in breast cancer.

scientific article

Association of cyclooxygenase-2 and matrix metalloproteinase-2 expression in human breast cancer

scientific article

Axillary and supraclavicular recurrences are rare after axillary lymph node dissection in breast cancer

scientific article published on 01 February 2012

Biokinetic analysis of tissue boron (¹⁰B) concentrations of glioma patients treated with BNCT in Finland.

scientific article published on 14 August 2015

Biological subtyping of early breast cancer: a study comparing RT-qPCR with immunohistochemistry.

scientific article published on 24 May 2016

Boron Neutron Capture Therapy in the Treatment of Recurrent Laryngeal Cancer.

scientific article published on 10 November 2015

Boron neutron capture therapy (BNCT) followed by intensity modulated chemoradiotherapy as primary treatment of large head and neck cancer with intracranial involvement

scientific article published on 11 March 2011

Boron neutron capture therapy for locally recurrent head and neck squamous cell carcinoma: An analysis of dose response and survival

scientific article published on 17 May 2019

Boron neutron capture therapy in the treatment of locally recurred head and neck cancer

scientific article published on 06 August 2007

Boron neutron capture therapy in the treatment of locally recurred head-and-neck cancer: final analysis of a phase I/II trial.

scientific article

Breast cancer biological subtypes and protein expression predict for the preferential distant metastasis sites: a nationwide cohort study

scientific article published on 13 September 2011

Breast cancer outcome prediction with tumour tissue images and machine learning

scientific article published on 22 May 2019

Breast cancer prognosis and isolated tumor cell findings in axillary lymph nodes after core needle biopsy and fine needle aspiration cytology: Biopsy method and breast cancer outcome

scientific article published on 25 September 2015

CD73 promotes resistance to HER2/ErbB2 antibody therapy

scientific article published on 30 August 2017

Cancer in young adults with ischemic stroke.

scientific article published on 28 April 2015

Cancer-derived exosomes from HER2-positive cancer cells carry trastuzumab-emtansine into cancer cells leading to growth inhibition and caspase activation.

scientific article published on 2 May 2018

Challenges of international oncology trial collaboration-a call to action

scientific article published on 05 August 2019

Chronic lymphocytic leukaemia patients have a high risk of Merkel-cell polyomavirus DNA-positive Merkel-cell carcinoma.

scientific article published on 15 September 2009

Clinical relevance of integrin alpha 4 in gastrointestinal stromal tumours.

scientific article

Comment on ESMO Magnitude of Clinical Benefit Scale

scientific article published on 14 September 2015

Comparison of solution-based exome capture methods for next generation sequencing

scientific article

Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer

scientific article published on 29 November 2021

Constitutive phosphorylated STAT3-associated gene signature is predictive for trastuzumab resistance in primary HER2-positive breast cancer

scientific article published on 3 August 2015

Correlation of c-Met Expression and Outcome in Patients With Renal Cell Carcinoma Treated With Sunitinib.

scientific article published in February 2017

Cutaneous T-cell lymphoma-associated lung cancers show chromosomal aberrations differing from primary lung cancer

scientific article published on 01 February 2008

Cytoplasmic HuR expression is a prognostic factor in invasive ductal breast carcinoma.

scientific article

Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion.

scientific article published on 13 July 2015

Design and construction of shoulder recesses into the beam aperture shields for improved patient positioning at the FiR 1 BNCT facility.

scientific article published in November 2004

Development and validation of prognostic nomograms for metastatic gastrointestinal stromal tumour treated with imatinib

scientific article published on 19 March 2015

Docetaxel 100 versus 80 mg/m2 as adjuvant treatments of early breast cancer: an exploratory analysis of a randomised trial

scientific article published on 19 January 2009

Dose planning with comparison to in vivo dosimetry for epithermal neutron irradiation of the dog brain

scientific article published in November 2002

Dovitinib in patients with gastrointestinal stromal tumour refractory and/or intolerant to imatinib

scientific article published on 29 August 2017

Drug-Sensitivity Screening and Genomic Characterization of 45 HPV-Negative Head and Neck Carcinoma Cell Lines for Novel Biomarkers of Drug Efficacy

scientific article published on 03 July 2018

Dual targeting of HER2 with lapatinib and trastuzumab

scientific article published on 14 August 2014

Duration of adjuvant trastuzumab: shorter beats longer

scientific article published on 18 July 2013

ERBB4 promoter polymorphism is associated with poor distant disease-free survival in high-risk early breast cancer

scientific article

Early pregnancy sex steroids and maternal breast cancer: a nested case-control study

scientific article

Effect of Adjuvant Trastuzumab for a Duration of 9 Weeks vs 1 Year With Concomitant Chemotherapy for Early Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: The SOLD Randomized Clinical Trial

scientific article published on 01 September 2018

Effect of KIT and PDGFRA Mutations on Survival in Patients With Gastrointestinal Stromal Tumors Treated With Adjuvant Imatinib: An Exploratory Analysis of a Randomized Clinical Trial

scientific article published on 23 March 2017

Effect of treatment of larynx and hypopharynx carcinomas on serum syndecan-1 concentrations

scientific article published on 24 March 2006

Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial

scientific article

Elevated levels of StAR-related lipid transfer protein 3 alter cholesterol balance and adhesiveness of breast cancer cells: potential mechanisms contributing to progression of HER2-positive breast cancers

scientific article published on 12 February 2015

Emerging Agents for the Treatment of Advanced, Imatinib-Resistant Gastrointestinal Stromal Tumors: Current Status and Future Directions

scientific article (publication date: August 2015)

Endothelial cell KIT expression in human tumours.

scientific article published in March 2007

Epidermal growth factor receptor domain II, IV, and kinase domain mutations in human solid tumors

scientific article published on 31 August 2005

Escalating and de-escalating treatment in HER2-positive early breast cancer

scientific article

Expression and prognostic value of transcription factor PROX1 in colorectal cancer.

scientific article published on 4 October 2011

Expression of CD11b/CD18 adhesion molecules on circulating phagocytes-a novel aid to diagnose infection in patients with cancer.

scientific article

Expression of cell cycle regulators and frequency of TP53 mutations in high risk gastrointestinal stromal tumors prior to adjuvant imatinib treatment

scientific article published on 16 February 2018

Fluorouracil, epirubicin, and cyclophosphamide with either docetaxel or vinorelbine, with or without trastuzumab, as adjuvant treatments of breast cancer: final results of the FinHer Trial

scientific article published on 2 November 2009

Follow-up strategies for patients with gastrointestinal stromal tumour treated with or without adjuvant imatinib after surgery.

scientific article published on 25 May 2015

Gastrointestinal Stromal Tumors.

scientific article published on 8 December 2017

Gastrointestinal stromal tumor: a method for optimizing the timing of CT scans in the follow-up of cancer patients.

scientific article

Gastrointestinal stromal tumors with KIT exon 11 deletions are associated with poor prognosis

scientific article published in May 2006

Gastrointestinal stromal tumors: risk assessment and adjuvant therapy.

scientific article published on 02 August 2013

Gastrointestinal stromal tumour

scientific article published on 24 April 2013

Gastrointestinal stromal tumours: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

scientific article published on 01 October 2018

Gene amplification, mutation, and protein expression of EGFR and mutations of ERBB2 in serous ovarian carcinoma

scientific article published on 11 April 2006

Generalisability of survival estimates for patients with breast cancer – A comparison across two population-based series

article

HER2-Overexpressing Breast Cancers Amplify FGFR Signaling upon Acquisition of Resistance to Dual Therapeutic Blockade of HER2.

scientific article published on 5 April 2017

HERA crosses over.

scientific article

High serum angiogenin at diagnosis predicts for failure on long-term treatment response and for poor overall survival in non-Hodgkin lymphoma.

scientific article published on 23 March 2011

Human Chorionic Gonadotropin Does Not Correlate with Risk for Maternal Breast Cancer: Results from the Finnish Maternity Cohort

scientific article published on 26 October 2016

Human breast cancer cells educate macrophages toward the M2 activation status

scientific article

Hypertension and clinical benefit of bevacizumab in the treatment of advanced renal cell carcinoma.

scientific article published in February 2009

Hypertension as predictor of sunitinib treatment outcome in metastatic renal cell carcinoma

scientific article published on 05 January 2011

Improved Treatment of Breast Cancer with Anti-HER2 Therapy Requires Interleukin-21 Signaling in CD8+ T Cells

scientific article published on 7 January 2016

Incidence of Merkel cell carcinoma in renal transplant recipients

scientific article published on 8 July 2009

Increased pancreatic cancer risk following radiotherapy for testicular cancer ⬇️

scientific article

Influence of isolated tumor cells in sentinel nodes on outcome in small, node-negative (pT1N0M0) breast cancer.

scientific article published on 9 October 2009

Integrative proteomic and gene expression analysis identify potential biomarkers for adjuvant trastuzumab resistance: analysis from the Fin-her phase III randomized trial

scientific article published on 3 September 2015

Ipsilateral breast recurrence after breast conserving surgery in patients with small (≤ 2cm) breast cancer treated with modern adjuvant therapies

scientific article published on 26 November 2010

KIT and PDGFRA mutations and the risk of GI stromal tumor recurrence

scientific article published on 20 January 2015

KIT and platelet-derived growth factor receptor alpha tyrosine kinase gene mutations and KIT amplifications in human solid tumors

scientific article published on 15 November 2004

Key Issues in the Clinical Management of Gastrointestinal Stromal Tumors: An Expert Discussion

scientific article published on 12 June 2015

L-boronophenylalanine-mediated boron neutron capture therapy for malignant glioma progressing after external beam radiation therapy: a Phase I study

scientific article

L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling

scientific article

Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: a randomised study

scientific article

Leukemia following breast cancer: an international population-based study of 376,825 women

scientific article published on 13 January 2007

Leukocyte trafficking is not affected by multikinase inhibitors sunitinib or sorafenib in mice.

scientific article published on 26 July 2016

Local recurrence of breast cancer after mastectomy and modern multidisciplinary treatment

scientific article published on 13 September 2012

Long-Term Solid Cancer Risk Among 5-Year Survivors of Hodgkin's Lymphoma

article by David C. Hodgson et al published 20 April 2007 in Journal of Clinical Oncology

Long-term prognosis of breast cancer detected by mammography screening or other methods

scientific article published on 28 December 2011

Long-term results from a randomized phase II trial of standard- versus higher-dose imatinib mesylate for patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT.

scientific article

Loss of ARID1A Activates ANXA1, which Serves as a Predictive Biomarker for Trastuzumab Resistance.

scientific article

Lymphatic vessel density in vocal cord carcinomas assessed with LYVE-1 receptor expression

scientific article published on 17 October 2005

Maintained efficacy of the tyrosine kinase inhibitor imatinib mesylate in a patient with rheumatoid arthritis

scientific article published in October 2008

Mammary-derived growth inhibitor alters traffic of EGFR and induces a novel form of cetuximab resistance

scientific article published on 13 October 2009

Merkel cell polyomavirus infection, large T antigen, retinoblastoma protein and outcome in Merkel cell carcinoma

scientific article published on 3 June 2011

Molecular correlates of imatinib resistance in gastrointestinal stromal tumors.

scientific article

Molecular subtypes of breast cancers detected in mammography screening and outside of screening

scientific article published on July 2008

Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis.

scientific article

Needle biopsy through the abdominal wall for the diagnosis of gastrointestinal stromal tumour - Does it increase the risk for tumour cell seeding and recurrence?

scientific article published on 28 March 2016

New fronts in the adjuvant treatment of GIST.

scientific article

Noncancer causes of death in survivors of testicular cancer

scientific article published on April 2007

Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription

scientific article published on 04 August 2016

Novel target for peptide-based imaging and treatment of brain tumors

scientific article

Optimizing tyrosine kinase inhibitor therapy in gastrointestinal stromal tumors: exploring the benefits of continuous kinase suppression

scientific article published on 17 October 2013

Outcome and Biomarker Supervised Deep Learning for Survival Prediction in Two Multicenter Breast Cancer Series

scientific article published on 18 January 2022

Outcome of patients with HER2-positive breast cancer treated with or without adjuvant trastuzumab in the Finland Capecitabine Trial (FinXX).

scientific article published on 19 August 2013

Pazopanib after sunitinib failure in patients with metastatic renal cell carcinoma

scientific article

Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy

scientific article published in Nature Communications

Phase II, open-label study evaluating the activity of imatinib in treating life-threatening malignancies known to be associated with imatinib-sensitive tyrosine kinases

scientific article published in May 2008

Plasma levels of hepatocyte growth factor and placental growth factor predict mortality in a general population: a prospective cohort study

scientific article

Practical management of tyrosine kinase inhibitor-associated side effects in GIST.

scientific article published on 31 May 2010

Predictive biomarkers for adjuvant capecitabine benefit in early stage triple negative breast cancer in the FinXX clinical trial

scientific article published on 31 January 2020

Predictive factors for blastoid transformation in the common variant of mantle cell lymphoma

scientific article published on 01 February 2003

Pretreatment serum syndecan-1 levels and outcome in small cell lung cancer patients treated with platinum-based chemotherapy

scientific article published in August 2003

Prognostic but not predictive role of platelet-derived growth factor receptors in patients with recurrent glioblastoma

scientific article

Prognostic impact of CD4-positive T cell subsets in early breast cancer: a study based on the FinHer trial patient population.

scientific article published on 26 February 2018

Prognostic value of isolated tumour cells in sentinel lymph nodes in early-stage breast cancer: a prospective study

scientific article published on 24 April 2018

Prokineticins and Merkel cell polyomavirus infection in Merkel cell carcinoma.

scientific article published on 04 February 2014

Proteolytic Processing of ErbB4 in Breast Cancer

scientific article

Quantification of Estrogen Receptor-Alpha Expression in Human Breast Carcinomas With a Miniaturized, Low-Cost Digital Microscope: A Comparison with a High-End Whole Slide-Scanner

scientific article published on 14 December 2015

Radiation dose and subsequent risk for stomach cancer in long-term survivors of cervical cancer

scientific article published on 22 May 2013

Radiotherapy after segmental resection of breast cancer with favorable prognostic features: 12-year follow-up results of a randomized trial

scientific article published on 29 December 2008

Radiotherapy for GIST progressing during or after tyrosine kinase inhibitor therapy: A prospective study

scientific article published on 27 July 2015

Radium-223 in combination with paclitaxel in cancer patients with bone metastases: safety results from an open-label, multicenter phase Ib study

scientific article published on 13 December 2018

Raltitrexed treatment promotes systemic inflammatory reaction in patients with colorectal carcinoma.

scientific article published on September 2002

Regorafenib for patients with previously untreated metastatic or unresectable renal-cell carcinoma: a single-group phase 2 trial.

scientific article published on 6 September 2012

Risk factors for gastrointestinal stromal tumor recurrence in patients treated with adjuvant imatinib.

scientific article

Risk of esophageal cancer following radiotherapy for Hodgkin lymphoma

scientific article published on October 2014

Risk of leukemia among survivors of testicular cancer: a population-based study of 42,722 patients

scientific article

Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts.

scientific article published on 06 December 2011

Risk of second non-hematological malignancies among 376,825 breast cancer survivors

article by Linda Morris Brown et al published 3 February 2007 in Breast Cancer Research and Treatment

Risk stratification of patients diagnosed with gastrointestinal stromal tumor.

scientific article published on October 2008

SLUG transcription factor: a pro-survival and prognostic factor in gastrointestinal stromal tumour

scientific article

SORLA regulates endosomal trafficking and oncogenic fitness of HER2

scientific article published on 28 May 2019

Safety of sentinel node biopsy in breast cancer patients who receive a second radioisotope injection after visualization failure in lymphoscintigraphy

scientific article published in November 2010

Scintigraphy in prediction of the salivary gland function after gland-sparing intensity modulated radiation therapy for head and neck cancer

scientific article published on 07 March 2008

Second cancers after squamous cell carcinoma and adenocarcinoma of the cervix

scientific article published on 29 December 2008

Second cancers following the diagnosis of Merkel cell carcinoma: a nationwide cohort study.

scientific article published on 12 January 2010

Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1.

scientific article published on 10 January 2013

Sentinel Node Biopsy in Breast Cancer Patients with Large or Multifocal Tumors

scientific article published on 26 February 2009

Soft tissue and visceral sarcomas: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

scientific article published on 01 October 2018

Somatic mutation profiling and associations with prognosis and trastuzumab benefit in early breast cancer

scientific article published on 05 June 2013

Sorafenib as third- or fourth-line treatment of advanced gastrointestinal stromal tumour and pretreatment including both imatinib and sunitinib, and nilotinib: A retrospective analysis.

scientific article

Sparing of the submandibular glands by intensity modulated radiotherapy in the treatment of head and neck cancer

scientific article published on 27 March 2006

Stomach Cancer Following Hodgkin Lymphoma, Testicular Cancer and Cervical Cancer: A Pooled Analysis of Three International Studies with a Focus on Radiation Effects

scientific article published on 24 January 2017

Stomach cancer risk after treatment for hodgkin lymphoma

scientific article published on 26 August 2013

Suicide after breast cancer: an international population-based study of 723,810 women.

scientific article published in October 2006

Sunitinib for imatinib-resistant GIST

scientific article published on 01 October 2006

Sunitinib-induced hypertension, neutropaenia and thrombocytopaenia as predictors of good prognosis in patients with metastatic renal cell carcinoma

scientific article

Surgical treatment in Paget's disease of the breast

scientific article published on 01 August 2010

Tamoxifen therapy for patients with breast cancer

scientific article published in The Lancet

Taxane Followed by Anthracycline or Vice Versa: Impact of Sequential Order on Breast Cancer Recurrence?-Reply.

scientific article published on 26 October 2017

The management and survival outcomes of nasopharyngeal cancer in the Nordic countries

scientific article published on 5 December 2017

The management of gastrointestinal stromal tumors: a model for targeted and multidisciplinary therapy of malignancy

scientific article published on 13 October 2011

The outcome of sentinel node biopsy in breast cancer patients with preoperative surgical biopsy

scientific article published on 01 June 2009

Trastuzumab Therapy for 9 Weeks vs 1 Year for Human Epidermal Growth Factor 2-Positive Breast Cancer-Reply

scientific article published on 01 January 2019

Trastuzumab emtansine: mechanisms of action and drug resistance

scientific article

Tumor Infiltrating Immune Cells and Outcome of Merkel Cell Carcinoma: A Population-Based Study

scientific article published on 30 March 2012

Tumor PIK3CA Genotype and Prognosis in Early-Stage Breast Cancer: A Pooled Analysis of Individual Patient Data.

scientific article published on 22 February 2018

Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: results from the FinHER trial

scientific article

Tumor-Infiltrating Lymphocytes and Prognosis: A Pooled Individual Patient Analysis of Early-Stage Triple-Negative Breast Cancers

scientific article published on 16 January 2019

Tumour microvessel endothelial cell KIT and stem cell factor expression in human solid tumours

scientific article published in November 2009

Ultrasonography of the axilla in the follow-up of breast cancer patients who have a negative sentinel node biopsy and who avoid axillary clearance

scientific article published on 01 January 2006

Undifferentiated sinonasal carcinoma may respond to single-fraction boron neutron capture therapy

scientific article published on 01 July 2004

Use of cancer-specific genomic rearrangements to quantify disease burden in plasma from patients with solid tumors

scientific article

VEGFR-3 expression is restricted to blood and lymphatic vessels in solid tumors.

scientific article published in June 2008

Validation of the Joensuu risk criteria for primary resectable gastrointestinal stromal tumour – The impact of tumour rupture on patient outcomes

scientific article published on 07 July 2011

Vatalanib for metastatic gastrointestinal stromal tumour (GIST) resistant to imatinib: final results of a phase II study.

scientific article

Very high quantitative tumor HER2 content and outcome in early breast cancer

scientific article published on 01 February 2011

Voice quality after treatment of early vocal cord cancer: a randomized trial comparing laser surgery with radiation therapy

scientific article

Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization.

scientific article

p95HER2 Methionine 611 Carboxy-Terminal Fragment Is Predictive of Trastuzumab Adjuvant Treatment Benefit in the FinHer Trial.

scientific article

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