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List of works by Outi Hovatta

A Combination of Culture Conditions and Gene Expression Analysis Can Be Used to Investigate and Predict hES Cell Differentiation Potential towards Male Gonadal Cells

scientific article published on 2 December 2015

A North European perspective in assisted reproduction-new legislation is coming in Finland and in Sweden

scientific article published on 01 March 2002

A Role for the Androgen Receptor in Follicular Atresia of Estrogen Receptor Beta Knockout Mouse Ovary1 ⬇️

scientific article published on January 1, 2002

A culture system using human foreskin fibroblasts as feeder cells allows production of human embryonic stem cells

scientific article

A defined and xeno-free culture method enabling the establishment of clinical-grade human embryonic, induced pluripotent and adipose stem cells

scientific article

A gene expression signature shared by human mature oocytes and embryonic stem cells

scientific article

A large Northern European observational study of follitropin alpha filled-by-mass pre-filled pen

scientific article published on 01 April 2009

A meta-analysis of human embryonic stem cells transcriptome integrated into a web-based expression atlas.

scientific article published on 4 January 2007

A missense mutation in SLC26A3 is associated with human male subfertility and impaired activation of CFTR.

scientific article published on 27 October 2017

A teratocarcinoma-like human embryonic stem cell (hESC) line and four hESC lines reveal potentially oncogenic genomic changes

scientific article

Activation of neural and pluripotent stem cell signatures correlates with increased malignancy in human glioma

scientific article

Adult Human and Mouse Ovaries Lack DDX4-Expressing Functional Oogonial Stem Cells

Adult human and mouse ovaries lack DDX4-expressing functional oogonial stem cells

scientific article published in October 2015

Advances in the Molecular Pathophysiology, Genetics, and Treatment of Primary Ovarian Insufficiency.

scientific article published on 26 April 2018

Allelic estrogen receptor 1 (ESR1) gene variants predict the outcome of ovarian stimulation in in vitro fertilization

scientific article

Alterations in the expression, structure and function of progesterone receptor membrane component-1 (PGRMC1) in premature ovarian failure

scientific article published on 09 September 2008

An effective serum- and xeno-free chemically defined freezing procedure for human embryonic and induced pluripotent stem cells

scientific article

Aromatase gene (CYP19A1) variants, female infertility and ovarian stimulation outcome: a preliminary report.

scientific article published in May 2009

Benefits of 8-bromo-guanosine 3',5'-cyclic monophosphate (8-br-cGMP) in human ovarian cortical tissue culture

scientific article published in March 2004

Biogrid--a microfluidic device for large-scale enzyme-free dissociation of stem cell aggregates

scientific article published on 17 August 2011

Birth of a healthy infant after in vitro oocyte maturation and ICSI in a woman with diminished ovarian response: case report

scientific article published on 19 May 2005

Birth of a healthy male after frozen thawed blastocyst transfer following intracytoplasmic injection of frozen thawed testicular spermatozoa from a man with nonmosaic Klinefelter's syndrome

scientific article

Bivalent histone modifications in stem cells poise miRNA loci for CpG island hypermethylation in human cancer

scientific article

CD marker expression profiles of human embryonic stem cells and their neural derivatives, determined using flow-cytometric analysis, reveal a novel CD marker for exclusion of pluripotent stem cells.

scientific article published on 16 September 2008

Challenges and approaches to the culture of pluripotent human embryonic stem cells

scientific article published on May 2007

Challenges for the Therapeutic use of Pluripotent Stem Derived Cells ⬇️

scientific article published on February 10, 2012

Changes in the plasma microvesicle proteome during the ovarian hyperstimulation phase of assisted reproductive technology

scientific article published on 12 August 2020

Changes in von Willebrand factor and ADAMTS13 during IVF

scientific article published on 01 March 2011

Characterization and target genes of nine human PRD-like homeobox domain genes expressed exclusively in early embryos

scientific article published on 14 July 2016

Characterization of human embryonic stem cell lines by the International Stem Cell Initiative

scientific article

Chondrogenic differentiation of human pluripotent stem cells in chondrocyte co-culture

scientific article published on 2 June 2013

Clinical aspects of fertility preservation in female patients

scientific article published on August 2009

Clinical grade vitrification of human ovarian tissue: an ultrastructural analysis of follicles and stroma in vitrified tissue ⬇️

scientific article published on January 8, 2011

Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment

scientific article published on January 2014

Co-existence of heparin-binding epidermal growth factor-like growth factor and pinopodes in human endometrium at the time of implantation

scientific article published on 01 August 2002

Co-localization of neural cell adhesion molecule and fibroblast growth factor receptor 2 in early embryo development

scientific journal article

Coexpression of pinopodes and leukemia inhibitory factor, as well as its receptor, in human endometrium

scientific article published in March 2003

Comparison of defined culture systems for feeder cell free propagation of human embryonic stem cells

scientific article

Concise review: animal substance-free human embryonic stem cells aiming at clinical applications

scientific article

Correction to: Defined serum- and xeno-free cryopreservation of mesenchymal stem cells

scientific article published on 01 June 2019

Corrigendum: Characterization and target genes of nine human PRD-like homeobox domain genes expressed exclusively in early embryos

scientific article published on 2 September 2016

Costimulation blockade induces foxp3(+) regulatory T cells to human embryonic stem cells

scientific article published on December 2013

Costimulation blockade induces tolerance to HESC transplanted to the testis and induces regulatory T-cells to HESC transplanted into the heart

scientific article published on 8 May 2008

Coxsackievirus and adenovirus receptor (CAR) is expressed in male germ cells and forms a complex with the differentiation factor JAM-C in mouse testis

scientific journal article

Cryobiology of ovarian and testicular tissue

scientific article

Cryopreservation and autotransplantation of human ovarian tissue prior to cytotoxic therapy--a technique in its infancy but already successful in fertility preservation

scientific article published on 04 March 2009

Cryopreservation and culture of human ovarian cortical tissue containing early follicles

scientific article published on April 2004

Cryopreservation of dissociated human embryonic stem cells in the presence of ROCK inhibitor

scientific article published on July 2009

Cryopreservation of follicles in human ovarian cortical tissue. Comparison of serum and human serum albumin in the cryoprotectant solutions ⬇️

scientific article published on November 1, 2003

Cryopreservation of prepubertal mouse testicular tissue by vitrification

scientific article published on 11 June 2010

Culture and expansion of the human embryonic stem cell line HS181, evaluated in a double-color system

scientific article published on August 2004

Culture conditions for human embryonic stem cells

scientific article published on November 2006

Cultures of human embryonic stem cells: serum replacement medium or serum-containing media and the effect of basic fibroblast growth factor

scientific article

Defined serum- and xeno-free cryopreservation of mesenchymal stem cells

scientific article published on 13 August 2014

Defined serum-free media for in vitro expansion of adipose-derived mesenchymal stem cells

scientific article published on 13 April 2014

Derivation of 30 human embryonic stem cell lines--improving the quality

scientific article

Derivation of Human Skin Fibroblast Lines for Feeder Cells of Human Embryonic Stem Cells

scientific article published on 3 February 2016

Derivation of human embryonic stem cell lines in serum replacement medium using postnatal human fibroblasts as feeder cells.

scientific article

Derivation of human embryonic stem cell lines, towards clinical quality

scientific article published on January 2006

Derivation of human skin fibroblast lines for feeder cells of human embryonic stem cells

scientific article published on June 2008

Derivation of the first Swiss human embryonic stem cell line from a single blastomere of an arrested four-cell stage embryo.

scientific article published on September 2008

Detection of a procoagulable state during controlled ovarian hyperstimulation for in vitro fertilization with global assays of haemostasis ⬇️

scientific article published on 07 December 2011

Development and characterization of an endometrial tissue culture system ⬇️

scientific article published on September 1, 2003

Differences in gene expression between mouse and human for dynamically regulated genes in early embryo

scientific article

Differential lipolytic regulation in human embryonic stem cell-derived adipocytes

scientific article published on April 2007

Differentiation of Human Embryonic Stem Cells to Endothelial Progenitor Cells on Laminins in Defined and Xeno-free Systems

scientific article published on 21 September 2016

Differentiation of stem cells upon deprivation of exogenous FGF2: a general approach to study spontaneous differentiation of hESCs in vitro.

scientific article

Distinct sets of developmentally regulated genes that are expressed by human oocytes and human embryonic stem cells

scientific article published on 27 November 2006

Disturbances in the LIF pathway in the endometrium among women with unexplained infertility

scientific article published on 5 August 2008

Donation of embryos for stem cell research--how many couples consent?

scientific article published on 01 June 2003

Effect of Previous Chemotherapy on the Quality of Cryopreserved Human Ovarian Tissue In Vitro

scientific article published on 30 July 2015

Efficient passage of human pluripotent stem cells on spider silk matrices under xeno-free conditions

scientific article published on October 2015

Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells

scholarly article

Embryo transfer by midwife or gynecologist: a prospective randomized study

scientific article published in May 2003

Embryo transfer is equally effective at cleavage stage and blastocyst stage: a randomized prospective study

scientific article published in December 2004

Endogenous Estrogens Lower Plasma PCSK9 and LDL Cholesterol But Not Lp(a) or Bile Acid Synthesis in Women ⬇️

scientific article published on December 29, 2011

Erratum to: Recommendations for fertility preservation in patients with lymphoma, leukemia, and breast cancer.

scientific article published on 23 August 2012

European scientific, ethical, and legal issues on human stem cell research and regenerative medicine

scientific article published in June 2010

Exclusion of coding-region mutations in luteinizing hormone and follicle-stimulating hormone receptor genes as the cause of ovarian hyperstimulation syndrome

article

Experience of in vitro fertilization surrogacy in Finland

scientific article published in August 2002

Expression analysis of the NLRP gene family suggests a role in human preimplantation development

scientific article

Expression of Pluripotency Markers in Nonpluripotent Human Neural Stem and Progenitor Cells

scientific article published on 28 March 2017

Expression of leukemia inhibitory factor and its receptors is increased during differentiation of human embryonic stem cells.

scientific article

Feeder-free derivation of human embryonic stem-cell lines

scientific article

Fertility preservation in girls with turner syndrome: prognostic signs of the presence of ovarian follicles

scientific article published on 28 October 2008

Few instead of many: human follicle collection from follicular aspirates at oocyte retrieval.

scientific article published in December 2002

Fibrillar β-amyloid 1-42 alters cytokine secretion, cholinergic signalling and neuronal differentiation

scientific article

Follicles are found in the ovaries of adolescent girls with Turner's syndrome

scientific article published in August 2002

Full-term newborn after repeated ovarian tissue transplants in a patient treated for Ewing sarcoma by sterilizing pelvic irradiation and chemotherapy

scientific article

Gene expression signatures of seven individual human embryonic stem cell lines

scientific article

Global Update: Sweden ⬇️

scientific article published on November 1, 2012

Glycodelin is present in pinopodes of receptive-phase human endometrium and is associated with down-regulation of progesterone receptor B

scientific article published on 01 June 2006

Good manufacturing practice and clinical-grade human embryonic stem cell lines

scientific article published on April 2008

Growth Differentiation Factor-9 Promotes the Growth, Development, and Survival of Human Ovarian Follicles in Organ Culture ⬇️

scientific article published on January 1, 2002

High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity

article

Hormone Production by Human First-Trimester Gonads in a Functional In Vitro System

scientific article published on 01 January 2019

Human Pluripotent Stem Cells in Reproductive Science-a Comparison of Protocols Used to Generate and Define Male Germ Cells from Pluripotent Stem Cells

scientific article published on 04 February 2020

Human embryonic stem cells

scientific article published on 11 September 2015

Human embryonic stem cells are immunogenic in allogeneic and xenogeneic settings

scientific article published on 01 November 2006

Human germ cell differentiation from fetal- and adult-derived induced pluripotent stem cells

scientific article

Human induced pluripotent stem cells from two azoospermic patients with Klinefelter syndrome show similar X chromosome inactivation behavior to female pluripotent stem cells

scientific article published on 01 November 2019

Human neural stem/progenitor cells derived from embryonic stem cells and fetal nervous system present differences in immunogenicity and immunomodulatory potentials in vitro

scientific article

Human ovarian tissue cultures: extracellular matrix composition, coating density and tissue dimensions

scientific article published on 01 September 2004

Human pluripotent stem cells differentiated in fully defined medium generate hematopoietic CD34- and CD34+ progenitors with distinct characteristics

scientific article (publication date: 2011)

Immortalized human skin fibroblast feeder cells support growth and maintenance of both human embryonic and induced pluripotent stem cells

scientific article

Immunogenicity of human embryonic stem cells

scientific article published on 11 September 2007

Impact of first-line cancer treatment on the follicle quality in cryopreserved ovarian samples from girls and young women

scientific article published on 01 September 2019

Improved Method of Producing Human Neural Progenitor Cells of High Purity and in Large Quantities from Pluripotent Stem Cells for Transplantation Studies ⬇️

scientific article published on October 31, 2012

Improved cryopreservation of human hepatocytes using a new xeno free cryoprotectant solution

scientific article

In Vivo Differentiated Human Embryonic Stem Cells Can Acquire Chromosomal Aberrations More Frequently Than In Vitro During the Same Period

article

In vitro effect of cyclic adenosine 3', 5'-monophosphate (cAMP) on early human ovarian follicles

scientific article

In vitro neural differentiation of human embryonic stem cells

scientific article published on 01 October 2004

Incidence of hypertension, stroke, coronary heart disease, and diabetes in women who have delivered after in vitro fertilization: a population-based cohort study from Sweden

scientific article published on 23 July 2014

Incidence of pulmonary and venous thromboembolism in pregnancies after in vitro fertilisation: cross sectional study ⬇️

scientific article published on January 15, 2013

Incidence of pulmonary and venous thromboembolism in pregnancies after in vitro fertilization with fresh respectively frozen-thawed embryo transfer: nationwide cohort study

scientific article published on 14 April 2020

Infectious problems associated with transplantation of cells differentiated from pluripotent stem cells ⬇️

scientific article published on 09 April 2011

In Vivo Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors

scientific article published on 01 March 2019

In Vivo Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors

scientific article published on 01 May 2020

Karolinska Institutet Human Embryonic Stem Cell Bank

scientific article published on 21 April 2020

Kit ligand and c-Kit are expressed during early human ovarian follicular development and their interaction is required for the survival of follicles in long-term culture

scientific article published in April 2006

Laminin 521 Stabilizes the Pluripotency Expression Pattern of Human Embryonic Stem Cells Initially Derived on Feeder Cells.

scientific article published on 18 February 2018

Lentiviral-mediated HoxB4 expression in human embryonic stem cells initiates early hematopoiesis in a dose-dependent manner but does not promote myeloid differentiation

scientific article published on 10 July 2008

Life-long in vivo cell-lineage tracing shows that no oogenesis originates from putative germline stem cells in adult mice

scientific article

Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511.

scientific article

Luteal phase progesterone increases live birth rate after frozen embryo transfer

scientific article published on 26 June 2010

Mature eggs from primordial follicles in vitro--a challenge in the near future

scientific article published on 01 January 2012

Measurements of salivary progesterone throughout the menstrual cycle in women suffering from unexplained infertility reveal high frequency of luteal phase defects**Supported by research contracts from The Finnish Life and Pension Insurance Companies

article

Mechanical isolation of the inner cell mass is effective in derivation of new human embryonic stem cell lines

scientific article published on 24 October 2007

Methods for cryopreservation of human ovarian tissue

scientific article

Methods of cryopreservation of testicular tissue with viable spermatogonia in pre-pubertal boys undergoing gonadotoxic cancer treatment

scientific article published on 26 January 2007

Microparticles reveal cell activation during IVF - a possible early marker of a prothrombotic state during the first trimester

scientific article published on 14 July 2016

Minimal residual disease of leukemia and the quality of cryopreserved human ovarian tissue in vitro

scientific article published on 30 June 2015

Monitoring and analysis of dynamic growth of human embryonic stem cells: comparison of automated instrumentation and conventional culturing methods

scientific article published on 12 April 2007

Monolayer culturing and cloning of human pluripotent stem cells on laminin-521-based matrices under xeno-free and chemically defined conditions

scientific article published on 11 September 2014

Neurogenic neuroepithelial and radial glial cells generated from six human embryonic stem cell lines in serum-free suspension and adherent cultures.

scientific article published on March 2007

Neurotrophic factors promote cholinergic differentiation in human embryonic stem cell-derived neurons

scientific article published on 3 October 2009

No Relationship between Embryo Morphology and Successful Derivation of Human Embryonic Stem Cell Lines ⬇️

scientific article published on December 31, 2010

Novel PRD-like homeodomain transcription factors and retrotransposon elements in early human development

scientific article

Optimizing cryopreservation of human testicular tissue: comparison of protocols with glycerol, propanediol and dimethylsulphoxide as cryoprotectants

scientific article published on 28 April 2005

Ovarian function and in vitro fertilization (IVF) in Turner syndrome

scientific article published on May 1, 2012

Ovarian wedge resection restores fertility in estrogen receptor beta knockout (ERbeta-/-) mice

scholarly article

Over Expression of NANOS3 and DAZL in Human Embryonic Stem Cells

scientific article

Perturbations of heart development and function in cardiomyocytes from human embryonic stem cells with trisomy 21.

scientific article

Phenotypic Screen Identifies a Small Molecule Modulating ERK2 and Promoting Stem Cell Proliferation.

scientific article

Pleomorphic Adenoma Gene 1 Is Needed For Timely Zygotic Genome Activation and Early Embryo Development.

scientific article published on 10 June 2019

Pregnancies after oocyte donation in women with ovarian failure caused by an inactivating mutation in the follicle stimulating hormone receptor ⬇️

scientific article published on January 1, 2002

Pregnancies in women with Turner's syndrome

article by Outi Hovatta published 1 April 1999 in Annals of Medicine

Preservation of human ovarian follicles within tissue frozen by vitrification in a xeno-free closed system using only ethylene glycol as a permeating cryoprotectant

scientific article published on 6 April 2013

Preservation of women fertility facing potential premature ovarian failure

scientific article published on October 2008

Prostatic volume in young adults after treatment of cryptorchidism in childhood

scientific article published on 01 January 2006

Quality Assurance in Stem Cell Banking: Emphasis on Embryonic and Induced Pluripotent Stem Cell Banking

scientific article published in January 2017

RNA Polymerase III Subunit POLR3G Regulates Specific Subsets of PolyA+ and SmallRNA Transcriptomes and Splicing in Human Pluripotent Stem Cells

scientific article published on May 2017

Receptors for thyroid-stimulating hormone and thyroid hormones in human ovarian tissue

scientific article

Recombinant LH is equally effective as recombinant hCG in promoting oocyte maturation in a clinical in-vitro maturation programme: a randomized study.

scientific article published in October 2003

Recommendations for fertility preservation in patients with lymphoma, leukemia, and breast cancer

scientific article

Reply: Impact of first-line cancer treatment on follicle quality in cryopreserved ovarian samples

scientific article published on 13 April 2020

Research resource: interactome of human embryo implantation: identification of gene expression pathways, regulation, and integrated regulatory networks

scientific article

Resveratrol supports and alpha-naphthoflavone disrupts growth of human ovarian follicles in an in vitro tissue culture model

scientific article published on 13 November 2017

Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage

scientific article

Selective microRNA-Offset RNA expression in human embryonic stem cells

scientific article

Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells

scientific article published on 02 March 2020

Spider silk for xeno-free long-term self-renewal and differentiation of human pluripotent stem cells

scientific article

Stem cell transplantation--a new era in medicine?

scientific article

Surrogacy is needed

scientific article published on May 22, 2013

Temporal analysis of genome alterations induced by single-cell passaging in human embryonic stem cells

scientific article published on 25 November 2014

Testing of nine different xeno-free culture media for human embryonic stem cell cultures

scientific article published on 24 January 2007

The Hydroxysteroid (17β) Dehydrogenase Family Gene HSD17B12 Is Involved in the Prostaglandin Synthesis Pathway, the Ovarian Function, and Regulation of Fertility.

scientific article published on 4 August 2016

The SPECT imaging shows the accumulation of neural progenitor cells into internal organs after systemic administration in middle cerebral artery occlusion rats

scientific article published on 21 June 2008

The derivation of clinical-grade human embryonic stem cell lines

scientific article

The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity

scientific article

The human PRD-like homeobox gene LEUTX has a central role in embryo genome activation

scientific article published on 30 August 2016

The liver X receptor-{beta} is essential for maintaining cholesterol homeostasis in the testis.

scientific article

The zebrafish transcriptome during early development

scientific article

Thyroid-stimulating hormone receptor and thyroid hormone receptors are involved in human endometrial physiology

scientific article published on 5 August 2010

Tissue factor and tissue factor pathway inhibitors TFPI and TFPI2 in human secretory endometrium--possible link to female infertility

scientific article published on 18 March 2011

Transcriptome profiling of human pre-implantation development

scientific article

Transplantation of embryonic stem cells: possibilities and challenges

scientific article published on 01 October 2003

Transplantation of human embryonic stem cell-derived neural precursor cells and enriched environment after cortical stroke in rats: cell survival and functional recovery

scientific article published on 17 January 2009

Transplanted Human Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Do Not Promote Functional Recovery of Pharmacologically Immunosuppressed Mice With Contusion Spinal Cord Injury

scientific article published on 08 September 2014

Unique gene expression signature by human embryonic stem cells cultured under serum-free conditions correlates with their enhanced and prolonged growth in an undifferentiated stage

scientific article published on 11 August 2005

Vitrification versus controlled-rate freezing in cryopreservation of human ovarian tissue

scientific article published on 9 April 2009

Who benefits from putting family life into ice?

scientific article published on 19 October 2016

Xeno-Free and Defined Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells Functionally Integrate in a Large-Eyed Preclinical Model

scientific article published on 18 December 2015

Xeno-free culture of human pluripotent stem cells

scientific article

[A lot of news on the fertility front]

scientific article published in April 2014

[Human cell nucleus to animal embryo. Ethically defendable British decision. but it's necessary to make the technique function]

scientific article published on 01 January 2008

[Oocyte donation to be legalized in Sweden. Excellent results reported from other countries]

scientific article published on 01 July 2002

[Preserved fertility despite disease with a risk of infertility in young age]

[Stem cells in therapy of multiple sclerosis]

scientific article published on 01 January 2009

[Welcomed improvement of IVF. Only one pre-embryo is transferred: no twins, unchanged pregnancy rate]

scientific article published on 01 August 2004

Β-amyloid 1-42 oligomers impair function of human embryonic stem cell-derived forebrain cholinergic neurons

scientific article (publication date: 17 December 2010)

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