List of works - Paul Knoepfler

N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation

scientific article (publication date: 15 October 2002)

Myc influences global chromatin structure.

scientific article

Sin meets NuRD and other tails of repression.

scientific article

Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation

scientific journal article

Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity

scientific article published on December 2008

Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1

scientific article published on December 23, 1997

Division and apoptosis of E2f-deficient retinal progenitors

scientific article published in December 2009

myc maintains embryonic stem cell pluripotency and self-renewal

scientific article

Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.

scientific article published on July 1995

N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth.

scientific article published in September 2006

Selling Stem Cells in the USA: Assessing the Direct-to-Consumer Industry

scientific article

N-Myc regulates a widespread euchromatic program in the human genome partially independent of its role as a classical transcription factor

scientific article

A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1

scientific article

Myc goes global: new tricks for an old oncogene.

scientific article published on June 2007

Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF: Potential mechanisms of cooperativity with Hoxa9 in myeloid leukemia

scientific article published on October 30, 2001

Direct interaction of two homeoproteins, homothorax and extradenticle, is essential for EXD nuclear localization and function.

scientific article published in March 2000

Histone H3.3 mutations: a variant path to cancer

scientific article

Induced Pluripotency and Oncogenic Transformation Are Related Processes

scientific article published on October 26, 2012

N-Myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28b

scientific article

Pbx-1 Hox heterodimers bind DNA on inseparable half-sites that permit intrinsic DNA binding specificity of the Hox partner at nucleotides 3' to a TAAT motif.

scientific article published on June 1996

HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations

scientific article

Induced pluripotent stem cells show metabolomic differences to embryonic stem cells in polyunsaturated phosphatidylcholines and primary metabolism

scientific article

Histone H3.3 regulates dynamic chromatin states during spermatogenesis

scientific article

Inducing iPSCs to escape the dish.

scientific article

Activities of N-Myc in the developing limb link control of skeletal size with digit separation

scientific journal article

N-myc controls proliferation, morphogenesis, and patterning of the inner ear

scientific article

An inhibitory switch derepressed by pbx, hox, and Meis/Prep1 partners regulates DNA-binding by pbx1 and E2a-pbx1 and is dispensable for myeloid immortalization by E2a-pbx1.

scientific article published on December 1999

N-Myc and GCN5 regulate significantly overlapping transcriptional programs in neural stem cells.

scientific article

The highest affinity DNA element bound by Pbx complexes in t(1;19) leukemic cells fails to mediate cooperative DNA-binding or cooperative transactivation by E2a-Pbx1 and class I Hox proteins - evidence for selective targetting of E2a-Pbx1 to a subse

scientific article published on 01 May 1997

Genomic binding and transcriptional regulation by the Drosophila Myc and Mnt transcription factors.

scientific article published in January 2005

N-myc coordinates retinal growth with eye size during mouse development.

scientific article

From bench to FDA to bedside: US regulatory trends for new stem cell therapies

scientific article

The Pbx family of proteins is strongly upregulated by a post-transcriptional mechanism during retinoic acid-induced differentiation of P19 embryonal carcinoma cells.

scientific article published in April 1997

Identification of DPPA4 and DPPA2 as a novel family of pluripotency-related oncogenes.

scientific article

Myc and Miz-1 have coordinate genomic functions including targeting Hox genes in human embryonic stem cells.

scientific article

Reviewing post-publication peer review

scientific article published on April 4, 2015

Epigenetic mechanisms of tumorigenicity manifesting in stem cells.

scientific article

Gene expression in a swine model of right ventricular hypertrophy: intercellular adhesion molecule, vascular endothelial growth factor and plasminogen activators are upregulated during pressure overload.

scientific article published in July 1995

Key anticipated regulatory issues for clinical use of human induced pluripotent stem cells.

scientific article published on 26 July 2012

Urokinase plasminogen activator activity is increased in the myocardium during coronary artery occlusion

scientific article published on 01 June 1995

Miz-1 activates gene expression via a novel consensus DNA binding motif

scientific article

The FDA and the US direct-to-consumer marketplace for stem cell interventions: a temporal analysis

scientific article published on 12 January 2018

Call for fellowship programs in stem cell-based regenerative and cellular medicine: new stem cell training is essential for physicians.

scientific article published on March 2013

CRISPR-mediated HDAC2 disruption identifies two distinct classes of target genes in human cells

scientific article published on 5 October 2017

Constitutive gray hair in mice induced by melanocyte-specific deletion of c-Myc

scientific article published on May 2012

Utf1: Goldilocks for ESC bivalency.

scientific article published on December 2012

Chromatin immunoprecipitation assays for Myc and N-Myc.

scientific article

Too Much Carrot and Not Enough Stick in New Stem Cell Oversight Trends

scientific article published on 21 June 2018

The Stem Cell Hard Sell: Report from a Clinic's Patient Recruitment Seminar

scientific article published on 2 August 2016

Anticipated impact of stem cell and other cellular medicine clinical trials for COVID-19

publication published in 2021

List of works by Paul Knoepfler

N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation

Myc influences global chromatin structure.

Sin meets NuRD and other tails of repression.

Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation

Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity

Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1

Division and apoptosis of E2f-deficient retinal progenitors

myc maintains embryonic stem cell pluripotency and self-renewal

Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.

N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth.

Selling Stem Cells in the USA: Assessing the Direct-to-Consumer Industry

N-Myc regulates a widespread euchromatic program in the human genome partially independent of its role as a classical transcription factor

A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1

Myc goes global: new tricks for an old oncogene.

Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF: Potential mechanisms of cooperativity with Hoxa9 in myeloid leukemia

Direct interaction of two homeoproteins, homothorax and extradenticle, is essential for EXD nuclear localization and function.

Histone H3.3 mutations: a variant path to cancer

Induced Pluripotency and Oncogenic Transformation Are Related Processes

N-Myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28b

Pbx-1 Hox heterodimers bind DNA on inseparable half-sites that permit intrinsic DNA binding specificity of the Hox partner at nucleotides 3' to a TAAT motif.

HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations

Induced pluripotent stem cells show metabolomic differences to embryonic stem cells in polyunsaturated phosphatidylcholines and primary metabolism

Histone H3.3 regulates dynamic chromatin states during spermatogenesis

Inducing iPSCs to escape the dish.

Activities of N-Myc in the developing limb link control of skeletal size with digit separation

N-myc controls proliferation, morphogenesis, and patterning of the inner ear

An inhibitory switch derepressed by pbx, hox, and Meis/Prep1 partners regulates DNA-binding by pbx1 and E2a-pbx1 and is dispensable for myeloid immortalization by E2a-pbx1.

N-Myc and GCN5 regulate significantly overlapping transcriptional programs in neural stem cells.

The highest affinity DNA element bound by Pbx complexes in t(1;19) leukemic cells fails to mediate cooperative DNA-binding or cooperative transactivation by E2a-Pbx1 and class I Hox proteins - evidence for selective targetting of E2a-Pbx1 to a subse

Genomic binding and transcriptional regulation by the Drosophila Myc and Mnt transcription factors.

N-myc coordinates retinal growth with eye size during mouse development.

From bench to FDA to bedside: US regulatory trends for new stem cell therapies

The Pbx family of proteins is strongly upregulated by a post-transcriptional mechanism during retinoic acid-induced differentiation of P19 embryonal carcinoma cells.

Identification of DPPA4 and DPPA2 as a novel family of pluripotency-related oncogenes.

Myc and Miz-1 have coordinate genomic functions including targeting Hox genes in human embryonic stem cells.

Reviewing post-publication peer review

Epigenetic mechanisms of tumorigenicity manifesting in stem cells.

Gene expression in a swine model of right ventricular hypertrophy: intercellular adhesion molecule, vascular endothelial growth factor and plasminogen activators are upregulated during pressure overload.

Key anticipated regulatory issues for clinical use of human induced pluripotent stem cells.

Urokinase plasminogen activator activity is increased in the myocardium during coronary artery occlusion

Miz-1 activates gene expression via a novel consensus DNA binding motif

The FDA and the US direct-to-consumer marketplace for stem cell interventions: a temporal analysis

Call for fellowship programs in stem cell-based regenerative and cellular medicine: new stem cell training is essential for physicians.

CRISPR-mediated HDAC2 disruption identifies two distinct classes of target genes in human cells

Constitutive gray hair in mice induced by melanocyte-specific deletion of c-Myc

Utf1: Goldilocks for ESC bivalency.

Chromatin immunoprecipitation assays for Myc and N-Myc.

Too Much Carrot and Not Enough Stick in New Stem Cell Oversight Trends

The Stem Cell Hard Sell: Report from a Clinic's Patient Recruitment Seminar

Anticipated impact of stem cell and other cellular medicine clinical trials for COVID-19