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List of works by Lynda Chin

A comparison of DNA copy number profiling platforms

scientific article published on 29 October 2007

A comprehensive catalogue of somatic mutations from a human cancer genome

scientific article

A genetic screen for candidate tumor suppressors identifies REST

scientific article

A genome-wide screen reveals functional gene clusters in the cancer genome and identifies EphA2 as a mitogen in glioblastoma

scientific article published on 6 November 2006

A landscape of driver mutations in melanoma

scientific article

A role for ATF2 in regulating MITF and melanoma development

scientific article

A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival

scientific article published on 24 June 2013

A systems biology approach to personalizing therapeutic combinations

scientific article published on December 2013

Abstract A9: The pancreatic ductal adenocarcinoma project at the Ontario Institute for Cancer Research

Advances in malignant melanoma: genetic insights from mouse and man.

scientific article

Alu elements mediate MYB gene tandem duplication in human T-ALL

scientific article published on 10 December 2007

Amplification of CDK4 and MDM2 in malignant melanoma.

scientific article

An X chromosome gene, WTX, is commonly inactivated in Wilms tumor

scientific article

Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade

scientific article published on 14 June 2016

Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer

scientific article published on February 2012

Array-CGH reveals recurrent genomic changes in Merkel cell carcinoma including amplification of L-Myc

scientific article

BRAF activation initiates but does not maintain invasive prostate adenocarcinoma

scientific article

Balanced-PCR amplification allows unbiased identification of genomic copy changes in minute cell and tissue samples

scientific article

Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma

scientific article

Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma

scholarly article

Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma

scientific article published on 28 April 2017

Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse

scholarly article

Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo

scientific article

Cancer Genomics in Clinical Context

scientific article

Characterization of HPV and host genome interactions in primary head and neck cancers

scientific article

Characterization of melanocyte-specific inducible Cre recombinase transgenic mice

scientific article published on 01 May 2006

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

scientific article published on 21 May 2007

Chromosome 10, frequently lost in human melanoma, encodes multiple tumor-suppressive functions

scientific article published on 22 January 2014

Clonal evolution of acute myeloid leukemia relapsed after 19 years of remission

scientific article published on July 2015

Co-clinical assessment identifies patterns of BRAF inhibitor resistance in melanoma

scientific article

Common and Contrasting Genomic Profiles among the Major Human Lung Cancer Subtypes

Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types

scientific article published on November 2007

Comparative Oncogenomics Identifies NEDD9 as a Melanoma Metastasis Gene

article

Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model

scientific article

Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma

article

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas

scientific article

Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration ⬇️

scientific article published on June 10, 2011

Correction: Targeting EGFR Induced Oxidative Stress by PARP1 Inhibition in Glioblastoma Therapy.

scientific article

DNA amplification method tolerant to sample degradation

scientific article published on November 2004

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival

scientific article

Direct transcriptional activation of promyelocytic leukemia protein by IFN regulatory factor 3 induces the p53-dependent growth inhibition of cancer cells

scientific article published in December 2007

Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma

Distinct clinical patterns and immune infiltrates are observed at time of progression on targeted therapy versus immune checkpoint blockade for melanoma

scientific article published on 2 February 2016

Diverse Mechanisms of Somatic Structural Variations in Human Cancer Genomes ⬇️

scientific article published on May 9, 2013

Double minute chromosomes in glioblastoma multiforme are revealed by precise reconstruction of oncogenic amplicons

scientific article published on 12 August 2013

Downregulation of Protection of Telomeres 1 expression in myelodysplastic syndromes with 7q deletion

scientific article published on 24 June 2015

Dual Roles of RNF2 in Melanoma Progression

scientific article

Emerging insights into the molecular and cellular basis of glioblastoma

scientific article published in April 2012

Emerging patterns of somatic mutations in cancer

scientific article

Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth

scientific article

Epigenetic transdifferentiation of normal melanocytes by a metastatic melanoma microenvironment

scientific article published on November 2005

Erratum: Corrigendum: Passenger deletions generate therapeutic vulnerabilities in cancer

scientific article published in Nature

Erratum: Telomere dysfunction induces metabolic and mitochondrial compromise

scholarly article published in Nature

Expression of high in normal-1 (HIN-1) and uteroglobin related protein-1 (UGRP-1) in adult and developing tissues

scientific article (publication date: June 2002)

Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development

scientific article

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

scientific article

FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis

scientific article

Frequent met oncogene amplification in a Brca1/Trp53 mouse model of mammary tumorigenesis

scientific article published on April 2006

From the Cover: Neutralization of terminal differentiation in gliomagenesis

scientific article published on 05 August 2013

Full complexity genomic hybridization on 60-mer oligonucleotide microarrays for array comparative genomic hybridization (aCGH).

scientific article

GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer

scientific article

Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice

scientific article

Genetics and genomics of melanoma

scientific article published on April 2009

Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer

scholarly article

Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion

scientific article published on 04 September 2011

Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor

scientific article

Growth factors and oncogenes as targets in melanoma: lost in translation?

scientific article published on January 2007

Guanylate binding protein 1 is a novel effector of EGFR-driven invasion in glioblastoma

scientific article published on 12 December 2011

HiCPlotter integrates genomic data with interaction matrices

scientific article

High-resolution characterization of the pancreatic adenocarcinoma genome

scholarly article

High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients

article

High-resolution genomic profiles of human lung cancer

scientific article

High-resolution global profiling of genomic alterations with long oligonucleotide microarray

scientific article published on July 2004

Identification of a novel fusion gene, IRF2BP2-RARA, in acute promyelocytic leukemia

scientific article published on January 2015

Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer

scientific article

Inactivation of LEF1 in T-cell acute lymphoblastic leukemia

scientific article

Increased H3K9me3 drives dedifferentiated phenotype via KLF6 repression in liposarcoma

scientific article

Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling

scientific article published on August 2008

Integrative functional genomics identifies RINT1 as a novel GBM oncogene ⬇️

scientific article published on October 16, 2012

Integrative genome comparison of primary and metastatic melanomas

scientific article

International network of cancer genome projects

scientific article

Intra-patient intra-tumoral immune heterogeneity is evident at progression on targeted therapy and immunotherapy for melanoma

Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells

scientific article

MAPK Pathway Inhibitors Sensitize BRAF-Mutant Melanoma to an Antibody-Drug Conjugate Targeting GPNMB.

scientific article

MTSS1 is a metastasis driver in a subset of human melanomas

scientific article published on 17 March 2014

Making sense of cancer genomic data

scientific article

Malignant astrocytic glioma: genetics, biology, and paths to treatment

scientific article (publication date: November 2007)

Malignant melanoma: genetics and therapeutics in the genomic era.

scientific article published on August 2006

Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities.

scientific article published on 17 November 2006

Melanoma genome sequencing reveals frequent PREX2 mutations

scientific article

Mig-6 controls EGFR trafficking and suppresses gliomagenesis

scientific article

Modeling Genomic Instability and Selection Pressure in a Mouse Model of Melanoma

scientific article

Molecular and immune heterogeneity in synchronous melanoma metastases.

scientific article published on 4 November 2015

Molecular characterization of the tumor microenvironment in breast cancer

scientific article

Mutant EGFR is required for maintenance of glioma growth in vivo, and its ablation leads to escape from receptor dependence

scientific article

Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice

scientific journal article

Non-germline genetically engineered mouse models for translational cancer research

scientific article

Nozzle: a report generation toolkit for data analysis pipelines

scientific article

Nuclear cloning of embryonal carcinoma cells

scholarly article

Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation

scientific article published on January 2009

Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

scientific article

Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma

scientific article published on 16 September 2012

PAF promotes stemness and radioresistance of glioma stem cells.

scientific article published on 9 October 2017

PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas

scientific article

PRKCI promotes immune suppression in ovarian cancer

scientific article published on 11 July 2017

PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network

scientific article published on 23 May 2011

Passenger deletions generate therapeutic vulnerabilities in cancer

scientific article

Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM

scientific article

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

scientific article

Polygenic in vivo validation of cancer mutations using transposons

scientific article

Post-translational Regulation of Cas9 during G1 Enhances Homology-Directed Repair

scientific article

Prognostically relevant gene signatures of high-grade serous ovarian carcinoma

scientific article

Proinvasion metastasis drivers in early-stage melanoma are oncogenes

scientific article

Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic stem cells in glioblastoma

scientific article published in January 2008

Reprogramming of a melanoma genome by nuclear transplantation

scientific article published on August 2004

Revealing the genomic heterogeneity of melanoma

scientific article

Role of epidermal growth factor receptor signaling in RAS-driven melanoma

scientific article

SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression

scientific article published on 02 February 2011

STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA

scientific article

Semiconductor-based DNA sequencing of histone modification states

scientific article published on January 2013

Signaling from the Golgi: mechanisms and models for Golgi phosphoprotein 3-mediated oncogenesis

scientific article published on 30 March 2010

Somatic mutations of PIK3R1 promote gliomagenesis

scientific article

Spectrum of somatic mitochondrial mutations in five cancers

scientific article

Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer.

scientific article published on 8 February 2017

Systematic Epigenomic Analysis Reveals Chromatin States Associated with Melanoma Progression

scientific article

Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy

scientific article

Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression

scientific article

Targeting YAP-dependent MDSC infiltration impairs tumor progression.

scientific article

Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases

scientific article published on 16 February 2012

Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome

scientific article published on May 2015

Telomere dysfunction induces metabolic and mitochondrial compromise.

scientific article

Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer

scientific article published on 17 February 2008

Telomere dysfunction provokes regional amplification and deletion in cancer genomes

scientific article

The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia

scientific article

The INK4a/ARF locus and melanoma

scientific article

The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF

scientific article

The Somatic Genomic Landscape of Glioblastoma

article

The brothers RAF.

scientific article

The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models

scientific article published on January 2013

The genetics of malignant melanoma: lessons from mouse and man.

scientific article

The genomic complexity of primary human prostate cancer

scientific article

The somatic genomic landscape of chromophobe renal cell carcinoma

scientific article (publication date: 8 September 2014)

The somatic genomic landscape of glioblastoma

scientific article

Towards patient-based cancer therapeutics

scientific article

Translating insights from the cancer genome into clinical practice

scientific article published on April 2008

Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma

scientific article published on 16 February 2016

What drives intense apoptosis resistance and propensity for necrosis in glioblastoma? A role for Bcl2L12 as a multifunctional cell death regulator

scientific article published on 11 September 2008

Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution

scientific article

Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer

scientific article published on 01 November 2019

Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer

scientific article

mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization

scholarly article

miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma

scientific article

p16(Ink4a) in melanocyte senescence and differentiation

scientific article published in March 2002

p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation

scientific article

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