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List of works by Douglas Cines

A chimeric platelet-targeted urokinase prodrug selectively blocks new thrombus formation

scientific article

ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 1. Structural and functional characterization in vitro

scientific article

ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 2. Pathogenicity in an animal model

scientific article

Advanced drug delivery systems for antithrombotic agents.

scientific article published on 24 June 2013

Anchoring fusion thrombomodulin to the endothelial lumen protects against injury-induced lung thrombosis and inflammation

scientific article

Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT ⬇️

scientific article published on July 19, 2011

Antigen and substrate withdrawal in the management of autoimmune thrombotic disorders.

scientific article

Atomic description of the immune complex involved in heparin-induced thrombocytopenia

scientific article

Atomic features of an autoantigen in heparin-induced thrombocytopenia (HIT).

scientific article

Bad (or good) things come in small packages.

scientific article published on November 2013

Biocompatible coupling of therapeutic fusion proteins to human erythrocytes

scientific article published on 01 February 2018

Can immune thrombocytopenia be cured with medical therapy?

scientific article

Clot contraction: compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin.

scientific article published on 13 December 2013

Congenital and acquired thrombocytopenia

scientific article

Controversies in the treatment of immune thrombocytopenia

scientific article

Defining a second epitope for heparin-induced thrombocytopenia/thrombosis antibodies using KKO, a murine HIT-like monoclonal antibody

scientific article

Delivery of drugs bound to erythrocytes: new avenues for an old intravascular carrier

scientific article

Determinants of PF4/heparin immunogenicity

scientific article

Distinct specificity and single-molecule kinetics characterize the interaction of pathogenic and non-pathogenic antibodies against platelet factor 4-heparin complexes with platelet factor 4.

scientific article

Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through β1-integrin and VEGFR2

scientific article published on 24 May 2013

Dynamic antibody-binding properties in the pathogenesis of HIT.

scientific article

Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia

scientific article published on 18 June 2018

Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice

scientific article

Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia

scientific article

Erythrocytes as Carriers for Drug Delivery in Blood Transfusion and Beyond

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Evidence-based mini-review: Is indium-labeled autologous platelet scanning predictive of response to splenectomy in patients with chronic immune thrombocytopenia?

scientific article

Fibrin affinity of erythrocyte-coupled tissue-type plasminogen activators endures hemodynamic forces and enhances fibrinolysis in vivo

scientific article

Final results of the ReoPro readministration registry

scientific article

Flow-dependent channel formation in clots by an erythrocyte-bound fibrinolytic agent ⬇️

scientific article published on March 9, 2011

Genetic analysis of autoantibodies in idiopathic thrombocytopenic purpura reveals evidence of clonal expansion and somatic mutation

scientific article

Heparin enhances uptake of platelet factor 4/heparin complexes by monocytes and macrophages

scientific article

Heparin-induced thrombocytopenia: an autoimmune disorder regulated through dynamic autoantigen assembly/disassembly

scientific article

How I treat heparin-induced thrombocytopenia ⬇️

scientific article published on January 13, 2012

How I treat idiopathic thrombocytopenic purpura (ITP).

scientific article

Human complement receptor type 1-directed loading of tissue plasminogen activator on circulating erythrocytes for prophylactic fibrinolysis

scientific article

Human neutrophil peptides inhibit cleavage of von Willebrand factor by ADAMTS13: a potential link of inflammation to TTP.

scientific article published on 13 May 2016

ICAM-1-targeted thrombomodulin mitigates tissue factor-driven inflammatory thrombosis in a human endothelialized microfluidic model

scientific article published on 08 August 2017

Immune thrombocytopenia

scientific article 2010

Immune thrombocytopenic purpura

scientific article 2002

Innate and adaptive immunity in immune thrombocytopenia

scientific article

Integrated analysis of long-term safety in patients with chronic immune thrombocytopaenia (ITP) treated with the thrombopoietin (TPO) receptor agonist romiplostim

scientific article

International consensus report on the investigation and management of primary immune thrombocytopenia

scientific article

Kinetics and mechanics of clot contraction are governed by the molecular and cellular composition of the blood

scientific article

Long-term safety and tolerability of romiplostim in patients with primary immune thrombocytopenia: a pooled analysis of 13 clinical trials

scientific article

Management of adult idiopathic thrombocytopenic purpura

scientific article

Management of antithrombotic therapy in adults with immune thrombocytopenia (ITP): a survey of ITP specialists and general hematologist-oncologists

scientific article published on 01 July 2018

Mechanisms of action of therapeutics in idiopathic thrombocytopenic purpura

scientific article

Molecular and cellular pathogenesis of heparin-induced thrombocytopenia (HIT)

scientific article published on 10 August 2018

Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia ⬇️

scientific article published on August 19, 2010

Multifunctional roles of urokinase plasminogen activator (uPA) in cancer stemness and chemoresistance of pancreatic cancer.

scientific article published on 17 July 2013

Novel diagnostic assays for heparin-induced thrombocytopenia

scientific article

Nuclear translocation of urokinase-type plasminogen activator

scientific article

PAI-1-derived peptide EEIIMD prevents hypoxia/ischemia-induced aggravation of endothelin- and thromboxane-induced cerebrovasoconstriction

scientific article published on February 2014

PF4/heparin complexes are T cell-dependent antigens

scientific article

Pathobiology of secondary immune thrombocytopenia

scientific article

Pathogenesis of chronic immune thrombocytopenic purpura

scientific article

Pathogenesis of heparin-induced thrombocytopenia and thrombosis

scientific article

Pathogenesis of immune thrombocytopenia

scientific article

Platelet Factor 4 Inhibits and Enhances HIV-1 Infection in a Concentration-Dependent Manner by Modulating Viral Attachment

scientific article published on 05 February 2016

Platelet factor 4 enhances the binding of oxidized low-density lipoprotein to vascular wall cells

scientific article

Platelet glycoprotein IIb/IIIa inhibitors and thrombocytopenia: possible link between platelet activation, autoimmunity and thrombosis

scientific article

Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia

scientific article

Platelet-Specific Chemokines Contribute to the Pathogenesis of Acute Lung Injury

scientific article published on 18 October 2016

Platelet-delivered ADAMTS13 inhibits arterial thrombosis and prevents thrombotic thrombocytopenic purpura in murine models.

scientific article

Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia

scientific article published on 22 November 2016

Prospective comparison of the HEP score and 4Ts score for the diagnosis of heparin-induced thrombocytopenia

scientific article published on 01 November 2018

Protamine-induced thrombocytopenia?

scientific article

Rapid Evaluation of Platelet Function With T2 Magnetic Resonance

scientific article published on 27 December 2016

Rational design and characterization of platelet factor 4 antagonists for the study of heparin-induced thrombocytopenia.

scientific article

Release of IL-6 After Stroke Contributes to Impaired Cerebral Autoregulation and Hippocampal Neuronal Necrosis Through NMDA Receptor Activation and Upregulation of ET-1 and JNK.

scientific article

Role of monocytes and endothelial cells in heparin-induced thrombocytopenia

scientific article

Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications

scientific article

Safety and efficacy of romiplostim in splenectomized and nonsplenectomized patients with primary immune thrombocytopenia

scientific article

Safety of the thrombopoiesis-stimulating agents for the treatment of immune thrombocytopenia

scientific article

Standardization of bleeding assessment in immune thrombocytopenia: report from the International Working Group

scientific article

Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group

scientific article

Structure of human urokinase plasminogen activator in complex with its receptor

scientific article

T2 Magnetic Resonance to Monitor Hemostasis

scientific article published on 17 August 2018

T2 magnetic resonance: a diagnostic platform for studying integrated hemostasis in whole blood--proof of concept.

scientific article

TMA: beware of complements

scientific article

Targeting plasminogen activator inhibitor-1 in tetracycline-induced pleural injury in rabbits.

scientific article published on 31 August 2017

Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis

scientific article

Targeting thrombomodulin to circulating red blood cells augments its protective effects in models of endotoxemia and ischemia-reperfusion injury.

scientific article published on 11 November 2016

The ITP syndrome: pathogenic and clinical diversity

scientific article

The antigenic complex in HIT binds to B-cells via complement and complement receptor 2 (CD21).

scientific article

The immune thrombocytopenia syndrome: a disorder of diverse pathogenesis and clinical presentation

scientific article

The role of surface PF4: glycosaminoglycan complexes in the pathogenesis of heparin-induced thrombocytopenia (HIT).

scientific article

Thrombocytopenia after treatment with platelet glycoprotein IIb/IIIa inhibitors

scientific article

Thrombocytopenia in pregnancy

scientific article published on 21 June 2017

Thrombocytopenia in pregnancy

scientific article published on 01 December 2017

Tissue-Type Plasminogen Activator-A296-299 Prevents Impairment of Cerebral Autoregulation After Stroke Through Lipoprotein-Related Receptor-Dependent Increase in cAMP and p38.

scientific article published on 28 June 2016

Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia

scientific article

Urokinase-type Plasminogen Activator (uPA) Promotes Angiogenesis by Attenuating Proline-rich Homeodomain Protein (PRH) Transcription Factor Activity and De-repressing Vascular Endothelial Growth Factor (VEGF) Receptor Expression

scientific article published on 04 May 2016

Urokinase-type plasminogen activator (uPA) is critical for progression of tuberous sclerosis complex 2 (TSC2)-deficient tumors.

scientific article published on 27 September 2017

tPA variant tPA-A296-299 Prevents impairment of cerebral autoregulation and necrosis of hippocampal neurons after stroke by inhibiting upregulation of ET-1.

scientific article published on 13 July 2017

tPA-S(481)A prevents impairment of cerebrovascular autoregulation by endogenous tPA after traumatic brain injury by upregulating p38 MAPK and inhibiting ET-1.

scientific article published on 24 August 2013

α-Defensins Induce a Post-translational Modification of Low Density Lipoprotein (LDL) That Promotes Atherosclerosis at Normal Levels of Plasma Cholesterol

scientific article published on 30 October 2015

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