List of works by Brendan Crabb

A Plasmodium Falciparum Bromodomain Protein Regulates Invasion Gene Expression

scientific article

A common cross-species function for the double epidermal growth factor-like modules of the highly divergent plasmodium surface proteins MSP-1 and MSP-8.

scientific article published on 19 February 2004

A common protein export pathway in malaria parasites

scientific article published on 20 October 2010

A genetic screen for improved plasmid segregation reveals a role for Rep20 in the interaction of Plasmodium falciparum chromosomes

scientific article published in March 2002

A model for the progression of receptor-ligand interactions during erythrocyte invasion by Plasmodium falciparum

scientific article published on 21 March 2012

A new rodent model to assess blood stage immunity to the Plasmodium falciparum antigen merozoite surface protein 119 reveals a protective role for invasion inhibitory antibodies ⬇️

scientific article

A new system for rapid plasmid integration in Plasmodium parasites

scientific article published on 28 November 2006

A newly discovered protein export machine in malaria parasites

scientific article

A novel family of Apicomplexan glideosome-associated proteins with an inner membrane-anchoring role

scientific article (publication date: 11 September 2009)

A parasite genome sheds light on an old enemy

scientific article

A set of glycosylphosphatidyl inositol-anchored membrane proteins of Plasmodium falciparum is refractory to genetic deletion

scientific article

A subset of Plasmodium falciparum SERA genes are expressed and appear to play an important role in the erythrocytic cycle

scientific article (publication date: 6 December 2002)

A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malaria

scientific article published on 28 December 2005

Acquisition of invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein 1 in a transmigrant population requires multiple infections

scientific article

Advances in molecular genetic systems in malaria

scientific article published on June 2015

Alterations in local chromatin environment are involved in silencing and activation of subtelomeric var genes in Plasmodium falciparum

scientific article

An aspartyl protease directs malaria effector proteins to the host cell

scientific article

Antimalarial activity of novel 4-cyano-3-methylisoquinoline inhibitors against Plasmodium falciparum: design, synthesis and biological evaluation

scientific article published on 22 April 2016

Association of iss and iucA, but not tsh, with plasmid-mediated virulence of avian pathogenic Escherichia coli

scientific article published on November 2004

Attenuation of chicken anemia virus by site-directed mutagenesis of VP2.

scientific article

Biochemical and functional analysis of two Plasmodium falciparum blood-stage 6-cys proteins: P12 and P41

scientific article

Biosynthesis, localization, and macromolecular arrangement of the Plasmodium falciparum translocon of exported proteins (PTEX)

scientific article (publication date: 9 March 2012)

Blood-stage Plasmodium berghei infection generates a potent, specific CD8+ T-cell response despite residence largely in cells lacking MHC I processing machinery

scientific article published on 13 October 2011

Blood-stage Plasmodium berghei infection leads to short-lived parasite-associated antigen presentation by dendritic cells

scientific article published in June 2010

Blood-stage Plasmodium infection induces CD8+ T lymphocytes to parasite-expressed antigens, largely regulated by CD8alpha+ dendritic cells

scholarly article

Broadly reactive antibodies specific for Plasmodium falciparum MSP-1(19) are associated with the protection of naturally exposed children against infection

scientific article

CD1d-restricted NKT cells contribute to malarial splenomegaly and enhance parasite-specific antibody responses

scientific article published in September 2003

CD8+ T cells from a novel T cell receptor transgenic mouse induce liver-stage immunity that can be boosted by blood-stage infection in rodent malaria

scientific article published on 22 May 2014

Characterisation of complexes formed by parasite proteins exported into the host cell compartment of Plasmodium falciparum infected red blood cells.

scientific article

Chicken anemia virus VP2 is a novel dual specificity protein phosphatase

scientific article published on 31 July 2002

Comparative genomics of the neglected human malaria parasite Plasmodium vivax

scientific article

Conditional expression of apical membrane antigen 1 in Plasmodium falciparum shows it is required for erythrocyte invasion by merozoites ⬇️

scientific article (publication date: May 2014)

Conservation of L and 3C proteinase activities across distantly related aphthoviruses.

scientific article published on December 2002

Contrasting Patterns of Serologic and Functional Antibody Dynamics to Plasmodium falciparum Antigens in a Kenyan Birth Cohort

scientific article published on 9 December 2015

Deletion of the Plasmodium falciparum merozoite surface protein 7 gene impairs parasite invasion of erythrocytes ⬇️

scientific article (publication date: December 2008)

Dendritic cell preactivation impairs MHC class II presentation of vaccines and endogenous viral antigens

scholarly article

Development of a Novel CD4+ TCR Transgenic Line That Reveals a Dominant Role for CD8+ Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria

scientific article published on 30 October 2017

Development of fluorescent Plasmodium falciparum for in vitro growth inhibition assays

scientific article

Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance

scientific article published on 11 November 2016

Discovery of GAMA, a Plasmodium falciparum merozoite micronemal protein, as a novel blood-stage vaccine candidate antigen

scientific article published on 6 September 2011

Disrupting the allosteric interaction between the Plasmodium falciparum cAMP-dependent kinase and its regulatory subunit

scientific article

Distinct protein classes including novel merozoite surface antigens in Raft-like membranes of Plasmodium falciparum

scientific article (publication date: 2 December 2005)

Do apicomplexan parasite-encoded proteins act as both ligands and receptors during host cell invasion?

scientific article

Effectiveness of repellent delivered through village health volunteers on malaria incidence in villages in South-East Myanmar: a stepped-wedge cluster-randomised controlled trial protocol

article

Embryonic age influences the capacity for cytokine induction in chicken thymocytes.

scientific article

Enzymic, phylogenetic, and structural characterization of the unusual papain-like protease domain of Plasmodium falciparum SERA5.

scientific article published on 17 September 2003

Evidence for a common role for the serine-type Plasmodium falciparum serine repeat antigen proteases: implications for vaccine and drug design

scientific article

Evidence that Plasmodium falciparum chromosome end clusters are cross-linked by protein and are the sites of both virulence gene silencing and activation

scientific article published on 30 August 2006

Evidence that invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein-1 (MSP-1 19) can play a protective role against blood-stage Plasmodium falciparum infection in individuals in a malaria endemic area of Africa

scientific article published in July 2004

Exploration of 3-methylisoquinoline-4-carbonitriles as protein kinase A inhibitors of Plasmodium falciparum

scientific article published on 28 March 2016

Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes

scientific article (publication date: 11 July 2008)

Functional analysis of Plasmodium falciparum merozoite antigens: implications for erythrocyte invasion and vaccine development ⬇️

scientific article

Functional conservation of the AMA1 host-cell invasion ligand between P. falciparum and P. vivax: a novel platform to accelerate vaccine and drug development

scientific article

Functional genomics: identifying drug targets for parasitic diseases

scientific article published on November 2003

Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum

scientific article published in April 2005

Hierarchical phosphorylation of apical membrane antigen 1 is required for efficient red blood cell invasion by malaria parasites

scientific article

Host cell remodelling in malaria parasites: a new pool of potential drug targets

scientific article published on 28 June 2016

IP-10-mediated T cell homing promotes cerebral inflammation over splenic immunity to malaria infection

scientific article

Identification and disruption of the gene encoding the third member of the low-molecular-mass rhoptry complex in Plasmodium falciparum

scientific article

Identification and prioritization of merozoite antigens as targets of protective human immunity to Plasmodium falciparum malaria for vaccine and biomarker development

scientific article published on 17 June 2013

Identification and stoichiometry of glycosylphosphatidylinositol-anchored membrane proteins of the human malaria parasite Plasmodium falciparum

scientific article (publication date: July 2006)

Identification of inhibitors that dually target the new permeability pathway and dihydroorotate dehydrogenase in the blood stage of Plasmodium falciparum

scientific article (publication date: 22 November 2016)

Identification of protein complexes in detergent-resistant membranes of Plasmodium falciparum schizonts

scientific article published on 27 April 2007

Immune-mediated mechanisms of parasite tissue sequestration during experimental cerebral malaria

scientific article published on 18 August 2010

Immunogenicity and protective efficacy of Escherichia coli expressed Plasmodium falciparum merozoite surface protein-1(42) using human compatible adjuvants

scientific article published on 6 December 2005

Inhibition of malaria parasite development by a cyclic peptide that targets the vital parasite protein SERA5.

scientific article

Insights and controversies into the role of the key apicomplexan invasion ligand, Apical Membrane Antigen 1.

scientific article

Intergenic regions in the rhoptry associated protein-1 (rap-1) locus promote exogenous gene expression in Babesia bovis

scientific article published on September 2004

Knockdown of the translocon protein EXP2 in Plasmodium falciparum reduces growth and protein export

scientific article published in PLoS ONE

Liver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection

scientific article published on 17 September 2016

Liver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection

scientific article published on 01 October 2019

MSP1(19) miniproteins can serve as targets for invasion inhibitory antibodies in Plasmodium falciparum provided they contain the correct domains for cell surface trafficking

scientific article published in April 2008

Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum ⬇️

scientific article

Mapping epitopes in equine rhinitis A virus VP1 recognized by antibodies elicited in response to infection of the natural host

scientific article published in June 2003

Molecular approaches to malaria: MAM 2004 and beyond

scientific article published in December 2004

Molecular genetic tools in Toxoplasma and Plasmodium: achievements and future needs

scientific article published on August 2007

Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites

scientific article published on 20 April 2009

Morphology and kinetics of the three distinct phases of red blood cell invasion by Plasmodium falciparum merozoites

scientific article

Mutation of chicken anemia virus VP2 differentially affects serine/threonine and tyrosine protein phosphatase activities.

scientific article published on March 2005

NK cells and conventional dendritic cells engage in reciprocal activation for the induction of inflammatory responses during Plasmodium berghei ANKA infection

scientific article published on 23 May 2012

Novel roles for erythroid Ankyrin-1 revealed through an ENU-induced null mouse mutant

scientific article published on 28 January 2009

Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity

scientific article published on 12 January 2017

Overlaying Molecular and Temporal Aspects of Malaria Parasite Invasion

scientific article

PTEX is an essential nexus for protein export in malaria parasites

scientific article (publication date: 31 July 2014)

Perspectives: The missing pieces

scientific article published on 25 April 2012

Plasmepsin V cleaves malaria effector proteins in a distinct endoplasmic reticulum translocation interactome for export to the erythrocyte

scholarly article by Danushka S Marapana et al published September 2018 in Nature Microbiology

Plasmodium falciparum Adhesins Play an Essential Role in Signalling and Activation of Invasion into Human Erythrocytes ⬇️

scientific article

Plasmodium falciparum merozoite surface protein 8 is a ring-stage membrane protein that localizes to the parasitophorous vacuole of infected erythrocytes

scientific article published in July 2005

Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate

scientific article (publication date: 2 March 2017)

Plasmodium falciparum transfected with ultra bright NanoLuc luciferase offers high sensitivity detection for the screening of growth and cellular trafficking inhibitors

scientific article

Plasmodium falciparum virulence determinants unveiled

scientific article

Plasmodium falciparum-encoded exported hsp70/hsp40 chaperone/co-chaperone complexes within the host erythrocyte

scientific article (publication date: November 2012)

Potential epigenetic regulatory proteins localise to distinct nuclear sub-compartments in Plasmodium falciparum

scientific article (publication date: 2010)

Prenatal malaria immune experience affects acquisition of Plasmodium falciparum merozoite surface protein-1 invasion inhibitory antibodies during infancy

scientific article published in November 2006

Promising functional readouts of immunity in a blood-stage malaria vaccine trial

scientific article

Protein export in Plasmodium parasites: from the endoplasmic reticulum to the vacuolar export machine

scientific article published on 17 February 2010

Protein export in malaria parasites: an update

scientific article published on 27 January 2014

Protein kinase a dependent phosphorylation of apical membrane antigen 1 plays an important role in erythrocyte invasion by the malaria parasite

scientific article

Proteomic analysis reveals novel proteins associated with the Plasmodium protein exporter PTEX and a loss of complex stability upon truncation of the core PTEX component, PTEX150

scientific article (publication date: November 2016)

Quantifying the importance of MSP1-19 as a target of growth-inhibitory and protective antibodies against Plasmodium falciparum in humans

scientific article

Recent insights into the export of PEXEL/HTS-motif containing proteins in Plasmodium parasites

scientific article published on 22 October 2012

Recruitment of Factor H as a Novel Complement Evasion Strategy for Blood-Stage Plasmodium falciparum Infection

scientific article (publication date: February 2016)

Revealing the molecular determinants of gender in malaria parasites

scientific article published in June 2005

Revealing the sequence and resulting cellular morphology of receptor-ligand interactions during Plasmodium falciparum invasion of erythrocytes ⬇️

scientific article (publication date: February 2015)

Several recombinant capsid proteins of equine rhinitis a virus show potential as diagnostic antigens

scientific article published on June 2005

Site-directed mutagenesis of the VP2 gene of Chicken anemia virus affects virus replication, cytopathology and host-cell MHC class I expression

scientific article published on April 2006

Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes

scientific article

Spotlight on malaria: MAM2008.

scientific article published on 17 October 2008

Structural insights into the protease-like antigen Plasmodium falciparum SERA5 and its noncanonical active-site serine

scientific article

Systematic analysis of FKBP inducible degradation domain tagging strategies for the human malaria parasite Plasmodium falciparum

scientific article

Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity

scientific article published on 15 January 2006

Temporal stability of naturally acquired immunity to Merozoite Surface Protein-1 in Kenyan adults

scientific article published on 16 July 2009

Tetracycline analogue-regulated transgene expression in Plasmodium falciparum blood stages using Toxoplasma gondii transactivators

scientific article

The Plasmodium falciparum erythrocyte invasion ligand Pfrh4 as a target of functional and protective human antibodies against malaria. ⬇️

scientific article

The Plasmodium falciparum genome--a blueprint for erythrocyte invasion

scientific article

The Plasmodium translocon of exported proteins (PTEX) component thioredoxin-2 is important for maintaining normal blood-stage growth

scientific article (publication date: September 2013)

The exported chaperone Hsp70-x supports virulence functions for Plasmodium falciparum blood stage parasites

scientific article published on 21 July 2017

The fine specificity, but not the invasion inhibitory activity, of 19-kilodalton merozoite surface protein 1-specific antibodies is associated with resistance to malarial parasitemia in a cross-sectional survey in The Gambia

scientific article published on October 2004

The importance of human FcgammaRI in mediating protection to malaria

scientific article

The malaria parasite Plasmodium falciparum has only one pyruvate dehydrogenase complex, which is located in the apicoplast

scientific article (publication date: 2005)

The role of osmiophilic bodies and Pfg377 expression in female gametocyte emergence and mosquito infectivity in the human malaria parasite Plasmodium falciparum

scientific article published on 11 December 2007

The serine repeat antigen (SERA) gene family phylogeny in Plasmodium: the impact of GC content and reconciliation of gene and species trees

scientific article

Toward forward genetic screens in malaria-causing parasites using the piggyBac transposon

scientific article

Towards a vaccine against Plasmodium vivax malaria

scientific article published in December 2007

Trafficking of STEVOR to the Maurer's clefts in Plasmodium falciparum-infected erythrocytes

scientific article

Trafficking of the exported P. falciparum chaperone PfHsp70x

scientific article (publication date: 8 November 2016)

Transfection of the human malaria parasite Plasmodium falciparum

scientific article published on 01 January 2004

Transfection technology and the study of drug resistance in the malaria parasite Plasmodium falciparum

scientific article

Truncation of Plasmodium berghei merozoite surface protein 8 does not affect in vivo blood-stage development

scientific article

Truncation of merozoite surface protein 3 disrupts its trafficking and that of acidic-basic repeat protein to the surface of Plasmodium falciparum merozoites

scientific article (publication date: March 2002)

VAR2CSA is the principal ligand for chondroitin sulfate A in two allogeneic isolates of Plasmodium falciparum

scientific article published on 7 April 2006

Why Australia needs a Medical Research Future Fund

scientific article published on February 2015

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