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List of works by Daved H. Fremont

A Gorilla Adenovirus-Based Vaccine against Zika Virus Induces Durable Immunity and Confers Protection in Pregnancy

scientific article published on 01 September 2019

A Library of Infectious Hepatitis C Viruses with Engineered Mutations in the E2 Gene Reveals Growth-Adaptive Mutations That Modulate Interactions with Scavenger Receptor Class B Type I.

scientific article

A Murine Herpesvirus Closely Related to Ubiquitous Human Herpesviruses Causes T-Cell Depletion.

scientific article

A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection

scientific article published on 26 June 2020

A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies

scientific article published on 10 June 2020

A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2

scientific article published on 19 August 2020

A Structural Explanation for the Antithrombotic Activity of ARC1172, a DNA Aptamer that Binds von Willebrand Factor Domain A1

scientific article

A Therapeutic Antibody against West Nile Virus Neutralizes Infection by Blocking Fusion within Endosomes

scientific article (publication date: May 2009)

A herpesvirus encoded Qa-1 mimic inhibits natural killer cell cytotoxicity through CD94/NKG2A receptor engagement

scientific article published on 21 December 2018

A host receptor enables type 1 pilus-mediated pathogenesis of Escherichia coli pyelonephritis

scientific article published in 2021

A molecular understanding of alphavirus entry

scientific article published on 22 October 2020

A short N-terminal peptide motif on flavivirus nonstructural protein NS1 modulates cellular targeting and immune recognition

scientific article published on 30 June 2010

A single intranasal or intramuscular immunization with chimpanzee adenovirus vectored SARS-CoV-2 vaccine protects against pneumonia in hamsters

scientific article published on 03 December 2020

Accessory protein recruitment motifs in clathrin-mediated endocytosis

scientific article

Adjuvanted H5N1 influenza vaccine enhances both cross-reactive memory B cell and strain-specific naive B cell responses in humans

scientific article published on 13 July 2020

Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses

scientific article published on 29 September 2020

Altered compensatory cytokine signaling underlies the discrepancy between Flt3-/- and Flt3l-/- mice

scientific article published on 23 March 2018

An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and Pathogenesis

scientific article published on 18 February 2020

An unusual Fc receptor-related protein expressed in human centroblasts

scientific article

Antibodies against West Nile Virus Nonstructural Protein NS1 Prevent Lethal Infection through Fc   Receptor-Dependent and -Independent Mechanisms

scientific article

Antibodies targeting epitopes on the cell-surface form of NS1 protect against Zika virus infection during pregnancy

scientific article published on 19 October 2020

Antibody Recognition and Neutralization Determinants on Domains I and II of West Nile Virus Envelope Protein

scientific article

Antibody Recognition of Cell Surface-Associated NS1 Triggers Fc- Receptor-Mediated Phagocytosis and Clearance of West Nile Virus-Infected Cells

scientific article

Antigen-specific cytotoxic T lymphocytes protect against lethal West Nile virus encephalitis.

scientific article

Basic and translational applications of engineered MHC class I proteins

scientific article published on 09 September 2010

Bile Salts Alter the Mouse Norovirus Capsid Conformation: Possible Implications for Cell Attachment and Immune Evasion

scientific article published on 12 September 2019

Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins ⬇️

scientific article

Biochemical features of the MHC-related protein 1 consistent with an immunological function

scientific article (publication date: 15 June 2003)

Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress

scientific article

CD300LF polymorphisms of inbred mouse strains confer resistance to murine norovirus infection in a cell type-dependent manner

scientific article published on 24 June 2020

Capturing a Flavivirus Pre-Fusion Intermediate

scientific article (publication date: November 2009)

Cellular and Humoral Immunity Protect against Vaginal Zika Virus Infection in Mice

scientific article published on 17 January 2018

Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion

scholarly article

Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion

scientific article

Complement Protein C1q Inhibits Antibody-Dependent Enhancement of Flavivirus Infection in an IgG Subclass-Specific Manner

scientific article

Complement Protein C1q Reduces the Stoichiometric Threshold for Antibody-Mediated Neutralization of West Nile Virus

scientific article (publication date: 22 October 2009)

Complex phenotypes in mosquitoes and mice associated with neutralization escape of a Dengue virus type 1 monoclonal antibody

scientific article published on 9 March 2012

Correlating RANK ligand/RANK binding kinetics with osteoclast formation and function

scientific article published on 10 April 2015

Costimulation through NKG2D enhances murine CD8+ CTL function: similarities and differences between NKG2D and CD28 costimulation.

scientific article

Cowpox virus employs a two-pronged strategy to outflank MHCI antigen presentation

scientific article

Cowpox virus encodes a protein that binds B7.1 and B7.2 and subverts T cell costimulation

scientific article published on 01 October 2019

Critical neutralizing fragment of Zika virus EDIII elicits cross-neutralization and protection against divergent Zika viruses

scientific article published on 24 January 2018

Cross-priming induces immunodomination in the presence of viral MHC class I inhibition

scientific article published on 14 February 2018

Cryo-EM Structure of Chikungunya Virus in Complex with the Mxra8 Receptor

scientific article published on 09 May 2019

Crystal Structure of I-Ak in Complex with a Dominant Epitope of Lysozyme ⬇️

scientific article published on March 1, 1998

Crystal Structure of the Cowpox Virus-Encoded NKG2D Ligand OMCP

scientific article

Crystal Structure of the Japanese Encephalitis Virus Envelope Protein

scientific article

Crystal Structure of the West Nile Virus Envelope Glycoprotein

scientific article (publication date: December 2006)

Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb

scientific article published on August 14, 1992

Cutting edge: FcR-like 5 on innate B cells is targeted by a poxvirus MHC class I-like immunoevasin

scientific article published on 2 June 2010

Cutting edge: murine UL16-binding protein-like transcript 1: a newly described transcript encoding a high-affinity ligand for murine NKG2D.

scientific article

Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice

scientific article published on 5 February 2019

Development of a highly protective combination monoclonal antibody therapy against Chikungunya virus

scientific article (publication date: 2013)

Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus

scientific article

Discovery of a proteinaceous cellular receptor for a norovirus

scientific article

Distinct B cell subsets give rise to antigen-specific antibody responses against SARS-CoV-2

scientific article published on 25 September 2020

Disulfide bond engineering to trap peptides in the MHC class I binding groove

scientific article published on May 2007

Dual GPCR and GAG mimicry by the M3 chemokine decoy receptor

scientific article

Dual engagement regulation of protein interactions with the AP-2 adaptor alpha appendage

scientific article

Ebola images emerge from the cave

scientific article published on August 2008

Emerging principles for the recognition of peptide antigens by MHC class I molecules

scientific article published on August 14, 1992

Endogenous MHC-related protein 1 is transiently expressed on the plasma membrane in a conformation that activates mucosal-associated invariant T cells

scientific article published on 14 March 2011

Enhanced immune presentation of a single-chain major histocompatibility complex class I molecule engineered to optimize linkage of a C-terminally extended peptide.

scientific article

Eukaryotic expression systems for structural studies

scientific article published on January 2014

Evidence for MR1 antigen presentation to mucosal-associated invariant T cells

scientific article

Evidence for a genetic and physical interaction between nonstructural proteins NS1 and NS4B that modulates replication of West Nile virus

scientific article

Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin Metabolites.

scientific article published on 10 June 2015

Functional analysis of antibodies against dengue virus type 4 reveals strain-dependent epitope exposure that impacts neutralization and protection

scientific article published on 19 June 2013

Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors

scientific article (publication date: August 2003)

Genotype-specific neutralization and protection by antibodies against dengue virus type 3.

scientific article published on 11 August 2010

Health Care Associated Outbreak of SARS CoV2 in a Rural Hospital - Missouri, March 2020

scientific article published on 20 October 2020

Hepatitis C virus epitope exposure and neutralization by antibodies is affected by time and temperature

scientific article

Human Antibodies Targeting Influenza B Virus Neuraminidase Active Site Are Broadly Protective

scientific article published on 22 September 2020

Human C-type lectin domain family 4, member C (CLEC4C/BDCA-2/CD303) is a receptor for asialo-galactosyl-oligosaccharides

scientific article published on 31 August 2011

Human major histocompatibility complex (MHC) class I molecules with disulfide traps secure disease-related antigenic peptides and exclude competitor peptides

scientific article published on 14 January 2008

Hydrogen–deuterium exchange mass spectrometry identifies spatially distinct antibody epitopes on domain III of the Zika virus envelope protein

scientific article published in 2020

Identification and sequencing of a novel rodent gammaherpesvirus that establishes acute and latent infection in laboratory mice

scientific article published on 5 January 2011

Identification of somatic JAK1 mutations in patients with acute myeloid leukemia

scientific article published on 26 December 2007

Immunoglobulin-like transcript receptors on human dermal CD14+ dendritic cells act as a CD8-antagonist to control cytotoxic T cell priming

scientific article

Induction of Epitope-Specific Neutralizing Antibodies against West Nile Virus

scientific article (publication date: November 2007)

LDLRAD3 is a receptor for Venezuelan equine encephalitis virus

scientific article published on 18 November 2020

Levels of Circulating NS1 Impact West Nile Virus Spread to the Brain

scientific article published on 04 August 2021

Ligands for murine NKG2D display heterogeneous binding behavior

scientific article published on March 2002

MMTV superantigens coerce an unconventional topology between the TCR and MHC class II.

scientific article published on 22 January 2014

MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution

scholarly article

MR1 uses an endocytic pathway to activate mucosal-associated invariant T cells

scientific article published on 28 April 2008

Manipulation of receptor oligomerization as a strategy to inhibit signaling by TNF superfamily members

scientific article

Mechanism of differential Zika and dengue virus neutralization by a public antibody lineage targeting the DIII lateral ridge

scientific article published on 01 February 2020

Molluscum contagiosum virus MC80 sabotages MHC-I antigen presentation by targeting tapasin for ER-associated degradation

scientific article published on 29 April 2019

Mouse and Human Monoclonal Antibodies Protect against Infection by Multiple Genotypes of Japanese Encephalitis Virus.

scientific article

Mxra8 is a receptor for multiple arthritogenic alphaviruses

scientific article published in Nature

Myeloid skewing in murine autoimmune arthritis occurs in hematopoietic stem and primitive progenitor cells

scientific article

N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation

scientific article published on 04 January 2004

Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor.

scientific article published on 20 December 2017

Natural killer cell-mediated lysis of dorsal root ganglia neurons via RAE1/NKG2D interactions.

scientific article published in January 2003

Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2

scientific article published on 27 May 2020

Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2

scientific article published on 03 July 2020

Neutralizing antibodies against Mayaro virus require Fc effector functions for protective activity

scientific article published on 23 July 2019

Neutralizing antibody and soluble ACE2 inhibition of a replication-competent VSV-SARS-CoV-2 and a clinical isolate of SARS-CoV-2

scientific article published on 19 May 2020

Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice

scientific article published on 7 November 2016

Neutralizing monoclonal antibodies against hepatitis C virus E2 protein bind discontinuous epitopes and inhibit infection at a postattachment step

scientific article

Oncogenic potential of the DNA replication licensing protein CDT1

scientific journal article

Optimal therapeutic activity of monoclonal antibodies against chikungunya virus requires Fc-FcγR interaction on monocytes

scientific article published on 01 February 2019

Oxidative refolding from inclusion bodies

scientific article published on January 2014

Parallel Evolution of Chemokine Binding by Structurally Related Herpesvirus Decoy Receptors

scientific article

Patterns of nonclassical MHC antigen presentation

scientific article published on 01 June 2007

Peptide selection by an MHC H-2Kb class I molecule devoid of the central anchor ("C") pocket ⬇️

scientific article published on March 15, 1998

Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion.

scientific article published in October 2017

Potent dengue virus neutralization by a therapeutic antibody with low monovalent affinity requires bivalent engagement

scientific article

Preparation of stable single-chain trimers engineered with peptide, beta2 microglobulin, and MHC heavy chain

scientific article published on 01 November 2009

Protective antibodies against Eastern equine encephalitis virus bind to epitopes in domains A and B of the E2 glycoprotein

scientific article published on 19 November 2018

RANKL Employs Distinct Binding Modes to Engage RANK and the Osteoprotegerin Decoy Receptor

scientific article

Recognition of a virus-encoded ligand by a natural killer cell activation receptor

scientific article

Recognition of open conformers of classical MHC by chaperones and monoclonal antibodies

scientific article

Replication-Competent Vesicular Stomatitis Virus Vaccine Vector Protects against SARS-CoV-2-Mediated Pathogenesis in Mice

scientific article published on 30 July 2020

Replication-competent vesicular stomatitis virus vaccine vector protects against SARS-CoV-2-mediated pathogenesis

scientific article published on 10 July 2020

Requisite Chromatin Remodeling for Myeloid and Erythroid Lineage Differentiation from Erythromyeloid Progenitors

scientific article published on 01 November 2020

Rodent herpesvirus Peru encodes a secreted chemokine decoy receptor

scientific article published on 30 October 2013

SARS-CoV-2 infection severity is linked to superior humoral immunity against the spike

scientific article published on 13 September 2020

Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist.

scientific article published on 14 June 2017

Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy

scientific article published on 21 September 2016

Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia

scientific article published on 12 February 2008

Structural Basis of Cytochrome c Presentation by IE k

scientific article

Structural Basis of Differential Neutralization of DENV-1 Genotypes by an Antibody that Recognizes a Cryptic Epitope

scientific article

Structural Basis of Zika Virus-Specific Antibody Protection

scientific article published on 26 July 2016

Structural Conservation and Functional Diversity of the Poxvirus Immune Evasion (PIE) Domain Superfamily

scientific article

Structural Engineering of pMHC Reagents for T Cell Vaccines and Diagnostics

scientific article

Structural Insights into the Mechanisms of Antibody-Mediated Neutralization of Flavivirus Infection: Implications for Vaccine Development

scientific article (publication date: 11 September 2008)

Structural Mechanism of ER Retrieval of MHC Class I by Cowpox

scientific article

Structural and Biophysical Analysis of BST-2/Tetherin Ectodomains Reveals an Evolutionary Conserved Design to Inhibit Virus Release

scientific article

Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor

article published in the Proceedings of the National Academy of Sciences of the United States of America

Structural basis for the preferential recognition of immature flaviviruses by a fusion-loop antibody

scientific article (publication date: 21 October 2009)

Structural basis for the restoration of TCR recognition of an MHC allelic variant by peptide secondary anchor substitution

scientific article

Structural basis of Flavivirus NS1 assembly and antibody recognition

scientific article

Structural basis of chemokine sequestration by a herpesvirus decoy receptor

scientific article

Structural definition of the F-actin-binding THATCH domain from HIP1R

scientific journal article

Structural definition of the H-2Kd peptide-binding motif

scientific article published on 10 February 2006

Structural determinants of chemokine binding by an Ectromelia virus-encoded decoy receptor

scientific article published in August 2006

Structural determinants of herpesvirus entry mediator recognition by murine B and T lymphocyte attenuator

scientific article

Structure and function analysis of therapeutic monoclonal antibodies against dengue virus type 2.

scientific article

Structure and intracellular targeting of the SARS-coronavirus Orf7a accessory protein

scientific article

Structure of the St. Louis Encephalitis Virus Postfusion Envelope Trimer

scientific article

Structure, expression, and intracellular localization of the SARS-CoV accessory proteins 7a and 7b.

scientific article

Subversion of cytokine networks by virally encoded decoy receptors

scientific article

T-cell tolerance for variability in an HLA class I-presented influenza A virus epitope

scientific article published on 24 June 2009

Target selection for structural genomics of infectious diseases

scientific article published on January 2014

Targeting of IL-2 to cytotoxic lymphocytes as an improved method of cytokine-driven immunotherapy

scientific article

The Development of Therapeutic Antibodies That Neutralize Homologous and Heterologous Genotypes of Dengue Virus Type 1

scientific article (publication date: April 2010)

The Fc region of an antibody impacts the neutralization of West Nile viruses in different maturation states

scientific article published on 09 October 2013

The Stoichiometry of Antibody-Mediated Neutralization and Enhancement of West Nile Virus Infection

scientific article

The chemokine binding protein M3 prevents diabetes induced by multiple low doses of streptozotocin

scientific article published on 01 April 2007

The low-density lipoprotein receptor promotes infection of multiple encephalitic alphaviruses

scientific article published in 2024

The mechanism of differential neutralization of dengue serotype 3 strains by monoclonal antibody 8A1.

scientific article published on 28 February 2013

The role of mhc polymorphism in anti-microbial resistance

scientific article published on April 2004

The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse

scientific article published on 8 March 2007

The structural immunology of antibody protection against West Nile virus

scientific article

The unusual dynamics of parasite actin result from isodesmic polymerization

scientific article

Type- and Subcomplex-Specific Neutralizing Antibodies against Domain III of Dengue Virus Type 2 Envelope Protein Recognize Adjacent Epitopes

scientific article

West Nile virus in complex with the Fab fragment of a neutralizing monoclonal antibody

scientific article (publication date: 15 August 2006)

West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H

scientific article (publication date: 12 December 2006)

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