Search filters

List of works by Hidde Ploegh

A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens

scientific article

A European slant on mol biol

journal article; published in Nature, 2001-10

A New MHC Locus That Influences Class I Peptide Presentation ⬇️

scientific article published on November 1, 1997

A Structural Element within the HUWE1 HECT Domain Modulates Self-ubiquitination and Substrate Ubiquitination Activities

scientific article

A biochemical characterization of feline MHC products: unusually high expression of class II antigens on peripheral blood lymphocytes

scientific article published on 01 January 1986

A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis

scientific article published on 31 August 2009

A catalytic independent function of the deubiquitinating enzyme USP14 regulates hippocampal synaptic short-term plasticity and vesicle number.

scientific article published on 11 November 2013

A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation.

scientific article published on 13 December 2012

A closer look at proteolysis and MHC-class-II-restricted antigen presentation.

scientific article

A conserved Bacteroidetes antigen induces anti-inflammatory intestinal T lymphocytes

scientific article published on 5 August 2022

A deubiquitinating activity is conserved in the large tegument protein of the herpesviridae

scientific article

A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae

scientific article

A feline class II alpha gene with striking similarity to the HLA-DPA pseudogene

scientific article

A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway

scientific article

A functional ubiquitin-specific protease embedded in the large tegument protein (ORF64) of murine gammaherpesvirus 68 is active during the course of infection

scientific article

A gammaherpesvirus ubiquitin-specific protease is involved in the establishment of murine gammaherpesvirus 68 infection

scientific article

A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised

scientific article

A herpesvirus ubiquitin-specific protease is critical for efficient T cell lymphoma formation.

scholarly article

A human herpesvirus 7 glycoprotein, U21, diverts major histocompatibility complex class I molecules to lysosomes

scientific article

A hydrophobic transmembrane segment at the carboxyl terminus of thy-1.

scientific article published in February 1985

A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum

scientific article published on July 2007

A membrane protein required for dislocation of misfolded proteins from the ER

scientific article

A microengraving method for rapid selection of single cells producing antigen-specific antibodies

scientific article

A molecule's right to choose: how diabetogenic class II MHC products bind peptides

scientific article published on August 2005

A monoclonal antibody that causes the heterotrimeric G-protein G(o) to release its beta gamma subunits

scientific article published on 01 May 1996

A mouse cytomegalovirus glycoprotein, gp34, forms a complex with folded class I MHC molecules in the ER which is not retained but is transported to the cell surface

scientific article

A mouse monoclonal antibody against Alexa Fluor 647.

scientific article

A myristoylated pseudosubstrate peptide, a novel protein kinase C inhibitor

scientific article published on 01 January 1993

A nanobody suite for yeast scaffold nucleoporins provides details of the nuclear pore complex structure

scientific article published on 02 December 2020

A nanobody that recognizes a 14-residue peptide epitope in the E2 ubiquitin-conjugating enzyme UBC6e modulates its activity

scientific article published on 10 September 2019

A new MHC locus that influences class I peptide presentation

scientific article published on 01 October 1999

A new TLR2 agonist promotes cross-presentation by mouse and human antigen presenting cells

scientific article

A nomenclature solution to mouse MHC confusion.

scientific article published in May 1999

A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14

scientific article

A novel immunoadsorption device for removing beta2-microglobulin from whole blood

scientific article published on 01 April 2001

A protease draws first blood

scientific article published in Nature

A proteolytic system that compensates for loss of proteasome function ⬇️

scientific article published on April 9, 1998

A pseudosubstrate peptide inhibits protein kinase C-mediated phosphorylation in permeabilized Rat-1 cells

scientific article published on February 1990

A reporter screen in a human haploid cell line identifies CYLD as a constitutive inhibitor of NF-κB.

scientific article

A role for N-glycanase in the cytosolic turnover of glycoproteins

scientific article

A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly

scientific article published on 11 April 2016

A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L

scientific journal article

A soluble, single-chain Kd molecule produced by yeast selects a peptide repertoire indistinguishable from that of cell-surface-associated Kd.

scientific article published on August 1993

A straight path to circular proteins

scientific article published on 09 April 2009

A subset of HLA-B27 molecules contains peptides much longer than nonamers

scientific article

A viral deubiquitylating enzyme restores dislocation of substrates from the endoplasmic reticulum (ER) in semi-intact cells.

scientific article

A viral peptide can mimic an endogenous peptide for allorecognition of a major histocompatibility complex class I product ⬇️

scientific article published on June 1, 1992

AID-/-mus-/- mice are agammaglobulinemic and fail to maintain B220-CD138+ plasma cells

scientific article published on 01 February 2007

Aberrant expression of HLA class-I antigens in Burkitt lymphoma cells

scientific article published on February 1991

Accessory molecules for Toll-like receptors and their function ⬇️

scientific article published on 03 February 2012

Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis

scientific article published in March 2004

Acidic amino acid residues in the juxtamembrane region of the nucleotide-sensing TLRs are important for UNC93B1 binding and signaling

scientific article published on 12 April 2013

Activation of human B cells: involvement of surface immunoglobulin as evidenced by two biochemically distinct types of response to Staphylococcus aureus.

scientific article

Activation of protein kinase C accelerates internalization of transferrin receptor but not of major histocompatibility complex class I, independent of their phosphorylation status ⬇️

scientific article published on November 5, 1992

Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib

scientific article

Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells

scholarly article

Allele and locus-specific differences in cell surface expression and the association of HLA class I heavy chain with beta 2-microglobulin: differential effects of inhibition of glycosylation on class I subunit association

scientific article published on 01 May 1988

Allele-specific down-regulation of MHC class I antigens in Burkitt lymphoma lines.

scientific article published in May 1989

Allosteric activation of apicomplexan calcium-dependent protein kinases.

scientific article published on 24 August 2015

Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection

scientific article

Altered natural killer cell repertoire in Tap-1 mutant mice

scientific article published on July 1994

Amino acid copolymers that alleviate experimental autoimmune encephalomyelitis in vivo interact with heparan sulfates and glycoprotein 96 in APCs

scientific article published on 5 June 2013

An HLA lost mutation may lead to leukemic relapse of recipient type six years after bone marrow transplantation

scientific article published on 01 January 1987

An RNA nanoparticle vaccine against Zika virus elicits antibody and CD8+ T cell responses in a mouse model

scientific article (publication date: 21 March 2017)

An analysis of class I antigens of man and other species by one-dimensional IEF and immunoblotting

scientific article published on 01 January 1986

An evaluation of the significance of amino acid sequence homologies in human histocompatibility antigens (HLA-A and HLA-B) with immunoglobulins and other proteins, using relatively short sequences

scientific article published on 01 January 1980

An improved biochemical method for the analysis of HLA-class I antigens. Definition of new HLA-class I subtypes

scientific article published on 01 June 1986

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration.

scientific article published in June 2012

Analysis of human class I antigens by two-dimensional gel electrophoresis. I. Polymorphism, evidence for additional (non-HLA-A, B, C) gene products, and identification of variant HLA-A, B antigens

scientific article published on 01 January 1983

Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation

scientific article

Anti-CTLA-4 therapy requires an Fc domain for efficacy

scientific article published on 26 March 2018

Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions

scientific article published on January 2006

Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2

scientific article

Antigen presentation: immunologists co-opt cell biology

scientific article published on 01 July 1996

Antigen presentation: untapped peptides

scientific article published on 01 June 1993

Antigen recognition

scientific article published on 01 February 1998

Antigen-Specific Induction of Regulatory T Cells In Vivo and In Vitro ⬇️

scientific article published on January 1, 2011

Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus

scientific article

Apicomplexan UCHL3 retains dual specificity for ubiquitin and Nedd8 throughout evolution

Are MHC-bound peptides a nuisance for positive selection?

scientific article published on December 1994

Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice.

scientific article published in June 2005

Assembly and intracellular targeting of the betagamma subunits of heterotrimeric G proteins

scientific article published on April 1997

Assembly and intracellular transport of major histocompatibility complex molecules ⬇️

scientific article published on August 1, 1991

Assembly of HLA DR1 molecules translated in vitro: binding of peptide in the endoplasmic reticulum precludes association with invariant chain.

scientific article

Association of mouse mammary tumor virus superantigen with MHC class II during biosynthesis

scientific article published in March 2001

Association with beta 2-microglobulin controls the expression of transfected human class I genes

scientific article published on 01 February 1987

Attachment of Chlamydia trachomatis L2 to host cells requires sulfation.

scientific article

Autoantibodies produced at the site of tissue damage provide evidence of humoral autoimmunity in inclusion body myositis

scientific article

B-cell receptor signaling in lymphoid malignancies and autoimmunity

scientific article published on January 2014

BAT3 Guides Misfolded Glycoproteins Out of the Endoplasmic Reticulum ⬇️

scientific article published on December 8, 2011

Behavioral responses of epidermal Langerhans cells in situ to local pathological stimuli.

scientific article published in April 2006

Biochemical analysis of variant HLA-B27 antigens

scientific article published on 01 February 1983

Biochemical and cellular identification of HLA-Bw44 subtypes

scientific article published on 01 October 1984

Biochemical evidence that the DLA-B locus codes for a class II determinant expressed on all canine peripheral blood lymphocytes

scientific article published on 01 January 1989

Biosynthesis and assembly of MHC antigens.

scientific article published on December 1990

Biosynthesis and assembly of MHC antigens.

scientific article published on January 1990

Biosynthesis and cell surface localization of nonglycosylated human histocompatibility antigens

scientific article published on 01 January 1981

Biosynthesis of major histocompatibility complex molecules and generation of T cells in Ii TAP1 double-mutant mice.

scientific article published on February 1996

Biosynthesis of murine immunoglobulin D: heterogeneity of glycosylation

scientific article published on 01 October 1982

Bispecific antibody generated with sortase and click chemistry has broad antiinfluenza virus activity

scientific article

Bridging B cell and T cell recognition of antigen

scientific article published on 01 December 2007

Bruton's Tyrosine Kinase (BTK) and Vav1 contribute to Dectin1-dependent phagocytosis of Candida albicans in macrophages

scientific article (publication date: 2013)

CD8(+) T cells from mice transnuclear for a TCR that recognizes a single H-2K(b)-restricted MHV68 epitope derived from gB-ORF8 help control infection

scientific article

CD82 controls CpG-dependent TLR9 signaling

scientific article published on 13 August 2019

CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites ⬇️

scientific article published on August 26, 2011

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

scientific journal article

CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance

scientific article (publication date: 14 January 2005)

Can viruses help us to understand and classify the MHC class I molecules at the maternal-fetal interface?

scientific article

Catching proteases in action with microarrays

scientific article published in October 2004

Catch‐and‐Release Probes Applied to Semi‐Intact Cells Reveal Ubiquitin‐Specific Protease Expression in Chlamydia trachomatis Infection ⬇️

scientific article published on January 18, 2013

Cathepsin L is essential for onset of autoimmune diabetes in NOD mice

scientific article

Cathepsin L: Critical Role in Ii Degradation and CD4 T Cell Selection in the Thymus ⬇️

scientific article published on April 17, 1998

Cathepsin S activity regulates antigen presentation and immunity ⬇️

scientific article published on June 1, 1998

Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells.

scientific article

Cathepsin S regulates class II MHC processing in human CD4+ HLA-DR+ T cells

scientific article published on 24 June 2009

Cathepsin S required for normal MHC class II peptide loading and germinal center development

scientific journal article

Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation ⬇️

scientific article published on April 14, 1998

Cell-free synthesis and processing of the heavy and light chains of HLA-DR antigens

scientific article published on 01 August 1980

Cell-free translation of the mRNAs for the heavy and light chains of HLA-A and HLA-B antigens

scientific article published on May 1979

Cell-specific TLR9 trafficking in primary APCs of transgenic TLR9-GFP mice

scientific article published on 12 December 2012

Cellular internalization of cytolethal distending toxin: a new end to a known pathway

scientific article published on July 2005

Chaperone AMPylation modulates aggregation and toxicity of neurodegenerative disease-associated polypeptides.

scientific article published on 14 May 2018

Characterization and structural studies of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3

scientific article

Characterization of a G-protein beta-subunit gene from the nematode Caenorhabditis elegans

scientific article published in May 1990

Characterization of in vivo expanded OspA-specific human T-cell clones

scientific article

Chemical biology: Dressed-up proteins

scientific article published in Nature

Chemical modification of the glucosidase inhibitor 1-deoxynojirimycin. Structure-activity relationships ⬇️

scientific article published on 01 August 1991

Chemical probes for the rapid detection of Fatty-acylated proteins in Mammalian cells

scientific article published on 17 February 2007

Chemistry in living cells: detection of active proteasomes by a two-step labeling strategy

scientific article published in August 2003

Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family

scientific article

Chemistry-based functional proteomics: mechanism-based activity-profiling tools for ubiquitin and ubiquitin-like specific proteases

scientific article published on March 2004

Chemoenzymatic Site-Specific Labeling of Influenza Glycoproteins as a Tool to Observe Virus Budding in Real Time ⬇️

scientific article published on March 22, 2012

Chlamydia trachomatis-derived deubiquitinating enzymes in mammalian cells during infection

scientific journal article

Cholera toxin activates nonconventional adjuvant pathways that induce protective CD8 T-cell responses after epicutaneous vaccination

scientific article published on 23 January 2012

Class I negative CD8 T cells reveal the confounding role of peptide-transfer onto CD8 T cells stimulated with soluble H2-Kb molecules

scientific article

Class II MHC peptide loading by the professionals

scientific article published on February 2004

Class II MHC self-antigen presentation in human B and T lymphocytes

scientific article

Class Ia MHC-deficient BALB/c mice generate CD8+ T cell-mediated protective immunity against Listeria monocytogenes infection

scientific article published in July 2003

Cocapture of cognate and bystander antigens can activate autoreactive B cells

scientific article published on 05 January 2017

Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: location of putative alloantigenic sites ⬇️

scientific article published on September 1, 1979

Competition by inhibitory oligonucleotides prevents binding of CpG to C‐terminal TLR9 ⬇️

scientific article published on September 6, 2011

Complete primary structure of human histocompatibility antigen HLA-B7: evolutionary and functional implications

scientific article published on 01 January 1980

Concanamycin B inhibits the expression of newly-synthesized MHC class II molecules on the cell surface

scientific article published on 01 June 1995

Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies

scientific article

Control of cross-presentation during dendritic cell maturation

scientific article published in February 2004

Correction: Live Imaging of Cysteine-Cathepsin Activity Reveals Dynamics of Focal Inflammation, Angiogenesis, and Polyp Growth.

scientific article

Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

scientific article published on 16 March 2016

Corrigendum: Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining.

scientific article published in February 2016

Cotranslational endoplasmic reticulum assembly of FcepsilonRI controls the formation of functional IgE-binding receptors

scientific article

Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors

scientific article

Crosses of two independently derived transgenic mice demonstrate functional complementation of the genes encoding heavy (HLA-B27) and light (beta 2-microglobulin) chains of HLA class I antigens

scientific article

Crystal Structure and Conformational Change Mechanism of a Bacterial Nramp-Family Divalent Metal Transporter

scientific article published on 8 November 2016

Crystal structure of a substrate-engaged SecY protein-translocation channel

scientific article published on 7 March 2016

Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome

scientific article

Cytokines regulate proteolysis in major histocompatibility complex class II-dependent antigen presentation by dendritic cells

scientific article published on April 2001

Cytomegaloviruses use multiple mechanisms to elude the host immune response

scientific article published on June 1997

DM exchange mechanism

scientific article published in Nature

Deficiency of antigen-presenting cell invariant chain reduces atherosclerosis in mice

scientific article

Definition of four HLA-A2 subtypes by CML typing and biochemical analysis

scientific article published on 01 January 1983

Degradation of Mouse Invariant Chain: Roles of Cathepsins S and D and the Influence of Major Histocompatibility Complex Polymorphism ⬇️

scientific article published on August 18, 1997

Degradation of proteins from the ER of S. cerevisiae requires an intact unfolded protein response pathway

scientific article published on 01 April 2000

Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose

scientific article published on 05 July 2016

Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes

scientific journal article

Destruction of proteins as a creative force

scientific article published on June 1997

Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it

scientific article

Determination of attachment sites for N-linked carbohydrate groups of class II histocompatibility alpha-chain and analysis of possible O-linked glycosylation of alpha- and gamma-chains

scientific article published on 01 January 1986

Development of an influenza virus protein array using Sortagging technology

scientific article published on 25 May 2012

Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases

scientific article

Development of intravital intermittent confocal imaging system for studying Langerhans cell turnover.

scientific article published on 22 June 2006

Deviant trafficking of I-Ad mutant molecules is reflected in their peptide binding properties

scientific article published on 01 September 1999

Diacylglycerol kinase is phosphorylated in vivo upon stimulation of the epidermal growth factor receptor and serine/threonine kinases, including protein kinase C-ε ⬇️

scientific article published on February 1, 1993

Different types of allospecific CTL clones identified by their ability to recognize peptide loading-defective target cells

scientific article published on 01 November 1991

Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation

scholarly article

Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity.

scientific article published on 15 August 2008

Differential priming of CD8 and CD4 T-cells in animal models of autoimmune hepatitis and cholangitis

article

Differential reactivity of residual CD8+ T lymphocytes in TAP1 and beta 2-microglobulin mutant mice

scientific article published on January 1995

Differential regulation of effector- and central-memory responses to Toxoplasma gondii Infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells

scientific article

Direct binding of peptide to empty MHC class I molecules on intact cells and in vitro.

scientific article published on August 1990

Discovery of CD8+ T cell epitopes in Chlamydia trachomatis infection through use of caged class I MHC tetramers

scientific article

Discovery of antivirals against smallpox

scientific article (publication date: 3 August 2004)

Dislocation of a type I membrane protein requires interactions between membrane-spanning segments within the lipid bilayer

scientific article

Dislocation of type I membrane proteins from the ER to the cytosol is sensitive to changes in redox potential

scientific article

Display of Native Antigen on cDC1 That Have Spatial Access to Both T and B Cells Underlies Efficient Humoral Vaccination

scientific article published on 24 August 2020

Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans

scientific article

Dissecting Intracellular Proteolysis Using Small Molecule Inhibitors and Molecular Probes

Dissecting Intracellular Proteolysis Using Small Molecule Inhibitors and Molecular Probes

Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin

scientific article (publication date: April 2004)

Distribution and elimination of the glycosidase inhibitors 1-deoxymannojirimycin and N-methyl-1-deoxynojirimycin in the rat in vivo

scientific article published on 01 November 1992

Don Craig Wiley (1944-2001).

scientific article

Down-regulation of MHC class I antigen presentation by HCMV; lessons for tumor immunology

scientific article

Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control

scientific article published on 20 August 2011

Durable antitumor responses to CD47 blockade require adaptive immune stimulation

scientific article published on 18 April 2016

ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function

scientific article published on 19 June 2021

Early BCR Events and Antigen Capture, Processing, and Loading on MHC Class II on B Cells

scientific article published on 10 March 2014

Early endosomal maturation of MHC class II molecules independently of cysteine proteases and H-2DM.

scientific article

Editorial overview

scientific article published on 01 February 2009

Editorial overview: Special section: Immunological engineering

scientific article published on 11 August 2015

Editorial: Crystal death: it's not always the inflammasome...

scientific article published in July 2017

Effect of reduced temperature on glycoprotein (Ig, HLA) processing and transport in lymphoid cells

scientific article published on 01 July 1985

Effects of PS-341 on the activity and composition of proteasomes in multiple myeloma cells

scientific article published on September 2005

Effects of the glucosidase inhibitors nojirimycin and deoxynojirimycin on the biosynthesis of membrane and secretory glycoproteins ⬇️

scientific article published on January 1, 1983

ElaD, a Deubiquitinating protease expressed by E. coli

scientific article published on 18 April 2007

Elimination In Vivo of Developing T Cells by Natural Killer Cells ⬇️

scientific article published on October 20, 2003

Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association

scientific article

End the wasteful tyranny of reviewer experiments ⬇️

scientific article published on April 28, 2011

Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease

scientific article published on 07 March 2017

Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes

scientific article

Engineered red blood cells carrying PCSK9 inhibitors persistently lower LDL and prevent obesity

scientific article published on 03 November 2021

Enhanced Cell Capture on Functionalized Graphene Oxide Nanosheets through Oxygen Clustering.

scientific article published on 13 January 2017

Enzymatic blockade of the ubiquitin-proteasome pathway

scientific article

Enzyme-Mediated Modification of Single-Domain Antibodies for Imaging Modalities with Different Characteristics

scientific article published on 2 December 2015

Epithelial-to-Mesenchymal Transition Contributes to Immunosuppression in Breast Carcinomas

scientific article published on 20 April 2017

Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress

scientific article published on 4 April 2014

Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading

scientific article

Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection

scientific article published on 16 January 2015

Exploiting Nanobodies' Singular Traits

scientific article published on 28 February 2018

Exploring cellular biochemistry with nanobodies

scientific article published on 31 August 2020

Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits

scientific article published in September 2001

Fluorophore-Conjugated Holliday Junctions for Generating Super-Bright Antibodies and Antibody Fragments

scientific article published on 7 August 2015

Free IL-12p40 monomer is a polyfunctional adaptor for generating novel IL-12-like heterodimers extracellularly

scientific article

Functional proteomics of the active cysteine protease content in Drosophila S2 cells

scientific article published on 16 September 2003

Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexes ⬇️

scientific article published on August 19, 1997

Fungal recognition is mediated by the association of dectin-1 and galectin-3 in macrophages.

scientific article

GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin

scientific article

Galectin-3 Regulates γ-Herpesvirus Specific CD8 T Cell Immunity

Gene conversion-like mechanisms may generate polymorphism in human class I genes

scientific article

Gene expression analysis of B-lymphoma cells resistant and sensitive to bortezomib*

article

Generation of Immunity against Pathogens via Single-Domain Antibody-Antigen Constructs.

scientific article published on 7 November 2016

Generation, translocation, and presentation of MHC class I-restricted peptides

scientific article

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

scientific article

Getting the inside out: the transporter associated with antigen processing (TAP) and the presentation of viral antigen

scientific article

Global gene disruption in human cells to assign genes to phenotypes by deep sequencing

scientific article

Granulin Is a Soluble Cofactor for Toll-like Receptor 9 Signaling ⬇️

scientific article published on April 14, 2011

Graphene Oxide Nanosheets Modified with Single-Domain Antibodies for Rapid and Efficient Capture of Cells.

scientific article

HLA-A- and HLA-B-specific monoclonal antibodies reactive with free heavy chains in western blots, in formalin-fixed, paraffin-embedded tissue sections and in cryo-immuno-electron microscopy

scientific article published on January 1990

HLA-G and HLA-C at the feto-maternal interface: lessons learned from pathogenic viruses

scientific article

HLA-restricted recognition of viral antigens in HLA transgenic mice

scientific article published in October 1987

Haploid genetic screens in human cells identify host factors used by pathogens

scientific article

Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host

scientific article

Hepta-Mutant Staphylococcus aureus Sortase A (SrtA7m) as a Tool for in Vivo Protein Labeling in Caenorhabditis elegans

scientific article published on 18 January 2017

Herman Eisen (1918–2014)

scientific article (publication date: 3 December 2014)

Herpes simplex virus blocks intracellular transport of HLA-G in placentally derived human cells.

scientific article published on October 1996

Herpes simplex virus turns off the TAP to evade host immunity

scientific article published on June 1995

Herpesvirus evasion of T-cell immunity

Hidde Ploegh: immunologist, journeyman. Interview by Nicole LeBrasseur

scientific article

High-molecular-weight protein (pUL48) of human cytomegalovirus is a competent deubiquitinating protease: mutant viruses altered in its active-site cysteine or histidine are viable

scientific article published on June 2006

High-resolution one-dimensional isoelectric focusing of mouse MHC class I antigens

scientific article published on 01 January 1990

How MHC class II molecules acquire peptide cargo: biosynthesis and trafficking through the endocytic pathway

scientific article published on January 1995

How MHC class II molecules reach the endocytic pathway

scientific article published on January 1995

How lamina-associated polypeptide 1 (LAP1) activates Torsin.

scientific article

Human cytomegalovirus US2 endoplasmic reticulum-lumenal domain dictates association with major histocompatibility complex class I in a locus-specific manner

scientific article

Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains

scientific article

Human cytomegalovirus down-regulates HLA class I expression by reducing the stability of class I H chains

scientific article published on 01 November 1993

Human cytomegalovirus gene products US2 and US11 differ in their ability to attack major histocompatibility class I heavy chains in dendritic cells

scientific article published on May 2002

Human cytomegalovirus open reading frame TRL11/IRL11 encodes an immunoglobulin G Fc-binding protein

scientific article

Human cytomegalovirus protein US11 provokes an unfolded protein response that may facilitate the degradation of class I major histocompatibility complex products

scientific article published on March 2005

Human histocompatibility antigens

scientific article published on 01 January 1983

HypE-specific nanobodies as tools to modulate HypE-mediated target AMPylation

scientific article

Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum

scientific article (publication date: September 2006)

Identification of a Novel CD8 T Cell Epitope Derived from Plasmodium berghei Protective Liver-Stage Antigen

scientific article published on 29 January 2018

Identification of host cell factors required for intoxication through use of modified cholera toxin

scientific article

Identification of new B27 subtypes (B27C and B27D) prevalent in oriental populations

scientific article

Identification of proteins associated with murine cytomegalovirus virions

scientific article

IgG1 + ovalbumin-specific B-cell transnuclear mice show class switch recombination in rare allelically included B cells ⬇️

scientific article published on August 6, 2012

Immune and other responses to viral infections.

scientific article

Immune escape by Epstein-Barr virus (EBV) carrying Burkitt's lymphoma: in vitro reconstitution of sensitivity to EBV-specific cytotoxic T cells

scientific article published on November 1992

Immune-privileged embryonic Swiss mouse STO and STO cell-derived progenitor cells: major histocompatibility complex and cell differentiation antigen expression patterns resemble those of human embryonic stem cell lines

scientific article published on 10 July 2006

Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the antitumor response under PD-1 blockade

scientific article published on 02 August 2019

Immunochemical analysis of glycosylated and nonglycosylated DLA class I antigens

scientific article published on 01 January 1984

Immunology at the millennium: looking forward

scientific article published on 01 October 1999

Immunology. Nothing 'gainst time's scythe can make defense...

scientific article

Impaired autophagy in the lipid-storage disorder Niemann-Pick type C1 disease

scientific article

Improved Antitumor Efficacy of Chimeric Antigen Receptor T Cells that Secrete Single-Domain Antibody Fragments

scientific article published on 04 February 2020

Improved GPCR Ligands Based on Genetically Impossible Nanobody-Peptide Fusions

Improved GPCR ligands from nanobody tethering

scientific article published on 29 April 2020

In Vitro Translation and Assembly of a Complete T Cell Receptor–CD3 Complex ⬇️

scientific article published on August 4, 1997

In vitro AMPylation Assays Using Purified, Recombinant Proteins.

scientific article published in July 2017

In vivo control of endosomal architecture by class II-associated invariant chain and cathepsin S

scientific article published on 01 September 2005

In vivo detection of antigen-specific CD8+ T cells by immuno-positron emission tomography

scientific article published on 14 September 2020

In vivo discovery of immunotherapy targets in the tumour microenvironment

scientific article

Increase in positive selection of CD8+ T cells in TAP1-mutant mice by human beta 2-microglobulin transgene

scientific article

Increased resistance to non-MHC-restricted cytotoxicity related to HLA A, B expression. Direct demonstration using beta 2-microglobulin-transfected Daudi cells.

scientific article

Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining

scientific article

Individual cathepsins degrade immune complexes internalized by antigen-presenting cells via Fcgamma receptors

scientific article published in May 2001

Influenza virus changes cell-surface glycoproteins including major histocompatibility complex determinants on lymphocytes

scientific article

Inhibition of Major Histocompatibility Complex Class I Antigen Presentation in Pig and Primate Cells by Herpes Simplex Virus Type 1 and 2 ICP47 ⬇️

scientific article published on June 1, 1998

Inhibition of N-linked oligosaccharide trimming does not interfere with surface expression of certain integral membrane proteins ⬇️

scientific article published on March 1, 1984

Inhibition of N-linked oligosaccharide trimming mannosidases blocks human B cell development

scientific article published on August 1986

Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes ⬇️

scientific article published on February 1, 1992

Inhibitors of oligosaccharide processing

scientific article published on June 1985

Intact sphingomyelin biosynthetic pathway is essential for intracellular transport of influenza virus glycoproteins.

scientific article published on April 2013

Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity

scientific article published on August 2000

Intercellular trafficking of the nuclear oncoprotein DEK.

scientific article

Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase

scientific article

Intermediates in the assembly and degradation of class I major histocompatibility complex (MHC) molecules probed with free heavy chain-specific monoclonal antibodies

scientific article

Internalization of Influenza Virus and Cell Surface Proteins Monitored by Site-Specific Conjugation of Protease-Sensitive Probes

scientific article published on 26 July 2019

Intestinal colonization by Candida albicans alters inflammatory responses in Bruton's tyrosine kinase-deficient mice

scientific article

Intracellular expression of camelid single-domain antibodies specific for influenza virus nucleoprotein uncovers distinct features of its nuclear localization.

scientific article

Intracellular interactions of transferrin and its receptor during biosynthesis

scientific article published on October 1990

Intracellular targeting of the proteasome

scientific article

Intracellular transport of MHC class II molecules

scientific article

Introduction of oxygen into the alkyl chain of N-decyl-dNM decreases lipophilicity and results in increased retention of glucose residues on N-linked oligosaccharides

scientific article published on April 1994

Invariant chain can bind MHC class II at a site other than the peptide binding groove

scientific article published on 01 November 1998

Invariant chain controls the activity of extracellular cathepsin L.

scientific article

Involvement of the vacuolar H(+)-ATPases in the secretory pathway of HepG2 cells.

scientific article published on September 1993

Isolation and characterization of the intracellular MHC class II compartment.

scientific article

Isolation and characterization of three cDNAs coding for Rab proteins from the albumen gland of the mollusc Lymnaea stagnalis

scientific article published on October 1993

Isolation, expression, and the primary structure of HLA-Cw1 and HLA-Cw2 genes: evolutionary aspects

scientific article

Kaposi's sarcoma-associated herpesvirus K3 utilizes the ubiquitin-proteasome system in routing class major histocompatibility complexes to late endocytic compartments

scientific article

LMP2 expression and proteasome activity in NOD mice

Lack of correlation between levels of MHC class I antigen and susceptibility to lysis of small cellular lung carcinoma (SCLC) by natural killer cells

scientific article published in June 1989

Lack of expression of HLA-B27 gene in transgenic mouse trophoblast. Conserved genetic pressures underlying extra-embryonic development

scientific article

Lessons from viral manipulation of protein disposal pathways

scientific article

Lipid modification of proteins through sortase-catalyzed transpeptidation

scientific article published on December 2008

Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth

scientific article (publication date: 2008)

Localized CD47 blockade enhances immunotherapy for murine melanoma.

scientific article published on 5 September 2017

Logic of the immune system.

scientific article

Longitudinal multiparameter assay of lymphocyte interactions from onset by microfluidic cell pairing and culture.

scientific article

Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity

scholarly article

Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice

scientific article published on 29 September 2005

Loss of transporter protein, encoded by the TAP-1 gene, is highly correlated with loss of HLA expression in cervical carcinomas.

scientific article

Lysosomal cysteine and aspartic proteases are heterogeneously expressed and act redundantly to initiate human invariant chain degradation

scientific journal article

M13 bacteriophage display framework that allows sortase-mediated modification of surface-accessible phage proteins

scientific article published on 3 July 2012

MHC class I antigen processing regulated by cytosolic proteolysis-short cuts that alter peptide generation

scientific article

MHC class I expression and CD8+ T cell development in TAP1/β2-microglobulin double mutant mice

scientific article published on 01 June 1995

MHC class II dimer of dimers

scientific article published in Nature

MHC products: biosynthesis, intracellular traffic, and "empty" molecules

scientific article published on January 1, 1992

Machinery that guides immunity

scientific article published in November 2017

Major histocompatibility antigens: the human (HLA-A, -B, -C) and murine (H-2K, H-2D) class I molecules

scientific article published on 01 May 1981

Major histocompatibility class I presentation of soluble antigen facilitated by Mycobacterium tuberculosis infection

scientific article published on October 1996

Major histocompatibility complex (MHC) class I KbDb−/− deficient mice possess functional CD8+ T cells and natural killer cells ⬇️

scientific article published on October 13, 1998

Major histocompatibility complex class II compartments in human B lymphoblastoid cells are distinct from early endosomes ⬇️

scientific article published on August 1, 1995

Making and Breaking Peptide Bonds: Protein Engineering Using Sortase ⬇️

scientific article published on April 27, 2011

Mapping functional regions in the lumenal domain of the class II-associated invariant chain

scientific article

Mechanism-based probe for the analysis of cathepsin cysteine proteases in living cells

scientific article published on December 2006

Mechanism-based proteomics tools based on ubiquitin and ubiquitin-like proteins: crystallography, activity profiling, and protease identification

scientific article published on 01 January 2005

Mechanism-based proteomics tools based on ubiquitin and ubiquitin-like proteins: synthesis of active site-directed probes.

scientific article

Mechanisms of induction of primary virus-specific cytotoxic T lymphocyte responses

scientific article published on November 1, 1992

Mechanisms, biology and inhibitors of deubiquitinating enzymes

scientific article published on November 2007

Membrane specializations and endosome maturation in dendritic cells and B cells.

scientific article published on April 2004

Membrane-specific, host-derived factors are required for US2- and US11-mediated degradation of major histocompatibility complex class I molecules

scientific article

Mice deficient in invariant-chain and MHC class II exhibit a normal mature B2 cell compartment

scientific article published on 01 August 2004

Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway

scientific journal article

Mice lacking the MHC class II-associated invariant chain

scientific journal article

Microbiology. Chemical warfare and mycobacterial defense

scientific article published in December 2003

Misfolded major histocompatibility complex class I molecules accumulate in an expanded ER-Golgi intermediate compartment

scientific article

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism.

scientific article

Molecular characterization of HLA-A, B homologues in owl monkeys and other nonhuman primates

scientific article published on 01 January 1980

Molecular cloning of a human histocompatibility antigen cDNA fragment

scientific article

Monoclonal Invariant NKT (iNKT) Cell Mice Reveal a Role for Both Tissue of Origin and the TCR in Development of iNKT Functional Subsets.

scientific article published on 2 June 2017

Monoclonal antibodies raised against denatured HLA-B locus heavy chains permit biochemical characterization of certain HLA-C locus products

scientific article published on 01 October 1986

Monoclonal antibodies that distinguish between free and complexed heterotrimeric G protein beta subunits

scientific article published on 01 February 1997

Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases

scientific article published on January 2013

Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells

scientific article published on 03 February 2014

Monovalent ligation of the B cell receptor induces receptor activation but fails to promote antigen presentation.

scholarly article

Mouse MHC class I tetramers that are unable to bind to CD8 reveal the need for CD8 engagement in order to activate naive CD8 T cells

scientific article published on 01 December 2002

Multiple associated proteins regulate proteasome structure and function

scientific article

Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane

scientific article

Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop

scientific article

Murine female reproductive tract intraepithelial lymphocytes display selection characteristics distinct from both peripheral and other mucosal T cells

scientific article published on 01 October 2001

Murine polyomavirus requires the endoplasmic reticulum protein Derlin-2 to initiate infection

scientific article

Myeloid differentiation factor 88 is required for cross-priming in vivo.

scientific article published in March 2004

N-linked glycan modification on antigen-presenting cells restores an allospecific cytotoxic T cell response

scientific article published on February 1990

N-linked glycosylation does not impair proteasomal degradation but affects class I major histocompatibility complex presentation

scientific article

Nanobodies as , non-invasive, imaging agents

Nanobodies in cancer

scientific article published on 30 November 2020

Nanobody immunostaining for correlated light and electron microscopy with preservation of ultrastructure

scientific article published on 5 November 2018

Nanobody-Antigen Conjugates Elicit HPV-Specific Antitumor Immune Responses

scientific article published on 23 May 2018

Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice

scientific article published on 01 April 2019

Negative self-regulation of TLR9 signaling by its N-terminal proteolytic cleavage product

scientific article

Neoleukin-2 enhances anti-tumour immunity downstream of peptide vaccination targeted by an anti-MHC class II VHH

scientific article published on 05 February 2020

Neuronal loss and brain atrophy in mice lacking cathepsins B and L

scientific article

Nobel Prize: A dark edge to the glory

journal article; published in Nature on 2012-06-20

Non-carrier-mediated uptake of the mannosidase I inhibitor 1-deoxymannojirimycin by K562 erythroleukemic cells

scientific article published on 01 June 1989

Noninvasive Imaging of Human Immune Responses in a Human Xenograft Model of Graft-Versus-Host Disease

scientific article published on 16 February 2017

Noninvasive imaging of immune responses

scientific article published on 20 April 2015

Noninvasive imaging of tumor progression, metastasis, and fibrosis using a nanobody targeting the extracellular matrix

scientific article published on 08 May 2019

Novel mannosidase inhibitor blocking conversion of high mannose to complex oligosaccharides.

scientific article

Obituary: Jacques H. van Boom (1937-2004).

scientific article published in October 2004

One-Pot Dual Labeling of IgG 1 and Preparation of C-to-C Fusion Proteins Through a Combination of Sortase A and Butelase 1

scientific article published on 21 September 2018

One-dimensional isoelectric focusing of proteins in slab gels

scientific article published on 01 May 2001

One-step enzymatic modification of the cell surface redirects cellular cytotoxicity and parasite tropism

scientific article

Optimized fluorescent labeling to identify memory B cells specific for Neisseria meningitidis serogroup B vaccine antigens ex vivo

scientific article published on 30 October 2013

Orthogonal labeling of M13 minor capsid proteins with DNA to self-assemble end-to-end multiphage structures.

scientific article published on 28 May 2013

PD-L1 is an activation-independent marker of brown adipocytes

scientific article published on 21 September 2017

PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling

scientific article (publication date: 25 July 2013)

Parasite stage-specific recognition of endogenous Toxoplasma gondii-derived CD8+ T cell epitopes

scientific article published on December 2008

Pathways accessory to proteasomal proteolysis are less efficient in major histocompatibility complex class I antigen production

scientific article

Peptide antagonism and T cell receptor interactions with peptide-MHC complexes

scientific article published on October 1998

Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus

scientific article published on 01 June 1993

Peptide influences the folding and intracellular transport of free major histocompatibility complex class I heavy chains

scientific article

Peptide length and sequence specificity of the mouse TAP1/TAP2 translocator

scientific article

Peptide loading of empty major histocompatibility complex molecules on RMA-S cells allows the induction of primary cytotoxic T lymphocyte responses

scientific article published on December 1991

Peptide selection by MHC class I molecules ⬇️

scientific article published on April 25, 1991

Peptide translocation by variants of the transporter associated with antigen processing

scientific article published on 01 December 1993

Peptide-induced stabilization and intracellular localization of empty HLA class I complexes ⬇️

scientific article published on July 1, 1992

Peripheral self-reactivity regulates antigen-specific CD8 T-cell responses and cell division under physiological conditions.

scientific article

Phenotypic lentivirus screens to identify functional single domain antibodies

scientific article published on 20 June 2016

Phosphoproteomic analysis with a solid-phase capture-release-tag approach

scientific article published in July 2005

Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization.

scientific article

Podocytes Exhibit a Specialized Protein Quality Control Employing Derlin-2 in Kidney Disease

scientific article published on 22 November 2017

Polymorphisms in pockets of major histocompatibility complex class I molecules influence peptide preference

scientific article published on June 1993

Polyubiquitination is required for US11-dependent movement of MHC class I heavy chain from endoplasmic reticulum into cytosol

scientific article

Positive selection of an MHC class-I restricted TCR in the absence of classical MHC class I molecules

scientific article

Posttranscriptional Regulation of Glycoprotein Quality Control in the Endoplasmic Reticulum Is Controlled by the E2 Ub-Conjugating Enzyme UBC6e.

scientific article published on 25 August 2016

Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells.

scientific article

Preferred in vivo ubiquitination sites

scientific article published on 15 July 2004

Preferred size of peptides that bind to H-2 Kb is sequence dependent

scientific article published on June 1, 1992

Preparation of bispecific antibody-protein adducts by site-specific chemo-enzymatic conjugation

scientific article published on 03 August 2018

Preparation of unnatural N-to-N and C-to-C protein fusions ⬇️

scientific article published on July 9, 2012

Production of unnaturally linked chimeric proteins using a combination of sortase-catalyzed transpeptidation and click chemistry

scientific article published on 29 August 2013

Profiling antibody responses by multiparametric analysis of primary B cells.

scholarly article

Profiling lymphocyte interactions at the single-cell level by microfluidic cell pairing

scientific article published on 13 January 2015

Proteases involved in MHC class II antigen presentation

scientific journal article

Proteasome inhibitors and antigen presentation ⬇️

scientific article published on January 1, 1997

Protection of tissue physicochemical properties using polyfunctional crosslinkers.

scientific article

Protein glycosylation

scientific article published on 01 December 1990

Protein ligation in living cells using sortase

scientific article published on 23 March 2012

Protein quality control in the ER: balancing the ubiquitin checkbook ⬇️

scientific article published on November 3, 2011

Protein quality control in the endoplasmic reticulum

scientific article published on 08 July 2014

Protein unfolding is not a prerequisite for endoplasmic reticulum-to-cytosol dislocation

scientific article published on 12 December 2002

Proteolysis and antigen presentation by MHC class II molecules

scientific journal article

Proteolysis in MHC class II antigen presentation: who's in charge?

scientific article

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

scientific article

Purification, cDNA-cloning and expression of human diacylglycerol kinase

scientific journal article

Putting together an MHC class I molecule

scientific article published on February 1993

Qa-2-dependent selection of CD8alpha/alpha T cell receptor alpha/beta(+) cells in murine intestinal intraepithelial lymphocytes

scientific article

Qa-2–Dependent Selection of Cd8α/α T Cell Receptor α/β1 Cells in Murine Intestinal Intraepithelial Lymphocytes

scientific article

Quality and quantity control at the endoplasmic reticulum

scientific article

Quantitative Analysis of Cellular Diacylglycerol Content.

scientific article published on August 2014

Rapid capture and labeling of cells on single domain antibodies-functionalized flow cell

scientific article published on 5 October 2016

Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response

scientific journal article

Ras (proto)oncogene induces N-linked carbohydrate modification: temporal relationship with induction of invasive potential

scientific article published on November 1988

Recent advances in sortase-catalyzed ligation methodology.

scientific article published on 16 June 2016

Recognition of Class II MHC Peptide Ligands That Contain β-Amino Acids

scientific article published on 07 August 2019

Recruitment of CD63 to Cryptococcus neoformans phagosomes requires acidification

scholarly article

Recycling glycoproteins do not return to the cis-Golgi

scientific article published on July 1988

Regulation of CD1 function and NK1.1(+) T cell selection and maturation by cathepsin S.

scientific article published in December 2001

Regulation of monoubiquitinated PCNA by DUB autocleavage

scientific journal article

Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor

scientific article

Remodeling of the Tumor Microenvironment by a Chemokine/Anti-PD-L1 Nanobody Fusion Protein

scientific article published on 29 April 2019

Repertoire-determining role of peptide in the positive selection of CD8+ T cells

scientific article

Requirements for T cell-polarized tubulation of class II+ compartments in dendritic cells

scientific article published on 01 December 2003

Retention of epidermal growth factor receptors in the endoplasmic reticulum of adenovirus-infected cells ⬇️

scientific article published on February 15, 1992

Retrograde transport from the Golgi region to the endoplasmic reticulum is sensitive to GTP gamma S.

scientific article published in March 1992

Road to Ruin: Targeting Proteins for Degradation in the Endoplasmic Reticulum ⬇️

scientific article published on November 25, 2011

Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages

scientific article

Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier

scientific article

SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins

scholarly article

SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER.

scientific article

Screen for ISG15-crossreactive deubiquitinases

scientific article

Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

scientific article

Secreted cathepsin L generates endostatin from collagen XVIII

scientific article

Secretion of circular proteins using sortase

scientific article published on January 2014

Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments ⬇️

scientific article published on February 21, 1991

Selective targeting of ligand-dependent and -independent signaling by GPCR conformation-specific anti-US28 intrabodies

scientific article published on 16 July 2021

Sequence and structure evolved separately in a ribosomal ubiquitin variant

scientific article

Sialylneolacto-N-tetraose c (LSTc)-bearing Liposomal Decoys Capture Influenza A Virus ⬇️

scientific article published on January 28, 2013

Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor

scientific article published on April 2001

Signal peptide peptidase is required for dislocation from the endoplasmic reticulum

scientific article (publication date: 15 June 2006)

Single-chain antibody fragment-based adsorbent for the extracorporeal removal of beta2-microglobulin

scientific article published in January 2004

Site-Specific Protein Labeling via Sortase-Mediated Transpeptidation.

scientific article published in August 2017

Site-Specific Sequential Protein Labeling Catalyzed by a Single Recombinant Ligase

scientific article published on 16 October 2019

Site-specific C-terminal and internal loop labeling of proteins using sortase-mediated reactions

scientific article published on 29 August 2013

Site-specific N- and C-terminal labeling of a single polypeptide using sortases of different specificity

scientific article published on August 2009

Site-specific N-terminal labeling of proteins using sortase-mediated reactions

scientific article published on 29 August 2013

Site-specific chemoenzymatic labeling of aerolysin enables the identification of new aerolysin receptors

scientific article

Site-specific protein labeling via sortase-mediated transpeptidation

scientific article

Site-specific protein modification using immobilized sortase in batch and continuous-flow systems

scientific article published on 26 February 2015

Small-Molecule Inhibitors and Probes for Ubiquitin- and Ubiquitin-Like-Specific Proteases

scientific article published on 01 February 2005

Soluble class I antigens: a conundrum with no solution?

scientific article published on 01 January 1987

Sortagging: a versatile method for protein labeling

scientific article

Sortase A as a tool for high-yield histatin cyclization

scientific article published on 27 April 2011

Sortase A: A Model for Transpeptidation and Its Biological Applications

scientific article published on 15 August 2018

Sortase-catalyzed transformations that improve the properties of cytokines ⬇️

scientific article published on February 4, 2011

Sortase-mediated modification of αDEC205 affords optimization of antigen presentation and immunization against a set of viral epitopes

scientific article

Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins

scientific article

Specific immune responses restored by alteration in carbohydrate chains of surface molecules on antigen-presenting cells

scientific article published on 01 March 1989

Specific role for cathepsin S in the generation of antigenic peptides in vivo

scientific article published in February 2002

Stable binding of the herpes simplex virus ICP47 protein to the peptide binding site of TAP

scientific article published in July 1996

Stochastic cytokine expression induces mixed T helper cell States

scientific article

Structural and functional analysis of human cytomegalovirus US3 protein

scientific article published on January 2004

Structural and functional studies on the G(o) protein ⬇️

scientific article published on March 5, 1993

Structural and sequence homologies between HLA-A and HLA-B antigens and immunoglobulins

scientific article published on 01 June 1979

Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor

scientific article

Structural heterogeneity of a human melanoma-associated antigen.

scientific article published in January 1989

Structural studies of the membrane-associated products of the human major histocompatibility complex

scientific article published on January 1980

Structurally Defined αMHC-II Nanobody-Drug Conjugates: A Therapeutic and Imaging System for B-Cell Lymphoma.

scientific article published on 14 January 2016

Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes

scientific article

Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate

scientific article

Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia.

scientific article published on 04 August 2016

Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes ⬇️

scientific article published on June 1, 1998

Substrate filtering by the active site crossover loop in UCHL3 revealed by sortagging and gain-of-function mutations

scientific article published in December 2008

Substrate specificity of allelic variants of the TAP peptide transporter

scientific article published on 01 December 1994

Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes

scientific article published on 06 October 2009

Subunit interactions of the Go protein

scientific article published on August 10, 1992

Suppression of class I human histocompatibility leukocyte antigen by c-myc is locus specific

scientific article

Synthetic peptide libraries in the determination of T cell epitopes and peptide binding specificity of class I molecules

scientific article published on June 1, 1992

T cells induce extended class II MHC compartments in dendritic cells in a Toll-like receptor-dependent manner

scientific article published on 01 October 2003

T-cell engagement of dendritic cells rapidly rearranges MHC class II transport.

scientific article published in August 2002

TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells

scientific article published on December 24, 1992

TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective

scientific article published on 01 August 1993

TLRs bent into shape

scientific article published on 01 July 2007

Targeted Delivery of Cyclotides via Conjugation to a Nanobody

scientific article published on 05 October 2018

Targeted antigen delivery by an anti-class II MHC VHH elicits focused αMUC1(Tn) immunity.

scientific article published on 26 May 2017

Targeting cytokine therapy to the pancreatic tumor microenvironment using PD-L1 specific VHHs

scientific article published on 19 February 2018

Targeting small molecule drugs to T cells with antibody-directed cell-penetrating gold nanoparticles

scientific article published on 01 December 2018

The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc.

scientific article

The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment

scientific article published on 13 December 2016

The B cell receptor promotes B cell activation and proliferation through a non-ITAM tyrosine in the Igalpha cytoplasmic domain

scientific journal article

The CD8 T-cell response against murine gammaherpesvirus 68 is directed toward a broad repertoire of epitopes from both early and late antigens

scientific article published on 15 October 2008

The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones

scientific article

The E2 ubiquitin-conjugating enzyme UBE2J1 is required for spermiogenesis in mice

scientific article

The ER-lumenal domain of the HHV-7 immunoevasin U21 directs class I MHC molecules to lysosomes.

scientific article published on December 2003

The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP

scientific article (publication date: May 1997)

The HCMV gene products US11 and US2 differ in their ability to attack allelic forms of murine major histocompatibility complex (MHC) class I heavy chains

scientific article

The HCMV membrane glycoprotein US10 selectively targets HLA-G for degradation

scientific article published on 16 August 2010

The SUMO-specific protease SENP5 is required for cell division

scientific article

The WD-40 repeat ⬇️

scientific article published on July 28, 1992

The active site of ICP47, a herpes simplex virus-encoded inhibitor of the major histocompatibility complex (MHC)-encoded peptide transporter associated with antigen processing (TAP), maps to the NH2-terminal 35 residues

scientific article

The activity of myeloid cell-specific VHH immunotoxins is target-, epitope-, subset- and organ dependent

scientific article published on 20 December 2017

The assembly of H2-Kb class I molecules translated in vitro requires oxidized glutathione and peptide

scientific article published on 01 June 1993

The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route

scientific article published on April 1990

The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites.

scientific article published on 18 June 2003

The cell biology of antigen presentation

scientific article

The chaperone BAG6 captures dislocated glycoproteins in the cytosol.

scientific article

The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK)

scientific article

The cytosolic tail of class I MHC heavy chain is required for its dislocation by the human cytomegalovirus US2 and US11 gene products

scientific article published on July 1999

The e S-Sence of -SH in the ER ⬇️

scientific article published on January 23, 1998

The effect of anchor residue modifications on the stability of major histocompatibility complex class I-peptide interactions

scientific article published on 01 April 1993

The fate of the three subunits of major histocompatibility complex class I molecules ⬇️

scientific article published on June 1, 1992

The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit

scientific article

The human cytomegalovirus US10 gene product delays trafficking of major histocompatibility complex class I molecules

scientific article published on November 2002

The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol

scientific article (publication date: 8 March 1996)

The human cytomegalovirus US8 glycoprotein binds to major histocompatibility complex class I products

scientific article

The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling

scientific journal article

The interest in various immunological subdisciplines waxes and wanes with every new discovery. Preface

scientific article published in January 2014

The known unknowns of antigen processing and presentation.

scientific article published on August 2008

The ligand recognized by ELAM-1 on HL60 cells is not carried by N-linked oligosaccharides ⬇️

scientific article published on 01 December 1991

The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance

scientific article

The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER

scientific article

The p41 isoform of invariant chain is a chaperone for cathepsin L

scientific article

The pathway of US11-dependent degradation of MHC class I heavy chains involves a ubiquitin-conjugated intermediate

scientific article

The peptide cargo of class I molecules: not just passive passengers

scientific article published on 01 October 2007

The phenotype of H-2M-deficient mice is dependent on the MHC class II molecules expressed

scientific article published on 01 September 1998

The primary structure of a feline class I gene: striking similarity to HLA-A.

scientific article

The protein synthesis inhibitor blasticidin s enters mammalian cells via leucine-rich repeat-containing protein 8D.

scientific article published on 29 April 2014

The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy.

scientific article published in April 2018

The tetraspanin CD82 is specifically recruited to fungal and bacterial phagosomes prior to acidification

scientific article

The tetraspanin protein CD82 associates with both free HLA class I heavy chain and heterodimeric beta 2-microglobulin complexes

scientific article published on March 1997

The transmembrane segment of a tail-anchored protein determines its degradative fate through dislocation from the endoplasmic reticulum

scientific article

The ubiquitin-proteasome pathway in thymocyte apoptosis: caspase-dependent processing of the deubiquitinating enzyme USP7 (HAUSP).

scientific article published in November 2002

The use of (18)F-2-fluorodeoxyglucose (FDG) to label antibody fragments for immuno-PET of pancreatic cancer

scientific article

The α Chain of the T Cell Antigen Receptor Is Degraded in the Cytosol ⬇️

scientific article published on 01 July 1997

The βγ subunits of heterotrimeric G proteins acquire detergent insolubility directly at the plasma membrane ⬇️

scientific article published on October 13, 1997

Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83.

scientific article published on 08 August 2016

Thymic Selection and Peripheral Activation of CD8 T Cells by the Same Class I MHC/Peptide Complex

scientific article published on 01 January 2004

Tissue-specific and cell surface expression of human major histocompatibility complex class I heavy (HLA-B7) and light (beta 2-microglobulin) chain genes in transgenic mice

scientific article

Tissue-specific emergence of regulatory and intraepithelial T cells from a clonal T cell precursor.

scientific article published on 26 August 2016

Toxoplasma gondii superinfection and virulence during secondary infection correlate with the exact ROP5/ROP18 allelic combination.

scientific article

Trafficking and assembly of MHC molecules: how viruses elude the immune system

scientific article published on January 1995

Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition

scientific article published on 01 October 2020

Translating cell biology in vitro to immunity in vivo.

scientific article published in July 2004

Transnuclear CD8 T cells specific for the immunodominant epitope Gra6 lower acute-phase Toxoplasma gondii burden

scientific article published on 5 July 2016

Transnuclear TRP1-specific CD8 T cells with high or low affinity TCRs show equivalent antitumor activity

scientific article published on August 2013

Transnuclear mice with pre-defined T cell receptor specificities against Toxoplasma gondii obtained via SCNT.

scientific article

Transnuclear mice with predefined T cell receptor specificities against Toxoplasma gondii obtained via SCNT.

scientific article

Transporters from H-2b, H-2d, H-2s, H-2k, and H-2g7 (NOD/Lt) haplotype translocate similar sets of peptides

scientific article

Trophoblast class I major histocompatibility complex (MHC) products are resistant to rapid degradation imposed by the human cytomegalovirus (HCMV) gene products US2 and US11.

scientific article

Tubulation of class II MHC compartments is microtubule dependent and involves multiple endolysosomal membrane proteins in primary dendritic cells.

scientific article

Turnip yellow mosaic virus protease binds ubiquitin suboptimally to fine-tune its deubiquitinase activity

scientific article published on 30 July 2020

Type I interferon imposes a TSG101/ISG15 checkpoint at the Golgi for glycoprotein trafficking during influenza virus infection.

scientific article published on November 2013

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

scientific article

US2, a Human Cytomegalovirus-encoded Type I Membrane Protein, Contains a Non-cleavable Amino-terminal Signal Peptide

scientific article published in Journal of Biological Chemistry

Ubiquitin C-terminal electrophiles are activity-based probes for identification and mechanistic study of ubiquitin conjugating machinery

scientific article published on April 2009

Ubiquitin--conserved protein or selfish gene?

scientific article

Ubiquitin-Like Proteins ⬇️

scientific article published on 09 March 2012

Ubiquitin-dependent control of class II MHC localization is dispensable for antigen presentation and antibody production.

scientific article

Ubiquitination, ubiquitin-like modifiers, and deubiquitination in viral infection

scientific article published on June 2009

Ubiquitinylation of the cytosolic domain of a type I membrane protein is not required to initiate its dislocation from the endoplasmic reticulum

scientific article published on 27 June 2003

Uncoating ATPase Hsc70 is recruited by invariant chain and controls the size of endocytic compartments

scientific article

Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response

scientific article published on 28 December 2016

Upregulation of the CLIP self peptide on mature dendritic cells antagonizes T helper type 1 polarization

scientific article published on 22 August 2004

Use of HLA loss mutants to analyse the structure of the human major histocompatibility complex

scientific article published in Nature

Using a small molecule inhibitor of peptide: N-glycanase to probe its role in glycoprotein turnover.

scientific article

Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling

scientific journal article

Uvomorulin: a nonintegral membrane protein of early mouse embryo

scientific article published on October 1983

Varicella-zoster virus retains major histocompatibility complex class I proteins in the Golgi compartment of infected cells

scientific article

Vesicular stomatitis virus N protein-specific single-domain antibody fragments inhibit replication.

scientific article published on 10 April 2017

Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy.

scientific article published on 8 June 2018

Viral Strategies of Immune Evasion ⬇️

scientific article published on April 10, 1998

Viral immune evasion strategies and the underlying cell biology

scientific article

Viral immunoevasive strategies and trophoblast class I major histocompatibility complex antigens

scientific article

Viral interference with B7-1 costimulation: a new role for murine cytomegalovirus fc receptor-1.

scientific article

Viral modulation of antigen presentation: manipulation of cellular targets in the ER and beyond

scientific article

Viral subversion of the immune system

scientific article

Virus subversion of immunity: a structural perspective

scientific article

Viruses use stealth technology to escape from the host immune system

scientific article published on March 1997

Visualization of the ER-to-cytosol dislocation reaction of a type I membrane protein

scientific article published on March 2002

Why certain antibodies cross-react with HLA-A and HLA-G: epitope mapping of two common MHC class I reagents.

scientific article published on February 1998

XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells

scientific article

XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells

scientific article

XBP-1-deficient plasmablasts show normal protein folding but altered glycosylation and lipid synthesis.

scientific article

Yeast N-glycanase distinguishes between native and non-native glycoproteins

scientific article

Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity

scientific article

Zwitterionic polysaccharides stimulate T cells by MHC class II-dependent interactions

scientific article published on 01 December 2002

rAMPing Up Stress Signaling: Protein AMPylation in Metazoans.

scientific article

tRNA thiolation links translation to stress responses in Saccharomyces cerevisiae

scientific article

z-VAD-fmk inhibits peptide:N-glycanase and may result in ER stress

scientific article published in January 2006

Paulina is supported by:

About Paulina

Help