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List of works by Heyo Klaus Kroemer

A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3

scientific article

A genome-wide association study of metabolic traits in human urine

scientific article

A network-based approach to visualize prevalence and progression of metabolic syndrome components

scientific article

Acute exposure to doxorubicin results in increased cardiac P-glycoprotein expression

scientific journal article

Advances in coronary stent technology--active drug-loaded stent surfaces for prevention of restenosis and improvement of biocompatibility.

scientific article published on January 2013

Antibodies Against Potassium Channel Interacting Protein 2 Induce Necrosis in Isolated Rat Cardiomyocytes

scientific article published on 01 April 2014

Antineoplastic agent busulfan regulates a network of genes related to coagulation and fibrinolysis.

scientific article published on June 2012

Beta‐Amyloid Downregulates MDR1‐P‐Glycoprotein (Abcb1) Expression at the Blood‐Brain Barrier in Mice ⬇️

scientific article published on May 29, 2011

Biodegradable sirolimus-loaded poly(lactide) nanoparticles as drug delivery system for the prevention of in-stent restenosis in coronary stent application

scientific article published on 17 March 2010

Busulfan induces activin A expression in vitro and in vivo: a possible link to venous occlusive disease

scientific article published on September 2003

CUBN is a gene locus for albuminuria

scientific article

CYP2D6 genotype and induction of intestinal drug transporters by rifampin predict presystemic clearance of carvedilol in healthy subjects.

scientific article

Calcium antagonists and deep gingival pockets in the population-based SHIP study

scientific article published in November 2005

Carbamazepine regulates intestinal P-glycoprotein and multidrug resistance protein MRP2 and influences disposition of talinolol in humans.

scientific article published in September 2004

Cell-specific expression of uptake transporters--a potential approach for cardiovascular drug delivery devices.

scientific article published on 19 February 2014

Cellular export of drugs and signaling molecules by the ATP-binding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5).

scientific article

Cholesterol, C-Reactive Protein, and Periodontitis: HMG-CoA-Reductase Inhibitors (Statins) as Effect Modifiers

scientific article

Cohort Profile: The Study of Health in Pomerania

article

Cohort profile: Greifswald approach to individualized medicine (GANI_MED)

scientific article

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

scientific article

Common variants in Mendelian kidney disease genes and their association with renal function

scientific article published on 12 September 2013

Common variants in the G protein beta3 subunit gene and thyroid disorders in a formerly iodine-deficient population

scientific article published in October 2009

Comparing different scientific approaches to personalized medicine: research ethics and privacy protection.

scientific article

Concentration of the macrolide antibiotic tulathromycin in broncho-alveolar cells is influenced by comedication of rifampicin in foals

scientific article

Creatine kinase elevation caused by a combination of fluvastatin and telmisartan in a patient heterozygous for the CYP2C9*3 and ABCC2 -24C > T variants: a case report

scientific article

Current understanding of hepatic and intestinal OATP-mediated drug-drug interactions.

scientific article

Development of a vessel-simulating flow-through cell method for the in vitro evaluation of release and distribution from drug-eluting stents

scientific article published on 19 May 2008

Disposition of oral and intravenous pravastatin in MRP2-deficient TR- rats

scientific article published on 17 August 2005

Dose optimization of a doxorubicin prodrug (HMR 1826) in isolated perfused human lungs: low tumor pH promotes prodrug activation by beta-glucuronidase

scientific article published on 01 April 2002

Doxorubicin enhances oxysterol levels resulting in a LXR-mediated upregulation of cardiac cholesterol transporters.

scientific article published on 11 August 2017

Drug efflux transporter multidrug resistance-associated protein 5 affects sensitivity of pancreatic cancer cell lines to the nucleoside anticancer drug 5-fluorouracil

scientific article published on 7 October 2010

Drug-drug interactions of beta-adrenoceptor blockers

scientific article published on January 2003

Effect of levothyroxine administration on intestinal P-glycoprotein expression: consequences for drug disposition.

scientific article published in September 2002

Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms

scientific article

Epidermal growth factor-mediated activation of the map kinase cascade results in altered expression and function of ABCG2 (BCRP).

scientific article published on 13 January 2006

Epigenetic modulation of the drug resistance genes MGMT, ABCB1 and ABCG2 in glioblastoma multiforme.

scientific article

Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

scientific article published in November 2011

Examination of drug release and distribution from drug-eluting stents with a vessel-simulating flow-through cell

scientific article

Expression and localization of the multidrug resistance protein 5 (MRP5/ABCC5), a cellular export pump for cyclic nucleotides, in human heart

scientific article

Expression of ABC-type transport proteins in human platelets

scientific article published in June 2010

Expression of ABCC-type nucleotide exporters in blasts of adult acute myeloid leukemia: relation to long-term survival

scientific article published on 24 February 2009

Expression of Organic Anion Transporting Polypeptide 1A2 in Red Blood Cells and Its Potential Impact on Antimalarial Therapy

scientific article published on 8 August 2016

Expression of active human beta-glucuronidase in Sf9 cells infected with recombinant baculovirus

scientific article published on August 2002

Expression of adenosine triphosphate-binding cassette (ABC) drug transporters in peripheral blood cells: relevance for physiology and pharmacotherapy

scientific article published on January 2007

Expression, localization, and function of MRP5 (ABCC5), a transporter for cyclic nucleotides, in human placenta and cultured human trophoblasts: effects of gestational age and cellular differentiation

scientific article

Expression, localization, and function of the carnitine transporter octn2 (slc22a5) in human placenta.

scientific article

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

scientific article

Genetic evidence of assortative mating in humans

scholarly article

Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data

scientific article

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

scientific article published on 6 October 2011

Genome-wide association analysis identifies multiple loci related to resting heart rate

scientific article

Genome-wide association and functional follow-up reveals new loci for kidney function

scientific article

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

scientific article

Glyburide and glimepiride pharmacokinetics in subjects with different CYP2C9 genotypes

scientific article published in September 2002

Hepatic uptake of the magnetic resonance imaging contrast agent Gd-EOB-DTPA: role of human organic anion transporters.

scientific article published on 20 April 2010

Histone deacetylase inhibitors and aspirin interact synergistically to induce cell death in ovarian cancer cells.

scientific article

Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms

scientific article

Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin

scientific article published on 23 February 2009

Implant-associated local drug delivery systems based on biodegradable polymers: customized designs for different medical applications

scientific article published on October 2013

In Vitro and In Vivo Evidence for the Importance of Breast Cancer Resistance Protein Transporters (BCRP/MXR/ABCP/ABCG2) ⬇️

scientific article published on January 1, 2011

In vitro dissolution testing of drug-eluting stents.

scientific article published on January 2013

In vitro study of dual drug-eluting stents with locally focused sirolimus and atorvastatin release.

scientific article published on 12 July 2013

Incidence of all-cause and cardiovascular mortality predicted by symmetric dimethylarginine in the population-based study of health in pomerania

scientific article

Increased lysyl oxidase expression and collagen cross-linking during atrial fibrillation ⬇️

scientific article published on January 6, 2011

Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function

scientific article published on 8 September 2012

Intestinal expression of P-glycoprotein (ABCB1), multidrug resistance associated protein 2 (ABCC2), and uridine diphosphate-glucuronosyltransferase 1A1 predicts the disposition and modulates the effects of the cholesterol absorption inhibitor ezetim

scientific article published on 7 February 2006

Involvement of AP-2 binding sites in regulation of human beta-glucuronidase

scientific article

Liver X receptor α and farnesoid X receptor are major transcriptional regulators of OATP1B1.

scientific article published on November 2010

MDR1 gene polymorphisms and risk of gingival hyperplasia induced by calcium antagonists

scientific article published in January 2006

MDR1-P-Glycoprotein (ABCB1) Mediates Transport of Alzheimer's amyloid-beta peptides--implications for the mechanisms of Abeta clearance at the blood-brain barrier

scientific article

Magnesium used in bioabsorbable stents controls smooth muscle cell proliferation and stimulates endothelial cells in vitro

scientific article

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

scientific article

Modification of OATP2B1-mediated transport by steroid hormones

scientific article

Myocardial gene expression profiles and cardiodepressant autoantibodies predict response of patients with dilated cardiomyopathy to immunoadsorption therapy

scientific article published on 25 October 2012

New loci associated with kidney function and chronic kidney disease

scientific article

Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy.

scientific article published in May 2009

Nuclear factor-kappaB mediates up-regulation of cathepsin B by doxorubicin in tumor cells

scientific article published on May 2004

OATP1B3 is expressed in pancreatic β-islet cells and enhances the insulinotropic effect of the sulfonylurea derivative glibenclamide

scientific article published on 22 October 2013

Open letter on access to the BIA 10-2474 clinical trial data

scientific article published on 7 December 2016

Organic anion transporting polypeptide 2B1 and breast cancer resistance protein interact in the transepithelial transport of steroid sulfates in human placenta.

scientific article published on 4 October 2006

Organic anion transporting polypeptide 2B1 is a high-affinity transporter for atorvastatin and is expressed in the human heart

scientific article

Overexpression of glutathione S-transferase A1-1 in ECV 304 cells protects against busulfan mediated G2-arrest and induces tissue factor expression

scientific article published on December 2002

Personalized cardiovascular medicine: concepts and methodological considerations.

scientific article published on 26 March 2013

Pharmacogenomics of heart failure -- focus on drug disposition and action

scientific article published in October 2004

Pharmacogenomics: the genetics of variable drug responses

scientific article

Pharmacogenomics: will the promise be fulfilled?

scientific article

Pharmacokinetics of intravenous etoposide in patients with breast cancer: influence of dose escalation and cyclophosphamide and doxorubicin coadministration

scientific article published on 3 July 2002

Prospective association of low total testosterone concentrations with an adverse lipid profile and increased incident dyslipidemia.

scientific article published in February 2011

Protease-activated receptor-2 regulates the innate immune response to viral infection in a coxsackievirus B3-induced myocarditis

scientific article

Proteomic analysis of doxorubicin-induced changes in the proteome of HepG2cells combining 2-D DIGE and LC-MS/MS approaches.

scientific article

Rac1-induced connective tissue growth factor regulates connexin 43 and N-cadherin expression in atrial fibrillation

scientific article published in February 2010

Rapid modulation of the organic anion transporting polypeptide 2B1 (OATP2B1, SLCO2B1) function by protein kinase C-mediated internalization.

scientific article

Reduced expression of Rho guanine nucleotide dissociation inhibitor-alpha modulates the cytotoxic effect of busulfan in HEK293 cells.

scientific article published on March 2007

Role of MRP4 (ABCC4) in platelet adenine nucleotide-storage: evidence from patients with delta-storage pool deficiencies

scientific article

Selective regulation of cardiac organic cation transporter novel type 2 (OCTN2) in dilated cardiomyopathy

scientific article

Stereoselective disposition of talinolol in man.

scientific article published on February 2002

Steroid hormones specifically modify the activity of organic anion transporting polypeptides.

scientific article

Structure and function of the MRP2 (ABCC2) protein and its role in drug disposition

scientific article published on June 2006

Tailored surface design of biodegradable endovascular implants by functionalization of poly (L-lactide) with elastin-like proteins

scientific article published on 8 October 2015

The ABC transporters MDR1 and MRP2: multiple functions in disposition of xenobiotics and drug resistance

scientific article

The ATP-binding cassette transporter ABCG2 (BCRP), a marker for side population stem cells, is expressed in human heart.

scientific article published on 22 August 2005

The adhesion and spreading of thrombocyte vesicles on electrode surfaces

scientific article published on 19 August 2008

The endothelin receptor blocker bosentan inhibits doxorubicin-induced cardiomyopathy

scientific article published in November 2007

The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage

scientific article

The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer's disease.

scientific article published on May 2004

Tooth loss, periodontitis, and statins in a population-based follow-up study

scientific article published on 5 December 2013

Transporters in human platelets: physiologic function and impact for pharmacotherapy

scientific article published on 14 February 2012

Uptake of cardiovascular drugs into the human heart: expression, regulation, and function of the carnitine transporter OCTN2 (SLC22A5).

scientific article published on 20 February 2006

Variable expression of MRP2 (ABCC2) in human placenta: influence of gestational age and cellular differentiation.

scientific article

Variants of Toll-like receptor 4 predict cardiac recovery in patients with dilated cardiomyopathy.

scientific article published on 29 May 2012

Verapamil decreases glucuronidase activity in the gut.

scientific article

Virus-induced dilated cardiomyopathy is characterized by increased levels of fibrotic extracellular matrix proteins and reduced amounts of energy-producing enzymes

scientific article

β-blocker therapy and heart rate control during exercise testing in the general population: role of a common G-protein β-3 subunit variant

scientific article

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