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List of works by Varda Rotter

A Mutant p53-Dependent Embryonic Stem Cell Gene Signature Is Associated with Augmented Tumorigenesis of Stem Cells

article

A novel translocation breakpoint within the BPTF gene is associated with a pre-malignant phenotype

scientific article

Abelson murine leukemia virus-transformed cells that lack p53 protein synthesis express aberrant p53 mRNA species

scientific article published on March 1984

Accentuated apoptosis in normally developing p53 knockout mouse embryos following genotoxic stress

scientific article

Activated p53 suppresses the histone methyltransferase EZH2 gene

scientific article published in July 2004

Activation of p53 protein by telomeric (TTAGGG)n repeats

scientific article published on December 2001

Amplification of the 20q Chromosomal Arm Occurs Early in Tumorigenic Transformation and May Initiate Cancer ⬇️

scientific article published on January 31, 2011

Amyloid-beta precursor-like protein APLP1 is a novel p53 transcriptional target gene that augments neuroblastoma cell death upon genotoxic stress.

scientific article published on 28 May 2007

An insight into the life of p53: a protein coping with many functions! Review of the 9th p53 Workshop, Crete, May 9-13, 1998

scientific article published on 01 November 1998

Autoimmunity to the p53 protein is a feature of systemic lupus erythematosus (SLE) related to anti-DNA antibodies

scientific article published on 01 August 2001

Beyond tumor suppression: p53 controls blastocyst implantation

scientific article published on 15 December 2011

COOH-terminal domain of p53 modulates p53-mediated transcriptional transactivation, cell growth, and apoptosis.

scientific article published in February 1999

Can an iPS cell secure its genomic fidelity? ⬇️

scientific article published on May 1, 2011

Cancer research, a field on the verge of a paradigm shift?

scientific article

Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides.

scientific article

Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery

scientific article published on July 2016

Cellular events and the pattern of p53 protein expression following cyclophosphamide-initiated cell death in various organs of developing embryo

scientific article published on 01 January 1999

Cellular heterogeneity mediates inherent sensitivity-specificity tradeoff in cancer targeting by synthetic circuits

scientific article published on 06 July 2016

ChIP-on-chip analysis of in vivo mutant p53 binding to selected gene promoters.

scientific article

Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53.

scientific article published on March 2001

Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3A4 by activating p53.

scientific article

Chromosomal Assignment of the Murine Gene Encoding the Transformation-Related Protein p53 ⬇️

scientific article published on February 1, 1984

Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy.

scientific article

Convergence of logic of cellular regulation in different premalignant cells by an information theoretic approach

scientific article

Correction: Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides

scientific article published on 07 May 2019

Corrigendum to 'p53 balances between tissue hierarchy and anarchy'

scientific article published on 01 December 2019

Coupling transcriptional and post-transcriptional miRNA regulation in the control of cell fate.

scientific article

DNA binding and 3′–5′ exonuclease activity in the murine alternatively-spliced p53 protein

scientific article published on 01 August 2002

DNA vaccination with CD25 protects rats from adjuvant arthritis and induces an antiergotypic response

scientific article published on March 2004

Deconstruction of p53 functions and regulation

scientific article published on 01 November 2002

Did experimental biology die? Lessons from 30 years of p53 research.

scientific article published on 04 August 2009

Differential expression of the regularly spliced wild-type p53 and its COOH-terminal alternatively spliced form during epidermal differentiation ⬇️

scientific article published on August 1, 1997

Differential influence of normal and cancer-associated fibroblasts on the growth of human epithelial cells in an in vitro cocultivation model of prostate cancer

scientific article

Differential regulated microRNA by wild type and mutant p53 in induced pluripotent stem cells

scientific article published on 29 December 2016

Direct involvement of p53 in the base excision repair pathway of the DNA repair machinery

scientific article published on 01 May 1999

Discovery of novel proteasome inhibitors using a high-content cell-based screening system

scientific article

Diverse functions of IGF/insulin signaling in malignant and noncancerous prostate cells: proliferation in cancer cells and differentiation in noncancerous cells

scientific article published on 17 August 2012

Diverse p53/DNA binding modes expand the repertoire of p53 response elements

scientific article

Does wild-type p53 play a role in normal cell differentiation?

scientific article published on 01 June 1994

Dysfunctional diversity of p53 proteins in adult acute myeloid leukemia: projections on diagnostic workup and therapy

scientific article published on 12 June 2017

Endothelial matrix assembly during capillary morphogenesis: insights from chimeric TagRFP-fibronectin matrix.

scientific article

Enhanced angiotensin II production by renal mesangium is responsible for apoptosis/proliferation of endothelial and epithelial cells in a model of malignant hypertension.

scientific article published on May 2007

Epigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues

scientific article published on 14 October 2012

Epithelial to mesenchymal transition of a primary prostate cell line with switches of cell adhesion modules but without malignant transformation

scientific article

Expression of p53 in human leukemia and lymphoma

scientific article published on 01 July 1986

Expression of p53 protein in spermatogenesis is confined to the tetraploid pachytene primary spermatocytes

scientific article published on 01 June 1993

Expression of prolyl-hydroxylase-1 (PHD1/EGLN2) suppresses hypoxia inducible factor-1alpha activation and inhibits tumor growth.

scientific article published in December 2003

Falkor, a novel cell growth regulator isolated by a functional genetic screen

scientific article

Gain-of-Function Mutant p53: All the Roads Lead to Tumorigenesis ⬇️

scientific article published on 08 December 2019

Genome-wide profiling of histone h3 lysine 4 and lysine 27 trimethylation reveals an epigenetic signature in prostate carcinogenesis ⬇️

scientific article

Global profiling of histone and DNA methylation reveals epigenetic-based regulation of gene expression during epithelial to mesenchymal transition in prostate cells ⬇️

scientific article published on November 25, 2010

High Throughput Analysis of Golgi Structure by Imaging Flow Cytometry

scientific article published on 11 April 2017

Human p53 gene localized to short arm of chromosome 17

scientific article published in Nature

Hypoxia-dependent regulation of PHD1: cloning and characterization of the human PHD1/EGLN2 gene promoter

scientific article published on June 2004

Identification of gene networks associated with erythroid differentiation

scientific article

Idiotypic immunization induces immunity to mutated p53 and tumor rejection

scientific article published in June 1998

Immune deficiency augments the prevalence of p53 loss of heterozygosity in spontaneous tumors but not bi-directional loss of heterozygosity in bone marrow progenitors

scientific article published on 22 December 2016

Immunity to p53 induced by an idiotypic network of anti-p53 antibodies: generation of sequence-specific anti-DNA antibodies and protection from tumor metastasis.

scientific article

In vitro expression of human p53 cDNA clones and characterization of the cloned human p53 gene

scientific article published on August 1985

Inactivation of myocardin and p16 during malignant transformation contributes to a differentiation defect.

scientific article published in February 2007

Inactivation of p53 Gene Expression by an Insertion of Moloney Murine Leukemia Virus-Like DNA Sequences ⬇️

scientific article published on July 1, 1984

Inactivation of the p53 tumor suppressor gene and activation of the Ras oncogene: cooperative events in tumorigenesis.

scientific article published on May 2010

Induction of HL-60 cells to undergo apoptosis is determined by high levels of wild-type p53 protein whereas differentiation of the cells is mediated by lower p53 levels.

scientific article

Induction of apoptosis and p53 expression in immature thymocytes by direct interaction with thymic epithelial cells

scientific article published on October 1996

Inhibition of cell growth mediated by plasmids encoding p53 anti-sense

scientific article published in January 1987

Integrity of the N-terminal transcription domain of p53 is required for mutant p53 interference with drug-induced apoptosis

scientific article

Involvement of p53 in cell differentiation and development ⬇️

scientific article published on August 8, 1997

Isolation and characterization of DNA sequences that are specifically bound by wild-type p53 protein

scientific article published on March 1993

Isolation of a full-length mouse cDNA clone coding for an immunologically distinct p53 molecule

scientific article published on January 1985

Liver and Steroid Hormones—Can a Touch of p53 Make a Difference?

scientific article

Meth A fibrosarcoma cells express two transforming mutant p53 species

scientific article

Modulated expression of WFDC1 during carcinogenesis and cellular senescence

scientific article published on 08 October 2008

Modulation of alternative splicing contributes to cancer development: focusing on p53 isoforms, p53β and p53γ.

scientific article published on September 2014

Modulation of the vitamin D3 response by cancer-associated mutant p53

scientific article

Monoclonal antibody to a DNA-binding domain of p53 mimics charge structure of DNA: anti-idiotypes to the anti-p53 antibody are anti-DNA.

scientific article

Mutant p53 Prolongs NF-kB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer

Mutant p53 attenuates the SMAD-dependent transforming growth factor beta1 (TGF-beta1) signaling pathway by repressing the expression of TGF-beta receptor type II

scientific article

Mutant p53 attenuates the anti-tumorigenic activity of fibroblasts-secreted interferon beta

scientific article

Mutant p53 enhances nuclear factor kappaB activation by tumor necrosis factor alpha in cancer cells

scientific article published on 01 March 2007

Mutant p53 facilitates somatic cell reprogramming and augments the malignant potential of reprogrammed cells

scientific article published on 9 August 2010

Mutant p53 gain of function is interwoven into the hallmarks of cancer ⬇️

scientific article published on 01 December 2011

Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers.

scientific article published on 18 January 2018

Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants

scientific article published on 01 August 2003

Mutant p53 gain-of-function in cancer

scientific article

Mutant p53 oncogenicity - dominant-negative or gain-of-function?

scientific article published on 07 November 2020

Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer.

scientific article published on May 2013

Mutant p53 protects cells from 12-O-tetradecanoylphorbol-13-acetate-induced death by attenuating activating transcription factor 3 induction

scientific article published on November 2006

Mutant p53 protein expression interferes with p53-independent apoptotic pathways ⬇️

scientific article published on June 25, 1998

Mutant p53 proteins bind DNA abnormally in vitro

scientific article published on 01 January 1991

Mutant p53(R175H) upregulates Twist1 expression and promotes epithelial-mesenchymal transition in immortalized prostate cells.

scientific article published on 6 August 2010

Mutant p53-a potential player in shaping the tumor-stroma crosstalk

scientific article published on 01 July 2019

Mutant p53-dependent mitochondrial metabolic alterations in a mesenchymal stem cell-based model of progressive malignancy

scientific article published on 09 November 2018

Mutant p53R273H attenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen species

scientific article published on 16 August 2012

Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis

scientific article published on April 2011

Mutations in the tetramerization domain of p53: more than just keeping monomers apart.

scientific article

Myocardin in tumor suppression and myofibroblast differentiation.

scientific article published on 9 May 2007

Nitric oxide-induced cellular stress and p53 activation in chronic inflammation

scholarly article

Novel p53 target genes secreted by the liver are involved in non-cell-autonomous regulation.

scientific article published on 11 September 2015

Nuclear localization is essential for the activity of p53 protein

scientific article published on November 1, 1991

On a fundamental structure of gene networks in living cells

scientific article published on 5 March 2012

Oncogenic Mutant p53 Gain of Function Nourishes the Vicious Cycle of Tumor Development and Cancer Stem-Cell Formation

scientific article published on 27 May 2016

Pla2g16 phospholipase mediates gain-of-function activities of mutant p53.

scientific article

Post-translational regulation of p53 function through 20S proteasome-mediated cleavage.

scientific article published on 8 September 2017

Prevalence of autoantibodies to the p53 protein in autoimmune hepatitis

scientific article published on 01 December 2002

Prolonged culture of telomerase-immortalized human fibroblasts leads to a premalignant phenotype.

scientific article

Prostate stromal cells produce CXCL-1, CXCL-2, CXCL-3 and IL-8 in response to epithelia-secreted IL-1.

scientific article published on 20 February 2009

Reconstitution of p53 expression in a nonproducer Ab-MuLV-transformed cell line by transfection of a functional p53 gene

scientific article

Regulation of AIF expression by p53.

scientific article published on 26 May 2006

Regulation of lipid metabolism by p53 - fighting two villains with one sword.

scientific article published on 20 July 2012

Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53

scientific article

Reprogramming of cell junction modules during stepwise epithelial to mesenchymal transition and accumulation of malignant features in vitro in a prostate cell model

scientific article published on 20 October 2010

Rescue of embryonic stem cells from cellular transformation by proteomic stabilization of mutant p53 and conversion into WT conformation.

scientific article

Retraction: Transactivation of the EGR1 Gene Contributes to Mutant p53 Gain of Function

scientific article published on 01 April 2019

Role of wild type p53 in the G2 phase: regulation of the γirradiation-induced delay and DNA repair ⬇️

scientific article published on November 20, 1997

SPATA18, a spermatogenesis-associated gene, is a novel transcriptional target of p53 and p63

scientific journal article

Same stem cells but different: Isogenic embryonic stem cells harboring different p53 mutants

scientific article published on 15 July 2011

Single chain antibody against the common epitope of mutant p53 restores wild-type activity to mutant p53 protein

scientific article published on 28 September 2005

Spot-1, a novel NLS-binding protein that interacts with p53 through a domain encoded by p(CA)n repeats

scientific article published on September 7, 1995

Structural and functional involvement of p53 in BER in vitro and in vivo

scientific article published on February 2001

Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations

scientific article

Systemic lupus erythematosus in mice, spontaneous and induced, is associated with autoimmunity to the C-terminal domain of p53 that recognizes damaged DNA

scientific article published on 01 April 2000

TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response.

scientific article published on 14 October 2016

TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model

scientific article

TP53 in hematological cancer: low incidence of mutations with significant clinical relevance

scientific article

Targeting mutant p53 for cancer therapy

scientific article published on 26 June 2016

Testicular Tissue-Specific Expression of the p53 Suppressor Gene ⬇️

scientific article published on 01 March 1993

The C-terminal domain of the Arabidopsis AtMBD7 protein confers strong chromatin binding activity

scientific article

The C-terminus of mutant p53 is necessary for its ability to interfere with growth arrest or apoptosis

scientific article published in August 2001

The DNA binding activity of wild type p53 is modulated by blocking its various antigenic epitopes

scientific article published on 01 March 1995

The HIV gp41 Fusion Protein Inhibits T-Cell Activation through the Lentiviral Lytic Peptide 2 Motif

scientific article published on 15 January 2019

The HTLV-1 gp21 fusion peptide inhibits antigen specific T-cell activation in-vitro and in mice.

scientific article

The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation

The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation.

scientific article

The human 1-8D gene (IFITM2) is a novel p53 independent pro-apoptotic gene.

scientific article

The inflammatory cytokine TNFα cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells

scientific article

The murine C'-terminally alternatively spliced form of p53 induces attenuated apoptosis in myeloid cells

scientific article published on February 1997

The murine telomerase catalytic subunit shares the PAb-240 mutant specific epitope of the p53 protein.

scientific article published on July 2003

The onset of p53 loss of heterozygosity is differentially induced in various stem cell types and may involve the loss of either allele

scientific article

The onset of p53-dependent DNA repair or apoptosis is determined by the level of accumulated damaged DNA.

scientific article published in June 2002

The onset of p53-dependent apoptosis plays a role in terminal differentiation of human normoblasts

scientific article published on 01 July 2003

The paradigm of mutant p53-expressing cancer stem cells and drug resistance

scientific article published on 21 March 2014

The promoters of human cell cycle genes integrate signals from two tumor suppressive pathways during cellular transformation.

scientific article published on 18 October 2005

The role of p53 in base excision repair following genotoxic stress

scientific article

The role of p53 in the induction of polyploidity of myelomonocytic leukemic M1/2 cells.

scientific article published on October 1996

The role of the C' terminus of murine p53 in the p53/mdm-2 regulatory loop.

scientific article published in May 2001

Transactivation of the EGR1 gene contributes to mutant p53 gain of function

scientific article

Transcription regulation by mutant p53.

scientific article published on April 2007

Transcriptional activity of ATF3 in the stromal compartment of tumors promotes cancer progression.

scientific article

Transcriptional control of the proliferation cluster by the tumor suppressor p53.

scientific article published on 24 August 2009

Transcriptional programs following genetic alterations in p53, INK4A, and H-Ras genes along defined stages of malignant transformation

scientific article published on 01 June 2005

Tumor-promoting circuits that regulate a cancer-related chemokine cluster: dominance of inflammatory mediators over oncogenic alterations

scientific article published on 20 January 2012

Two promoters that map to 5'-sequences of the human p53 gene are differentially regulated during terminal differentiation of human myeloid leukemic cells

scientific article published on 01 August 1989

Unleash the wild type: Restoration of p53 suppressive activity in skin cancer

scientific article published on 03 March 2011

Unleash the wild type: restoration of p53 suppressive activity in skin cancer

scientific article published on March 1, 2011

Upregulation of survivin during immortalization of nontransformed human fibroblasts transduced with telomerase reverse transcriptase.

scientific article

Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature

scientific article

Various stress stimuli rewire the profile of liver secretome in a p53-dependent manner.

scientific article

Visual barcodes for clonal-multiplexing of live microscopy-based assays

scientific article published on 18 May 2022

When mutants gain new powers: news from the mutant p53 field.

scientific article published on 20 August 2009

Wide-scale analysis of human functional transcription factor binding reveals a strong bias towards the transcription start site

scientific article

Wild type p53 functions as a control protein in the differentiation pathway of the B-cell lineage.

scientific article published on December 1993

Wild-type but not mutant p53 can repress transcription initiation in vitro by interfering with the binding of basal transcription factors to the TATA motif

scientific article published on May 1993

c-Myc trans-activates the p53 promoter through a required downstream CACGTG motif

scientific article published on February 1993

hTERT-immortalized prostate epithelial and stromal-derived cells: an authentic in vitro model for differentiation and carcinogenesis

scientific article

p53 Regulates the Ras circuit to inhibit the expression of a cancer-related gene signature by various molecular pathways

scientific article published on 2 March 2010

p53 and its mutants on the slippery road from stemness to carcinogenesis

scientific article published on 15 March 2017

p53 and the Viral Connection: Back into the Future ‡.

scientific article published on 4 June 2018

p53 balances between tissue hierarchy and anarchy

scientific article published on 01 July 2019

p53 controls low DNA damage-dependent premeiotic checkpoint and facilitates DNA repair during spermatogenesis

scientific article published on 01 October 1999

p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes

scientific article published on 29 March 2011

p53 counteracts reprogramming by inhibiting mesenchymal-to-epithelial transition

scientific article published on 21 September 2012

p53 in liver pathologies-taking the good with the bad.

scientific article

p53 increases experimental metastatic capacity of murine carcinoma cells

scientific article published on May 1988

p53 is a regulator of macrophage differentiation.

scientific article published in April 2004

p53 is balancing development, differentiation and de-differentiation to assure cancer prevention.

scientific article published on 26 May 2010

p53 is required for brown adipogenic differentiation and has a protective role against diet-induced obesity

scientific article published on 15 February 2013

p53 mediates density-dependent growth arrest.

scientific article published on February 2004

p53 modulates base excision repair activity in a cell cycle-specific manner after genotoxic stress.

scientific article

p53 on the crossroad between regeneration and cancer

scientific article

p53 orchestrates between normal differentiation and cancer.

scientific article published on 07 January 2014

p53 plays a regulatory role in differentiation and apoptosis of central nervous system-associated cells

scientific article published on September 1996

p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner

scientific article

p53 promotes the expression of gluconeogenesis-related genes and enhances hepatic glucose production

scientific article published on 4 February 2013

p53 tumor suppressor gene expression in the mouse ovary during an artificially induced ovulatory cycle

scientific article published on 01 February 1999

p53, a novel regulator of lipid metabolism pathways

p53, a novel regulator of lipid metabolism pathways.

scientific article

p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation.

scientific article

p53-dependent apoptosis is regulated by a C-terminally alternatively spliced form of murine p53

scientific article published on 01 July 2000

p53-dependent down-regulation of telomerase is mediated by p21waf1.

scientific article published on 15 September 2004

p53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

scientific journal article

p53: balancing tumour suppression and implications for the clinic

scientific article published in September 2009

p53: the barrier to cancer stem cell formation.

scientific article

p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model

scientific article

‘Cancer associated fibroblasts’ – more than meets the eye ⬇️

scientific article published on June 13, 2013

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