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List of works by C. Ronald Kahn

125I-insulin binding to cultured human lymphocytes. Initial localization and fate of hormone determined by quantitative electron microscopic autoradiography

scientific article published on April 1978

35th Annual Meeting of the European Association for the Study of Diabetes

article

35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999

article

4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice

scientific article

A Kex2-related endopeptidase activity present in rat liver specifically processes the insulin proreceptor

scientific article published on July 1994

A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor.

scientific article

A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies

scientific article published on June 1996

A family of polypeptide substrates and inhibitors of insulin receptor kinase

scientific article published on April 1990

A guide to analysis of mouse energy metabolism

scientific article published on 28 December 2011

A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes

scientific article published in December 2000

A patient with type B insulin resistance syndrome, responsive to immune therapy

scientific article published in December 2007

A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response

scientific article

ATP induces a conformational change of the 90-kDa heat shock protein (hsp90).

scientific article

Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones

scientific article

Abnormality of insulin binding and receptor phosphorylation in an insulin-resistant melanoma cell line

scientific article

Absence of Diabetes and Pancreatic Exocrine Dysfunction in a Transgenic Model of Carboxyl-Ester Lipase-MODY (Maturity-Onset Diabetes of the Young) ⬇️

scientific article published on April 2, 2013

Absence of insulin receptor substrate-1 expression does not alter GLUT1 or GLUT4 abundance or contraction-stimulated glucose uptake by mouse skeletal muscle

scientific article published in December 2001

Absence of insulin signalling in skeletal muscle is associated with reduced muscle mass and function: evidence for decreased protein synthesis and not increased degradation

scientific article

Acute and chronic regulation of phosphoenolpyruvate carboxykinase mRNA by insulin and glucose

scientific article published on May 1989

Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor

scientific article published on 4 January 2017

Adipose depots possess unique developmental gene signatures

scientific article

Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance

scientific article

Adipose-derived circulating miRNAs regulate gene expression in other tissues

scientific article published on 15 February 2017

Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance

scientific article published on 15 November 2012

Adrenocortical Carcinoma and Hypoglycemia: Evidence for Production of Nonsuppressible Insulin-Like Activity by the Tumor ⬇️

scientific article published on June 1, 1977

Adriamycin Therapy for Advanced Insulinoma ⬇️

scientific article published on January 1, 1977

Akt signaling mediates postnatal heart growth in response to insulin and nutritional status

scientific article published on 5 August 2002

Alterations in Insulin Binding Induced by Changes in Vivo in the Levels of Glucocorticoids and Growth Hormone* ⬇️

scientific article published on October 1, 1978

Alterations in insulin receptor and substrate phosphorylation in hypertensive rats.

scientific article published on October 1992

Alterations in insulin receptor autophosphorylation in insulin resistance: correlation with altered sensitivity to glucose transport and antilipolysis to insulin

scientific article published in May 1988

Alterations in skeletal muscle gene expression of ob/ob mice by mRNA differential display ⬇️

scientific article published on September 1, 1998

Alterations in the hepatic insulin receptor kinase in genetic and acquired obesity in rats.

scientific article

Altered expression and function of the insulin receptor in a family with lipoatrophic diabetes.

scientific article published in December 1988

Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines

scientific article

Altered insulin distribution and metabolism in type I diabetics assessed by [123I]insulin scanning

scientific article published in April 1987

Altered insulin signaling in retinal tissue in diabetic states

scientific article

Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy

scientific article

Altered signaling and cell cycle regulation in embryonal stem cells with a disruption of the gene for phosphoinositide 3-kinase regulatory subunit p85alpha

scientific article

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

scientific article published in November 1994

Amino Acid Deficiency and the Skin Rash Associated with Glucagonoma

scientific article published on August 1, 1979

Ammonium inhibits processing and cytotoxicity of reovirus, a nonenveloped virus

scientific article

An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events

scientific article (publication date: May 2002)

Analysis of a peptide hormone–receptor interaction in the yeast two-hybrid system ⬇️

scientific article published on November 25, 1997

Analysis of gene expression in pathophysiological states: balancing false discovery and false negative rates

scientific article

Analysis of insulin action using differentiated and dedifferentiated hepatoma cells

scientific article published on October 1983

Analysis of the insulin receptor by anti-receptor antibodies and flow cytometry

scientific article published on December 1984

Analysis of the insulin receptor gene in noninsulin-dependent diabetes mellitus by denaturing gradient gel blots: a clinical research center study.

scientific article published in June 1995

Anatomical and Functional Assessment of Brown Adipose Tissue by Magnetic Resonance Imaging ⬇️

scientific article published on February 20, 2012

Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk

scientific article

Anti-insulin receptor antibodies inhibit insulin binding and stimulate glucose metabolism in skeletal muscle.

scientific article published in May 1978

Antibiotic effects on gut microbiota and metabolism are host dependent

scientific article published on 24 October 2016

Antibodies That Impair Insulin Receptor Binding in an Unusual Diabetic Syndrome with Severe Insulin Resistance ⬇️

scientific article published on October 3, 1975

Antibodies to the insulin receptor as tools in the study of receptor structure and function

scientific article published on January 1987

Antibody-induced desensitization of the insulin receptor. Studies of the mechanism of desensitization in 3T3-L1 fatty fibroblasts

scientific article

Antioxidants prevent health-promoting effects of physical exercise in humans

scientific article

Antireceptor antibodies as probes of insulinlike growth factor receptor structure ⬇️

scientific article published on October 1, 1983

Application of radioreceptor assay to circulating insulin, growth hormone, and to their tissue receptors in animals and man.

scientific article published on June 1973

Approaches to the molecular cloning of protein-tyrosine phosphatases in insulin-sensitive tissues ⬇️

scientific article published on February 12, 1992

Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability

scientific article

Attenuation of PKCδ enhances metabolic activity and promotes expansion of blood progenitors

scientific article published on 16 November 2018

Atypical beta-adrenergic effects on insulin signaling and action in beta(3)-adrenoceptor-deficient brown adipocytes

scientific article published on July 2002

Augmented desensitization to epidermal growth factor (EGF) immediate actions: A novel mechanism for altered EGF growth response in mutant A431 cells ⬇️

scientific article published on February 1, 1990

Autoantibodies to Insulin Receptors in Man: Immunological Determinants and Mechanism of Action ⬇️

scientific article published on January 1, 1982

Autoantibodies to insulin receptors

scientific article published on June 1981

Autoantibodies to the insulin receptor activate glycogen synthase in rat adipocytes ⬇️

scientific article published on December 22, 1978

Autoantibodies to the insulin receptor. Effect on the insulin-receptor interaction in IM-9 lymphocytes ⬇️

scientific article published on October 1, 1977

Autoantibodies to the insulin receptor: clinical and molecular aspects

scientific article published on November 1, 1979

Autoantibodies to the insulin receptor: clinical significance and experimental applications

scientific article published on January 1980

Autoimmunity and the aetiology of insulin-dependent diabetes mellitus

scientific article published in Nature

Autophosphorylation and kinase activity of insulin receptor in diabetic rats.

scientific article

Autophosphorylation within insulin receptor .beta.-subunits can occur as an intramolecular process ⬇️

scientific article published on August 6, 1991

Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes

scientific article

Beneficial effects of subcutaneous fat transplantation on metabolism

scientific article

Berson, Yalow, and the JCI: the agony and the ecstasy

scientific article published on October 2004

Beta-Cell hyperplasia induced by hepatic insulin resistance: role of a liver-pancreas endocrine axis through insulin receptor A isoform

scientific article published on 9 January 2009

Bi-directional regulation of brown fat adipogenesis by the insulin receptor

scientific article published on December 2016

Bi-directional regulation of brown fat adipogenesis by the insulin receptor

scientific article

Bidirectional modulation of insulin action by amino acids ⬇️

scientific article published on April 1, 1998

Binding and degradation of insulin by human peripheral granulocytes. Demonstration of specific receptors with high affinity ⬇️

scientific article published on May 10, 1976

Biosynthesis and glycosylation of the insulin receptor. Evidence for a single polypeptide precursor of the two major subunits

scientific article published in August 1983

Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage

scientific article published on December 2005

Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance

scientific article

Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance

scholarly article by Carmen Guerra et al published 2 January 2019 in Journal of Clinical Investigation

Brown fat as a therapy for obesity and diabetes

scientific article

CDK4 is an essential insulin effector in adipocytes

scientific journal article

Calorie restriction increases insulin-stimulated glucose transport in skeletal muscle from IRS-1 knockout mice

scientific article published in October 1999

Cascade of autophosphorylation in the beta-subunit of the insulin receptor

scientific article published on April 1989

Cell Membrane Receptors for Polypeptide Hormones: Applications to the Study of Disease States in Mice and Men ⬇️

scientific article published on May 1, 1975

Cell culture studies on patients with extreme insulin resistance. I. Receptor defects on cultured fibroblasts.

scientific article

Cell culture studies on patients with extreme insulin resistance. II. Abnormal biological responses in cultured fibroblasts.

scientific article

Cellular and molecular mechanisms of adipose tissue plasticity in muscle insulin receptor knockout mice

scientific article published on 18 December 2003

Cellular bioenergetics as a target for obesity therapy

scientific article

Cellular compartmentalization in insulin action: altered signaling by a lipid-modified IRS-1.

scientific article

Central insulin action regulates peripheral glucose and fat metabolism in mice

scientific article published on June 2008

Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse

scientific article

Characterization and regulation of the mouse insulin receptor substrate gene promoter

scientific article

Characterization of Rad, a new member of Ras/GTPase superfamily, and its regulation by a unique GTPase-activating protein (GAP)-like activity

scientific article

Characterization of a membrane regulator of insulin receptor affinity ⬇️

scientific article published on June 10, 1983

Characterization of antibodies to the insulin receptor: a cause of insulin-resistant diabetes in man ⬇️

scientific article published on December 1, 1976

Characterization of binding and phosphorylation defects of erythrocyte insulin receptors in the type A syndrome of insulin resistance

scientific article

Characterization of insulin-mediated phosphorylation of the insulin receptor in a cell-free system ⬇️

scientific article published on January 10, 1983

Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis

scientific article published on 29 May 2003

Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85alpha

scientific article

Circulating NSILA-s in Man: Preliminary Studies of Stimuliin Vivoand of Binding to Plasma Components ⬇️

scientific article published on September 1, 1975

Citation for the 2000 Roy O. Greep Award Lecture of The Endocrine Society to Dr. Christin Carter-Su

scientific article published in August 2000

Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms

scientific article published on December 2010

Cloning of the mouse insulin receptor substrate-1 (IRS-1) gene and complete sequence of mouse IRS-1.

scientific article published in April 1994

Cold but not sympathomimetics activates human brown adipose tissue in vivo ⬇️

scientific article published on June 4, 2012

Common and distinct elements in insulin and PDGF signaling

scientific article published on September 1995

Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism.

scientific article published in November 2016

Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction

scientific article

Conditional mutagenesis--second generation knockout mice as models for internal diseases

scientific article published in October 1999

Conditions promoting creativity in group rearing of children

scientific article published in January 1974

Congenital hypothyroidism in a young man with growth hormone, thyrotropin, and prolactin deficiencies ⬇️

scientific article published on June 1, 1976

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

scientific article (publication date: 13 September 2001)

Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice

scientific article

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

scientific article

Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι

scientific article published on 05 January 2012

Correlation among insulin binding, degradation, and biological activity in human breast cancer cells in long-term tissue culture ⬇️

scientific article published on January 1, 1978

Corrigendum: Adipose-derived circulating miRNAs regulate gene expression in other tissues.

scientific article

Critical nodes in signalling pathways: insights into insulin action

scientific article (publication date: February 2006)

Cross-talk between insulin and Wnt signaling in preadipocytes. ROLE OF Wnt CO-RECEPTOR LDL RECEPTOR-RELATED PROTEIN-5 (LRP5).

scientific article published on August 2016

Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5).

scientific article published on 15 February 2012

Cross-talk between phorbol ester-mediated signaling and tyrosine kinase proto-oncogenes. I. Activation of protein kinase C stimulates tyrosine phosphorylation and activation of ErbB2 and ErbB3.

scientific article

Cross-talk between phorbol ester-mediated signaling and tyrosine kinase proto-oncogenes. II. Comparison of phorbol ester and sphingomyelinase-induced phosphorylation of ErbB2 and ErbB3.

scientific article published on December 1997

Cross-talk between the insulin and angiotensin signaling systems

scientific article published on October 1996

Crosstalk between insulin and angiotensin II signalling systems

scientific article

Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma

scientific article

Cysteine 647 in the insulin receptor is required for normal covalent interaction between alpha- and beta-subunits and signal transduction ⬇️

scientific article published on April 5, 1992

Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus

scientific article

Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

scientific article

Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets

scientific article published on 31 August 2009

Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death

scientific article

Deletion of a highly conserved tetrapeptide sequence of the proinsulin connecting peptide (C-peptide) inhibits proinsulin to insulin conversion by transfected pituitary corticotroph (AtT20) cells

scientific article published on December 1989

Demonstration that monocytes rather than lymphocytes are the insulin-binding cells in preparations of humah peripheral blood mononuclear leukocytes: implications for studies of insulin-resistant states in man ⬇️

scientific article published on February 1, 1975

Desensitization of the insulin receptor at an early postreceptor step by prolonged exposure to antireceptor antibody

scientific article published on February 1979

Determinants of IDDM and Perinatal Mortality in Children of Diabetic Mothers ⬇️

scientific article published on October 1, 1988

Development of an in vitro reconstitution assay for glucose transporter 4 translocation

scientific article published on December 1999

Developmental and functional heterogeneity of white adipocytes within a single fat depot

scientific article published on 10 December 2018

Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in the mammary gland

scientific article published in June 2003

Developmental origin of fat: tracking obesity to its source.

scientific article

Dexamethasone-induced changes in phosphorylation of the insulin and epidermal growth factor receptors and their substrates in intact rat hepatocytes

scientific article published in November 1988

Diabetes and Insulin in Regulation of Brain Cholesterol Metabolism ⬇️

scientific article published on December 1, 2010

Diabetes primes neutrophils to undergo NETosis, which impairs wound healing

scientific article

Diabetes. Causes of insulin resistance.

scientific article published in February 1995

Diabetes: a strategic plan for the 21st century

scientific article published in March 1999

Dietary leucine--an environmental modifier of insulin resistance acting on multiple levels of metabolism

scientific article (publication date: 2011)

Different pathways of postreceptor desensitization following chronic insulin treatment and in cells overexpressing constitutively active insulin receptors

scientific article

Differential Role of Insulin/IGF-1 Receptor Signaling in Muscle Growth and Glucose Homeostasis ⬇️

scientific article published on 14 May 2015

Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity

scientific article

Differential effects of viral infection on islet and pituitary cell lines

scientific article published in June 1985

Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse ⬇️

scientific article published on December 15, 1997

Differential responsiveness to insulin of endothelial and support cells from micro- and macrovessels ⬇️

scientific article published on April 1, 1983

Differential roles of insulin receptor substrates in brown adipocyte differentiation

scientific article

Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulin

scientific article published on 24 June 2002

Differential roles of the insulin and insulin-like growth factor-I (IGF-I) receptors in response to insulin and IGF-I.

scientific article published on 7 July 2004

Differential roles of the insulin and insulin-like growth factor-I (IGF-I) receptors in response to insulin and IGF-I.

scientific article published on October 2016

Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells

scientific article published on March 1997

Differentiation-dependent phosphorylation of a 175,000 molecular weight protein in response to insulin and insulin-like growth factor-I in L6 skeletal muscle cells

scientific article published in September 1989

Differing effects of antiinsulin serum and antiinsulin receptor serum on 123I-insulin metabolism in rats

scientific article published on May 1985

Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression

scientific article published in January 1999

Direct demonstration of glycosylation of insulin receptor subunits by biosynthetic and external labeling: evidence for heterogeneity

scientific article

Direct demonstration of separate receptors for growth and metabolic activities of insulin and multiplication-stimulating activity (an insulinlike growth factor) using antibodies to the insulin receptor

scientific article published on July 1980

Direct demonstration that receptor crosslinking or aggregation is important in insulin action ⬇️

scientific article published on September 1, 1978

Direct inhibition of growth and antagonism of insulin action by glucocorticoids in human breast cancer cells in culture ⬇️

scientific article published on July 1, 1979

Direct method for detection and characterization of cell surface receptors for insulin by means of 125I-labeled autoantibodies against the insulin receptor ⬇️

scientific article published on November 1, 1976

Dissection of the insulin signaling pathway via quantitative phosphoproteomics

scholarly article

Distinct biologically active receptors for insulin, insulin-like growth factor I, and insulin-like growth factor II in cultured skeletal muscle cells.

scientific article published in December 1985

Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice

scholarly article

Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling

scientific article published on 3 October 2017

Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling.

scientific article published in March 2018

Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKCλ/ζ

article

Divergent regulation of the Glut 1 and Glut 4 glucose transporters in isolated adipocytes from Zucker rats ⬇️

scientific article published on June 1, 1992

Divergent roles of growth factors in the GnRH regulation of puberty in mice

scientific article

Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise

scientific article published on 08 September 2020

Dynamics of insulin signaling in 3T3-L1 adipocytes. Differential compartmentalization and trafficking of insulin receptor substrate (IRS)-1 and IRS-2.

scientific article published on May 1998

Dysfunctional Subcutaneous Fat With Reduced Dicer and Brown Adipose Tissue Gene Expression in HIV-Infected Patients

scientific article published on 12 January 2016

Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice

scholarly article

Ectopic production of chorionic gonadotropin and its subunits by islet-cell tumors. A specific marker for malignancy

scientific article published on September 1977

Effect of cholesterol reduction on receptor signaling in neurons

scientific article

Effect of cross-linking agents on insulin associated responses in adipocytes.

scientific article published on January 1982

Effect of dexamethasone on the carbohydrate chains of the insulin receptor

scientific article published on April 1994

Effect of phospholipase treatment on insulin receptor signal transduction ⬇️

scientific article published on February 1, 1992

Effect of the insulin mimetic L-783,281 on intracellular Ca2+ and insulin secretion from pancreatic beta-cells

scientific article

Effective structures for ethical choices

Effects of autoantibodies to the insulin receptor on isolated adipocytes. Studies of insulin binding and insulin action ⬇️

scientific article published on November 1, 1977

Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome

scientific article published in May 2005

Effects of heparin on insulin binding and biological activity

scientific article

Effects of insulin-sensitising agents in mice with hepatic insulin resistance

scientific article published on 17 January 2004

Effects of phosphorylation on function of the Rad GTPase ⬇️

scientific article published on August 1, 1998

Elevated GH/IGF-I, due to somatotrope-specific loss of both IGF-I and insulin receptors, alters glucose homeostasis and insulin sensitivity in a diet-dependent manner

scientific article published on 11 October 2011

Endocrine regulation of ageing

scientific article

Endogenous peroxisome proliferator-activated receptor-gamma augments fatty acid uptake in oxidative muscle

scientific article published on 24 July 2008

Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice

scientific article

Epidemiologic approach to the etiology of type I diabetes mellitus and its complications

scientific article published on November 1987

Epidermal growth factor receptor defects in leprechaunism. A multiple growth factor-resistant syndrome

scientific article

Epidermal growth factor stimulated phosphorylation of a 120-kilodalton endogenous substrate protein in rat hepatocytes

scientific article published on October 1990

Erratum: Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling

scientific article published in October 2017

Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function

scientific article published on 22 December 2006

Essential role of insulin receptor substrate 1 in differentiation of brown adipocytes

scientific article published on January 2001

Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes

scientific article

Evidence for a circulating islet cell growth factor in insulin-resistant states

scientific article

Evidence for a role of developmental genes in the origin of obesity and body fat distribution

scholarly article

Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents

scientific article published on 19 April 2010

Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice

scientific article

Expression and function of IRS-1 in insulin signal transmission.

scientific article published on November 1992

Expression of insulin receptors and insulin action in cell hybrids and cybrids

scientific article published on August 1983

Expression of the gene encoding glycogen phosphorylase is elevated in diabetic rat skeletal muscle and is regulated by insulin and cyclic AMP.

scientific article published on February 1996

Extended longevity in mice lacking the insulin receptor in adipose tissue

scientific article (publication date: 24 January 2003)

FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis

scientific article published on 17 March 2020

Familial hyperproinsulinemia due to a proposed defect in conversion of proinsulin to insulin

scientific article published in September 1984

Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation

scientific article

Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dieting

scientific article published in November 1976

Four RFLPs of the human insulin receptor gene: PstI, KpnI, RsaI (2 RFLPs).

scientific article

FoxO Transcription Factors Are Critical Regulators of Diabetes-Related Muscle Atrophy

scientific article published on 06 December 2018

FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization

scientific article published on 12 May 2015

Frataxin activates mitochondrial energy conversion and oxidative phosphorylation

scientific article

Frataxin promotes antioxidant defense in a thiol-dependent manner resulting in diminished malignant transformation in vitro

scientific article published on April 2002

From mice to men: insights into the insulin resistance syndromes

scientific article

GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor-stimulated muscle glucose utilization

scientific article

Gab-1-mediated IGF-1 signaling in IRS-1-deficient 3T3 fibroblasts

scientific article published on April 2000

Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice

scientific article published in December 2004

Genetic insulin resistance is a potent regulator of gene expression and proliferation in human iPS cells

scientific article

Genetics of non-insulin-dependent (type-II) diabetes mellitus

scientific article

Genotype-phenotype relationships in Berardinelli-Seip congenital lipodystrophy

scientific article

Glucagon resistance of hepatoma cells. Evidence for receptor and post-receptor defects

scientific article published on September 1983

Glucose homeostasis and tissue transcript content of insulin signaling intermediates in four inbred strains of mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1.

scientific article published on 24 March 2004

Glypican-4 enhances insulin signaling via interaction with the insulin receptor and serves as a novel adipokine

scientific article

Gut Microbiota Regulate Pancreatic Growth, Exocrine Function, and Gut Hormones

scientific article published on 01 May 2022

Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism.

scientific article

Health care reform--need for less emotion and more science

scientific article published on October 2009

Hepatic deletion of p110α and p85α results in insulin resistance despite sustained IRS1-associated phosphatidylinositol kinase activity.

scientific article published on 30 August 2017

Hepatic insulin resistance directly promotes formation of cholesterol gallstones

scientific article published on 29 June 2008

Hepatic phosphotyrosine phosphatase activity and its alterations in diabetic rats

scientific article published on September 1989

Heterogeneity of expression and secretion of native and mutant [AspB10]insulin in AtT20 cells

scientific article published on March 1991

Heterogeneity of the insulin-receptor interaction in lipoatropic diabetes

scientific article published in March 1981

Heterozygous expansion of the GAA tract of the X25/frataxin gene is associated with insulin resistance in humans.

scientific article published in September 2000

Heterozygous knockout of the IRS-1 gene in mice enhances obesity-linked insulin resistance: a possible model for the development of type 2 diabetes

scientific article published in August 2002

High baseline vitamin C levels do not prevent a positive outcome of a lifestyle intervention: response to Thamer et al.

scientific article published in January 2010

High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice

scientific article published on 07 June 2007

High fat feeding causes insulin resistance and a marked decrease in the expression of glucose transporters (Glut 4) in fat cells of rats

scientific article published on August 1991

Hormonal regulation of the affinity and concentration of hormone receptors in target cells ⬇️

scientific article published on November 1, 1976

Hormone Resistance and Hormone Sensitivity ⬇️

scientific article published on February 3, 1977

Human Skeletal Muscle Insulin Receptor Substrate-1: Characterization of the cDNA, Gene, and Chromosomal Localization

article

Human corneal epithelial primary cultures and cell lines with extended life span: in vitro model for ocular studies ⬇️

scientific article published on November 1, 1993

Human insulin receptor substrate-1 (IRS-1) polymorphism G972R causes IRS-1 to associate with the insulin receptor and inhibit receptor autophosphorylation

scientific article published on 7 December 2004

Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization

scientific journal article

Hypoglycemia Associated with Non-Islet-Cell Tumor and Insulin-like Growth Factors ⬇️

scientific article published on December 10, 1981

Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets

scientific journal article

IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance

scientific article published on 12 October 2007

Identification and High Yield Purification of Insulin-Like Growth Factors (Nonsuppressible Insulin-Like Activities and Somatomedins) from Human Plasma by Use of Endogenous Binding Proteins* ⬇️

scientific article published on January 1, 1979

Identification and importance of brown adipose tissue in adult humans

scientific article

Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance

scientific article published in June 2003

Identification of persistent defects in insulin receptor structure and function capillary endothelial cells from diabetic rats

scientific article

Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13.

scientific article

Immunologic Reactions to Insulin: Insulin Allergy, Insulin Resistance, and the Autoimmune Insulin Syndrome ⬇️

scientific article published on May 1, 1979

Immunoprecipitation of the Insulin Receptor: A Sensitive Assay for Receptor Antibodies and a Specific Technique for Receptor Purification* ⬇️

scientific article published on January 1, 1979

Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice

scientific article published in June 2003

Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal

scientific article published on April 2012

Impaired sodium excretion and increased blood pressure in mice with targeted deletion of renal epithelial insulin receptor

scholarly article

Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling ⬇️

scientific article published on June 12, 2012

Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan

scientific article published on 22 May 2017

In vitro lymphocyte proliferation response to therapeutic insulin components. Evidence for genetic control by the human major histocompatibility complex

scientific article

In vivo and in vitro studies of vanadate in human and rodent diabetes mellitus

scientific article published on December 1995

Increased expression of mitochondrial-encoded genes in skeletal muscle of humans with diabetes mellitus

scientific article published on March 1995

Increased insulin sensitivity in IGF-I receptor--deficient brown adipocytes

scientific article published on March 2002

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase

scientific article

Increased protein kinase C activity is linked to reduced insulin receptor autophosphorylation in liver of starved rats.

scientific article published on June 1990

Initial processing of the insulin receptor precursor in vivo and in vitro ⬇️

scientific article published on September 15, 1988

Insulin Receptor Deficiency in Genetic and Acquired Obesity ⬇️

scientific article published on October 1, 1975

Insulin Receptor Regulation and Desensitization in Rat Hepatoma Cells: Concomitant Changes in Receptor Number and in Binding Affinity ⬇️

scientific article published on May 1, 1984

Insulin Receptor Substrate Proteins Create a Link between the Tyrosine Phosphorylation Cascade and the Ca2+-ATPases in Muscle and Heart ⬇️

scientific article published on September 19, 1997

Insulin Receptors, Receptor Antibodies, and the Mechanism of Insulin Action

scientific article published on January 1, 1981

Insulin Resistance in Human iPS Cells Reduces Mitochondrial Size and Function

scientific article published on 7 March 2016

Insulin Resistance, Acanthosis Nigricans, and Normal Insulin Receptors in a Young Woman: Evidence for a Postreceptor Defect ⬇️

scientific article published on September 1, 1978

Insulin action and the insulin signaling network

scientific article published on April 1995

Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production

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Insulin action in brain regulates systemic metabolism and brain function

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Insulin action in the brain regulates mitochondrial stress responses and reduces diet-induced weight gain

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Insulin activates glycogen synthase in cultured human fibroblasts

scientific article published on September 1980

Insulin activation of glycogen synthase in cultured human fibroblasts is not mediated solely via the insulin receptor.

scientific article published in May 1986

Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms.

scientific article published on 13 May 2013

Insulin and antibodies against insulin receptor cap on the membrane of cultured human lymphocytes

scientific article published in Nature

Insulin and dexamethasone regulate insulin receptors, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in Fao hepatoma cells

scientific article published in April 1995

Insulin and epidermal growth factor stimulate phosphorylation of a 170-kDa protein in intact hepatocytes immunologically related to lipocortin 1.

scientific article published in December 1988

Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes

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Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription

scientific article

Insulin and the beta3-adrenoceptor differentially regulate uncoupling protein-1 expression

scientific article published on June 2000

Insulin augmentation of glucose-stimulated insulin secretion is impaired in insulin-resistant humans

scientific article published on February 2012

Insulin binding to liver plasm membranes in the obese hyperglycemic (ob/ob) mouse. Demonstration of a decreased number of functionally normal receptors ⬇️

scientific article published on June 25, 1975

Insulin differentially regulates protein phosphotyrosine phosphatase activity in rat hepatoma cells

scientific article published on October 27, 1992

Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway ⬇️

scientific article published on November 1, 2003

Insulin enhances glucose-stimulated insulin secretion in healthy humans

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Insulin induces rapid accumulation of insulin receptors and increases tyrosine kinase activity in the nucleus of cultured adipocytes

scientific article published on November 1993

Insulin induces the phosphorylation of DNA-binding nuclear proteins including lamins in 3T3-F442A

scientific article published on October 20, 1992

Insulin induces the phosphorylation of nucleolin. A possible mechanism of insulin-induced RNA efflux from nuclei ⬇️

scientific article published on May 5, 1993

Insulin inhibits pertussis toxin-catalyzed ADP-ribosylation of G-proteins. Evidence for a novel interaction between insulin receptors and G-proteins

scientific article

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

scientific article published in Nature

Insulin receptor carbohydrate units contain poly-N-acetyllactosamine chains

scientific article published on October 1990

Insulin receptor defect in insulin resistance: studies in the obese-hyperglycimic mouse.

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Insulin receptor function in fibroblasts from patients with leprechaunism. Differential alterations in binding, autophosphorylation, kinase activity, and receptor-mediated internalization

scientific article published on October 1988

Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy

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Insulin receptor kinase domain autophosphorylation regulates receptor enzymatic function ⬇️

scientific article published on August 15, 1992

Insulin receptor knockout mice

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Insulin receptor messenger ribonucleic acid sequence alterations detected by ribonuclease cleavage in patients with syndromes of insulin resistance.

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Insulin receptor plays a central role in skin carcinogenesis by regulating cytoskeleton assembly

scientific article published on 17 October 2018

Insulin receptor signaling in normal and insulin-resistant states

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Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain

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Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling

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Insulin receptor/IRS-1/PI 3-kinase signaling system in corticosteroid-induced insulin resistance

scientific article published on September 1996

Insulin receptors and syndromes of insulin resistance.

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Insulin receptors and the molecular mechanism of insulin action.

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Insulin regulates astrocyte gliotransmission and modulates behavior.

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Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

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Insulin regulation of mitogen-activated protein kinase kinase (MEK), mitogen-activated protein kinase and casein kinase in the cell nucleus: a possible role in the regulation of gene expression

scientific article published on May 1997

Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle

scientific article published on February 2000

Insulin resistance is a poor predictor of type 2 diabetes in individuals with no family history of disease

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Insulin resistance, insulin insensitivity, and insulin unresponsiveness: a necessary distinction

scientific article published on December 1, 1978

Insulin resistance: a common feature of diabetes mellitus.

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Insulin resistance: a look at the role of insulin receptor kinase

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Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression

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Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes: requirement of IRS-1 for lipid synthesis

scientific article published on November 1999

Insulin signaling in the central nervous system is critical for the normal sympathoadrenal response to hypoglycemia

scientific article published in May 2005

Insulin signaling is required for insulin's direct and indirect action on hepatic glucose production

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Insulin signaling to the glomerular podocyte is critical for normal kidney function

scientific article published on October 2010

Insulin signalling and the regulation of glucose and lipid metabolism

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Insulin stimulates phosphorylation of c-Jun, c-Fos, and Fos-related proteins in cultured adipocytes.

scientific article published on April 1994

Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor

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Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system ⬇️

scientific article published on August 12, 1982

Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat.

scientific article published on November 1992

Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine

scientific article published on September 1982

Insulin substrates 1 and 2 are corequired for activation of atypical protein kinase C and Cbl-dependent phosphatidylinositol 3-kinase during insulin action in immortalized brown adipocytes

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Insulin's discovery: New insights on its ninetieth birthday ⬇️

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Insulin-induced dissociation of its receptor into subunits: possible molecular concomitant of negative cooperativity

scientific article published in December 1976

Insulin-induced receptor loss in cultured human lymphocytes is due to accelerated receptor degradation

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Insulin-like growth factor 1-mediated hyperthermia involves anterior hypothalamic insulin receptors

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Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling.

scientific article published on September 2003

Insulin-like growth factor-mediated phosphorylation and protooncogene induction in Madin-Darby canine kidney cells

scientific article published on January 1991

Insulin-receptor antibodies mimic a late insulin effect

scientific article published on August 1979

Insulin-receptor gene and its expression in patients with insulin resistance

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Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase

scientific article published on November 1993

Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins

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Integrating Extracellular Flux Measurements and Genome-Scale Modeling Reveals Differences between Brown and White Adipocytes

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Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy

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Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation

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Interaction of the insulin receptor kinase with serine/threonine kinases in vitro.

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Interactions between Gut Microbiota, Host Genetics and Diet Modulate the Predisposition to Obesity and Metabolic Syndrome

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Interactions between host genetics and gut microbiome in diabetes and metabolic syndrome

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Interactive roles of Ras, insulin receptor substrate-1, and proteins with Src homology-2 domains in insulin signaling in Xenopus oocytes

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Interplay between FGF21 and insulin action in the liver regulates metabolism

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Interplay between FGF21 and insulin action in the liver regulates metabolism

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Interview: C. Ronald Kahn. Interview by Misia Landau

scientific article published on 30 November 2010

Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression

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Iris Malformation and Anterior Segment Dysgenesis in Mice and Humans With a Mutation in PI 3-Kinase

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Kinetic properties and sites of autophosphorylation of the partially purified insulin receptor from hepatoma cells ⬇️

scientific article published on January 10, 1984

Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes

scientific article published on July 2003

Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes mellitus.

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Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance

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Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization

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Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways

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Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c

scientific article published on July 2006

Lessons from transgenic and knockout animals about noninsulin-dependent diabetes mellitus

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Lessons on conditional gene targeting in mouse adipose tissue

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Letter: Insulin activity: the solid matrix

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Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice

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Lipodystrophy Due to Adipose Tissue-Specific Insulin Receptor Knockout Results in Progressive NAFLD.

scientific article published on 10 May 2016

Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes

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Loss of Akt1 in mice increases energy expenditure and protects against diet-induced obesity

scientific article published on 28 October 2011

Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism

scientific article published on 17 January 2017

Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells

scientific article published on 14 May 2008

MIRO: Microwave Instrument for Rosetta Orbiter

Magnitude and determinants of coronary artery disease in juvenile-onset, insulin-dependent diabetes mellitus

scientific article published in April 1987

Maintenance of 3T3-L1 cells in culture media containing saturated fatty acids decreases insulin binding and insulin action

scientific article published on November 1981

Male Brown Fat-Specific Double Knockout of IGFIR/IR: Atrophy, Mitochondrial Fission Failure, Impaired Thermogenesis, and Obesity.

scientific article published on 10 October 2017

Measurement of human brown adipose tissue volume and activity using anatomic MR imaging and functional MR imaging

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Medicine. Can we nip obesity in its vascular bud?

scientific article published in October 2008

Membrane metallo-endopeptidase (Neprilysin) regulates inflammatory response and insulin signaling in white preadipocytes

Membrane receptors for hormones and neurotransmitters ⬇️

scientific article published on August 1, 1976

Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies ⬇️

scientific article published on November 1, 1995

Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies

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Metabolically healthy and unhealthy obese--the 2013 Stock Conference report

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Mice Carrying a Dominant-Negative Human PI 3-Kinase Mutation are Protected From Obesity and Hepatic Steatosis But Not Diabetes.

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Mir193b–365 is essential for brown fat differentiation ⬇️

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Mitochondria, obesity and aging

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Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice

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Modulation of expression of insulin and IGF-I receptor by Epstein-Barr virus and its gene products LMP and EBNA-2 in lymphocyte cell lines

scientific article published on March 1993

Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats

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Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.

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Molecular biology. HNFs--linking the liver and pancreatic islets in diabetes

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Molecular defects in insulin action.

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Molecular defects in the insulin receptor in patients with leprechaunism and in their parents

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Molecular determinants of insulin action

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Molecular determinants of insulin action

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Molecular scanning of beta-3-adrenergic receptor gene in total congenital lipoatrophic diabetes mellitus

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Monoclonal antibodies to the major Lolium perenne (rye grass) pollen allergen Lol p I (Rye I).

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Mosaic analysis of insulin receptor function

scientific article published on January 2004

Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids.

scientific article published on 31 May 2018

Multi-Omic Profiling Reveals the Opposing Forces of Excess Dietary Sugar and Fat on Liver Mitochondria Protein Acetylation and Succinylation

scholarly article published 10 February 2018

Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo.

scientific article published in March 2019

Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones

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Muscle-specific Pten deletion protects against insulin resistance and diabetes

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Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism

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Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes

scientific article published in August 2007

Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

scientific article published in August 1988

Myeloid cell-restricted insulin receptor deficiency protects against obesity-induced inflammation and systemic insulin resistance

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Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis

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Myotubes derived from human-induced pluripotent stem cells mirror in vivo insulin resistance

scientific article published on February 2016

New concepts in the pathogenesis of diabetes mellitus.

scientific article published on January 1996

New mechanisms of glucocorticoid-induced insulin resistance: make no bones about it.

scientific article published on 24 October 2012

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

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Non-parallel evolution of metabolic and growth-promoting functions of insulin

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Nonsuppressible insulin-like activity of human serum. A potent inhibitor of insulin degradation ⬇️

scientific article published on February 1, 1976

Novel adipocyte lines from brown fat: a model system for the study of differentiation, energy metabolism, and insulin action

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Obesity associated with a mutation in a genetic regulator of adipocyte differentiation

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Optimizing transmembrane domain helicity accelerates insulin receptor internalization and lateral mobility

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Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level

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Overexpression of Rad inhibits glucose uptake in cultured muscle and fat cells

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P2F-9 A Novel Model for Contrast Enhanced Ultrasound Video and Its Applications

PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance

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PI 3-Kinase Regulatory Subunits as Regulators of the Unfolded Protein Response ⬇️

scientific article published on January 1, 2011

PI3-kinase mutation linked to insulin and growth factor resistance in vivo

scientific article published on 14 March 2016

PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans

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Pancreatic Cholera: Beneficial Effects of Treatment with Streptozotocin ⬇️

scientific article published on May 1, 1975

Pancreatic function in carboxyl-ester lipase knockout mice

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Partial diversion of a mutant proinsulin (B10 aspartic acid) from the regulated to the constitutive secretory pathway in transfected AtT-20 cells

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Pathways of insulin degradation in isolated adipocytes: evaluation by gel filtration and differential precipitation

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Persistent infection with a nontransforming RNA virus leads to impaired growth factor receptors and response

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Pertussis toxin inhibits autophosphorylation and activation of the insulin receptor kinase ⬇️

scientific article published on December 31, 1991

Perverted priorities. The physician/scientist as spokesman and salesman for biomedical research. Presidential address to the American Society for Clinical Investigation, Washington, DC, 29 April 1989.

scientific article published on September 1989

Phlorizin: a review

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Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells

scientific article published on December 1984

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

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Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.

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Phosphorylation of the solubilized insulin receptor by the gene product of the Rous sarcoma virus, pp60src

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Plasma proinsulin-like components

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Platform-independent and label-free quantitation of proteomic data using MS1 extracted ion chromatograms in skyline: application to protein acetylation and phosphorylation

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Positive and Negative Roles of p85α and p85β Regulatory Subunits of Phosphoinositide 3-Kinase in Insulin Signaling ⬇️

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Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit

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Positive and negative roles of p85α and p85β regulatory subunits of phosphoinositide 3-kinase in insulin signaling

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Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin

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Predominance of tyrosine phosphorylation of insulin receptors during the initial response of intact cells to insulin

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Prevalence of mutations in AGPAT2 among human lipodystrophies

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Processing of insulin by bovine endothelial cells in culture. Internalization without degradation

scientific article published on August 1984

Properties and partial purification of the detergent-solubilized insulin receptor A demonstration of negative cooperativity in micellar solution ⬇️

scientific article published on August 3, 1978

Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

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Pyruvate induces torpor in obese mice

scientific article published on 8 January 2018

Quantitative aspects of the insulin-receptor interaction in liver plasma membranes.

scientific article published in April 1974

Quantitative dissociation between EGF effects onc-myc andc-fos gene expression, DNA synthesis, and epidermal growth factor receptor tyrosine kinase activity ⬇️

scientific article published on January 1, 1992

Rad GTPase deficiency leads to cardiac hypertrophy

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Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II

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Rad, a novel Ras-related GTPase, interacts with skeletal muscle beta-tropomyosin

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Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans

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Radioimmunoassay of the Insulin Receptor: A New Probe of Receptor Structure and Function ⬇️

scientific article published on February 9, 1979

Radioreceptor Assay of Insulin: Comparison of Plasma and Pancreatic Insulins and Proinsulins ⬇️

scientific article published on September 1, 1975

Reactive hypoglycemia and insulin autoantibodies in drug-induced lupus erythematosus

scientific article published in August 1983

Receptor antibodies as novel therapeutics for diabetes

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Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor beta-subunit

scientific article published on September 1990

Receptors and growth-promoting effects of insulin and insulinlike growth factors on cells from bovine retinal capillaries and aorta

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Receptors for Insulin, NSILA-s, and Growth Hormone: Applications to Disease States in Man

scientific article published on January 1, 1975

Receptors for insulin and insulin-like growth factors in disease

scientific article published on January 1, 1980

Receptors for peptide hormones. New insights into the pathophysiology of disease states in man.

scientific article published on February 1977

Receptors, Antireceptor Antibodies and Mechanisms of Insulin Resistance ⬇️

scientific article published on February 22, 1979

Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle

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Reduced expression of the NADPH oxidase NOX4 is a hallmark of adipocyte differentiation

scientific article published on 19 March 2007

Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

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Reduced β-cell mass and altered glucose sensing impair insulin-secretory function in βIRKO mice ⬇️

scientific article published on September 30, 2003

Reduction of the cholesterol sensor SCAP in the brains of mice causes impaired synaptic transmission and altered cognitive function

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Regional differences in brain glucose metabolism determined by imaging mass spectrometry.

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Regulation of Insulin Receptors and Insulin Responsiveness in 3T3-L1 Fatty Fibroblasts ⬇️

scientific article published on May 1, 1979

Regulation of growth and tumorigenicity of breast cancer cells by the low molecular weight GTPase Rad and nm23.

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Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance ⬇️

scientific article published on November 1, 1992

Regulation of insulin receptor, insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-F442A adipocytes. Effects of differentiation, insulin, and dexamethasone

scientific article published on May 1994

Regulation of insulin receptors in normal and abnormal physiology in humans

scientific article published on January 1, 1979

Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

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Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus

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Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia

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Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor

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Response to Comment on Ussar et al. Regulation of Glucose Uptake and Enteroendocrine Function by the Intestinal Epithelial Insulin Receptor. Diabetes 2017;66:886-896.

scientific article published in May 2017

Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue

scientific article published on June 2012

Ribosomal subunit kinase-2 is required for growth factor-stimulated transcription of the c-Fos gene

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Role for neuronal insulin resistance in neurodegenerative diseases

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Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease

scientific article published on 8 February 2016

Role of Foxa-2 in adipocyte metabolism and differentiation

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Role of MicroRNA Processing in Adipose Tissue in Stress Defense and Longevity ⬇️

scientific article published on September 5, 2012

Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance

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Role of brain insulin receptor in control of body weight and reproduction

scientific article published in September 2000

Role of hepatic STAT3 in brain-insulin action on hepatic glucose production

scientific article published in April 2006

Role of insulin action and cell size on protein expression patterns in adipocytes

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Role of suppressors of cytokine signaling SOCS-1 and SOCS-3 in hepatic steatosis and the metabolic syndrome

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Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in beta -cells

scientific article published in July 2000

Rosalyn Sussman Yalow (1921–2011).

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SHORT syndrome with partial lipodystrophy due to impaired phosphatidylinositol 3 kinase signaling

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SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation

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SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome

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SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

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SOCS-1 deficiency does not prevent diet-induced insulin resistance

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Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells

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Selective interaction between leptin and insulin signaling pathways in a hepatic cell line

scholarly article

Sex and depot differences in adipocyte insulin sensitivity and glucose metabolism

scientific article published on 09 January 2009

Sharing of biological effect and receptors between guinea pig insulin and platelet-derived growth factor

scientific article published on March 1983

Short-lived cytoplasmic regulators of gene expression in cell cybrids

scientific article published in Nature

Shox2 is a molecular determinant of depot-specific adipocyte function

scientific article published on 24 June 2013

Single-cell transcriptional networks in differentiating preadipocytes suggest drivers associated with tissue heterogeneity

scientific article published on 30 April 2020

Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation

scientific article published on 08 July 2013

Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production

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Site and mechanism of leptin action in a rodent form of congenital lipodystrophy

scientific article published on February 2004

Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3

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Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents

scientific article published in December 1990

Specific plasma membrane receptors for reovirus on rat pituitary cells in culture

scientific article published on August 1983

Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation

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Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

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Subpopulations of antibodies directed against evolutionarily conserved regions of the insulin molecule in insulin-treated patients

scientific article published on December 1982

Substitution of the erbB-2 oncoprotein transmembrane domain activates the insulin receptor and modulates the action of insulin and insulin-receptor substrate 1 ⬇️

scientific article published on August 1, 1993

Substitution of the insulin receptor transmembrane domain with the c-neu/erbB2 transmembrane domain constitutively activates the insulin receptor kinase in vitro ⬇️

scientific article published on June 25, 1992

Suppression of aging in mice by the hormone Klotho

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Suppressor of Cytokine Signaling 1 (SOCS-1) and SOCS-3 Cause Insulin Resistance through Inhibition of Tyrosine Phosphorylation of Insulin Receptor Substrate Proteins by Discrete Mechanisms.

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Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms

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T-cell vaccination in experimental myasthenia gravis: a double-edged sword

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TRB3 blocks adipocyte differentiation through the inhibition of C/EBPbeta transcriptional activity

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TRPV1 neurons regulate β-cell function in a sex-dependent manner.

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Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes

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Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance

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Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis

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Tbx15 Defines a Glycolytic Subpopulation and White Adipocyte Heterogeneity

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Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose

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The 90-kDa heat shock protein (hsp-90) possesses an ATP binding site and autophosphorylating activity.

scientific article published in March 1991

The Cellular Fate of Glucose and Its Relevance in Type 2 Diabetes

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The Differential Role of Hif1β/Arnt and the Hypoxic Response in Adipose Function, Fibrosis, and Inflammation ⬇️

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The Evolving Clinical Course of Patients with Insulin Receptor Autoantibodies: Spontaneous Remission or Receptor Proliferation with Hypoglycemia ⬇️

scientific article published on November 1, 1978

The Gordon Wilson Lecture. Lessons about the control of glucose homeostasis and the pathogenesis of diabetes from knockout mice.

scientific article published on January 2003

The Insulin Receptor and Insulin of the Atlantic Hagfish: Extraordinary Conservation of Binding Specificity and Negative Cooperativity in the Most Primitive Vertebrate ⬇️

scientific article published on March 1, 1979

The Insulin Receptor in Vertebrates Is Functionally More Conserved during Evolution than Insulin Itself ⬇️

scientific article published on May 1, 1979

The Insulin Receptor of the Turkey Erythrocyte: Similarity to Mammalian Insulin Receptors ⬇️

scientific article published on January 1, 1977

The Insulin Resistance of Acromegaly: Evidence for Two Alterations in the Insulin Receptor on Circulating Monocytes ⬇️

scientific article published on January 1, 1979

The Joslin Diabetes Center

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The NSILA-s receptor in liver plasma membranes. Characterization and comparison with the insulin receptor ⬇️

scientific article published on December 10, 1975

The Ras-Related Protein Rad Associates with the Cytoskeleton in a Non-Lipid-Dependent Manner ⬇️

scientific article published on August 1, 1998

The Underlying Insulin Receptor in Patients with Antireceptor Autoantibodies: Demonstration of Normal Binding and Immunological Properties ⬇️

scientific article published on July 1, 1979

The branch point enzyme of the mevalonate pathway for protein prenylation is overexpressed in the ob/ob mouse and induced by adipogenesis

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The changing natural history of nephropathy in type I diabetes

scientific article published on May 1985

The dissociation and degradation of internalized insulin occur in the endosomes of rat hepatoma cells

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The early intracellular signaling pathway for the insulin/insulin-like growth factor receptor family in the mammalian central nervous system

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The emerging genetic architecture of type 2 diabetes

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The human erythrocyte insulin-like growth factor I receptor: characterization and demonstration of ligand-stimulated autophosphorylation.

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The immune response to insulin in man. Interaction of HLA alloantigens and the development of the immune response.

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The immunology of the insulin receptor

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The insulin receptor and the molecular mechanism of insulin action

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The insulin receptor gene and its expression in insulin-resistant mice

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The insulin receptor of the turkey erythrocyte characterization of the membrane-bound receptor ⬇️

scientific article published on August 16, 1976

The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth

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The insulin receptor--a critical link in glucose homeostasis and insulin action

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The insulin signaling system

scientific journal article

The molecular mechanism of insulin action

scientific article

The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance

scientific article published on 5 February 2007

The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling

scientific article published on 8 June 2010

The riddle of tumour hypoglycaemia revisited.

scientific article published on July 1980

The role and importance of brown adipose tissue in energy homeostasis

scientific article published on August 2010

The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance

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The role of insulin and IGF-1 signaling in longevity

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The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man.

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Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling

scientific article published on 12 June 2017

Thioesterase superfamily member 2/Acyl-CoA thioesterase 13 (Them2/Acot13) regulates adaptive thermogenesis in mice

scientific article published on 26 September 2013

Thymic lymphocytes in obese (ob-ob) mice. A mirror of the insulin receptor defect in liver and fat.

scientific article

Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis

scientific article

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

scientific article published on January 2000

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

scientific article

Tissue–Specific Insulin Signaling, Metabolic Syndrome, and Cardiovascular Disease ⬇️

scientific article published on September 1, 2012

Transfer of heritable properties by cell cybridization: Specificity and the role of selective pressure ⬇️

scientific article published on September 1, 1981

Transplantation of adipose tissue and stem cells: role in metabolism and disease

scientific article

Treatment by plasma exchange of a patient with autoantibodies to the insulin receptor

scientific article published on March 1, 1979

Trinucleotide repeats at the rad locus. Allele distributions in NIDDM and mapping to a 3-cM region on chromosome 16q.

scientific article

Tumstatin, an endothelial cell-specific inhibitor of protein synthesis

scientific article

Turning on Brown Fat and Muscle Metabolism: Hedging Your Bets ⬇️

scientific article published on October 12, 2012

Two steps of insulin receptor internalization depend on different domains of the beta-subunit

scientific article

Tyrosine phosphorylation of the insulin receptor during insulin-stimulated internalization in rat hepatoma cells.

scientific article published in January 1989

Tyrosine phosphorylation of the insulin receptor is not required for receptor internalization: studies in 2,4-dinitrophenol-treated cells

scientific article

Tyrosine-specific protein kinase activity is associated with the purified insulin receptor

scientific article published on April 1983

Unbalanced expression of the different subunits of elongation factor 1 in diabetic skeletal muscle

scholarly article

Understanding the pathogenesis and treatment of insulin resistance and type 2 diabetes mellitus: what can we learn from transgenic and knockout mice?

scientific article

Unraveling the Paradox of Selective Insulin Resistance in the Liver: the Brain-Liver Connection

scientific article published on June 2016

Unraveling the mechanism of action of thiazolidinediones

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Vanadate normalizes hyperglycemia and phosphoenolpyruvate carboxykinase mRNA levels in ob/ob mice

scientific article

Vanadate normalizes hyperglycemia in two mouse models of non-insulin-dependent diabetes mellitus ⬇️

scientific article published on April 1, 1991

Variation in insulin receptor messenger ribonucleic acid expression in human and rodent tissues

scientific article published in November 1987

Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host-microbe interactions.

scientific article

Virus-induced decrease of insulin receptors in cultured human cells ⬇️

scientific article published on November 1, 1980

Visualization of viral clearance in the living animal

scientific article

beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass

scientific article

p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity

scientific article

p85α deficiency protects β-cells from endoplasmic reticulum stress-induced apoptosis

scientific article published on 06 January 2014

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