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List of works by Moussa B. H. Youdim

A Novel Iron Chelator-Radical Scavenger Ameliorates Motor Dysfunction and Improves Life Span and Mitochondrial Biogenesis in SOD1G93A ALS Mice

scientific article published on 8 November 2016

A Novel iron-chelating derivative of the neuroprotective peptide NAPVSIPQ shows superior antioxidant and antineurodegenerative capabilities

scientific article published on 14 December 2007

A model of MPTP-induced Parkinson's disease in the goldfish

scientific article published in January 2007

A molecular signature in blood identifies early Parkinson's disease

scientific article

A multifunctional, neuroprotective drug, ladostigil (TV3326), regulates holo-APP translation and processing

scientific article published on 25 August 2006

A novel anti-Alzheimer's disease drug, ladostigil neuroprotective, multimodal brain-selective monoamine oxidase and cholinesterase inhibitor

scientific article published on January 2011

A novel antioxidant multitarget iron chelator M30 protects hepatocytes against ethanol-induced injury

scientific article

A novel approach of proteomics and transcriptomics to study the mechanism of action of the antioxidant-iron chelator green tea polyphenol (-)-epigallocatechin-3-gallate

scientific article

A novel cholinesterase and brain-selective monoamine oxidase inhibitor for the treatment of dementia comorbid with depression and Parkinson's disease

scientific article

A novel role for glyceraldehyde-3-phosphate dehydrogenase and monoamine oxidase B cascade in ethanol-induced cellular damage

scientific journal article

A promising drug candidate for the treatment of glaucoma based on a P2Y6-receptor agonist

scientific article published on 17 July 2018

A review of the mechanisms and role of monoamine oxidase inhibitors in Parkinson's disease

scientific article published in October 2004

A screening system of prodrugs selective for MAO-A or MAO-B.

scientific article published in January 2004

A sporadic Parkinson disease model via silencing of the ubiquitin-proteasome/E3 ligase component SKP1A

scientific article published on 11 September 2009

Activation of tyrosine kinase receptor signaling pathway by rasagiline facilitates neurorescue and restoration of nigrostriatal dopamine neurons in post-MPTP-induced parkinsonism

scientific article published on 20 October 2006

Additive Neuroprotective Effects of the Multifunctional Iron Chelator M30 with Enriched Diet in a Mouse Model of Amyotrophic Lateral Sclerosis

scientific article

Aminoindan and hydroxyaminoindan, metabolites of rasagiline and ladostigil, respectively, exert neuroprotective properties in vitro

scientific article

Amyloid processing and signal transduction properties of antiparkinson-antialzheimer neuroprotective drugs rasagiline and TV3326.

scientific article

An anti-Parkinson's disease drug, N-propargyl-1(R)-aminoindan (rasagiline), enhances expression of anti-apoptotic bcl-2 in human dopaminergic SH-SY5Y cells

scientific article

Anti-apoptotic action of anti-Alzheimer drug, TV3326 [(N-propargyl)-(3R)-aminoindan-5-yl]-ethyl methyl carbamate, a novel cholinesterase-monoamine oxidase inhibitor

scientific article published in May 2003

Anti-inflammatory and protective effects of MT-031, a novel multitarget MAO-A and AChE/BuChE inhibitor in scopolamine mouse model and inflammatory cells

scientific article published on 28 October 2016

Attenuation of 6-hydroxydopamine (6-OHDA)-induced nuclear factor-kappaB (NF-kappaB) activation and cell death by tea extracts in neuronal cultures

scientific article published in January 2002

Attenuation of MPTP-induced dopaminergic neurotoxicity by TV3326, a cholinesterase-monoamine oxidase inhibitor

scientific article published in July 2003

Beneficial Effects of Multitarget Iron Chelator on Central Nervous System and Gastrocnemius Muscle in SOD1(G93A) Transgenic ALS Mice

scientific article

Beneficial behavioral, neurochemical and molecular effects of 1-(R)-aminoindan in aged mice

scientific article published on 15 June 2015

Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseases

scientific article

Binding preference of p62 towards LC3-ll during dopaminergic neurotoxin-induced impairment of autophagic flux

scientific article published on January 2011

Biomarkers for evaluation of clinical efficacy of multipotential neuroprotective drugs for Alzheimer's and Parkinson's diseases

scientific article published on January 2009

Cardiovascular activity of rasagiline, a selective and potent inhibitor of mitochondrial monoamine oxidase B: comparison with selegiline.

scientific article

Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases

scientific article published in August 2004

Cell signaling pathways and iron chelation in the neurorestorative activity of green tea polyphenols: special reference to epigallocatechin gallate (EGCG).

scientific article published on October 2008

Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (-)-epigallocatechin-3-gallate: implications for neurodegenerative diseases.

scientific article published on March 2004

Cellular Uptake and Organ Accumulation of Amphipolar Metallocorroles with Cytoprotective and Cytotoxic Properties ⬇️

scientific article published on May 1, 2011

Chronic treatment with serotonin reuptake inhibitor antidepressant (SSRI) combined with an antipsychotic regulates GABA-A receptor in rat prefrontal cortex

scientific article published on 12 October 2011

Clinical review 112: Does serum growth hormone (GH) binding protein reflect human GH receptor function?

scientific article (publication date: March 2000)

Comparative neuroprotective effects of rasagiline and aminoindan with selegiline on dexamethasone-induced brain cell apoptosis

scientific article published on 28 February 2009

Comparison of neuroprotective and neurorestorative capabilities of rasagiline and selegiline against lactacystin-induced nigrostriatal dopaminergic degeneration

scientific article published on 8 April 2008

Contrasting neuroprotective and neurotoxic actions of respective metabolites of anti-Parkinson drugs rasagiline and selegiline

scientific article (publication date: 30 January 2004)

Contribution of Intracellular Non-Haem Iron, NF-kB Activation and Inflammatory Responses to Neurodegeneration in Parkinson’s Disease: Prospects for Neuroprotection

article

Correction: I1 Imidazoline Receptor: Novel Potential Cytoprotective Target of TVP1022, the S-Enantiomer of Rasagiline

scientific article published on 10 June 2013

Creation of a gene expression classifier for predicting Parkinson's disease rate of progression

scientific article published on 08 May 2020

DJ-1 deficiency triggers microglia sensitivity to dopamine toward a pro-inflammatory phenotype that is attenuated by rasagiline

scientific article published on 6 January 2014

Design, synthesis and evaluation of novel dual monoamine-cholinesterase inhibitors as potential treatment for Alzheimer's disease

scientific article published on 15 June 2016

Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer's, Parkinson's, and other neurodegenerative diseases.

scientific article

Does 1-(R)-aminoindan Possess Neuroprotective Properties Against Experimental Parkinson's Disease? ⬇️

scientific article published on December 28, 2010

Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease

scientific article published on 29 April 2014

Early and late gene changes in MPTP mice model of Parkinson's disease employing cDNA microarray

scientific article published in October 2002

Effect of TV3326, a novel monoamine-oxidase cholinesterase inhibitor, in rat models of anxiety and depression

scientific article

Effect of long-term treatment with rasagiline on cognitive deficits and related molecular cascades in aged mice

scientific article

Effects of R- and S-apomorphine on MPTP-induced nigro-striatal dopamine neuronal loss

scholarly article by Edna Grünblatt et al published 28 June 2008 in Journal of Neurochemistry

Effects of novel neuroprotective and neurorestorative multifunctional drugs on iron chelation and glucose metabolism ⬇️

scientific article published on March 25, 2012

From Anti-Parkinson's Drug Rasagiline to Novel Multitarget Iron Chelators with Acetylcholinesterase and Monoamine Oxidase Inhibitory and Neuroprotective Properties for Alzheimer's Disease ⬇️

scientific article published on January 1, 2012

From single target to multitarget/network therapeutics in Alzheimer's therapy

scientific article (publication date: 23 January 2014)

Gel-based protease proteomics for identifying the novel calpain substrates in dopaminergic neuronal cell

scientific article

Gene and protein expression profiles of anti- and pro-apoptotic actions of dopamine, R-apomorphine, green tea polyphenol (-)-epigallocatechine-3-gallate, and melatonin

scientific article

Gene and protein signatures in sporadic Parkinson's disease and a novel genetic model of PD.

scientific article published on January 2007

Gene expression changes in peripheral mononuclear cells from schizophrenic patients treated with a combination of antipsychotic with fluvoxamine

scientific article published on 29 April 2007

Gene expression profiling of sporadic Parkinson's disease substantia nigra pars compacta reveals impairment of ubiquitin-proteasome subunits, SKP1A, aldehyde dehydrogenase, and chaperone HSC-70.

scientific article

Genes and oxidative stress in parkinsonism: cDNA microarray studies.

scientific article

Genetic reduction of the E3 ubiquitin ligase element, SKP1A and environmental manipulation to emulate cardinal features of Parkinson's disease ⬇️

scientific article published on January 1, 2012

Genomic and proteomic study to survey the mechanism of action of the anti-Parkinson's disease drug, rasagiline compared with selegiline, in the rat midbrain.

scientific article published on 25 April 2009

Genomic aspects of sporadic Parkinson's disease

scientific article published on 27 June 2008

Glyceraldehyde-3-phosphate dehydrogenase-monoamine oxidase B-mediated cell death-induced by ethanol is prevented by rasagiline and 1-R-aminoindan

scientific article

Green tea catechins as brain-permeable, natural iron chelators-antioxidants for the treatment of neurodegenerative disorders

scientific article

Green tea polyphenol (-) -epigallocatechin-3-gallate promotes the rapid protein kinase C- and proteasome-mediated degradation of Bad: implications for neuroprotection

scientific article published on 29 November 2006

Green tea polyphenol (-)-epigallocatechin-3-gallate protects rat PC12 cells from apoptosis induced by serum withdrawal independent of P13-Akt pathway

scientific article

I1 imidazoline receptor: novel potential cytoprotective target of TVP1022, the S-enantiomer of rasagiline

scientific article

Impaired autophagic flux is critically involved in drug-induced dopaminergic neuronal death

scientific article published on January 2014

Implications of co-morbidity for etiology and treatment of neurodegenerative diseases with multifunctional neuroprotective-neurorescue drugs; ladostigil

scientific article published on December 2006

Improvement in verbal memory following SSRI augmentation of antipsychotic treatment is associated with changes in the expression of mRNA encoding for the GABA-A receptor and BDNF in PMC of schizophrenic patients

scientific article published in May 2015

In the Rush for Green Gold: Can Green Tea Delay Age-Progressive Brain Neurodegeneration? ⬇️

scientific article published on December 1, 2012

Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues

scientific article published in March 2004

Induction of neurotrophic factors GDNF and BDNF associated with the mechanism of neurorescue action of rasagiline and ladostigil: new insights and implications for therapy

scientific article

Inhibition of caspase-9 aggravates acute liver injury through suppression of cytoprotective autophagy.

scientific article published on September 2016

Involvement of MAP kinase in the regulation of amyloid precursor protein processing by novel cholinesterase inhibitors derived from rasagiline

scientific article

Involvement of protein kinase C activation and cell survival/ cell cycle genes in green tea polyphenol (-)-epigallocatechin 3-gallate neuroprotective action

scientific article

Iron and alpha-synuclein in the substantia nigra of MPTP-treated mice: effect of neuroprotective drugs R-apomorphine and green tea polyphenol (-)-epigallocatechin-3-gallate

scientific article published in January 2004

Iron dysregulation in Alzheimer's disease: multimodal brain permeable iron chelating drugs, possessing neuroprotective-neurorescue and amyloid precursor protein-processing regulatory activities as therapeutic agents

scientific article published on 19 June 2007

Iron, brain ageing and neurodegenerative disorders

scientific article (publication date: November 2004)

Iron-Chelating Drugs Enhance Cone Photoreceptor Survival in a Mouse Model of Retinitis Pigmentosa

scientific article published in October 2017

Iron-binding characteristics of neuromelanin of the human substantia nigra.

scientific article published in August 2003

Ironing iron out in Parkinson's disease and other neurodegenerative diseases with iron chelators: a lesson from 6-hydroxydopamine and iron chelators, desferal and VK-28.

scientific article published in March 2004

Ladostigil: A Novel Multimodal Neuroprotective Drug with Cholinesterase and Brain-Selective Monoamine Oxidase Inhibitory Activities for Alzheimers Disease Treatment ⬇️

scientific article published on April 1, 2012

Lithium and oxidative stress lessons from the MPTP model of Parkinson's disease ⬇️

scientific article published on March 28, 2012

Lithium’s Gene Expression Profile, Relevance to Neuroprotection A cDNA Microarray Study ⬇️

scientific article published on January 17, 2013

Low dosage of rasagiline and epigallocatechin gallate synergistically restored the nigrostriatal axis in MPTP-induced parkinsonism

scientific article

M30 Antagonizes Indoleamine 2,3-Dioxygenase Activation and Neurodegeneration Induced by Corticosterone in the Hippocampus

scientific article

M30, a brain permeable multi target neurorestorative drug in post nigrostriatal dopamine neuron lesion of parkinsonism animal models ⬇️

scientific article published on January 1, 2012

Manganese corroles prevent intracellular nitration and subsequent death of insulin-producing cells

scientific article

Mechanism of neuroprotective action of the anti-Parkinson drug rasagiline and its derivatives

scientific article published on 01 April 2005

Metallocorroles as cytoprotective agents against oxidative and nitrative stress in cellular models of neurodegeneration

scientific article

Microarray expression profiling in 6-hydroxydopamine-induced dopaminergic neuronal cell death ⬇️

scientific article published on September 9, 2011

Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan

scientific article published in August 2002

Modeling sporadic Parkinson's disease by silencing the ubiquitin E3 ligase component, SKP1A.

scientific article published on December 2009

Molecular mechanisms of the neuroprotective neurorescue action of multi-target green tea polyphenols ⬇️

scientific article published on January 1, 2012

Molecular mechanisms underlying synergistic effects of SSRI-antipsychotic augmentation in treatment of negative symptoms in schizophrenia

scientific article published on 04 July 2009

Molecular targets of the multifunctional iron-chelating drug, M30, in the brains of mouse models of type 2 diabetes mellitus

scientific article

Monoamine oxidase A and B inhibitors in Parkinson's disease

scientific article published on 01 January 2007

Monoamine oxidase A upregulated by chronic intermittent hypoxia activates indoleamine 2,3-dioxygenase and neurodegeneration

scientific article

Monoamine oxidase inhibitors, and iron chelators in depressive illness and neurodegenerative diseases

scientific article published on 19 October 2018

Monoamine oxidase: isoforms and inhibitors in Parkinson's disease and depressive illness

scientific article published on January 2006

Multi target neuroprotective and neurorestorative anti-Parkinson and anti-Alzheimer drugs ladostigil and m30 derived from rasagiline

scientific article published on 31 March 2013

Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease

scientific article published in 2016

Multi-functional drugs for various CNS targets in the treatment of neurodegenerative disorders

scientific article

Multi-target iron-chelators improve memory loss in a rat model of sporadic Alzheimer's disease

scientific article published on 6 July 2015

Multi-target, Neuroprotective and Neurorestorative M30 Improves Cognitive Impairment and Reduces Alzheimer's-Like Neuropathology and Age-Related Alterations in Mice ⬇️

scientific article published on July 31, 2012

Multifunctional activities of green tea catechins in neuroprotection. Modulation of cell survival genes, iron-dependent oxidative stress and PKC signaling pathway

scientific article

Multifunctional drugs as neurotherapeutics

scientific article published on January 2009

Multifunctional drugs with different CNS targets for neuropsychiatric disorders

scientific article published on 18 October 2006

Multifunctional neuroprotective derivatives of rasagiline as anti-Alzheimer's disease drugs

scientific article

Multifunctional neuroprotective drugs targeting monoamine oxidase inhibition, iron chelation, adenosine receptors, and cholinergic and glutamatergic action for neurodegenerative diseases

scientific article published on August 2006

Multifunctional pharmacotherapy: what can we learn from study of selective serotonin reuptake inhibitor augmentation of antipsychotics in negative-symptom schizophrenia?

scientific article published on January 2009

N-Methyl, N-propynyl-2-phenylethylamine (MPPE), a Selegiline Analog, Attenuates MPTP-induced Dopaminergic Toxicity with Guaranteed Behavioral Safety: Involvement of Inhibitions of Mitochondrial Oxidative Burdens and p53 Gene-elicited Pro-apoptotic C

scientific article published on 13 November 2015

Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases

scientific article published in September 2004

Neuromelanin and its interaction with iron as a potential risk factor for dopaminergic neurodegeneration underlying Parkinson's disease

scientific article

Neuropharmacological, neuroprotective and amyloid precursor processing properties of selective MAO-B inhibitor antiparkinsonian drug, rasagiline

scientific article

Neuroprotection and neuroregeneration in Alzheimer's disease

scientific article

Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (-)-epigallocatechin-3-gallate

scientific article published on 28 March 2003

Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats

scientific article published in February 2004

Neuroprotection by the multitarget iron chelator M30 on age-related alterations in mice ⬇️

scientific article published on March 10, 2012

Neuroprotection via pro-survival protein kinase C isoforms associated with Bcl-2 family members

scientific article published on 9 July 2004

Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis

scientific article

Neuroprotective and neurorestorative activities of a novel iron chelator-brain selective monoamine oxidase-A/monoamine oxidase-B inhibitor in animal models of Parkinson's disease and aging

scientific article published on 22 October 2014

Neuroprotective effects of multifaceted hybrid agents targeting MAO, cholinesterase, iron and β-amyloid in ageing and Alzheimer's disease

scientific article published on 29 August 2015

Neuroprotective molecular mechanisms of (-)-epigallocatechin-3-gallate: a reflective outcome of its antioxidant, iron chelating and neuritogenic properties

scientific article published on 10 September 2009

Neuroprotective multifunctional iron chelators: from redox-sensitive process to novel therapeutic opportunities

scientific article published on September 2010

Neuroprotective profile of the multitarget drug rasagiline in Parkinson's disease

scientific article published on January 1, 2011

Neuroprotective strategies in Parkinson's disease : an update on progress

scientific article

Neurorescue activity, APP regulation and amyloid-beta peptide reduction by novel multi-functional brain permeable iron- chelating- antioxidants, M-30 and green tea polyphenol, EGCG.

scientific article

Neurorescue by a ROS Decomposition Catalyst

scientific article published on 21 July 2016

New approaches to treating Alzheimer's disease

scientific article

Nigericin-induced impairment of autophagic flux in neuronal cells is inhibited by overexpression of Bak.

scientific article

Non-steroidal anti-inflammatory drugs stimulate secretion of non-amyloidogenic precursor protein

scientific article

Novel Chelators Targeting Cell Cycle Arrest, Acetylcholinesterase, and Monoamine Oxidase for Alzheimer's Therapy ⬇️

scientific article published on July 1, 2012

Novel Therapeutic Approach for Neurodegenerative Pathologies: Multitarget Iron-Chelating Drugs Regulating Hypoxia-Inducible Factor 1 Signal Transduction Pathway ⬇️

scientific article published on 09 December 2011

Novel multifunctional anti-Alzheimer drugs with various CNS neurotransmitter targets and neuroprotective moieties

scientific article published on December 2007

Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases. In vivo selective brain monoamine oxidase inhibition and prevention of MPTP-induced striatal dopamine depletion

scientific article published in October 2005

Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition

scientific article published in October 2005

Novel neuroprotective anti-Alzheimer drugs with anti-depressant activity derived from the anti-Parkinson drug, rasagiline

scientific article

Novel neuroprotective mechanism of action of rasagiline is associated with its propargyl moiety: interaction of Bcl-2 family members with PKC pathway

scientific article

Novel potential neuroprotective agents with both iron chelating and amino acid-based derivatives targeting central nervous system neurons

scientific article

Nuclear translocation of DJ-1 during oxidative stress-induced neuronal cell death ⬇️

scientific article published on June 7, 2012

Pharmacological properties of the anti-Parkinson drug rasagiline; modification of endogenous brain amines, reserpine reversal, serotonergic and dopaminergic behaviours

scientific article

Physiological and pathological aspects of Abeta in iron homeostasis via 5'UTR in the APP mRNA and the therapeutic use of iron-chelators

scientific article

Prevention and restoration of lactacystin-induced nigrostriatal dopamine neuron degeneration by novel brain-permeable iron chelators

scientific article published on 09 August 2007

Prevention of MPTP (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) dopaminergic neurotoxicity in mice by chronic lithium: involvements of Bcl-2 and Bax.

scientific article published in June 2004

Proceedings from the "Third International Conference on Mechanism of Action of Nutraceuticals"

scientific article published on 01 September 2005

Promises of novel multi-target neuroprotective and neurorestorative drugs for Parkinson's disease

scientific article published on January 2014

Promising anti-Alzheimer's dimer bis(7)-tacrine reduces beta-amyloid generation by directly inhibiting BACE-1 activity

scientific article published on 26 November 2007

Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of alpha-secretase and BACE-1 concurrently

scientific article published on 16 September 2009

Propargylamine containing compounds as modulators of proteolytic cleavage of amyloid-beta protein precursor: involvement of MAPK and PKC activation

scientific article published on January 2010

Psychiatric, nonmotor aspects of Parkinson's disease

scientific article published on January 1, 2012

Rasagiline in Parkinson's disease

scientific article

Rasagiline: a novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity

scientific article published on 19 June 2010

Rasagiline: neurodegeneration, neuroprotection, and mitochondrial permeability transition

scientific article

Recent advances in amyotrophic lateral sclerosis research: perspectives for personalized clinical application ⬇️

scientific article published on June 29, 2010

Redox imbalance

scientific article published on 10 September 2004

Regulation of Bcl-2 family proteins, neurotrophic factors, and APP processing in the neurorescue activity of propargylamine

scientific article published on 7 September 2005

Regulation of protein kinase C by the anti-Parkinson drug, MAO-B inhibitor, rasagiline and its derivatives, in vivo

scientific article

Restoration of nigrostriatal dopamine neurons in post-MPTP treatment by the novel multifunctional brain-permeable iron chelator-monoamine oxidase inhibitor drug, M30.

scientific article published on 16 July 2009

Role of iron in neurodegenerative disorders

scientific article

SSRI augmentation of antipsychotic alters expression of GABAA receptor and related genes in PMC of schizophrenia patients ⬇️

scientific article published on December 16, 2010

Selective acetylcholinesterase inhibitor activated by acetylcholinesterase releases an active chelator with neurorescuing and anti-amyloid activities

scientific article

Silencing/overexpressing selected genes as a model of sporadic Parkinson's disease

scientific article

Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective strategy for Alzheimer and Parkinson diseases.

scientific article published on January 2008

Site-Activated Chelators Derived from Anti-Parkinson Drug Rasagiline as a Potential Safer and More Effective Approach to the Treatment of Alzheimer’s Disease ⬇️

scientific article published on October 28, 2010

Site-activated chelators targeting acetylcholinesterase and monoamine oxidase for Alzheimer's therapy

scientific article

Site-activated multifunctional chelator with acetylcholinesterase and neuroprotective-neurorestorative moieties for Alzheimer's therapy

scientific article

Striatal dopa and glucose metabolism in PD patients with freezing of gait

scientific article published in September 2006

TVP1022 Attenuates Cardiac Remodeling and Kidney Dysfunction in Experimental Volume Overload-Induced Congestive Heart Failure

scientific article published on 10 May 2011

TVP1022 and propargylamine protect neonatal rat ventricular myocytes against doxorubicin-induced and serum starvation-induced cardiotoxicity.

scientific article published on September 2008

TVP1022: A Novel Cardioprotective Drug Attenuates Left Ventricular Remodeling After Ischemia/Reperfusion in Pigs.

scientific article published in August 2015

Targeting Skp1, an Ubiquitin E3 Ligase Component Found Decreased in Sporadic Parkinson’s Disease ⬇️

scientific article published on December 23, 2011

Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators ⬇️

scientific article published on January 30, 2013

Targeting multiple Alzheimer's disease etiologies with multimodal neuroprotective and neurorestorative iron chelators

scientific article

Targeting multiple neurodegenerative diseases etiologies with multimodal-acting green tea catechins

scientific article

The MPTP-induced parkinsonian syndrome in the goldfish is associated with major cell destruction in the forebrain and subtle changes in the optic tectum

scientific article

The New Inhibitor of Monoamine Oxidase, M30, has a Neuroprotective Effect Against Dexamethasone-Induced Brain Cell Apoptosis ⬇️

scientific article published on November 2, 2010

The Novel Multi-Target Iron Chelating-Radical Scavenging Compound M30 Possesses Beneficial Effects on Major Hallmarks of Alzheimer's Disease ⬇️

scientific article published on April 17, 2012

The Role of GABA-A Receptor in the Synergism Between SSRI and Antipsychotic in Schizophrenia; Implications for Antipsychotic Modes of Actions ⬇️

scientific article published on January 1, 2013

The application of proteomics and genomics to the study of age-related neurodegeneration and neuroprotection

scientific article published on February 2007

The application of proteomics for studying the neurorescue activity of the polyphenol (-)-epigallocatechin-3-gallate

scientific article published on 13 January 2008

The cardioprotective efficacy of TVP1022 in a rat model of ischaemia/reperfusion.

scientific article

The effect of chronic co-administration of fluvoxamine and haloperidol compared to clozapine on the GABA system in the rat frontal cortex

scientific article published on 21 June 2005

The emergence of designed multiple ligands for neurodegenerative disorders ⬇️

scientific article published on April 22, 2011

The essentiality of Bcl-2, PKC and proteasome–ubiquitin complex activations in the neuroprotective-antiapoptotic action of the anti-Parkinson drug, rasagiline ⬇️

scientific article published on October 15, 2003

The importance of propargylamine moiety in the anti-Parkinson drug rasagiline and its derivatives in MAPK-dependent amyloid precursor protein processing

scientific article published on 2 October 2003

The involvement of BDNF-CREB signaling pathways in the pharmacological mechanism of combined SSRI- antipsychotic treatment in schizophrenia

scientific article published on 11 April 2017

The involvement of GABA(A) receptor in the molecular mechanisms of combined selective serotonin reuptake inhibitor-antipsychotic treatment

scientific article

The neurochemical and behavioral effects of the novel cholinesterase-monoamine oxidase inhibitor, ladostigil, in response to L-dopa and L-tryptophan, in rats

scientific article published on October 2005

The neuroprotective effect of Activin A and B: implication for neurodegenerative diseases

scientific article published on 6 August 2007

The neuroprotective effect of ladostigil against hydrogen peroxide-mediated cytotoxicity

scientific journal article

The neuroprotective mechanism of 1-(R)-aminoindan, the major metabolite of the anti-parkinsonian drug rasagiline

scientific article published on 10 December 2009

The neuroprotective mechanism of action of the multimodal drug ladostigil

scientific article published on May 2008

The novel cholinesterase-monoamine oxidase inhibitor and antioxidant, ladostigil, confers neuroprotection in neuroblastoma cells and aged rats

scientific article

The novel multi-target iron chelator, M30 modulates HIF-1α-related glycolytic genes and insulin signaling pathway in the frontal cortex of APP/PS1 Alzheimer's disease mice

scientific article

The novel multifunctional, iron-chelating drugs M30 and HLA20 protect pancreatic beta-cell lines from oxidative stress damage

scientific article published on 17 March 2010

The novel multitarget iron chelating and propargylamine drug M30 affects APP regulation and processing activities in Alzheimer's disease models

scientific article published on 29 May 2017

The path from anti Parkinson drug selegiline and rasagiline to multifunctional neuroprotective anti Alzheimer drugs ladostigil and m30.

scientific article published on December 2006

The potential role of iron chelators in the treatment of Parkinson's disease and related neurological disorders

scientific article published on April 1997

The relevance of iron in the pathogenesis of Parkinson's disease

scientific article published on 31 January 2011

The relevance of iron in the pathogenesis of Parkinson's disease.

scientific article published on March 2004

The therapeutic potential of monoamine oxidase inhibitors

scientific article

Theodore Lionel Sourkes obituary.

scientific article

Therapeutic applications of selective and non-selective inhibitors of monoamine oxidase A and B that do not cause significant tyramine potentiation

scientific article (publication date: 2004)

Therapeutic potential of a novel multifunctional iron chelator on cognitive decicits and insulin degrading enzyme expression in a rat model of sporadic Alzheimer's disease.

scientific article published on 17 September 2012

Therapeutic targets and potential of the novel brain- permeable multifunctional iron chelator-monoamine oxidase inhibitor drug, M-30, for the treatment of Alzheimer's disease

scientific article published on 27 November 2006

Translocation and oligomerization of Bax is regulated independently by activation of p38 MAPK and caspase-2 during MN9D dopaminergic neurodegeneration ⬇️

scientific article published on November 1, 2011

Tribute to professor Toshiharu Nagatsu

scientific article published in September 2002

Understanding the Broad-Spectrum Neuroprotective Action Profile of Green Tea Polyphenols in Aging and Neurodegenerative Diseases ⬇️

scientific article published on January 1, 2011

Using cDNA microarray to assess Parkinson's disease models and the effects of neuroprotective drugs

scientific article

Using cDNA microarray to assess Parkinson's disease models and the effects of neuroprotective drugs

scientific article published in December 2004

Why do we need multifunctional neuroprotective and neurorestorative drugs for Parkinson's and Alzheimer's diseases as disease modifying agents

scientific article published on 30 June 2010

Why do we need multifunctional neuroprotective and neurorestorative drugs for Parkinson's and Alzheimer's disorders?

scientific article published on 31 October 2010

Why should we use multifunctional neuroprotective and neurorestorative drugs for Parkinson's disease?

scientific article published on January 2007

cDNA gene expression profile homology of antioxidants and their antiapoptotic and proapoptotic activities in human neuroblastoma cells

scientific article published on 5 March 2003

limited potentiation of blood pressure in response to oral tyramine by the anti-Parkinson brain selective multifunctional monoamine oxidase-AB inhibitor, M30.

scientific article published on 6 November 2009

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