List of works -

A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model

scientific article

A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons

scientific article published on 23 June 2013

A subpopulation of nociceptors specifically linked to itch ⬇️

scientific article published on December 23, 2012

Activation of MrgC receptor inhibits N-type calcium channels in small-diameter primary sensory neurons in mice

scientific article

Activation of Peripheral μ-opioid Receptors by Dermorphin [D-Arg2, Lys4] (1-4) Amide Leads to Modality-preferred Inhibition of Neuropathic Pain

scientific article published on 12 January 2016

Activation of cannabinoid CB1 receptor contributes to suppression of spinal nociceptive transmission and inhibition of mechanical hypersensitivity by Aβ-fiber stimulation

scientific article published on 28 July 2016

Agonists of the MAS-related gene (Mrgs) orphan receptors as novel mediators of mast cell-sensory nerve interactions

scientific article published on February 2008

An Itch To Be Scratched ⬇️

scientific article published on November 4, 2010

Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family

scientific article

BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine release

scientific article

Central terminal sensitization of TRPV1 by descending serotonergic facilitation modulates chronic pain

scientific article published on 23 January 2014

Conventional and kilohertz-frequency spinal cord stimulation produces intensity- and frequency-dependent inhibition of mechanical hypersensitivity in a rat model of neuropathic pain

scientific article published on August 2013

Development and evaluation of small peptidomimetic ligands to protease-activated receptor-2 (PAR2) through the use of lipid tethering

scientific article (publication date: 2014)

Different activation signals induce distinct mast cell degranulation strategies

scientific article

Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1.

scientific article

Distinct and common expression of receptors for inflammatory mediators in vagal nodose versus jugular capsaicin-sensitive/TRPV1-positive neurons detected by low input RNA sequencing

scientific article

Electrical stimulation of dorsal root entry zone attenuates wide-dynamic-range neuronal activity in rats

scientific article

Electrical stimulation of low-threshold afferent fibers induces a prolonged synaptic depression in lamina II dorsal horn neurons to high-threshold afferent inputs in mice

scientific article published on June 2015

Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain

scientific article published on 18 February 2014

Functional Coupling with Cardiac Muscle Promotes Maturation of hPSC-Derived Sympathetic Neurons

scientific article

Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions

scientific article

Investigating the role of MRGPRC11 and capsaicin-sensitive afferent nerves in the anti-influenza effects exerted by SLIGRL-amide in murine airways

scientific article published on 23 May 2016

Investigation of Pain Mechanisms by Calcium Imaging Approaches

scientific article

Itch mechanisms and circuits

scientific article

Itch: Cells, Molecules, and Circuits

scientific article published on January 2011

Mas-Related G Protein-Coupled Receptors Offer Potential New Targets for Pain Therapy

scientific article published on January 2016

Mas-Related G Protein-Coupled Receptors and the Biology of Itch Sensation

scientific article published in November 2017

Mas-related G-protein–coupled receptors inhibit pathological pain in mice ⬇️

scientific article published on August 19, 2010

Mechanisms of Itch Evoked by β-Alanine ⬇️

scientific article published on October 17, 2012

MrgC agonism at central terminals of primary sensory neurons inhibits neuropathic pain

scientific article published on 11 December 2013

Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway

scientific article

Peripheral mechanisms of itch ⬇️

scientific article published on April 1, 2012

Pirt contributes to uterine contraction-induced pain in mice

scientific article

Pirt functions as an endogenous regulator of TRPM8.

scientific article published on January 2013

Pirt, a TRPV1 Modulator, Is Required for Histamine-Dependent and -Independent Itch ⬇️

scientific article published on May 31, 2011

Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1

scientific journal article

Preso1 dynamically regulates group I metabotropic glutamate receptors ⬇️

scientific article published on June 1, 2012

Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs

scientific article

Saikosaponin A inhibits compound 48/80-induced pseudo-allergy via the Mrgprx2 pathway in vitro and in vivo

scientific article published on 20 December 2017

Selective keratinocyte stimulation is sufficient to evoke nociception in mice

scientific article

Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus

scientific article published on 10 December 2009

Sensory neurons and circuits mediating itch

scientific article published on January 2014

TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice

scientific article

TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch

scientific article published on 03 April 2011

Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain

scientific article published on 21 February 2017

The cell biology of acute itch

scientific article

The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia

scientific article

The role of the Mrgpr receptor family in itch

scientific article published on January 2015

Three functionally distinct classes of C-fibre nociceptors in primates

scientific article

Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain

scientific journal article

Tolerance develops to the antiallodynic effects of the peripherally acting opioid loperamide hydrochloride in nerve-injured rats

scientific article published on 20 July 2013

Trp channels and itch

scientific article published on 18 September 2015

Use of the relative release index for histamine in LAD2 cells to evaluate the potential anaphylactoid effects of drugs

scientific article

Voltage-gated potassium channels involved in regulation of physiological function in MrgprA3-specific itch neurons

scientific article published on 10 February 2016

miR-365 targets β-arrestin 2 to reverse morphine tolerance in rats

scientific article published on 06 December 2016

List of works by

A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model

A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons

A subpopulation of nociceptors specifically linked to itch ⬇️

Activation of MrgC receptor inhibits N-type calcium channels in small-diameter primary sensory neurons in mice

Activation of Peripheral μ-opioid Receptors by Dermorphin [D-Arg2, Lys4] (1-4) Amide Leads to Modality-preferred Inhibition of Neuropathic Pain

Activation of cannabinoid CB1 receptor contributes to suppression of spinal nociceptive transmission and inhibition of mechanical hypersensitivity by Aβ-fiber stimulation

Agonists of the MAS-related gene (Mrgs) orphan receptors as novel mediators of mast cell-sensory nerve interactions

An Itch To Be Scratched ⬇️

Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family

BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine release

Central terminal sensitization of TRPV1 by descending serotonergic facilitation modulates chronic pain

Conventional and kilohertz-frequency spinal cord stimulation produces intensity- and frequency-dependent inhibition of mechanical hypersensitivity in a rat model of neuropathic pain

Development and evaluation of small peptidomimetic ligands to protease-activated receptor-2 (PAR2) through the use of lipid tethering

Different activation signals induce distinct mast cell degranulation strategies

Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1.

Distinct and common expression of receptors for inflammatory mediators in vagal nodose versus jugular capsaicin-sensitive/TRPV1-positive neurons detected by low input RNA sequencing

Electrical stimulation of dorsal root entry zone attenuates wide-dynamic-range neuronal activity in rats

Electrical stimulation of low-threshold afferent fibers induces a prolonged synaptic depression in lamina II dorsal horn neurons to high-threshold afferent inputs in mice

Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain

Functional Coupling with Cardiac Muscle Promotes Maturation of hPSC-Derived Sympathetic Neurons

Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions

Investigating the role of MRGPRC11 and capsaicin-sensitive afferent nerves in the anti-influenza effects exerted by SLIGRL-amide in murine airways

Investigation of Pain Mechanisms by Calcium Imaging Approaches

Itch mechanisms and circuits

Itch: Cells, Molecules, and Circuits

Mas-Related G Protein-Coupled Receptors Offer Potential New Targets for Pain Therapy

Mas-Related G Protein-Coupled Receptors and the Biology of Itch Sensation

Mas-related G-protein–coupled receptors inhibit pathological pain in mice ⬇️

Mechanisms of Itch Evoked by β-Alanine ⬇️

MrgC agonism at central terminals of primary sensory neurons inhibits neuropathic pain

Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway

Peripheral mechanisms of itch ⬇️

Pirt contributes to uterine contraction-induced pain in mice

Pirt functions as an endogenous regulator of TRPM8.

Pirt, a TRPV1 Modulator, Is Required for Histamine-Dependent and -Independent Itch ⬇️

Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1

Preso1 dynamically regulates group I metabotropic glutamate receptors ⬇️

Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs

Saikosaponin A inhibits compound 48/80-induced pseudo-allergy via the Mrgprx2 pathway in vitro and in vivo

Selective keratinocyte stimulation is sufficient to evoke nociception in mice

Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus

Sensory neurons and circuits mediating itch

TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice

TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch

Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain

The cell biology of acute itch

The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia

The role of the Mrgpr receptor family in itch

Three functionally distinct classes of C-fibre nociceptors in primates

Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain

Tolerance develops to the antiallodynic effects of the peripherally acting opioid loperamide hydrochloride in nerve-injured rats

Trp channels and itch

Use of the relative release index for histamine in LAD2 cells to evaluate the potential anaphylactoid effects of drugs

Voltage-gated potassium channels involved in regulation of physiological function in MrgprA3-specific itch neurons

miR-365 targets β-arrestin 2 to reverse morphine tolerance in rats