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List of works by Eicke Latz

A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization

scientific article published on 30 September 2002

AIM2 inflammasome-derived IL-1β induces postoperative ileus in mice

scientific article published on 22 July 2019

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

scientific article

Activation of the NLRP3 Inflammasome by IAV Virulence Protein PB1-F2 Contributes to Severe Pathophysiology and Disease ⬇️

scientific article (publication date: 2013)

Alternative splicing regulates stochastic NLRP3 activity

scientific article published on 19 July 2019

Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation

scientific article published on 09 December 2019

Assembly and regulation of ASC specks

scientific article

Author Correction: A guiding map for inflammation

scientific article published on 07 December 2020

Author Correction: AIM2 inflammasome-derived IL-1β induces postoperative ileus in mice

scientific article published on 21 February 2020

Author Correction: Inflammasome signalling in brain function and neurodegenerative disease

scientific article published on 01 March 2019

Author Correction: Trained immunity, tolerance, priming and differentiation: distinct immunological processes

scientific article published in 2021

Cell Distributions and Functions of Toll-like Receptor 4 Studied by Fluorescent Gene Constructs ⬇️

scientific article published on January 1, 2003

Charcot-Leyden Crystals Activate the NLRP3 Inflammasome and Cause IL-1β Inflammation in Human Macrophages

scientific article published on 17 December 2018

Cholesterol Crystals and Inflammation ⬇️

scientific article published on March 1, 2013

Cholesterol crystals induce complement-dependent inflammasome activation and cytokine release

scientific article published on 19 February 2014

Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis

scientific article published on 11 September 2020

Contact-dependent inhibition of HIV-1 replication in <i>ex vivo</i> human tonsil cultures by polymorphonuclear neutrophils

scientific article published on 15 June 2021

Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation

scientific article published on 30 August 2017

Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming

scientific article

Direct measurement of the interaction force between immunostimulatory CpG-DNA and TLR9 fusion protein

scientific article

Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity

scientific article

Erratum: NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

scientific article published in Nature

Higher order structure of short immunostimulatory oligonucleotides studied by atomic force microscopy

scientific article published on 23 February 2010

IFI16 is an innate immune sensor for intracellular DNA

scientific article

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

scientific article (publication date: May 2003)

Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling

scientific article

Inflammasome signalling in brain function and neurodegenerative disease

scientific article published on 01 October 2018

Inflammasome-induced extracellular vesicles harbour distinct RNA signatures and alter bystander macrophage responses

scientific article published on 02 August 2021

Inflammasomes: too big to miss

scientific article

Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers

scientific article published on 27 June 2002

Jack of all trades inhibits inflammation (in sober people)

scientific article published on 01 July 2020

KIAA1797/FOCAD encodes a novel focal adhesion protein with tumour suppressor function in gliomas

scientific article

LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF

scientific article

Ligand-induced conformational changes allosterically activate Toll-like receptor 9.

scientific article published on 17 June 2007

Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction

scientific article (publication date: 6 December 2002)

Long-term activation of the innate immune system in atherosclerosis

scientific article

Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction

scientific article (publication date: 28 November 2003)

Mechanisms of TLR9 activation.

scientific article

Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling.

scientific article published in December 2015

Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes

scientific article published on 22 September 2021

Microglial PD-1 stimulation by astrocytic PD-L1 suppresses neuroinflammation and Alzheimer's disease pathology

scientific article published on 26 November 2021

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

scientific article published on 2 May 2017

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

scientific article (publication date: 29 April 2010)

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice ⬇️

scientific article published on December 19, 2012

Non-linear optical imaging of atherosclerotic plaques in the context of SIV and HIV infection prominently detects crystalline cholesterol esters

scientific article published on 13 May 2021

RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA

scientific article

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

scientific article

Recent insights into the molecular mechanisms of the NLRP3 inflammasome activation

scientific article

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus

scientific article

Reconstituted High-Density Lipoprotein Attenuates Cholesterol Crystal-Induced Inflammatory Responses by Reducing Complement Activation

scientific article published on 29 May 2015

STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression

scientific article published on 30 July 2020

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

scientific article

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

scientific article

TAK1ng control: TAK1 restrains NLRP3 activation.

scientific article

TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects.

scientific article published on 11 April 2017

TLR9 signals after translocating from the ER to CpG DNA in the lysosome

scientific article published on 11 January 2004

Targeting hormone refractory prostate cancer by in vivo selected DNA libraries in an orthotopic xenograft mouse model

scientific article published on 21 March 2019

The LPS receptor generates inflammatory signals from the cell surface

scientific article published on January 2003

The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes

scientific article

The Western lifestyle has lasting effects on metaflammation

scientific article published on 01 May 2019

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

scientific article (publication date: August 2014)

The intra- and extracellular functions of ASC specks

scientific article published in January 2018

The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction

scientific article

Trained immunity, tolerance, priming and differentiation: distinct immunological processes

scientific article published on 08 December 2020

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming.

scientific article published in January 2018

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