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List of works by Helmut Denk

24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice

scientific article published in February 2006

A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis

scientific article

Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis.

scientific article

Allelic imbalances in endometrial stromal neoplasms: frequent genetic alterations in the nontumorous normal-appearing endometrial and myometrial tissues

scientific article published on 01 December 2004

Androgen receptors frequently are expressed in breast carcinomas: potential relevance to new therapeutic strategies.

scientific article published on August 2003

Animal models of NAFLD from the pathologist's point of view

scientific article published on 08 May 2018

Assessment of liver phenotype in adults with severe alpha-1 antitrypsin deficiency (Pi*ZZ genotype)

scientific article published on 05 October 2019

Ballooned hepatocytes in steatohepatitis: the value of keratin immunohistochemistry for diagnosis

scientific article published on 22 February 2008

Bile acid-induced Mallory body formation in drug-primed mouse liver

scientific article published on December 2002

Bile acids trigger cholemic nephropathy in common bile-duct-ligated mice

scientific article

Broad spectrum of hepatocyte inclusions in humans, animals, and experimental models

scientific article published on October 2013

CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice

scientific article published in August 2005

Causability and explainability of artificial intelligence in medicine

scientific article published on 02 April 2019

Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA.

scientific article

Chromosomal alterations in low-grade endometrial stromal sarcoma and undifferentiated endometrial sarcoma as detected by comparative genomic hybridization

scientific article published on 01 May 2005

Clinical epidemiology of invasive cutaneous malignant melanoma in the Austrian province Styria in the years 2001-2003 and its relationship with local geographical, meteorological and economic data.

scientific article

Clusterin associates with altered elastic fibers in human photoaged skin and prevents elastin from ultraviolet-induced aggregation in vitro

scientific article

Clusterin expression in cholestasis, hepatocellular carcinoma and liver fibrosis

scientific article

Comparative analysis and modeling of the severity of steatohepatitis in DDC-treated mouse strains

scientific article

Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids

scientific article published on 15 December 2005

Cross β-sheet conformation of keratin 8 is a specific feature of Mallory-Denk bodies compared with other hepatocyte inclusions.

scientific article published on 27 May 2011

Cytokeratins as targets for bile acid-induced toxicity

scientific article published on February 2002

Cytokine-independent repression of rodent Ntcp in obstructive cholestasis

scientific article published on 01 March 2005

Differential effects of norUDCA and UDCA in obstructive cholestasis in mice

scientific article published on 29 January 2013

Effects of targeting endometrial stromal sarcoma cells via histone deacetylase and PI3K/AKT/mTOR signaling

scientific article

Endometrial stromal sarcomas frequently express epidermal growth factor receptor (EGFR, HER-1): potential basis for a new therapeutic approach

scientific article

Expression of androgen receptors in benign and malignant endometrial stromal neoplasms

scientific article published on 06 March 2004

Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosis

scientific article published on September 2007

Farnesoid X receptor critically determines the fibrotic response in mice but is expressed to a low extent in human hepatic stellate cells and periductal myofibroblasts

scientific article

Fifty years of impact on liver pathology: a history of the Gnomes

scientific article published on 30 June 2020

Genetic background effects of keratin 8 and 18 in a DDC-induced hepatotoxicity and Mallory-Denk body formation mouse model

scientific article published on 26 March 2012

Hepatobiliary transporter expression in human hepatocellular carcinoma.

scientific article published in April 2005

Hepatobiliary transporter expression in intercellular adhesion molecule 1 knockout and Fas receptor-deficient mice after common bile duct ligation is independent of the degree of inflammation and oxidative stress

scientific article published on 18 June 2007

Hepatocellular carcinomas with intracellular hyaline bodies have a poor prognosis

scientific article published on 25 November 2016

High-fat diet triggers Mallory-Denk body formation through misfolding and crosslinking of excess keratin 8.

scientific article published on 27 May 2014

Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo

scientific article

Histopathological diagnosis of non-alcoholic and alcoholic fatty liver disease

scientific article published on 26 March 2011

How many lymph nodes are necessary to stage early and advanced adenocarcinoma of the sigmoid colon and upper rectum?

scientific article published on 03 July 2003

Immunofluorescence and Immunohistochemical Detection of Keratins

scientific article published on 24 October 2015

Immunohistochemical analysis of Mallory bodies in Wilsonian and non-Wilsonian hepatic copper toxicosis

scientific article

In vitro production of Mallory bodies and intracellular hyaline bodies: the central role of sequestosome 1/p62.

scientific article published on September 2007

Induction of short heterodimer partner 1 precedes downregulation of Ntcp in bile duct-ligated mice

scientific article published in January 2002

Interaction of stress proteins with misfolded keratins

scientific article published in March 2005

Intermediate filament protein inclusions.

scientific article published in January 2004

Inverse correlation of secreted frizzled-related protein 4 and beta-catenin expression in endometrial stromal sarcomas

scientific article published in September 2004

JAZF1/JJAZ1 gene fusion in endometrial stromal sarcomas: molecular analysis by reverse transcriptase-polymerase chain reaction optimized for paraffin-embedded tissue

scientific article published on August 2005

Keratin 18-deficiency results in steatohepatitis and liver tumors in old mice: A model of steatohepatitis-associated liver carcinogenesis.

scientific article published on 28 September 2016

Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice.

scientific article

Liver Phenotypes of European Adults Heterozygous or Homozygous for Pi*Z Variant of AAT (Pi*MZ vs Pi*ZZ genotype) and Non-carriers

scientific article published on 03 May 2020

Long-term results of early gastric cancer accomplished in a European institution by Japanese-type radical resection

scientific article published on 01 August 1999

Mallory body formation in primary biliary cirrhosis is associated with increased amounts and abnormal phosphorylation and ubiquitination of cytokeratins

scientific article published on 01 April 2003

Mallory body--a disease-associated type of sequestosome

scientific article published in May 2002

Mallory-Denk bodies and hepatocellular senescence: a causal relationship?

scholarly article

Metaplastic breast carcinomas: are they of myoepithelial differentiation?: immunohistochemical profile of the sarcomatoid subtype using novel myoepithelial markers

scientific article published on March 2005

Oncosis represents the main type of cell death in mouse models of cholestasis

scientific article published in March 2005

Ovarian granulosa cell tumors frequently express EGFR (Her-1), Her-3, and Her-4: An immunohistochemical study

scientific article published on 05 December 2005

Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice

scientific article published in July 2004

Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice

scientific article published in September 2003

Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine

scientific article published in October 2003

Role of nuclear receptors and hepatocyte-enriched transcription factors for Ntcp repression in biliary obstruction in mouse liver

scientific article published on 7 July 2005

Sequestosome 1/p62-related pathways as therapeutic targets in hepatocellular carcinoma

scientific article published on 15 April 2019

Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2-/- mice

scientific article

The PPARα Agonist Fenofibrate Prevents Formation of Protein Aggregates (Mallory-Denk bodies) in a Murine Model of Steatohepatitis-like Hepatotoxicity

scientific article published in Scientific Reports

The canine copper toxicosis gene MURR1 does not cause non-Wilsonian hepatic copper toxicosis

scientific article (publication date: February 2003)

The keratin cytoskeleton in liver diseases

scientific article published in November 2004

The role of osteopontin and tumor necrosis factor alpha receptor-1 in xenobiotic-induced cholangitis and biliary fibrosis in mice

scientific article

The role of the hepatocyte cytokeratin network in bile formation and resistance to bile acid challenge and cholestasis in mice.

scientific article published in September 2009

Transcription factor Fra-1 induces cholangitis and liver fibrosis

scientific article published on 01 April 2011

Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles

scientific article published in October 2002

Valproate inhibition of histone deacetylase 2 affects differentiation and decreases proliferation of endometrial stromal sarcoma cells

scientific article published on September 2006

What is expected from the pathologist in the diagnosis of viral hepatitis? ⬇️

scientific article published on February 26, 2011

Wilson disease

scientific article published on 17 June 2004

p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases

scientific article published on January 2002

p62 protein is expressed in pancreatic beta cells

scientific article published on 01 August 2005

p62/Sequestosome-1 Is Indispensable for Maturation and Stabilization of Mallory-Denk Bodies

scientific article (publication date: 2016)

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