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List of works by William G. Kaelin

(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible

scientific article published on 07 February 2013

2-Oxoglutarate-dependent dioxygenases in cancer

scientific article published on 21 October 2020

A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo

scientific article published on 31 August 2009

A role for mammalian Sin3 in permanent gene silencing

scientific article

An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells

scientific article

Analysis of von Hippel-Lindau hereditary cancer syndrome: implications of oxygen sensing.

scientific article published in January 2004

Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase.

scientific article published on 2 April 2018

Binding of pRB to the PHD protein RBP2 promotes cellular differentiation

scientific article

Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C ⬇️

scientific article published on September 8, 1995

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

scientific article

Bioluminescent imaging of Cdk2 inhibition in vivo

scientific article published on 2 May 2004

Bioluminescent imaging of ubiquitin ligase activity: measuring Cdk2 activity in vivo through changes in p27 turnover

scientific article published on January 2005

CANCER-RELEVANT CULLIN-RING UBIQUITIN LIGASES

article

Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle

scientific article

Climate Change: What Would Lincoln Do?

scientific article published in August 2017

Clusterin is a secreted marker for a hypoxia-inducible factor-independent function of the von Hippel-Lindau tumor suppressor protein

scientific article

Common pitfalls in preclinical cancer target validation

scientific article published on 19 May 2017

Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase

scientific article

Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation

scientific article

Cyclin D1 suppresses retinoblastoma protein-mediated inhibition of TAFII250 kinase activity

scientific article (publication date: 23 November 2000)

Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product

scientific article

Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

scientific article (publication date: 11 March 2004)

Detection of peptides, proteins, and drugs that selectively interact with protein targets

scientific article published in November 2002

DisABLing kidney cancers caused by fumarate hydratase mutations

scientific article

Diverse effects of mutations in exon II of the von Hippel-Lindau (VHL) tumor suppressor gene on the interaction of pVHL with the cytosolic chaperonin and pVHL-dependent ubiquitin ligase activity

scientific article

Divining cancer cell weaknesses

scientific article published in Nature

Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes

scientific article published in July 2004

E2F1 as a target: promoter-driven suicide and small molecule modulators

scientific article published on July 1, 2003

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection

scientific article published on February 2016

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection.

scientific article

EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer

scientific article

Erlotinib therapy for central nervous system hemangioblastomatosis associated with von Hippel-Lindau disease: a case report

scientific article published on 04 June 2010

Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo

scientific article

Fifteenth annual Pezcoller symposium: molecular in vivo visualization of cancer cells

scientific article published in April 2004

FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis

scientific article

Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes

scientific article published on 23 December 2015

Functions of the von Hippel–Lindau tumour suppressor protein ⬇️

scientific article published on June 1, 1998

Gene expression profiling in a renal cell carcinoma cell line: dissecting VHL and hypoxia-dependent pathways

scientific article published on April 2003

Genetic and Functional Studies Implicate HIF1α as a 14q Kidney Cancer Suppressor Gene ⬇️

scientific article published on June 7, 2011

Genetic evidence of a precisely tuned dysregulation in the hypoxia signaling pathway during oncogenesis

scientific article published on 4 November 2014

Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma

scientific article published on 4 January 2018

Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion

scientific article published on 04 September 2011

Gleevec: prototype or outlier?

scientific article published on 16 March 2004

Good COP1 or bad COP1? In vivo veritas ⬇️

scientific article published on March 14, 2011

HIF activation causes synthetic lethality between the VHL tumor suppressor and the EZH1 histone methyltransferase.

scientific article published in July 2017

HIF hydroxylation and the mammalian oxygen-sensing pathway

scientific article

HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species

scientific article published on 01 October 2019

HIF2 Inhibitor Joins the Kidney Cancer Armamentarium

scientific article published on 31 January 2018

HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice

scientific article published on August 2009

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

scientific article

Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate

scientific article published on 14 March 2019

How oxygen makes its presence felt

scientific article

Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product ⬇️

scientific article (publication date: 8 February 1991)

Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL-/- clear cell renal carcinoma

scientific article published on 12 January 2017

Influence of metabolism on epigenetics and disease

scientific article published on March 2013

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

scientific article published in April 2002

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

scientific article

Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle

scientific article

Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist

scholarly article

Innovations and challenges in renal cancer: consensus statement from the first international conference

scientific article published in September 2004

Innovations and challenges in renal cancer: summary statement from the Third Cambridge Conference

scientific article

Innovations and challenges in renal cell carcinoma: summary statement from the Second Cambridge Conference

scientific article published on January 2007

Kinase requirements in human cells: III. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screen

scholarly article

Leveraging insights into cancer metabolism-a symposium report

scientific article published on 02 December 2019

Loss of Hypoxia-Inducible Factor Prolyl Hydroxylase Activity in Cardiomyocytes Phenocopies Ischemic Cardiomyopathy ⬇️

scientific article published on August 23, 2010

Many vessels, faulty gene

scientific article published in Nature

Molecular basis of the VHL hereditary cancer syndrome

scientific article (publication date: September 2002)

Molecular biology. Use and abuse of RNAi to study mammalian gene function

scientific article published in July 2012

Molecular pathogenesis of the von Hippel-Lindau hereditary cancer syndrome: implications for oxygen sensing.

scientific article

Molecular pathways in renal cell carcinoma--rationale for targeted treatment

scientific article published on October 2006

Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production

scholarly article

Mouse reporter strain for noninvasive bioluminescent imaging of cells that have undergone Cre-mediated recombination

scientific article

Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility

scientific article

Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression

scientific article

Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

scientific article published on October 1996

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

scientific article

New Insights into the Biology of Renal Cell Carcinoma ⬇️

scientific article published on August 1, 2011

New cancer targets emerging from studies of the Von Hippel‐Lindau tumor suppressor protein ⬇️

scientific article published on October 1, 2010

Nineteenth Annual Pezcoller Symposium: hypothesis-driven clinical investigation in cancer

scientific article published on 28 November 2007

On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models

scientific article

PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2.

scientific article published on September 2016

Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine

scientific article published on June 2016

Pathways for Oxygen Regulation and Homeostasis: The 2016 Albert Lasker Basic Medical Research Award

scientific article

Patterns of gene expression and copy-number alterations in von-hippel lindau disease-associated and sporadic clear cell carcinoma of the kidney

scientific article published on June 2009

Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21.

scientific article

Proceedings of the Oxygen Homeostasis/Hypoxia Meeting

scientific article published in May 2004

Proline hydroxylation and gene expression

scientific article

Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase

scientific article

Publish houses of brick, not mansions of straw.

scientific article

Q&A: Cancer: clues from cell metabolism

scientific article published in June 2010

RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins

scientific article

Rapid and durable recovery of visual function in a patient with von hippel-lindau syndrome after systemic therapy with vascular endothelial growth factor receptor inhibitor su5416.

scientific article

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

scientific journal article

Reactivation of hepatic EPO synthesis in mice after PHD loss

scientific article published on July 2010

Recent insights into the molecular pathogenesis of pheochromocytoma and paraganglioma

scientific article published on January 2006

Regulation of Hypoxia-Inducible mRNAs by the von Hippel-Lindau Tumor Suppressor Protein Requires Binding to Complexes Containing Elongins B/C and Cul2 ⬇️

scientific article published on February 1, 1998

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

scientific article

Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein

scientific article

Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit

scientific article published on 24 December 2006

Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes

scientific journal article

Role of VHL gene mutation in human cancer

scientific article

Role of the retinoblastoma protein in the pathogenesis of human cancer ⬇️

scientific article published on November 1, 1997

SDH5 mutations and familial paraganglioma: somewhere Warburg is smiling

scientific article published in September 2009

SQSTM1 is a pathogenic target of 5q copy number gains in kidney cancer

scientific article published on December 2013

Senator McCain and Our Shared Humanity

scientific article published on 8 December 2017

Senescence triggered by the loss of the VHL tumor suppressor

scientific article published on 16 June 2008

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

scientific article

Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth ⬇️

scientific article published on January 1, 1998

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

scientific article

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

scientific article

Suppression of tumor growth through disruption of hypoxia-inducible transcription

scientific article published in December 2000

Synthetic lethality: a framework for the development of wiser cancer therapeutics

scientific article published on 27 October 2009

Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein

scientific article

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

scientific article published in August 2003

Targeting HIF2 in Clear Cell Renal Cell Carcinoma

scientific article

The EGLN-HIF O2-Sensing System: Multiple Inputs and Feedbacks

scientific article

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

scientific article

The UTX Tumor Suppressor Directly Senses Oxygen to Control Chromatin and Cell Fate

The VHL Tumor Suppressor Gene: Insights into Oxygen Sensing and Cancer

scientific article published on January 2017

The VHL/HIF axis in clear cell renal carcinoma

scientific article published on 13 June 2012

The concept of synthetic lethality in the context of anticancer therapy

scientific article

The human p73 promoter: characterization and identification of functional E2F binding sites

scientific article

The hypoxia-inducible factor 2alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo

scientific article published on 12 January 2007

The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor

scientific article published on 11 March 2008

The molecular basis of von Hippel-Lindau disease

scientific article

The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins ⬇️

scientific article

The retinoblastoma binding protein RBP2 is an H3K4 demethylase

scientific article published on 22 February 2007

The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase

scientific article published in July 2005

The von Hippel-Lindau Gene, Kidney Cancer, and Oxygen Sensing ⬇️

scientific article published on November 1, 2003

The von Hippel-Lindau Tumor Suppressor Protein Is Required for Proper Assembly of an Extracellular Fibronectin Matrix ⬇️

scientific article published on June 1, 1998

The von Hippel-Lindau protein, HIF hydroxylation, and oxygen sensing

scientific article

The von Hippel-Lindau tumor suppressor gene

scientific article (publication date: 10 March 2001)

The von Hippel-Lindau tumor suppressor gene and kidney cancer

scientific article

The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells ⬇️

scientific article

The von Hippel-Lindau tumor suppressor protein

scientific article

The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma

scientific article

The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer

scientific article

The von Hippel-Lindau tumor suppressor protein: roles in cancer and oxygen sensing

scientific article

The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer

scientific article published on 16 October 2008

The von Hippel-Lindau tumour suppressor protein: new perspectives

scientific article

The von hippel-lindau tumor suppressor protein: an update

scientific article published on January 2007

Treatment of erythropoietin deficiency in mice with systemically administered siRNA.

scientific article

Treatment of kidney cancer: insights provided by the VHL tumor-suppressor protein

scientific article published on May 2009

Tumour suppression by the human von Hippel-Lindau gene product ⬇️

scientific article published on August 1, 1995

Twenty-fifth annual Pezcoller Symposium: Metabolism and tumorigenesis

scientific article published on 4 October 2013

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

scientific article (publication date: July 2000)

Using cancer genetics to guide the selection of anticancer drug targets

scientific article

VHL and Kidney Cancer

scientific article published on January 1, 2003

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.

scientific article published on 24 February 2008

VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma

scientific article

Viral oncoproteins discriminate between p53 and the p53 homolog p73.

scientific article published on November 1998

Von Hippel-Lindau disease

scientific article published in January 2007

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

scientific article published on April 2013

p73 is a simian [correction of human] p53-related protein that can induce apoptosis

scientific article published on September 1997

pVHL 19 is a biologically active product of the von Hippel–Lindau gene arising from internal translation initiation ⬇️

scientific article published on September 29, 1998

pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2

scientific article

pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development

scientific article published on April 2004

pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner

scientific article

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

scientific article

von Hippel–Lindau-associated malignancies: Mechanisms and therapeutic opportunities

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