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List of works by Michael Wakelam

3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

scientific article published on 26 November 2018

3T3-L1 adipocytes express two isoforms of phospholipase D in distinct subcellular compartments.

scientific article published on January 1999

A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel immunoreceptor tyrosine-based inhibitory motif protein

scientific article

A dual role for diacylglycerol kinase generated phosphatidic acid in autoantibody-induced neutrophil exocytosis.

scientific article published on 8 August 2011

A nutritional memory effect counteracts benefits of dietary restriction in old mice

scientific article published on 21 October 2019

A phase II study of the 5-lipoxygenase inhibitor, CV6504, in advanced pancreatic cancer: correlation of clinical data with pharmacokinetic and pharmacodynamic endpoints.

scientific article

A prospective study to assess the value of MMP-9 in improving the appropriateness of urgent referrals for colorectal cancer

scientific article published on 23 October 2006

Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress

scientific article

Acetyl-coA synthetase 2 promotes acetate utilization and maintains cell growth under metabolic stress.

scientific article published on 28 May 2014

Activation of Syk in neutrophils by antineutrophil cytoplasm antibodies occurs via Fcgamma receptors and CD18.

scientific article published in March 2004

Activation of phospholipase D and phosphatidylinositol 4-phosphate 5-kinase in HL60 membranes is mediated by endogenous Arf but not Rho

scientific article published on 01 July 1996

Activation of the G(i) heterotrimeric G protein by ANCA IgG F(ab')2 fragments is necessary but not sufficient to stimulate the recruitment of those downstream mediators used by intact ANCA IgG.

scientific article published in March 2003

Activation of two signal-transduction systems in hepatocytes by glucagon

scientific article published in Nature

Activation of vascular adhesion protein-1 on liver endothelium results in an NF-kappaB-dependent increase in lymphocyte adhesion

scientific article published on 01 February 2007

Acute manipulation of diacylglycerol reveals roles in nuclear envelope assembly & endoplasmic reticulum morphology

scientific article

An intracellular motif of GLUT4 regulates fusion of GLUT4-containing vesicles

scientific article

Analysis of intact phosphoinositides in biological samples

scientific article published on 21 April 2006

Angiotensin II enhances responses to endothelin-1 in bovine bronchial smooth muscle

scientific article published on 01 December 1994

Antigen-stimulated activation of phospholipase D1b by Rac1, ARF6, and PKCalpha in RBL-2H3 cells

scientific journal article

Antineutrophil Cytoplasm Antibody-Stimulated Neutrophil Adhesion Depends on Diacylglycerol Kinase-Catalyzed Phosphatidic Acid Formation

scientific article published on 14 March 2007

Assays to study phospholipase D regulation by inositol phospholipids and ADP-ribosylation factor 6.

scientific article published on January 2005

Assessment of novel combinations of biomarkers for the detection of colorectal cancer

scientific article published on 01 January 2010

Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development

scientific article published on July 2006

Autotaxin-lysophosphatidic acid receptor signalling regulates hepatitis C virus replication.

scientific article published on 23 January 2017

Breast cancer cell-derived EMMPRIN stimulates fibroblast MMP2 release through a phospholipase A(2) and 5-lipoxygenase catalyzed pathway

scientific article (publication date: 22 August 2002)

C. elegans Eats Its Own Intestine to Make Yolk Leading to Multiple Senescent Pathologies

scientific article published on 01 October 2018

C. elegans Eats Its Own Intestine to Make Yolk Leading to Multiple Senescent Pathologies

scientific article published on 09 August 2018

C13orf31 (FAMIN) is a central regulator of immunometabolic function

scientific journal article

CD151 regulates expression of FGFR2 in breast cancer cells via PKC-dependent pathways

scientific article published on 29 October 2018

Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis.

scientific article

Chapter 15 Structure and function of the receptor for insulin

Confounding Effects of Benign Lung Diseases on Non-Small Cell Lung Cancer Serum Biomarker Discovery

Cross-talk between phospholipase D and MAP kinases activities

scientific article published on 05 November 2009

De novo synthesis of glucokinase in hepatocytes isolated from neonatal rats

scientific article published on 01 February 1980

Deciphering lipid structures based on platform-independent decision rules.

scientific article

Determination of phospholipase D, lysophospholipase D and DG kinase signaling pathways in disease states by mass spectrometry

scientific article published on 07 March 2008

Diacylglycerol induces fusion of nuclear envelope membrane precursor vesicles.

scientific article

Diacylglycerol kinase epsilon, but not zeta, selectively removes polyunsaturated diacylglycerol, inducing altered protein kinase C distribution in vivo.

scientific article published on December 1999

Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration.

scientific article published on January 2012

Diacylglycerol--when is it an intracellular messenger?

scientific article

Diacylglycerols and phosphatidates: which molecular species are intracellular messengers?

scientific article

Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism

scientific article published on 28 March 2017

Distinct phospholipase C-regulated signalling pathways in Swiss 3T3 fibroblasts induce the rapid generation of the same polyunsaturated diacylglycerols.

scientific article published on May 1998

Elevated serum matrix metalloproteinase 9 (MMP-9) concentration predicts the presence of colorectal neoplasia in symptomatic patients.

scientific article published on 2 October 2007

Establishing the added benefit of measuring MMP9 in FOB positive patients as a part of the Wolverhampton colorectal cancer screening programme.

scientific article

Evaluation of the accuracy of serum MMP-9 as a test for colorectal cancer in a primary care population.

scientific article published on 31 October 2006

Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells

scientific article

Exosomes bind to autotaxin and act as a physiological delivery mechanism to stimulate LPA receptor signalling in cells

scientific article published on 24 August 2016

Extracellular vesicles: lipids as key components of their biogenesis and functions

scientific article published on 15 May 2018

Fast targeted multidimensional NMR metabolomics of colorectal cancer

scientific article published on 01 December 2009

Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation

scientific article published on 25 September 2014

Flotillin proteins recruit sphingosine to membranes and maintain cellular sphingosine-1-phosphate levels.

scientific article published on 22 May 2018

G-proteins and second messengers in mitogenesis.

scientific article published on January 1989

Generation of diacylglycerol molecular species through the cell cycle: a role for 1-stearoyl, 2-arachidonyl glycerol in the activation of nuclear protein kinase C-betaII at G2/M.

scientific article published in March 2002

Growing pains

Heterologous desensitization of bombesin‐ and vasopressin‐stimulated phospholipase D activity in Swiss 3T3 fibroblasts ⬇️

scientific article published on March 20, 1995

Host lipidome analysis during rhinovirus replication in HBECs identifies potential therapeutic targets

scientific article published in 2018

Identification of serum biomarkers for colon cancer by proteomic analysis

scientific article published on 6 June 2006

Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells

scientific article published on 2 June 2005

Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments.

scientific article

Inhibition of phosphatidylinositol 3-kinase- and ERK MAPK-regulated protein synthesis reveals the pro-apoptotic properties of CD40 ligation in carcinoma cells

scientific article published on 27 October 2003

Inhibition of phospholipid signalling and proliferation of Swiss 3T3 cells by the wortmannin analogue demethoxyviridin.

scientific article published on November 1997

Inhibition of the amplified bombesin-stimulated inositol phosphate response in N-ras transformed cells by high density culturing

scientific article published on 01 February 1988

Insulin and platelet-derived growth factor acutely stimulate glucose transport in 3T3-L1 fibroblasts independently of protein kinase C.

scientific article

Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations

scientific article published on 20 October 2016

Inter-regulatory dynamics of phospholipase D and the actin cytoskeleton.

scientific article published on 05 May 2009

Introduction: Signal activated phospholipases

scientific article published on 01 June 1997

Knockdown of diacylglycerol kinase delta inhibits adipocyte differentiation and alters lipid synthesis

scientific article published on 23 May 2013

L6 skeletal muscle cells have functional V1-vasopressin receptors coupled to stimulated inositol phospholipid metabolism

scientific article published on 01 January 1987

LIPID MAPS: Serving the next generation of lipid researchers with tools, resources, data, and training

scientific article published on 08 January 2019

Lipid droplet formation in response to oleic acid in Huh-7 cells is mediated by the fatty acid receptor FFAR4.

scientific article

Lipid systems and techniques. Introduction

scientific article published on 01 January 2009

LipidHome: a database of theoretical lipids optimized for high throughput mass spectrometry lipidomics

scientific article published on 7 May 2013

Lipidome analysis of rotavirus-infected cells confirms the close interaction of lipid droplets with viroplasms

scientific article published on 20 March 2013

Lipidomic analysis of signaling pathways.

scientific article

Lipidomics in the analysis of malignancy

scientific article

Lipidomics: Current state of the art in a fast moving field

scientific article published on 23 October 2019

MS-based lipidomics of human blood plasma - a community-initiated position paper to develop accepted guidelines

article

MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer

scientific article published on 16 January 2020

Mammalian phospholipase D: Function, and therapeutics

scientific article published on 09 December 2019

Mass measurement of inositol phosphates.

scientific article published on December 1989

Mechanical and biochemical responses to endothelin-1 and endothelin-3 in human bronchi

scientific article published on 01 December 1994

Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal

scientific article (publication date: October 2014)

Methods for analyzing phosphoinositides using mass spectrometry

scientific article published on 23 September 2011

Modeling Meets Metabolomics-The WormJam Consensus Model as Basis for Metabolic Studies in the Model Organism ⬇️

article

Modulation of triglyceride and cholesterol ester synthesis impairs assembly of infectious hepatitis C virus.

scientific article

Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA

scientific article

MyosinIIa contractility is required for maintenance of platelet structure during spreading on collagen and contributes to thrombus stability

scientific article

Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans

scientific article published on 01 November 2021

Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine

publication published on 27 April 2021

P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation.

scientific article published on 23 December 2014

PLCgamma is enriched on poly-phosphoinositide-rich vesicles to control nuclear envelope assembly

scientific article published on 11 November 2006

PLD1 rather than PLD2 regulates phorbol-ester-, adhesion-dependent and Fc{gamma}-receptor-stimulated ROS production in neutrophils

scientific article published on 24 May 2011

PTEN mutations as a cause of constitutive insulin sensitivity and obesity.

scientific article

Phosphatidylinositol 3′-Kinase-independent p70 S6 Kinase Activation by Fibroblast Growth Factor Receptor-1 Is Important for Proliferation but Not Differentiation of Endothelial Cells ⬇️

scientific article published on September 12, 1997

Phosphatidylinositolphosphate phosphatase activities and cancer

scientific article published on 24 August 2015

Phosphoinositide 3-kinase-related overgrowth: cellular phenotype and future therapeutic options

scientific article

Phospholipase D

scientific article

Phospholipase D

scientific article published on 01 June 1997

Phospholipase D activity couples plasma membrane endocytosis with retromer dependent recycling.

scientific article

Phospholipase D activity is essential for actin localization and actin-based motility in Dictyostelium

scientific article

Phospholipase D1b and D2a generate structurally identical phosphatidic acid species in mammalian cells ⬇️

scientific article published on December 15, 2001

Phospholipase D2 stimulates integrin-mediated adhesion via phosphatidylinositol 4-phosphate 5-kinase Igamma b

scientific journal article

Potential Role of Oral Rinses Targeting the Viral Lipid Envelope in SARS-CoV-2 Infection

scientific article published on 05 June 2020

Prostaglandins and cyclic AMP stimulate creatine kinase synthesis but not fusion in cultured embryonic chick muscle cells

scientific article published on 01 October 1984

Protein kinase C: Current concepts and future perspectives

Proteomic profiling of urine for the detection of colon cancer.

scientific article published on 16 June 2008

Purification, characterization and crystallization of the F-ATPase from Paracoccus denitrificans

scientific article

Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry.

scientific article

Reply: Elevated serum matrix metalloproteinase 9 (MMP-9) concentration predicts the presence of colorectal neoplasia in symptomatic patients

scientific article published on 29 July 2008

Rhabdomere biogenesis in Drosophila photoreceptors is acutely sensitive to phosphatidic acid levels.

scientific article published on April 2009

Role and regulation of phospholipase D activity in normal and cancer cells

scientific article published on 01 January 1997

Runx regulation of sphingolipid metabolism and survival signaling.

scientific article published on 29 June 2010

Runx1 Orchestrates Sphingolipid Metabolism and Glucocorticoid Resistance in Lymphomagenesis.

scientific article published on 21 November 2016

Second messengers. Sphingolipid signalling.

scientific article published on April 1994

Second-messenger pathways involved in the regulation of survival in germinal-centre B cells and in Burkitt lymphoma lines

scientific article published on 01 December 1992

Securin induces genetic instability in colorectal cancer by inhibiting double-stranded DNA repair activity.

scientific article published on 27 October 2006

Serum matrix metalloproteinase 9 and colorectal neoplasia: a community-based evaluation of a potential diagnostic test.

scientific article published on 20 March 2012

Shorthand notation for lipid structures derived from mass spectrometry.

scientific article

SnapShot: Lipid kinase and phosphatase reaction pathways

scientific article published on 01 January 2014

SnapShot: lipid kinases and phosphatases.

scientific article

Speed and sensitivity of phototransduction in Drosophila depend on degree of saturation of membrane phospholipids

scientific article

Stable adhesion and migration of human neutrophils requires phospholipase D-mediated activation of the integrin CD11b/CD18

scientific article published on 07 March 2007

Steps Towards Minimal Reporting Standards for Lipidomics Mass Spectrometry in Biomedical Research Publications

scientific article published on 16 November 2020

Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth.

scientific article published on 23 January 2013

Stimulated phosphatidylcholine hydrolysis as a signal transduction pathway in mitogenesis.

scientific article published on January 1991

TAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid

scientific article (publication date: 2 August 2002)

THP-1 macrophage cholesterol efflux is impaired by palmitoleate through Akt activation

scientific article published on 21 May 2020

The Effect of a Pex3 Mutation on Hearing and Lipid Content of the Inner Ear

scientific article published in 2022

The Phospholipase D2 Knock Out Mouse Has Ectopic Purkinje Cells and Suffers from Early Adult-Onset Anosmia.

scientific article

The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication

scientific article published in Nature Communications

The p85 subunit of phosphoinositide 3-kinase is associated with β-catenin in the cadherin-based adhesion complex ⬇️

scientific article published on December 1, 2001

The proto-oncogene PBF binds p53 and is associated with prognostic features in colorectal cancer.

scientific article

The regulation by phosphorylation of ‘priming’ of phospholipase A2 activity in the neutrophil model system, differentiated HL60 cells ⬇️

scientific article published on September 1, 1997

The regulation of phospholipase D by inositol phospholipids and small GTPases

scientific article

The role of protein kinase C in the induction of nitric oxide synthesis by murine macrophages.

scientific article published on November 1992

The search for new targets for cancer chemotherapeutics

scientific article published on 01 August 2005

The uses and limitations of the analysis of cellular phosphoinositides by lipidomic and imaging methodologies.

scientific article published on 24 April 2014

Thyroid hormones and the precocious induction of hepatic glucokinase in the neonatal rat

scientific article published on 01 October 1979

Transmitter-like action of ATP on patched membranes of cultured myoblasts and myotubes

scientific article published in Nature

Update of the LIPID MAPS comprehensive classification system for lipids

scientific article

Update on LIPID MAPS Classification, Nomenclature and Shorthand Notation for MS-derived Lipid Structures

scientific article published on 09 October 2020

Using lipidomics analysis to determine signalling and metabolic changes in cells.

scientific article published on 3 November 2016

Wortmannin and its structural analogue demethoxyviridin inhibit stimulated phospholipase A2 activity in Swiss 3T3 cells. Wortmannin is not a specific inhibitor of phosphatidylinositol 3-kinase.

scientific article published on October 1995

lazaro encodes a lipid phosphate phosphohydrolase that regulates phosphatidylinositol turnover during Drosophila phototransduction.

scientific article published in February 2006

v-Src induces elevated levels of diglyceride by stimulation of phosphatidylcholine hydrolysis

scientific article published on May 1, 1992

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