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List of works by Maria Grazia Spillantini

100 years of Lewy pathology ⬇️

scientific article published on November 27, 2012

A Brief History of Tau.

scientific article

A century of Alzheimer's disease

scientific article published on November 2006

A novel role for Sema3A in neuroprotection from injury mediated by activated microglia.

scientific article published on February 2006

Abnormal tau phosphorylation in primary progressive multiple sclerosis

scientific article published on 21 March 2010

Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein.

scientific article published in November 2002

Alpha-Synuclein Produces Early Behavioral Alterations via Striatal Cholinergic Synaptic Dysfunction by Interacting With GluN2D N-Methyl-D-Aspartate Receptor Subunit.

scientific article published on 20 August 2015

Alpha-synuclein dysfunction in Lewy body diseases

scientific article

Alpha-synuclein modulates NR2B-containing NMDA receptors and decreases their levels after rotenone exposure.

scientific article

Alpha-synuclein/synapsin III pathological interplay boosts the motor response to methylphenidate

scientific article published on 04 February 2020

Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy

scientific article published on 13 December 2007

Animal models of Parkinson's disease: limits and relevance to neuroprotection studies.

scientific article

Anti-amyloid compounds inhibit α-synuclein aggregation induced by protein misfolding cyclic amplification (PMCA)

scientific article published on 28 February 2014

Antibody recognizing 4-sulfated chondroitin sulfate proteoglycans restores memory in tauopathy-induced neurodegeneration. ⬇️

scientific article published on 9 August 2017

Association between tau H2 haplotype and age at onset in frontotemporal dementia

scientific article

Astrocytes in mouse models of tauopathies acquire early deficits and lose neurosupportive functions.

scientific article published on 29 November 2017

Atypical, non-standard functions of the microtubule associated Tau protein

scientific article published on 29 November 2017

Behavioural deficits in transgenic mice expressing human truncated (1-120 amino acid) alpha-synuclein

scientific article published on 20 November 2014

Cell-Mediated Neuroprotection in a Mouse Model of Human Tauopathy ⬇️

scientific article published on July 28, 2010

Clinical comparison of progressive aphasia associated with Alzheimer versus FTD-spectrum pathology

scientific article published on 14 September 2010

Clinical, imaging and pathological correlates of a hereditary deficit in verb and action processing

scientific article published on 05 December 2005

Closing the tau loop: the missing tau mutation

scientific article

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

scientific article

Compound heterozygosity of 2 novel MAPT mutations in frontotemporal dementia

scientific article published on 03 February 2011

Correction: Redistribution of DAT/α-Synuclein Complexes Visualized by “In Situ” Proximity Ligation Assay in Transgenic Mice Modelling Early Parkinson's Disease.

scientific article

Depletion of Perineuronal Nets Enhances Recognition Memory and Long-Term Depression in the Perirhinal Cortex ⬇️

scientific article published on April 17, 2013

Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model

scientific article published on 31 May 2019

Dimebon does not ameliorate pathological changes caused by expression of truncated (1-120) human alpha-synuclein in dopaminergic neurons of transgenic mice.

scientific article published on 12 May 2011

Early behavioural markers of disease in P301S tau transgenic mice

scientific article published on 11 December 2009

Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations.

scientific article

Early-onset dementia with Lewy bodies

scientific article published in April 2004

Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition

scientific article published on August 2008

Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra

scientific article published on 8 August 2013

Evidence for abnormal tau phosphorylation in early aggressive multiple sclerosis

scientific article published on 14 March 2009

Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model

scientific article published on 25 December 2012

Frontotemporal Dementia: Implications for Understanding Alzheimer Disease ⬇️

scientific article published on February 1, 2012

Frontotemporal dementia and its subtypes: a genome-wide association study

scientific article

Frontotemporal dementia linked to chromosome 3

scientific article published on 01 January 2004

Frontotemporal dementia with tau pathology.

scientific article published on January 2007

Frontotemporal lobar degeneration through loss of progranulin function

scientific article published on November 2006

Genetic and pathological links between Parkinson's disease and the lysosomal disorder Sanfilippo syndrome

scientific article

Hereditary frontotemporal dementia caused by Tau gene mutations.

scientific article

Heritability in frontotemporal tauopathies

Human stem cell-derived neurons: a system to study human tau function and dysfunction

scientific article

Impairments in impulse control in mice transgenic for the human FTDP-17 tauV337M mutation are exacerbated by age.

scientific article

In vitro high affinity alpha-synuclein binding sites for the amyloid imaging agent PIB are not matched by binding to Lewy bodies in postmortem human brain

scientific article published on 21 January 2008

Increased Dickkopf-1 expression in transgenic mouse models of neurodegenerative disease

scientific article

Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein

scientific article published on November 2004

Interaction of tau protein with the dynactin complex

scientific article

L444P Gba1 mutation increases formation and spread of α-synuclein deposits in mice injected with mouse α-synuclein pre-formed fibrils

scientific article published on 24 August 2020

Labeling and identifying cell-specific proteomes in the mouse brain.

scientific article published on 18 December 2017

Late-onset Parkinsonism in NFκB/c-Rel-deficient mice

scientific article

Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia

scientific article published on 01 August 2018

Living in Promiscuity: The Multiple Partners of Alpha-Synuclein at the Synapse in Physiology and Pathology ⬇️

scientific article published on 02 January 2019

Locus coeruleus pathology in progressive supranuclear palsy, and its relation to disease severity

scientific article published on 04 February 2020

Mechanisms underlying the impairment of hippocampal long-term potentiation and memory in experimental Parkinson's disease.

scientific article

Mixed tau, TDP-43 and p62 pathology in FTLD associated with a C9ORF72 repeat expansion and p.Ala239Thr MAPT (tau) variant

scientific article published on 28 September 2012

Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia

scientific article

Mutations in the tau gene (MAPT) in FTDP-17: the family with Multiple System Tauopathy with Presenile Dementia (MSTD).

scientific article published in January 2006

Neurodegeneration and the ordered assembly of α-synuclein

scientific article published on 8 November 2017

Neuronal expression of pathological tau accelerates oligodendrocyte progenitor cell differentiation

scientific article

Neuropathological validation of the MDS-PSP criteria with PSP and other frontotemporal lobar degeneration

Novel Cathepsin D Inhibitors Prevent the β-Secretase-Derived Intracellular Formation of a 12 kDa Potentially Amyloidogenic Product in Human Cells

Ordered Assembly of Tau Protein and Neurodegeneration

scientific article published on 01 January 2019

Organisation and tyrosine hydroxylase and calretinin immunoreactivity in the main olfactory bulb of paca (Cuniculus paca): a large caviomorph rodent

scientific article

P3-193

PART is part of Alzheimer disease

scientific article

Parkinson's disease as a member of Prion-like disorders

scientific article

Pathogenesis of the Tauopathies ⬇️

scientific article published on July 23, 2011

Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders.

scientific article

Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology

scientific article

Phenotypic variation of autosomal-dominant corticobasal degeneration

scientific article published on 18 January 2012

Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo

scientific article published on 21 August 2019

Presence of Reactive Microglia and Neuroinflammatory Mediators in a Case of Frontotemporal Dementia with P301S Mutation ⬇️

scientific article published on January 5, 2011

Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice

scientific article

Progressive tauopathy in P301S tau transgenic mice is associated with a functional deficit of the olfactory system

scientific article published on 16 July 2016

Propagation of Tau aggregates

scientific article

Proteasomal degradation of tau protein

scientific article published in October 2002

Redistribution of DAT/α-synuclein complexes visualized by "in situ" proximity ligation assay in transgenic mice modelling early Parkinson's disease

scientific article

Reduced axonal transport and increased excitotoxic retinal ganglion cell degeneration in mice transgenic for human mutant P301S tau.

scientific article

Regional expression of the MAPT gene is associated with loss of hubs in brain networks and cognitive impairment in Parkinson disease and progressive supranuclear palsy

scientific article

Release of growth factors by neuronal precursor cells as a treatment for diseases with tau pathology

scientific article published on June 1, 2011

Retiring the term FTDP-17 as MAPT mutations are genetic forms of sporadic frontotemporal tauopathies.

scientific article published on 14 December 2017

SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease

scientific article

Semantic dementia: demography, familial factors and survival in a consecutive series of 100 cases

scientific article published on 05 October 2009

Synaptic dysfunction in synucleinopathies.

scientific article

Synaptic failure and α-synuclein

scientific article

Tau Protein in Familial and Sporadic Diseases ⬇️

scientific article published on January 1, 2003

Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease

scientific article published on August 2007

Tau and alpha-synuclein inclusions in a case of familial frontotemporal dementia and progressive aphasia

scientific article published on March 2005

Tau gene mutations: dissecting the pathogenesis of FTDP-17.

scientific article

Tau inclusions in retinal ganglion cells of human P301S tau transgenic mice: effects on axonal viability.

scientific article published on 7 April 2009

Tau pathology and neurodegeneration

scientific article published on June 2013

Tau pathology is present in vivo and develops in vitro in sensory neurons from human P301S tau transgenic mice: a system for screening drugs against tauopathies

scientific article

Tau protein in frontotemporal dementia linked to chromosome 3 (FTD-3).

scientific article

Tau-Driven Neuronal and Neurotrophic Dysfunction in a Mouse Model of Early Tauopathy.

scientific article published on February 2016

Tauopathy-induced retinal dysfunction in the P301S mutant human tau transgenic mouse.

scientific article published on 4 October 2013

The L444P Gba1 mutation enhances alpha-synuclein induced loss of nigral dopaminergic neurons in mice

scientific article published on October 2017

The Synucleinopathies: Twenty Years On.

scientific article published on January 2017

The Transcellular Propagation and Intracellular Trafficking of α-Synuclein.

scientific article published on 5 December 2016

The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice.

scientific article published on 29 May 2015

The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons

scientific article

The role of tau in the pathological process and clinical expression of Huntington's disease

scientific article

The tauopathy associated with mutation +3 in intron 10 of Tau: characterization of the MSTD family

scientific article published on 07 December 2007

Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function

scientific article published on 15 August 2003

Unpicking frontotemporal lobar degeneration ⬇️

scientific article published on August 22, 2011

[18F]AV-1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation.

scientific article published on 18 October 2016

pFTAA: a high affinity oligothiophene probe that detects filamentous tau in vivo and in cultured neurons

scientific article

α-synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons

scientific article published on 12 May 2015

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