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List of works by Tony Kouzarides

A Chemical Probe for the ATAD2 Bromodomain

scientific article

A Chemical Probe for the ATAD2 Bromodomain

article

A chromodomain switch mediated by histone H3 Lys 4 acetylation regulates heterochromatin assembly

scientific article

A computational platform for high-throughput analysis of RNA sequences and modifications by mass spectrometry

scientific article published on 17 February 2020

A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation

scientific article published on 18 August 2017

A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription

scientific article

ALKBH1 is a histone H2A dioxygenase involved in neural differentiation

scientific article published on December 2012

Acetylation of beta-catenin by CREB-binding protein (CBP).

scientific article

Amplification of the BRCA2 Pathway Gene EMSY in Sporadic Breast Cancer Is Related to Negative Outcome

article

An E2F-like repressor of transcription

scientific article published in December 1997

An operational definition of epigenetics

scientific article

Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169.

scientific article published on January 1990

Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation

scientific article

BET inhibitor resistance emerges from leukaemia stem cells

scientific article published on 14 September 2015

BET protein inhibition shows efficacy against JAK2V617F-driven neoplasms

scientific article published on 9 August 2013

Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69

scientific article

Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells

scientific article

CBP/p300 as a co-factor for the Microphthalmia transcription factor ⬇️

article by S Sato et al published 26 June 1997 in Oncogene

Cancer epigenetics: from mechanism to therapy

scientific article (publication date: 6 July 2012)

Chromatin modifications and their function

scientific article (publication date: 23 February 2007)

Citrullination of HP1γ chromodomain affects association with chromatin

scientific article published on 02 April 2019

Citrullination regulates pluripotency and histone H1 binding to chromatin

scientific journal article

Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development

scientific journal article

Conserved motifs in Fos and Jun define a new class of activation domain

scientific article published on September 1, 1992

Crosstalk between CARM1 methylation and CBP acetylation on histone H3.

scientific article

Crystal structure of the ENT domain of human EMSY.

scientific article

DDX3X RNA helicase affects breast cancer cell cycle progression by regulating expression of KLF4

scholarly article by Ester Cannizzaro published in July 2018

DNA methyltransferase Dnmt1 associates with histone deacetylase activity

scientific article (publication date: 2000)

DNA methyltransferases get connected to chromatin

scientific article (publication date: June 2002)

Decoding the chromatin modification landscape

scientific article published on 15 January 2011

Differential expression of selected histone modifier genes in human solid cancers

scientific article published on 25 April 2006

Differentiation and gene regulation

article

Direct binding of INHAT to H3 tails disrupted by modifications

scientific article

Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition

scientific article

Distinct transcriptional outputs associated with mono- and dimethylated histone H3 arginine 2.

scientific article

Dnmt3L is a transcriptional repressor that recruits histone deacetylase

scientific article

Dynamic distribution of the replacement histone variant H3.3 in the mouse oocyte and preimplantation embryos

scientific article published in January 2006

E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction ⬇️

scientific article published on July 15, 1997

EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer

scientific article (publication date: 26 November 2003)

Epstein-Barr virus nuclear antigen 3C interacts with histone deacetylase to repress transcription

scientific article published on July 1999

Functional interdependence of BRD4 and DOT1L in MLL leukemia

scientific article published on 13 June 2016

Further Evidence Supporting N7-Methylation of Guanosine (m7G) in Human MicroRNAs

scientific article published on 01 July 2020

Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy

scientific article

Genome-wide studies of histone demethylation catalysed by the fission yeast homologues of mammalian LSD1

scientific article published on 18 April 2007

Genomic positional conservation identifies topological anchor point (tap)RNAs linked to developmental loci

Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci.

scientific article

Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification

scientific article

Heritable gene repression through the action of a directed DNA methyltransferase at a chromosomal locus

scientific article published on 13 February 2008

Histone H3 lysine 4 methylation disrupts binding of nucleosome remodeling and deacetylase (NuRD) repressor complex

scientific article

Histone H3 lysine 4 methylation is associated with the transcriptional reprogramming efficiency of somatic nuclei by oocytes

scientific article

Histone H3 tail clipping regulates gene expression

scientific article published on 14 December 2008

Histone arginine methylation regulates pluripotency in the early mouse embryo

scientific article

Histone core modifications regulating nucleosome structure and dynamics

scientific article

Histone deimination antagonizes arginine methylation

scientific article

Histone methylation defines epigenetic asymmetry in the mouse zygote

scientific article

Histone methylation: dynamic or static?

scientific article

Histone methylation: recognizing the methyl mark

scientific article published on January 2004

Human RNA methyltransferase BCDIN3D regulates microRNA processing

scientific article

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

scientific article

Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains

scientific article

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

scientific article

Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway

scientific article published on 3 July 2018

Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells

scientific article published on 09 May 2019

Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity

scientific article published on October 2005

JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin

scientific article

LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease

scientific article

Large-scale rearrangement of homologous regions in the genomes of HCMV and EBV.

scientific article

METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation

scientific article published on 25 April 2019

Map position and nucleotide sequence of the gene for the large structural phosphoprotein of human cytomegalovirus

scientific article

Mechanisms of P/CAF auto-acetylation

scientific article

Methylation at arginine 17 of histone H3 is linked to gene activation

scientific article

Methylation of H3 lysine 4 at euchromatin promotes Sir3p association with heterochromatin

scientific article

Methylation of Histone H3 K4 Mediates Association of the Isw1p ATPase with Chromatin

scientific article published on 07 June 2018

Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin

scientific article published in November 2003

Methylation of histone H3 Lys 4 in coding regions of active genes

scientific article

Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage

scientific article (publication date: 24 November 2004)

Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor

scientific article (publication date: 8 February 2002)

Modulation of Fos-mediated AP-1 transcription by the promyelocytic leukemia protein ⬇️

scientific article published on June 4, 1998

Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not in primary tumours

scientific article

Mutations truncating the EP300 acetylase in human cancers

Myc represses transcription through recruitment of DNA methyltransferase corepressor

scientific article

Nuclear JAK2.

scientific article published in December 2011

Nucleosome-interacting proteins regulated by DNA and histone methylation

scientific article

Phosphorylation of Histone H4T80 Triggers DNA Damage Checkpoint Recovery

scientific article published on 25 October 2018

Phosphorylation of histone H3 Thr-45 is linked to apoptosis

scientific article

Post transcriptional control of the epigenetic stem cell regulator PLZF by sirtuin and HDAC deacetylases

scientific article published on 24 September 2015

Proline isomerization of histone H3 regulates lysine methylation and gene expression

scientific article

Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control.

scientific article published on 27 November 2017

RNA Binding by Histone Methyltransferases Set1 and Set2.

scientific article published on 8 May 2017

RNA modifications detection by comparative Nanopore direct RNA sequencing

scientific article

RNA modifications detection by comparative Nanopore direct RNA sequencing

scientific article published on 10 December 2021

RNA-modifying enzymes and their function in a chromatin context

scientific article published on 03 October 2019

Rb targets histone H3 methylation and HP1 to promoters

scientific article (publication date: 2 August 2001)

Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia

scientific article published on 13 November 2013

Regulation of chromatin by histone modifications ⬇️

scientific article published on February 15, 2011

Regulation of histone H3 lysine 56 acetylation in Schizosaccharomyces pombe

scientific article published on 16 March 2007

Repression of RNA polymerase III transcription by the retinoblastoma protein

scientific article published in Nature

Retinoblastoma protein recruits histone deacetylase to repress transcription

scientific article

Reversing histone methylation

scientific article

Role of RNA modifications in cancer

scientific article published on 16 April 2020

S6 kinase 2 is bound to chromatin-nuclear matrix cellular fractions and is able to phosphorylate histone H3 at threonine 45 in vitro and in vivo.

scientific article published on June 2014

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4

scientific article published in Nature Communications

Sequence and transcription analysis of the human cytomegalovirus DNA polymerase gene

scientific article published on January 1987

SnapShot: Histone-Modifying Enzymes

scientific article published on 01 February 2007

SnapShot: Histone-modifying enzymes

scientific article

Spatial distribution of di- and tri-methyl lysine 36 of histone H3 at active genes

scientific article

Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9

scientific article

Targeting epigenetic readers in cancer.

scientific article published on August 2012

Targeting the m<sup>6</sup>A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication

scientific article published on 24 June 2021

Temporal recruitment of the mSin3A-histone deacetylase corepressor complex to the ETS domain transcription factor Elk-1.

scientific article published on April 2001

The Breast Cancer Oncogene EMSY Represses Transcription of Antimetastatic microRNA miR-31.

scientific article published on 10 April 2014

The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase

scientific article

The DNA sequence of the human cytomegalovirus genome

scientific article

The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4

scientific article published on 7 May 2012

The S. pombe Histone H2A Dioxygenase Ofd2 Regulates Gene Expression during Hypoxia ⬇️

scientific article published on January 3, 2012

The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase

scientific article

The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains

scientific article (publication date: February 2003)

The breast cancer oncogene EMSY represses transcription of antimetastatic microRNA miR-31.

scientific article published on 27 February 2014

The human cytomegalovirus 80-kilodalton but not the 72-kilodalton immediate-early protein transactivates heterologous promoters in a TATA box-dependent mechanism and interacts directly with TFIID.

scientific article published in July 1992

The human cytomegalovirus 86K immediate early (IE) 2 protein requires the basic region of the TATA-box binding protein (TBP) for binding, and interacts with TBP and transcription factor TFIIB via regions of IE2 required for transcriptional regulatio

scientific article published on 01 December 1993

The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation

scientific article published on 9 November 2002

The non-coding snRNA 7SK controls transcriptional termination, poising, and bidirectionality in embryonic stem cells

scientific article published on January 2013

Three distinct patterns of histone H3Y41 phosphorylation mark active genes.

scientific article

Transcriptional Repression by the Promyelocytic Leukemia Protein, PML ⬇️

scientific article published on December 15, 1997

Transcriptional control by the retinoblastoma protein ⬇️

scientific article published on April 1, 1995

Unsafe SETs: histone lysine methyltransferases and cancer

scientific article

Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cells

scientific article

Viral oncoproteins target the DNA methyltransferases

scientific article

cis-acting DNA from fission yeast centromeres mediates histone H3 methylation and recruitment of silencing factors and cohesin to an ectopic site

scientific article

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