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List of works by Phillip Thomas Hawkins

ARAP3 is a PI3K- and rap-regulated GAP for RhoA

ARAP3 is essential for formation of lamellipodia after growth factor stimulation

scientific article published on 17 January 2006

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B ⬇️

scientific article published on July 25, 1997

FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments

scientific article

Functional redundancy of class I phosphoinositide 3-kinase (PI3K) isoforms in signaling growth factor-mediated human neutrophil survival

scientific article

GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4.

scientific article

Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils

scientific article published on 15 October 2006

Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils

scientific article published on 03 November 2020

Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices

scientific article

Is Vasopressin-Stimulated Inositol Lipid Breakdown Intrinsic to the Mechanism of Ca2+-Mobilization at V1 Vasopressin Receptors?

scientific article published on January 1, 1983

L-myo-inositol 1,4,5,6-tetrakisphosphate (3-hydroxy)kinase

scientific article

Localizing the lipid products of PI3Kγ in neutrophils

scientific article

Mechanism of the regulation of type IB phosphoinositide 3OH-kinase byG-protein betagamma subunits

scientific article published on March 2002

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

scientific article

P-Rex2, a new guanine-nucleotide exchange factor for Rac

scientific article

PI3K signalling: the path to discovery and understanding ⬇️

scientific article published on February 23, 2012

PI3Kβ plays a critical role in neutrophil activation by immune complexes.

scientific article

Phosphatidylinositol 3-kinase-γ activates Bruton’s tyrosine kinase in concert with Src family kinases ⬇️

scientific article published on December 9, 1997

Phosphoinositide 3-OH kinase regulates integrin-dependent processes in neutrophils by signaling through its effector ARAP3.

scientific article published on 23 November 2012

Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage

scientific article

Phosphoinositide 3-kinases as drug targets in cancer

scientific article

Phosphorylation of threonine 154 in p40phox is an important physiological signal for activation of the neutrophil NADPH oxidase ⬇️

scientific article published on September 22, 2010

Protein Kinase B and Rac Are Activated in Parallel within a Phosphatidylinositide 3OH-kinase-controlled Signaling Pathway ⬇️

scientific article published on May 1, 1998

Purification of ARAP3 and characterization of GAP activities

scientific article published on January 2006

Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry.

scientific article

Quantitative measurement of phosphatidylinositol 3,4,5-trisphosphate

scientific article published on January 2007

Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits

scientific article

RhoG regulates the neutrophil NADPH oxidase

scientific article (publication date: May 2006)

SCFAs Induce Mouse Neutrophil Chemotaxis through the GPR43 Receptor ⬇️

scientific article published on June 15, 2011

Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils

scientific article

Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism

scientific article

Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes

scientific article

The role of phosphoinositides and phosphorylation in regulation of NADPH oxidase

scientific article

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

scientific article

Use of the GRP1 PH domain as a tool to measure the relative levels of PtdIns(3,4,5)P3 through a protein-lipid overlay approach

scientific article published on 27 November 2006

cAMP Signaling of Adenylate Cyclase Toxin Blocks the Oxidative Burst of Neutrophils through Epac-Mediated Inhibition of Phospholipase C Activity

scientific article published on 30 December 2016

myo-inositol pentakisphosphates. Structure, biological occurrence and phosphorylation to myo-inositol hexakisphosphate ⬇️

scientific article published on April 15, 1991

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