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List of works by Phillip Thomas Hawkins

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Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

scientific article published on July 25, 1997
PI3K signalling: the path to discovery and understanding

scientific article published on February 23, 2012
P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

scientific article
Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage

scientific article
Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

scientific article
Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices

scientific article
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils

scientific article
Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry.

scientific article
PI3K signalling in inflammation

scientific article published on December 13, 2014
Phosphatidylinositol 3-kinase-γ activates Bruton’s tyrosine kinase in concert with Src family kinases

scientific article published on December 9, 1997
SCFAs Induce Mouse Neutrophil Chemotaxis through the GPR43 Receptor

scientific article published on June 15, 2011
Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils

scientific article published on 15 October 2006
Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism

scientific article
PI3Kβ plays a critical role in neutrophil activation by immune complexes

scientific article
Protein Kinase B and Rac Are Activated in Parallel within a Phosphatidylinositide 3OH-kinase-controlled Signaling Pathway

scientific article published on May 1, 1998
Phosphoinositide 3-kinases as drug targets in cancer

scientific article
ARAP3 is a PI3K- and rap-regulated GAP for RhoA

P-Rex2, a new guanine-nucleotide exchange factor for Rac

scientific article
myo-inositol pentakisphosphates. Structure, biological occurrence and phosphorylation to myo-inositol hexakisphosphate

scientific article published on April 15, 1991
Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits

scientific article
FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments

scientific article
ARAP3 is essential for formation of lamellipodia after growth factor stimulation

scientific article published on 17 January 2006
Emerging evidence of signalling roles for PI(3,4)P2 in Class I and II PI3K-regulated pathways

scientific article published on February 1, 2016
L-myo-inositol 1,4,5,6-tetrakisphosphate (3-hydroxy)kinase

scientific article
Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis

scientific article published on December 23, 2013
The role of phosphoinositides and phosphorylation in regulation of NADPH oxidase

scientific article
RhoG regulates the neutrophil NADPH oxidase

scientific article (publication date: May 2006)
GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4.

scientific article
Functional redundancy of class I phosphoinositide 3-kinase (PI3K) isoforms in signaling growth factor-mediated human neutrophil survival

scientific article
Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes

scientific article
Quantitative measurement of phosphatidylinositol 3,4,5-trisphosphate

scientific article published on January 2007
Phosphorylation of threonine 154 in p40phox is an important physiological signal for activation of the neutrophil NADPH oxidase

scientific article published on September 22, 2010
cAMP Signaling of Adenylate Cyclase Toxin Blocks the Oxidative Burst of Neutrophils through Epac-Mediated Inhibition of Phospholipase C Activity

scientific article published on 30 December 2016
Use of the GRP1 PH domain as a tool to measure the relative levels of PtdIns(3,4,5)P3 through a protein-lipid overlay approach

scientific article published on 27 November 2006
Activation of the neutrophil NADPH oxidase by Aspergillus fumigatus

scientific article published on December 1, 2012
Mechanism of the regulation of type IB phosphoinositide 3OH-kinase byG-protein betagamma subunits

scientific article published on March 2002
Phosphoinositide 3-OH kinase regulates integrin-dependent processes in neutrophils by signaling through its effector ARAP3.

scientific article published on 23 November 2012
The regulatory subunits of PI3Kγ control distinct neutrophil responses

scientific article published on January 20, 2015
Localizing the lipid products of PI3Kγ in neutrophils

scientific article
Purification of ARAP3 and characterization of GAP activities

scientific article published on January 2006
More Paths to PI3Kγ

scientific article published on June 25, 2013
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration

scientific article published on 24 May 2023
Is Vasopressin-Stimulated Inositol Lipid Breakdown Intrinsic to the Mechanism of Ca2+-Mobilization at V1 Vasopressin Receptors?

scientific article published on January 1, 1983
Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils

scientific article published on 03 November 2020

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