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List of works by Edith Heard

3D solutions to complex gene regulation

scientific article published in November 2016

A Conserved Noncoding Locus Regulates Random Monoallelic Xist Expression across a Topological Boundary

scientific article published on 20 November 2019

A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced

scientific article

A phosphorylated subpopulation of the histone variant macroH2A1 is excluded from the inactive X chromosome and enriched during mitosis

scientific article

A symmetric toggle switch explains the onset of random X inactivation in different mammals

scientific article published on 08 April 2019

Advances in epigenetics link genetics to the environment and disease

scientific article published on 24 July 2019

Antisense RNA in imprinting: spreading silence through Air.

scientific article

Author Correction: In-cell identification and measurement of RNA-protein interactions

scientific article published on 08 July 2020

Bioinformatic Analysis of Single-Cell Hi-C Data from Early Mouse Embryo

scientific article published on 01 January 2021

Cell nucleus

scientific article published on 05 June 2013

Challenges and guidelines toward 4D nucleome data and model standards

scientific article published on 27 September 2018

Changes in the organization of the genome during the mammalian cell cycle

scientific article published on 24 December 2013

Chromosome structural proteins and RNA-mediated epigenetic silencing.

scientific article

Closing the loop: 3C versus DNA FISH

scientific article

Cohesin-based chromatin interactions enable regulated gene expression within preexisting architectural compartments

scientific article published on 03 September 2013

Combined immunofluorescence, RNA fluorescent in situ hybridization, and DNA fluorescent in situ hybridization to study chromatin changes, transcriptional activity, nuclear organization, and X-chromosome inactivation

scientific article published in January 2008

Contribution of epigenetic landscapes and transcription factors to X-chromosome reactivation in the inner cell mass

scientific article

Correction: RNAi-Dependent and Independent Control of LINE1 Accumulation and Mobility in Mouse Embryonic Stem Cells

scientific article published on 14 May 2015

Corrigendum: Landscape of monoallelic DNA accessibility in mouse embryonic stem cells and neural progenitor cells.

scientific article

Deep-sequencing protocols influence the results obtained in small-RNA sequencing

scientific article (publication date: 2012)

Delving into the diversity of facultative heterochromatin: the epigenetics of the inactive X chromosome

scientific article

Deterministic and stochastic allele specific gene expression in single mouse blastomeres

scientific article

Developmental dynamics and disease potential of random monoallelic gene expression

scientific article published on February 2014

Differential histone H3 Lys-9 and Lys-27 methylation profiles on the X chromosome

scientific article

Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes

scientific article published on 10 December 2001

Dosage compensation in mammals: fine-tuning the expression of the X chromosome

scientific article

Dynamic changes in paternal X-chromosome activity during imprinted X-chromosome inactivation in mice

scholarly article

Dynamic plasticity of large-scale chromatin structure revealed by self-assembly of engineered chromosome regions ⬇️

scientific article published on September 6, 2010

Effective normalization for copy number variation in Hi-C data

scientific article published on 06 September 2018

Effective normalization for copy number variation in Hi-C data

Efficient and versatile CRISPR engineering of human neurons in culture to model neurological disorders

scientific article

Epigenetic dynamics of imprinted X inactivation during early mouse development

scientific article

Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes

scientific journal article

Epigenetic mechanisms in development and disease

scientific article published on 14 January 2010

Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development.

scientific article

Evidence for de novo imprinted X-chromosome inactivation independent of meiotic inactivation in mice

scientific article published in Nature

Evolutionary diversity and developmental regulation of X-chromosome inactivation ⬇️

scientific article published on June 18, 2011

Fifty years of X-inactivation research.

scientific article published on December 2011

Foreword: Coping with sex chromosome imbalance

scientific article published on January 2009

Function of the Sex Chromosomes in Mammalian Fertility ⬇️

scientific article published on October 1, 2011

Gene regulation in time and space during X-chromosome inactivation

scientific article published on 10 January 2022

Genetic and epigenetic features direct differential efficiency of Xist-mediated silencing at X-chromosomal and autosomal locations

scientific article published on 25 September 2017

Genomes of Ellobius species provide insight into the evolutionary dynamics of mammalian sex chromosomes

scientific article published on 10 August 2016

Girafe--an R/Bioconductor package for functional exploration of aligned next-generation sequencing reads

scientific article published on 21 September 2010

H4K20me1 and H3K27me3 are concurrently loaded onto the inactive X chromosome but dispensable for inducing gene silencing

scientific article published on 19 February 2021

HiC-Pro: an optimized and flexible pipeline for Hi-C data processing

scientific article

HiTC: exploration of high-throughput 'C' experiments

scientific article published on 24 August 2012

High-resolution 3D DNA FISH using plasmid probes and computational correction of optical aberrations to study chromatin structure at the sub-megabase scale

scientific article published on January 2015

High-resolution analysis of epigenetic changes associated with X inactivation.

scientific article published on 06 July 2009

Highly dynamic and sex-specific expression of microRNAs during early ES cell differentiation

scientific article

Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts

scientific article published on 01 April 2005

In-cell identification and measurement of RNA-protein interactions

scientific article published on 22 November 2019

Initiation of X chromosome inactivation during early embryogenesis in mice and in humans

scientific article

Initiation of epigenetic reprogramming of the X chromosome in somatic nuclei transplanted to a mouse oocyte

scientific article

Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome

scientific article published on 01 January 2014

Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation.

scientific article

Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2.

scientific article

Kinetics of Xist-induced gene silencing can be predicted from combinations of epigenetic and genomic features

article

Kinetics of Xist-induced gene silencing can be predicted from combinations of epigenetic and genomic features

scientific article published on 07 June 2019

LINE-1 Activity in Facultative Heterochromatin Formation during X Chromosome Inactivation

scientific article published in July 2016

LINE-1 activity in facultative heterochromatin formation during X chromosome inactivation

scientific article published on June 2010

Landscape of monoallelic DNA accessibility in mouse embryonic stem cells and neural progenitor cells

scientific article published on 23 January 2017

Lessons from comparative analysis of X-chromosome inactivation in mammals

scientific article published on January 2009

Live Imaging of Xist RNA

scientific article published on 01 January 2018

Live-cell chromosome dynamics and outcome of X chromosome pairing events during ES cell differentiation

scientific article

Live-cell imaging combined with immunofluorescence, RNA, or DNA FISH to study the nuclear dynamics and expression of the X-inactivation center

scientific article published in January 2013

Locus specific epigenetic modalities of random allelic expression imbalance

scientific article published on 09 September 2021

Locus specific epigenetic modalities of random allelic expression imbalance

scientific article published on 4 March 2021

MOF-associated complexes ensure stem cell identity and Xist repression.

scientific article

Mapping of Chromosome Territories by 3D-Chromosome Painting During Early Mouse Development

scientific article published on 01 January 2021

Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation

scientific article

MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation

scientific article

Molecular Mechanisms of Facultative Heterochromatin Formation: An X-Chromosome Perspective

scientific article published on 07 April 2020

Molecular biologists: let’s reconnect with nature

scientific article published on 3 January 2022

Molecular insights into the pathways underlying naked mole-rat eusociality

Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development

scientific article published on 17 February 2009

Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin

scientific journal article

Naive and primed murine pluripotent stem cells have distinct miRNA expression profiles

scientific article published on 27 December 2011

Non-rigid registration of 3D multi-channel microscopy images of cell nuclei

scientific article published on 01 January 2006

Noncoding RNAs and epigenetic mechanisms during X-chromosome inactivation.

scientific article published on 27 June 2014

Novel players in X inactivation: insights into Xist-mediated gene silencing and chromosome conformation

scientific article published on March 2017

Nuclear Organization and Dosage Compensation ⬇️

scientific article published on October 13, 2010

Nuclear positioning and pairing of X-chromosome inactivation centers are not primary determinants during initiation of random X-inactivation

scientific article published on 14 January 2019

Ordered chromatin changes and human X chromosome reactivation by cell fusion-mediated pluripotent reprogramming

scientific article published on 10 August 2016

Parental-to-embryo switch of chromosome organization in early embryogenesis

scientific article published on 25 March 2020

PlantACT! – how to tackle the climate crisis

Predictive polymer modeling reveals coupled fluctuations in chromosome conformation and transcription

scientific article published on May 2014

Preface

scientific article published on 01 November 2017

Priorities for ocean microbiome research

scientific article published on 30 June 2022

RNA FISH to Study Zygotic Genome Activation in Early Mouse Embryos

scientific article published on January 2017

RNA polymerase II depletion from the inactive X chromosome territory is not mediated by physical compartmentalization

RNAi-dependent and independent control of LINE1 accumulation and mobility in mouse embryonic stem cells

scientific article

Random monoallelic expression of genes on autosomes: Parallels with X-chromosome inactivation.

scientific article published on 18 April 2016

Recent advances in X-chromosome inactivation

scientific article

Recent advances in X-chromosome inactivation research

scientific article

Regulation of X-chromosome inactivation by the X-inactivation centre.

scientific article

Relationship of XIST expression and responses of ovarian cancer to chemotherapy

scientific article published on August 2002

Retraction: RNAi-Dependent and Independent Control of LINE1 Accumulation and Mobility in Mouse Embryonic Stem Cells

article

Rnf12—A Jack of All Trades in X Inactivation? ⬇️

scientific article published on January 27, 2011

Role and control of X chromosome dosage in mammalian development ⬇️

scientific article published on 04 March 2013

Role of histone methyltransferase G9a in CpG methylation of the Prader-Willi syndrome imprinting center

scientific article

SPEN integrates transcriptional and epigenetic control of X-inactivation

scientific article published on 05 February 2020

Segmental folding of chromosomes: a basis for structural and regulatory chromosomal neighborhoods?

scientific article published on 05 July 2013

Small RNAs derived from structural non-coding RNAs

scientific article

Smchd1-dependent and -independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome.

scientific article

Structural Fluctuations of the Chromatin Fiber within Topologically Associating Domains

scientific article published on March 2016

Structural and functional diversity of Topologically Associating Domains

scientific article

Structural organization of the inactive X chromosome in the mouse.

scientific article

Systematic discovery of Xist RNA binding proteins

scientific article

Ten years of genetics and genomics: what have we achieved and where are we heading?

scientific article

The Ftx Noncoding Locus Controls X Chromosome Inactivation Independently of Its RNA Products

scientific article published on 01 May 2018

The Implication of Early Chromatin Changes in X Chromosome Inactivation

scientific article published on 27 December 2018

The X chromosome from telomere to telomere: key achievements and future opportunities

scientific article published in 2021

The bipartite TAD organization of the X-inactivation center ensures opposing developmental regulation of Tsix and Xist

scientific article published on 27 May 2019

The dynamics of epigenetic changes in a range of organisms

scientific article published in January 2013

The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA.

scientific article

The inactive X chromosome is epigenetically unstable and transcriptionally labile in breast cancer

scientific article

The ins and outs of gene regulation and chromosome territory organisation

scientific article published on 30 April 2007

The legacy of Mary F. Lyon (1925-2014)

scientific article published in June 2015

The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome

scientific article published in Nature Communications

The pluripotent genome in three dimensions is shaped around pluripotency factors

scientific article published on 24 July 2013

The role of Xist-mediated Polycomb recruitment in the initiation of X-chromosome inactivation

scientific article published on 27 August 2019

The two active X chromosomes in female ESCs block exit from the pluripotent state by modulating the ESC signaling network

scientific article

Topologically Associating Domains in Chromosome Architecture and Gene Regulatory Landscapes during Development, Disease, and Evolution

scientific article published on 01 January 2017

Transcriptional Analysis by Nascent RNA FISH of In Vivo Trophoblast Giant Cells or In Vitro Short-term Cultures of Ectoplacental Cone Explants

scientific article published on 31 August 2016

Transcriptome Profiling of Single Mouse Oocytes

scientific article published on 01 January 2018

Transgenerational epigenetic inheritance: myths and mechanisms

scientific article

Transient colocalization of X-inactivation centres accompanies the initiation of X inactivation

scientific article published on 24 January 2006

Unusual chromatin status and organization of the inactive X chromosome in murine trophoblast giant cells

scientific article published on 01 February 2013

Voices in methods development

scientific article published on 01 October 2019

X chromosome inactivation: new players in the initiation of gene silencing

scientific article published on 27 March 2017

X chromosome inactivation: when dosage counts

scientific journal article

X inactivation and the complexities of silencing a sex chromosome

scientific article

X inactive-specific transcript RNA coating and genetic instability of the X chromosome in BRCA1 breast tumors

scientific article

X-Chromosome Inactivation: A Crossroads Between Chromosome Architecture and Gene Regulation

scientific article published on 26 September 2018

X-chromosome inactivation in development and cancer.

scientific article

X-chromosome inactivation in mouse embryonic stem cells: analysis of histone modifications and transcriptional activity using immunofluorescence and FISH.

scientific article published on January 2004

X-chromosome inactivation: new insights into cis and trans regulation.

scientific article published on 21 May 2015

XACT Noncoding RNA Competes with XIST in the Control of X Chromosome Activity during Human Early Development.

scientific article published on December 2016

Xist RNA in action: Past, present, and future

scientific article published on 19 September 2019

Xist-dependent imprinted X inactivation and the early developmental consequences of its failure

scientific article published on 30 January 2017

[Cross talk between the Xics]

scientific article published on 01 November 2006

[Establishing transcriptional silencing of the X chromosome during early embryogenesis]

scientific article published on 13 October 2010

[France, a refuge for researchers in danger]

scientific article published on 01 August 2018

[Inactivation of X chromosome: cells know how to count two X chromosomes]

scientific article published on 01 June 2008

ncPRO-seq: a tool for annotation and profiling of ncRNAs in sRNA-seq data

scientific article

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