List of works - Andrea Ablasser

A carrier for cyclic dinucleotides

scientific article published on 01 November 2019

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

scientific article

An unexpected role for RNA in the recognition of DNA by the innate immune system

scientific article published on 28 March 2010

BAF restricts cGAS on nuclear DNA to prevent innate immune activation

scientific article published on 01 August 2020

COPA silences STING

scientific article published on 01 November 2020

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.

scientific article

DNA sensing unchained

scientific article published on 19 February 2013

Editorial overview 'Network news: Reporting from the frontlines of cell signaling'

scientific article published on 08 April 2020

Human cGAS Has a Slightly Different Taste for dsDNA

scientific article published on 01 August 2018

Induction of type I IFNs by intracellular DNA-sensing pathways

scientific article published on 27 March 2012

Inflammasome Activation and Function During Infection with Mycobacterium Tuberculosis

scientific article

Inflammasomes: current understanding and open questions

scientific article published on 31 October 2010

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence.

scientific article published on 31 July 2017

Innate immunosensing of DNA in cellular senescence

article

Inside Job: Viruses Transfer cGAMP between Cells

scientific article published on September 2015

Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signalling

scientific article published on 25 February 2019

Latest advances in aging research and drug discovery

scientific article published on 21 November 2019

Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome

scientific article published on June 2010

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1.

scientific article published on 2 June 2015

Nucleic acid driven sterile inflammation

scientific article published on 19 January 2013

OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids

scientific article published on 18 July 2014

Phase separation focuses DNA sensing

scientific article published on 01 August 2018

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

scientific article

ReGLUation of cGAS.

scientific article published on March 2016

Regulation of cGAS- and RLR-mediated immunity to nucleic acids

scientific article published on 09 December 2019

Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytes.

scientific article

Self-priming determines high type I IFN production by plasmacytoid dendritic cells

scientific article published on 16 January 2014

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

scientific article

Signalling strength determines proapoptotic functions of STING.

scientific article

Species-specific detection of the antiviral small-molecule compound CMA by STING

scientific article

Structural mechanism of cGAS inhibition by the nucleosome

scientific article published on 10 September 2020

Structural mechanism of cytosolic DNA sensing by cGAS

scientific article

Structures of STING protein illuminate this key regulator of inflammation

scientific article published on 01 March 2019

T cell-independent, TLR-induced IL-12p70 production in primary human monocytes

scientific article published on June 2006

TLR8-driven IL-12-dependent reciprocal and synergistic activation of NK cells and monocytes by immunostimulatory RNA.

scientific article

TREX1 deficiency triggers cell-autonomous immunity in a cGAS-dependent manner.

scientific article published on 9 May 2014

Targeting STING with covalent small-molecule inhibitors

scientific article published in Nature

The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation

scientific article published in 2024

The cGAS-STING pathway drives type I IFN immunopathology in COVID-19

scientific article published on 19 January 2022

The role of cGAS in innate immunity and beyond

scientific article published on 6 May 2016

Virology: Poxins Soothe the STING

scientific article published on 01 May 2019

Where, in antiviral defense, does IFIT1 fit?

scientific article published on 20 June 2011

cGAS in action: Expanding roles in immunity and inflammation

scientific article

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.

scientific article

List of works by Andrea Ablasser

A carrier for cyclic dinucleotides

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

An unexpected role for RNA in the recognition of DNA by the innate immune system

BAF restricts cGAS on nuclear DNA to prevent innate immune activation

COPA silences STING

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.

DNA sensing unchained

Editorial overview 'Network news: Reporting from the frontlines of cell signaling'

Human cGAS Has a Slightly Different Taste for dsDNA

Induction of type I IFNs by intracellular DNA-sensing pathways

Inflammasome Activation and Function During Infection with Mycobacterium Tuberculosis

Inflammasomes: current understanding and open questions

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence.

Innate immunosensing of DNA in cellular senescence

Inside Job: Viruses Transfer cGAMP between Cells

Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signalling

Latest advances in aging research and drug discovery

Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1.

Nucleic acid driven sterile inflammation

OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids

Phase separation focuses DNA sensing

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

ReGLUation of cGAS.

Regulation of cGAS- and RLR-mediated immunity to nucleic acids

Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytes.

Self-priming determines high type I IFN production by plasmacytoid dendritic cells

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

Signalling strength determines proapoptotic functions of STING.

Species-specific detection of the antiviral small-molecule compound CMA by STING

Structural mechanism of cGAS inhibition by the nucleosome

Structural mechanism of cytosolic DNA sensing by cGAS

Structures of STING protein illuminate this key regulator of inflammation

T cell-independent, TLR-induced IL-12p70 production in primary human monocytes

TLR8-driven IL-12-dependent reciprocal and synergistic activation of NK cells and monocytes by immunostimulatory RNA.

TREX1 deficiency triggers cell-autonomous immunity in a cGAS-dependent manner.

Targeting STING with covalent small-molecule inhibitors

The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation

The cGAS-STING pathway drives type I IFN immunopathology in COVID-19

The role of cGAS in innate immunity and beyond

Virology: Poxins Soothe the STING

Where, in antiviral defense, does IFIT1 fit?

cGAS in action: Expanding roles in immunity and inflammation

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.

cGAS–STING drives ageing-related inflammation and neurodegeneration