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List of works by Gillian Griffiths

A new direction for Traffic

scientific article published on 01 December 2020

A role for Rab7 in the movement of secretory granules in cytotoxic T lymphocytes

scientific article published on 21 April 2011

A single amino acid change, A91V, leads to conformational changes that can impair processing to the active form of perforin

scientific article published on 01 March 2005

Actin depletion initiates events leading to granule secretion at the immunological synapse

scientific article published on May 2015

Activated CD4+ and CD8+ cytotoxic cells are present in increased numbers in the intestinal mucosa from patients with active inflammatory bowel disease

scientific article published on January 1998

Adaptor protein 3-dependent microtubule-mediated movement of lytic granules to the immunological synapse

scientific article

Albinism and immunity: what's the link?

scientific article

An early history of T cell-mediated cytotoxicity.

scientific article published on 16 April 2018

Analysis of natural killer-cell function in familial hemophagocytic lymphohistiocytosis (FHL): defective CD107a surface expression heralds Munc13-4 defect and discriminates between genetic subtypes of the disease

scientific article (publication date: October 2006)

Analysis of the lysosomal storage disease Chediak-Higashi syndrome

scientific article

Anti-oxazolone hybridomas and the structure of the oxazolone idiotype.

scientific article published in February 1983

Arming a killer: mitochondrial regulation of CD8+ T cell cytotoxicity

scientific article published in 2022

Atypical familial hemophagocytic lymphohistiocytosis due to mutations in UNC13D and STXBP2 overlaps with primary immunodeficiency diseases

scientific article

CTL secretory lysosomes: biogenesis and secretion of a harmful organelle

scientific article

Ca2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor

scientific article

Cell polarisation and the immunological synapse

scientific article

Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems

scientific article

Centrosome docking at the immunological synapse is controlled by Lck signaling

scientific article

Centrosome polarization delivers secretory granules to the immunological synapse

scientific article published in September 2006

Communication, the centrosome and the immunological synapse

scientific article

Cortical actin recovery at the immunological synapse leads to termination of lytic granule secretion in cytotoxic T lymphocytes

scientific article published on 17 July 2017

Cytotoxic T lymphocyte effector function is independent of nucleus-centrosome dissociation

scientific article published on August 2012

Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells

scientific article published on January 1999

Delivering the kiss of death

scientific article

Diagnosing XLP1 in patients with hemophagocytic lymphohistiocytosis

scientific article published on 27 June 2014

Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL

scientific article published on 04 March 2014

Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy

scientific article published on 20 January 2020

Endocytosing the death sentence

scientific article

Enhanced interaction of HLA-DM with HLA-DR in enlarged vacuoles of hereditary and infectious lysosomal diseases.

scientific article published on January 1999

Erratum: Centrosome polarization delivers secretory granules to the immunological synapse

scientific article published in Nature

Expression of perforin and granzymes in vivo: potential diagnostic markers for activated cytotoxic cells

scientific article published on November 1991

Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11

scientific article

Familial hemophagocytic lymphohistiocytosis: a model for understanding the human machinery of cellular cytotoxicity

scientific article published on 12 October 2011

Familial hemophagocytic lymphohistiocytosis: when rare diseases shed light on immune system functioning

scientific article published on 16 April 2014

Fas Ligand localizes to intraluminal vesicles within NK cell cytolytic granules and is enriched at the immune synapse.

scientific article published on 11 April 2018

Fas ligand is targeted to secretory lysosomes via a proline-rich domain in its cytoplasmic tail.

scientific article

Fratricide among CD8(+) T lymphocytes naturally infected with human T cell lymphotropic virus type I.

scientific article

Gaucher Disease: Forging a New Path to the Lysosome

scientific article published on 01 November 2007

Genetic predisposition to hemophagocytic lymphohistiocytosis: Report on 500 patients from the Italian registry

scientific article

Genotype-phenotype study of familial haemophagocytic lymphohistiocytosis type 3

scientific article

Gillian Griffiths: how T cells get on target. Interview by Caitlin Sedwick

scientific article published on January 2013

Granzyme A and perforin as markers for rejection in cardiac transplantation

article

Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor

scientific article published on February 1993

Griscelli Syndrome Type 2 Sine Albinism: Unraveling Differential RAB27A Effector Engagement

scientific article published on 10 December 2020

Hedgehog signaling controls T cell killing at the immunological synapse

scientific article

High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation

scientific article published on 16 December 2019

Imaging the Effector CD8 Synapse

scientific article published in January 2017

Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8+ CTLs

scientific article published on 17 February 2017

Innate immunity defects in Hermansky-Pudlak type 2 syndrome

scientific article published on 28 February 2006

L is for lytic granules: lysosomes that kill

scientific article published on February 1998

Light chain germ-line genes and the immune response to 2-phenyloxazolone.

scientific article

Linking albinism and immunity: the secrets of secretory lysosomes

scientific article published in July 2004

Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity

scientific article published on 01 December 2019

Loss of cytotoxic T lymphocyte function in Chediak-Higashi syndrome arises from a secretory defect that prevents lytic granule exocytosis

scientific article

Lytic granules, secretory lysosomes and disease

scientific article published on October 2003

Methods for detecting lytic granules in natural killer cells

scientific article

Microtubule-dependent transport of secretory vesicles in RBL-2H3 cells

scientific article published in May 2003

Molecular basis of familial hemophagocytic lymphohistiocytosis

scientific article published on April 2010

Molecular events during maturation of the immune response to oxazolone

scientific article published in Nature

Mother Centriole Distal Appendages Mediate Centrosome Docking at the Immunological Synapse and Reveal Mechanistic Parallels with Ciliogenesis

scientific article published on 5 December 2015

Munc18-2 is required for Syntaxin 11 Localization on the Plasma Membrane in Cytotoxic T-Lymphocytes

scientific article published on 2 November 2015

Mutations affecting mRNA splicing are the most common molecular defect in patients with familial hemophagocytic lymphohistiocytosis type 3

scientific article

Mutations in AP3D1 associated with immunodeficiency and seizures define a new type of Hermansky-Pudlak syndrome

scientific article published on 7 January 2016

Normal and abnormal secretion by haemopoietic cells

scientific article

Normal lytic granule secretion by cytotoxic T lymphocytes deficient in BLOC-1, -2 and -3 and myosins Va, VIIa and XV.

scientific article published in March 2005

Novel Munc13-4 mutations in children and young adult patients with haemophagocytic lymphohistiocytosis

scientific article

Open questions: missing pieces from the immunological jigsaw puzzle ⬇️

scientific article published on January 31, 2013

Origins of the cytolytic synapse

scientific article published on 6 June 2016

PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes

article

Patients with Griscelli syndrome and normal pigmentation identify RAB27A mutations that selectively disrupt MUNC13-4 binding

scientific article published on 11 October 2014

Perforin and granzyme A expression identifying cytolytic lymphocytes in rheumatoid arthritis

scientific article published on January 1992

Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain.

scientific article published in December 1997

Phospholipids: Pulling Back the Actin Curtain for Granule Delivery to the Immune Synapse

Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis

scientific article

Protein sorting and secretion during CTL killing

scientific article published on April 1997

Rab27a is required for regulated secretion in cytotoxic T lymphocytes

scientific article published on February 2001

Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency

scientific article

Regulated secretion from hemopoietic cells

scientific article

Regulating secretory lysosomes

scientific article published on July 2006

STXBP2 mutations in children with familial haemophagocytic lymphohistiocytosis type 5

scientific article

Secretion from Myeloid Cells: Secretory Lysosomes

scientific article

Secretory Lysosome Biogenesis in Cytotoxic T Lymphocytes from Normal and Chediak Higashi Syndrome Patients

scientific article published on 01 May 2000

Secretory lysosomes

scientific article

Secretory lysosomes - a special mechanism of regulated secretion in haemopoietic cells

scientific article published in September 1996

Secretory mechanisms in cell-mediated cytotoxicity

scientific article published on January 2007

Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re-filling of the lytic granules and secretion of lytic proteins via a non-granule pathway

scientific article published on April 1995

Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse

scientific article

Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

scientific article published in Nature

Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation

scientific article published on 12 December 2006

Sorting out the multiple roles of Fas ligand

scientific article

Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton

scientific article

Stimulation strength controls the rate of initiation but not the molecular organization of TCR-induced signalling

scientific article published on 15 May 2020

Structural and kinetic basis for heightened immunogenicity of T cell vaccines

scientific article

Structure and biogenesis of lytic granules.

scientific article published on January 1995

Syntaxin 11 is required for NK and CD8⁺ T-cell cytotoxicity and neutrophil degranulation

scientific journal article

Syntaxin binding mechanism and disease-causing mutations in Munc18-2

scientific article

T cell cytolytic capacity is independent of initial stimulation strength

scholarly article by Arianne C Richard et al published 16 July 2018 in Nature Immunology

The Influence of External Focus Instruction Characteristics on Children’s Motor Performance

scientific article published on 26 September 2018

The biogenesis of lysosomes and lysosome-related organelles

scientific article published on 02 September 2014

The cell biology of CTL killing

scientific article published on June 1995

The cytotoxic T lymphocyte immune synapse at a glance

scientific article

The immunological synapse of CTL contains a secretory domain and membrane bridges

scientific article published in November 2001

The immunological synapse: a focal point for endocytosis and exocytosis

scientific article published on May 2010

The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes

scientific journal article

The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation

scientific article published on 7 May 2007

The risk of hemophagocytic lymphohistiocytosis in Hermansky-Pudlak syndrome type 2

scientific article published on 12 February 2013

The role of the cytoskeleton at the immunological synapse

scientific article

The role of the secretory immunological synapse in killing by CD8+ CTL.

scientific article published on December 2003

The secretory synapse: the secrets of a serial killer

scientific article

The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse

scientific article published on October 2009

The synapse and cytolytic machinery of cytotoxic T cells

scientific article

The use of granzyme A as a marker of heart transplant rejection in cyclosporine or anti-CD4 monoclonal antibody-treated rats.

scientific article published in January 1993

Two patients with Hermansky Pudlak syndrome type 2 and novel mutations in AP3B1.

scientific article

What's special about secretory lysosomes?

scientific article

mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification

scientific article published in July 1983

mRNA sequences define an unusually restricted IgG response to oxazolone

scientific article published on 01 January 1984

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