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List of works by Hans Westerhoff

'Slave' metabolites and enzymes. A rapid way of delineating metabolic control

scientific article

(Im)Perfect robustness and adaptation of metabolic networks subject to metabolic and gene-expression regulation: marrying control engineering with metabolic control analysis

scientific article

A Systems Biology Approach to Deciphering the Etiology of Steatosis Employing Patient-Derived Dermal Fibroblasts and iPS Cells

scientific article

A community-driven global reconstruction of human metabolism. ⬇️

scientific article

A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology

scientific article

A domino effect in drug action: from metabolic assault towards parasite differentiation

scientific article published on 5 November 2010

A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations

scientific article (publication date: 2001)

A mathematical modelling approach to assessing the reliability of biomarkers of glutathione metabolism

scientific article published on 24 August 2011

A metabolic core model elucidates how enhanced utilization of glucose and glutamine, with enhanced glutamine-dependent lactate production, promotes cancer cell growth: The WarburQ effect

scientific article published on 28 September 2017

A method for studying plasma membrane transport with intact cells using computerized fluorometry

scientific article published in October 1998

A minimal hypothesis for membrane-linked free-energy transduction. The role of independent, small coupling units

scientific article

A model for fluid secretion in the exocrine pancreas

scientific article published in August 1989

A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes

scientific article published on 04 July 2013

A new regulatory principle for in vivo biochemistry: pleiotropic low affinity regulation by the adenine nucleotides--illustrated for the glycolytic enzymes of Saccharomyces cerevisiae

scientific article published on 12 July 2013

A plasma membrane 'vacuum cleaner' for daunorubicin in non-P-glycoprotein multidrug-resistant SW-1573 human non-small cell lung carcinoma cells. A study using fluorescence resonance energy transfer

scientific article published on December 1993

A probabilistic approach to identify putative drug targets in biochemical networks

scientific article published on December 2010

A reason for intermittent fasting to suppress the awakening of dormant breast tumors.

scientific article published on 4 November 2014

A turbo engine with automatic transmission? How to marry chemicomotion to the subtleties and robustness of life

scientific article

A wave of reactive oxygen species (ROS)-induced ROS release in a sea of excitable mitochondria

scientific article published on September 2006

Absorption Spectroscopy

scientific article published on 01 January 2011

Acetaldehyde Mediates the Synchronization of Sustained Glycolytic Oscillations in Populations of Yeast Cells

scientific article published on 01 January 1996

Advice from a systems-biology model of the Corona epidemics

scientific article published on 30 March 2020

Advice from a systems-biology model of the corona epidemics

scientific article published on 12 June 2020

Ample Arsenite Bio-Oxidation Activity in Bangladesh Drinking Water Wells: A Bonanza for Bioremediation?

scientific article published on 08 August 2019

AmtB-mediated NH3 transport in prokaryotes must be active and as a consequence regulation of transport by GlnK is mandatory to limit futile cycling of NH4(+)/NH3.

scientific article

An additional PII in Escherichia coli: a new regulatory protein in the glutamine synthetase cascade

scientific article published in October 1995

An alternative PII protein in the regulation of glutamine synthetase in Escherichia coli

scientific article published in July 1996

An in vivo control map for the eukaryotic mRNA translation machinery

scientific article published on January 2013

Analyses of dose-response curves to compare the antimicrobial activity of model cationic alpha-helical peptides highlights the necessity for a minimum of two activity parameters

scientific article published on 15 December 2005

Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport

article

Approaches to biosimulation of cellular processes

scientific article published on October 2006

Around the growth phase transition S. cerevisiae's make-up favours sustained oscillations of intracellular metabolites

scientific article published on 01 February 1993

Arsenic Contamination of Groundwater Is Determined by Complex Interactions between Various Chemical and Biological Processes

scientific article published on 19 January 2024

Attractive models: how to make the silicon cell relevant and dynamic

scientific article published on January 2003

Autoamplification of a two-component regulatory system results in "learning" behavior

scientific article published on August 2001

BDI-modelling of complex intracellular dynamics

scientific article

Bacteriorhodopsin in liposomes. I. A description using irreversible thermodynamics

scientific article published in September 1979

Bacteriorhodopsin in liposomes. II. Experimental evidence in support of a theoretical model

scientific article published in September 1979

Branched-chain alpha-keto acid catabolism via the gene products of the bkd operon in Enterococcus faecalis: a new, secreted metabolite serving as a temporary redox sink

scientific article

Building the cellular puzzle: control in multi-level reaction networks

scientific article

CONTROL THEORY OF CELL METABOLISM: TOWARDS MORE REALISTIC “NON-IDEAL” SYSTEMS

Calcium indirectly increases the control exerted by the adenine nucleotide translocator over 2-oxoglutarate oxidation in rat heart mitochondria.

scientific article published in December 1995

Can free energy be transduced from electric noise?

scientific article

Can yeast glycolysis be understood in terms of in vitro kinetics of the constituent enzymes? Testing biochemistry

scientific article published on 01 September 2000

Cancer: a Systems Biology disease

scientific article

Cellular information transfer regarded from a stoichiometry and control analysis perspective

scientific article

Changes in the Cellular Energy State Affect the Activity of the Bacterial Phosphotransferase System

scientific article published on 01 January 1996

Channelling can decrease pool size

scientific article published in February 1992

Clusters of reaction rates and concentrations in protein networks such as the phosphotransferase system

scientific article published on 23 December 2013

Co-operativity and enzymatic activity in polymer-activated enzymes

scientific article published on 01 July 1986

Comparative systems biology: from bacteria to man ⬇️

scientific article published on September 1, 2010

Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomes

scholarly article

Compartmentation protects trypanosomes from the dangerous design of glycolysis

scholarly article

Complex Stability and an Irrevertible Transition Reverted by Peptide and Fibroblasts in a Dynamic Model of Innate Immunity

scientific article published on 01 January 2019

Composite control of cell function: metabolic pathways behaving as single control units

scientific article published on 01 July 1995

Computing life: Add logos to biology and bios to physics

scientific article published on 24 October 2012

Contribution of glucose transport to the control of the glycolytic flux in Trypanosoma brucei

scientific article published on August 1999

Control analysis for autonomously oscillating biochemical networks

scientific article

Control analysis of glycolytic oscillations

scientific article published in November 1996

Control analysis of metabolic systems

article

Control analysis of metabolic systems involving quasi-equilibrium reactions

scientific article published on March 1998

Control analysis of the dependence of Escherichia coli physiology on the H(+)-ATPase

scientific article published on September 1993

Control and regulation of gene expression: quantitative analysis of the expression of phosphoglycerate kinase in bloodstream form Trypanosoma brucei

scientific article published on 8 November 2007

Control by Enzymes, Coenzymes and Conserved Moieties. A Generalisation of the Connectivity Theorem of Metabolic Control Analysis

article

Control in channelled pathways. A matrix method calculating the enzyme control coefficients

scientific article published in February 1995

Control involving metabolism and gene expression: the square-matrix method for modular decomposition

scientific article published in June 1993

Control of MAPK signalling: from complexity to what really matters

Control of frequency and amplitudes is shared by all enzymes in three models for yeast glycolytic oscillations

scientific article published on 01 July 1996

Control of glycolytic dynamics by hexose transport in Saccharomyces cerevisiae

scientific article

Control of glycolytic flux in Zymomonas mobilis by glucose 6-phosphate dehydrogenase activity

scientific article published in July 1996

Control of spatially heterogeneous and time-varying cellular reaction networks: a new summation law

scientific article published on 01 December 2003

Control theory of metabolic channelling.

scientific article published in February 1995

Control theory of metabolic channelling.

scientific article published on April 1994

Control theory of one enzyme

scientific article published in October 1994

Control theory of regulatory cascades

scientific article published in November 1991

Control, regulation and thermodynamics of free-energy transduction

scientific article published on August 1989

Control, responses and modularity of cellular regulatory networks: a control analysis perspective

scientific article

Cooperative P-glycoprotein mediated daunorubicin transport into DNA-loaded plasma membrane vesicles

scientific article published on 01 June 1994

Coordinated behavior of mitochondria in both space and time: a reactive oxygen species-activated wave of mitochondrial depolarization

scientific article

Coupling of vectorial proton flow to a biochemical reaction by local electric interactions

scientific article

Crystallization and preliminary X-ray analysis of Escherichia coli GlnK

article

Cytochromes c(550), c(552), and c(1) in the electron transport network of Paracoccus denitrificans: redundant or subtly different in function?

scientific article published on December 2001

Cytosolic triglycerides and oxidative stress in central obesity: the missing link between excessive atherosclerosis, endothelial dysfunction, and beta-cell failure?

scientific article

DNA supercoiling by gyrase is linked to nucleoid compaction.

scientific article

DNA supercoiling depends on the phosphorylation potential in Escherichia coli.

scientific article

DNA supercoiling in Escherichia coli is under tight and subtle homeostatic control, involving gene-expression and metabolic regulation of both topoisomerase I and DNA gyrase.

scientific article

Defining control coefficients in non-ideal metabolic pathways

article

Demonstration of coupling between the protonmotive force across bacteriorhodopsin and the flow through its photochemical cycle

scientific article published on August 1978

Design principles of nuclear receptor signaling: how complex networking improves signal transduction.

scientific article

Determining and understanding the control of flux. An illustration in submitochondrial particles of how to validate schemes of metabolic control

scientific article published on 01 September 1999

Development and evaluation of a harmonized whole body physiologically based pharmacokinetic (PBPK) model for flutamide in rats and its extrapolation to humans

scientific article published on 26 November 2019

Dramatic changes in control properties that accompany channelling and metabolite sequestration.

scientific article published in December 1993

Dupuytren's disease metabolite analyses reveals alterations following initial short-term fibroblast culturing

scientific article published on 6 July 2012

Dupuytren's: a systems biology disease

scientific article published on 12 September 2011

ECA: control in ecosystems

scientific article published in January 2002

Ecological control analysis: being(s) in control of mass flux and metabolite concentrations in anaerobic degradation processes

scientific article published on February 2007

Effects of cadmium and mercury on the upper part of skeletal muscle glycolysis in mice

scientific article (publication date: 2014)

Effects of oscillations and energy-driven fluctuations on the dynamics of enzyme catalysis and free-energy transduction

article

Effects of sequestration on signal transduction cascades

scientific article published in March 2006

Electric potentiation, cooperativity, and synergism of magainin peptides in protein-free liposomes

scientific article published on 01 May 1993

Elusive control

scientific article published on October 1995

Emergence of the silicon human and network targeting drugs

article

Energetics and control aspects of channelling

scientific article published in September 1991

Energetics of microbial growth: an analysis of the relationship between growth and its mechanistic basis by mosaic non-equilibrium thermodynamics

article

Energization-induced redistribution of charge carriers near membranes

scientific article published in June 1988

Engineering a living cell to desired metabolite concentrations and fluxes: pathways with multifunctional enzymes

scientific article published in January 2000

Engineering of self-sustaining systems: substituting the yeast glucose transporter plus hexokinase for the Lactococcus lactis phosphotransferase system in a Lactococcus lactis network in silico.

scientific article

Enzyme kinetics for systems biology when, why and how.

scientific article published in January 2011

Epidermal growth factor receptor-induced activator protein 1 activity controls density-dependent growth inhibition in normal rat kidney fibroblasts

scientific article published in October 2006

Evaluating limited specificity of drug pumps reduced relative resistance in human MDR phenotypes

scientific article published on September 2000

Experimental determination of control by the H(+)-ATPase in Escherichia coli.

scientific article

Expression of nitrite reductase in Nitrosomonas europaea involves NsrR, a novel nitrite-sensitive transcription repressor.

scientific article published in October 2004

Extensive regulation compromises the extent to which DNA gyrase controls DNA supercoiling and growth rate of Escherichia coli

scientific article published on 01 December 1999

Flux control of the bacterial phosphoenolpyruvate:glucose phosphotransferase system and the effect of diffusion

scientific article published in January 2002

FnrP and NNR of Paracoccus denitrificans are both members of the FNR family of transcriptional activators but have distinct roles in respiratory adaptation in response to oxygen limitation

article

Frequency-dependent incidence in models of sexually transmitted diseases: portrayal of pair-based transmission and effects of illness on contact behaviour.

scientific article published in March 2004

Functional Synergism of the Magainins PGLa and Magainin-2 in Escherichia coli, Tumor Cells and Liposomes

scientific article published on 01 March 1995

Functioning of oxidative phosphorylation in liver mitochondria of high-fat diet fed rats.

scientific article published on 10 November 2006

GLNK, A SIGNAL PROTEIN FROM E. COLI

scholarly article

GLNK, A SIGNAL PROTEIN FROM E. COLI

Gear Shifting in Biological Energy Transduction

scientific article published on 28 June 2023

Geobacteraceae community composition is related to hydrochemistry and biodegradation in an iron-reducing aquifer polluted by a neighboring landfill

scientific article

Getting to the inside of cells using metabolic control analysis

article

GlnK, a PII-homologue: structure reveals ATP binding site and indicates how the T-loops may be involved in molecular recognition ⬇️

scientific article published on September 11, 1998

Glucose and the ATP paradox in yeast

scientific article published on December 2000

Glutathione metabolism modeling: a mechanism for liver drug-robustness and a new biomarker strategy

scientific article published on 30 April 2013

HIERARCHIES IN CONTROL

article published in 1995

HPLC-MS/MS methods for the quantitative analysis of 5-oxoproline (pyroglutamate) in rat plasma and hepatic cell line culture medium

scientific article published on 13 June 2011

HPLC-MS/MS methods for the quantitative analysis of ophthalmic acid in rodent plasma and hepatic cell line culture medium

scientific article published on 2 December 2010

Health technology assessment in the era of personalized health care

scientific article published on 30 March 2011

Henrik Kacser, 1918-1995.

scientific article published in August 1995

Hierarchical and metabolic regulation of glucose influx in starved Saccharomyces cerevisiae.

scientific article

How Geobacteraceae may dominate subsurface biodegradation: physiology of Geobacter metallireducens in slow-growth habitat-simulating retentostats.

scientific article published on 22 July 2009

How do enzyme activities control metabolite concentrations? An additional theorem in the theory of metabolic control

scientific article published in July 1984

How enzymes can capture and transmit free energy from an oscillating electric field

scientific article published on July 1986

How molecular competition influences fluxes in gene expression networks

scientific article

How to distinguish between the vacuum cleaner and flippase mechanisms of the lmrA multi-drug transporter in Lactococcus lactis

scientific article

How to recognize monofunctional units in a metabolic system

scientific article published in April 1996

How yeast cells synchronize their glycolytic oscillations: a perturbation analytic treatment.

scientific article

Identification of Three Early Phases of Cell-Fate Determination during Osteogenic and Adipogenic Differentiation by Transcription Factor Dynamics

scientific article published on 16 March 2017

Implications of macromolecular crowding for signal transduction and metabolite channeling

scientific article published on September 1998

In vitro transepithelial drug transport by on-line measurement: cellular control of paracellular and transcellular transport

scientific article

Increased glucose metabolism and ATP level in brain tissue of Huntington's disease transgenic mice

scientific article published on 21 August 2008

Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains

scientific article published in Nature Communications

Integrating systems approaches into pharmaceutical sciences

scientific article published on 14 June 2008

Integration of single-cell RNA-seq data into population models to characterize cancer metabolism

scientific article published on 28 February 2019

Inter-level relations in computer science, biology, and psychology

scholarly article by Fred Boogerd et al published December 2002 in Philosophical Psychology

Interactions between a new class of eukaryotic antimicrobial agents and isolated rat liver mitochondria

scientific article published on 01 August 1989

Intermediate instability at high temperature leads to low pathway efficiency for an in vitro reconstituted system of gluconeogenesis in Sulfolobus solfataricus

scientific article published on 22 August 2013

Internal regulation of a modular system: the different faces of internal control

scientific article published on 01 January 1997

Is there an optimal ribosome concentration for maximal protein production?

scientific article published in September 2006

Kinetics of daunorubicin transport by P-glycoprotein of intact cancer cells

scientific article published on July 1992

Kinetics of histone gene expression during early development of Xenopus laevis

scientific article published on 01 November 1988

Limits to inducer exclusion: inhibition of the bacterial phosphotransferase system by glycerol kinase

scientific article published in July 1998

Linear relations between proton current and pH gradient in bacteriorhodopsin liposomes.

scientific article published in September 1981

Loss of fermentative capacity in baker's yeast can partly be explained by reduced glucose uptake capacity

scientific article published in January 2002

MUFINS: multi-formalism interaction network simulator. ⬇️

scientific article

Macromolecular intelligence in microorganisms

scientific article

Macromolecular networks and intelligence in microorganisms

scientific article published in 2014

Magainin 2 amide and analogues Antimicrobial activity, membrane depolarization and susceptibility to proteolysis

article

Magainin Oligomers Reversibly Dissipate .DELTA..mu.H+ in Cytochrome Oxidase Liposomes

scientific article published on 01 April 1994

Magainins affect respiratory control, membrane potential and motility of hamster spermatozoa

scientific article published on November 1991

Magainins and the disruption of membrane-linked free-energy transduction

scientific article

Mathematical and theoretical biology for systems biology, and then ... vice versa

scientific article published in January 2007

Mathematical modelling of miRNA mediated BCR.ABL protein regulation in chronic myeloid leukaemia vis-a-vis therapeutic strategies

scientific article published in March 2013

Matrix method for determining steps most rate-limiting to metabolic fluxes in biotechnological processes

scientific article published in July 1987

Measuring enzyme activities under standardized in vivo-like conditions for systems biology

scientific article published on 7 January 2010

Mechanisms for the interaction between nonstationary electric fields and biological systems I. Linear dielectric theory and its limitations

article

Mechanisms for the interaction between nonstationary electric fields and biological systems II. Nonlinear dielectric theory and free-energy transduction

article

Metabolic channelling and control of the flux

scientific article published on 01 March 1993

Metabolic control analysis indicates a change of strategy in the treatment of cancer

scientific article published on 25 June 2010

Metabolic control analysis of glycolysis in trypanosomes as an approach to improve selectivity and effectiveness of drugs.

scientific article

Metabolic control and compartmentation in single living cells

scientific article published in April 1983

Metabolic control in integrated biochemical systems

scientific article

Metabolic control of mitochondrial properties by adenine nucleotide translocator determines palmitoyl-CoA effects. Implications for a mechanism linking obesity and type 2 diabetes.

scientific article published on 24 October 2006

Metabolic design: How to engineer a living cell to desired metabolite concentrations and fluxes

scientific article published on 01 July 1998

Metabolic engineering of lactic acid bacteria, the combined approach: kinetic modelling, metabolic control and experimental analysis.

scientific article

Metabolic flexibility of a prospective bioremediator: Desulfitobacterium hafniense Y51 challenged in chemostats

scientific article published on 01 July 2018

Metabolite profiling of CHO cells: Molecular reflections of bioprocessing effectiveness

scientific article published on 14 July 2015

Metabolite profiling of recombinant CHO cells: designing tailored feeding regimes that enhance recombinant antibody production

scientific article published on 10 August 2011

Mixed and diverse metabolic and gene-expression regulation of the glycolytic and fermentative pathways in response to a HXK2 deletion in Saccharomyces cerevisiae.

scientific article

Modern theories of metabolic control and their applications

scientific article

Modular Kinetic Analysis of the Adenine Nucleotide Translocator-Mediated Effects of Palmitoyl-CoA on the Oxidative Phosphorylation in Isolated Rat Liver Mitochondria

article

Modular analysis of the control of complex metabolic pathways

scientific article published in November 1993

Modular control analysis of slipping enzymes

scientific article published on 01 January 1999

Modular response analysis of cellular regulatory networks.

scientific article

Molecular Control Analysis: Control within Proteins and Molecular Processes

article

Molecular assessment of bacterial vaginosis by Lactobacillus abundance and species diversity

scientific article

Monte-Carlo modeling of the central carbon metabolism of Lactococcus lactis: insights into metabolic regulation

scientific article

Mosaic nonequilibrium thermodynamics describes biological energy transduction

scientific article

Mosaic protonic coupling hypothesis for free energy transduction.

scientific article published on January 1984

Movement of fatty acids, fatty acid analogues, and bile acids across phospholipid bilayers

scientific article published in October 1993

Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes

scientific article

Multichannel analysis of intracellular control and intercellular transfer of molecules

scientific article published in July 1980

Multiplex Eukaryotic Transcription (In)activation: Timing, Bursting and Cycling of a Ratchet Clock Mechanism

scientific article published on 24 April 2015

Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione-depletion biomarkers ophthalmic acid and 5-oxoproline in humans and rats

scientific article

Network-based pharmacology through systems biology

scientific article published on 17 July 2015

Network-based selectivity of antiparasitic inhibitors

scientific article published on 01 January 2002

News

scientific article published on 01 June 2005

Nitrite and nitric oxide reduction in Paracoccus denitrificans is under the control of NNR, a regulatory protein that belongs to the FNR family of transcriptional activators

article

Nitrite reductase of Nitrosomonas europaea is not essential for production of gaseous nitrogen oxides and confers tolerance to nitrite

scientific article published on May 2002

Nitrogen assimilation in Escherichia coli: putting molecular data into a systems perspective

scientific article

Nitrosomonas europaea expresses a nitric oxide reductase during nitrification.

scientific article

Noise management by molecular networks

scientific article

Non-equilibrium thermodynamics of light absorption

article by Géza Meszéna & Hans Westerhoff published 1 January 1999 in Journal of Physics A

Novel nirK cluster genes in Nitrosomonas europaea are required for NirK-dependent tolerance to nitrite.

scientific article published on October 2005

On paradoxes between optimal growth, metabolic control analysis, and flux balance analysis

scientific article published in November 2023

On the evaluation of data from flow-dialysis experiments

scientific article

On the expected relationship between Gibbs energy of ATP hydrolysis and muscle performance

scientific article published in April 1995

On the origin of the limited control of mitochondrial respiration by the adenine nucleotide translocator

scientific article published on 01 August 1987

Oncogenes Are to Lose Control on Signaling Following Mutation: Should We Aim Off Target?

scientific article published on 01 October 2006

Optimization of stress response through the nuclear receptor-mediated cortisol signalling network

scientific article

Palmitate and oleate have distinct effects on the inflammatory phenotype of human endothelial cells

scientific article published on 20 December 2006

Population-level transcription cycles derive from stochastic timing of single-cell transcription

scientific article

Predictable Irreversible Switching Between Acute and Chronic Inflammation

scientific article published on 07 August 2018

Principles behind the multifarious control of signal transduction

scientific article published on 01 January 2005

Product dependence and bifunctionality compromise the ultrasensitivity of signal transduction cascades

scientific article

Pumping capacity of bacterial reaction centers and backpressure regulation of energy transduction.

scientific article

Putting intentions into cell biochemistry: an artificial intelligence perspective

scientific article published in January 2002

Quantification of information transfer via cellular signal transduction pathways ⬇️

scientific article published on September 8, 1997

Quantifying heterogeneity: flow cytometry of bacterial cultures

scientific article published on October 1991

Quantitative analysis of drug effects at the whole-body level: a case study for glucose metabolism in malaria patients

scientific article

Quantitative analysis of flux regulation through hierarchical regulation analysis

scientific article published in January 2011

Quantitative approaches to the analysis of the control and regulation of microbial metabolism

scientific article published on October 1991

Ranking network mechanisms by how they fit diverse experiments and deciding on 's ammonium transport and assimilation network

scientific article published on 12 April 2019

Rate limitation within a single enzyme is directly related to enzyme intermediate levels

scientific article published on 01 July 1994

Rational cell culture optimization enhances experimental reproducibility in cancer cells

scientific article published on 14 February 2018

Recommendations for terminology and databases for biochemical thermodynamics

scientific article published on 24 March 2011

Recurrent design patterns in the feedback regulation of the mammalian signalling network

scientific article published on 6 May 2008

Regulation and control of compartmentalized glycolysis in bloodstream form Trypanosoma brucei

scientific article published on October 1995

Regulation of expression of terminal oxidases in Paracoccus denitrificans

scientific article published on 01 April 2001

Regulation of the activity of lactate dehydrogenases from four lactic acid bacteria

scientific article published on 17 May 2013

Regulation of the expression of the Pseudomonas stutzeri recA gene

scientific article published on January 1993

Relating multidrug resistance phenotypes to the kinetic properties of their drug-efflux pumps

scientific article published on September 2000

Relationship between chemiosomotic flows and thermodynamic forces in oxidative phosphorylation

scientific article published in July 1980

Reply to Comment on `Non-equilibrium thermodynamics of light absorption'

Restriction point control of the mammalian cell cycle via the cyclin E/Cdk2:p27 complex

scientific article published on 10 December 2009

Reversal of Multidrug Resistance by Valinomycin is Overcome by CCCP

scientific article published on 01 February 1996

STRENDA DB: enabling the validation and sharing of enzyme kinetics data

scholarly article by Neil Swainston published in June 2018

Saturable P-glycoprotein kinetics assayed by fluorescence studies of drug efflux from suspended human KB8-5 cells

scientific article published in January 1996

Selectivity in Overlapping MAP Kinase Cascades

scientific article published on 01 October 2002

Sensitivity analysis of metabolic cascades catalyzed by bifunctional enzymes

article

Sigmoidal relation between mitochondrial respiration and log ([ATP]/[ADP])out under conditions of extramitochondrial ATP utilization. Implications for the control and thermodynamics of oxidative phosphorylation

scientific article published on 01 October 1988

Signal transduction in bacteria: phospho-neural network(s) in Escherichia coli?

scientific article

Signalling control strength

scientific article published on 05 December 2007

Silence on the relevant literature and errors in implementation

scientific article published in April 2015

Simplicity in complexity: the photosynthetic reaction center performs as a simple 0.2 V battery

scientific article published on 01 January 2002

Simplified yet highly accurate enzyme kinetics for cases of low substrate concentrations

scientific article published on 28 August 2009

Simulation of the distribution of parental strains’ genomes in RC strains of mice

scientific article published on 01 December 1997

Steady-state cyclic electron transfer through solubilized Rhodobacter sphaeroides reaction centres

scientific article published on 01 December 2000

Stochastic free energy transduction

scientific article published on May 1985

Strong control on the transit time in metabolic channelling

scientific article published on 01 July 1996

Structure and partitioning of bacterial DNA: determined by a balance of compaction and expansion forces?

scientific article published on September 1995

Subtleties in control by metabolic channelling and enzyme organization

scientific article published in July 1998

Subtlety in control — metabolic pathway engineering

scientific article published on 01 July 1995

SulfoSYS (Sulfolobus Systems Biology): towards a silicon cell model for the central carbohydrate metabolism of the archaeon Sulfolobus solfataricus under temperature variation.

scientific article published in February 2009

Summation theorems for flux and concentration control coefficients of dynamic systems

scientific article published in September 2006

Super life--how and why 'cell selection' leads to the fastest-growing eukaryote

scientific article published in January 2009

Sustained oscillations in free-energy state and hexose phosphates in yeast

scientific article published on 01 June 1996

Synchronization of glycolytic oscillations in a yeast cell population

scientific article

Synthetic biology and regulatory networks: where metabolic systems biology meets control engineering

scientific article

Systematic integration of experimental data and models in systems biology ⬇️

scientific article (publication date: 29 November 2010)

Systems Biology Left and Right

scientific article published on 01 January 2011

Systems Biology in ELIXIR: modelling in the spotlight

scientific article published on 31 May 2024

Systems Biology: Towards Realistic and Useful Models of Molecular Networks

Systems Pharmacology: An opinion on how to turn the impossible into grand challenges.

scientific article published on 25 July 2015

Systems biochemistry in practice: experimenting with modelling and understanding, with regulation and control

scientific article published on October 2010

Systems biology and food microbiology

Systems biology tools for toxicology

scientific article published on 09 May 2012

Systems biology towards life in silico: mathematics of the control of living cells.

scientific article published on 16 February 2008

Systems biology … in action

Systems biology: the elements and principles of life

scientific article published on December 2009

Targeting pathogen metabolism without collateral damage to the host

scientific article

Temperature compensation through systems biology

scientific article published on 12 January 2007

Testing biochemistry revisited: how in vivo metabolism can be understood from in vitro enzyme kinetics

scientific article

The Escherichia coli signal transducers PII (GlnB) and GlnK form heterotrimers in vivo: fine tuning the nitrogen signal cascade

scientific article published on April 2000

The NosX and NirX proteins of Paracoccus denitrificans are functional homologues: their role in maturation of nitrous oxide reductase

scientific article

The Peculiar Glycolytic Pathway in Hyperthermophylic Archaea: Understanding Its Whims by Experimentation In Silico.

scientific article published on 20 April 2017

The Silicon Cell Initiative

The Silicon Cell, Not Dead but Live!

scientific article published on 01 July 2001

The danger of metabolic pathways with turbo design

scientific journal article

The dynamics of electrostatic interactions between membrane proteins

article

The effect of ionophores and light intensity on the initial rate of proton uptake into bacteriorhodopsin liposomes can be quantitatively described by mosaic non-equilibrium thermodynamics

article by Hans Westerhoff et al published August 1981 in BBA - Bioenergetics

The evolution of molecular biology into systems biology

scientific article published in October 2004

The extent to which ATP demand controls the glycolytic flux depends strongly on the organism and conditions for growth

scientific article published in January 2002

The fluxes through glycolytic enzymes in Saccharomyces cerevisiae are predominantly regulated at posttranscriptional levels

scholarly article

The glycolytic flux in Escherichia coli is controlled by the demand for ATP.

scientific article published on July 2002

The macroworld versus the microworld of biochemical regulation and control

scientific article

The multidrug-resistance-reverser verapamil interferes with cellular P-glycoprotein-mediated pumping of daunorubicin as a non-competing substrate

scientific article published on April 1994

The multifarious short-term regulation of ammonium assimilation of Escherichia coli: dissection using an in silico replica

scientific article

The nature of systems biology

scientific article

The pivotal regulator GlnB of Escherichia coli is engaged in subtle and context-dependent control

scientific article published on 7 May 2009

The potential role of adenosine in the pathophysiology of the insulin resistance syndrome

scientific article published in April 2001

The probability to initiate X chromosome inactivation is determined by the X to autosomal ratio and X chromosome specific allelic properties

scientific article published on 19 May 2009

The reduction state of the Q-pool regulates the electron flux through the branched respiratory network of Paracoccus denitrificans

scientific article published on 01 May 1999

The regulatory strength: how to be precise about regulation and homeostasis

scientific article published in June 1993

The relative importance of passive and P-glycoprotein mediated anthracycline efflux from multidrug-resistant cells

scientific article

The silicon trypanosome.

scientific article published on 06 May 2010

The two opposing activities of adenylyl transferase reside in distinct homologous domains, with intramolecular signal transduction

scientific article

The use of lac-type promoters in control analysis.

scientific article

Thermodynamic efficiency of microbial growth is low but optimal for maximal growth rate

scientific article published on January 1983

Thermodynamics of complexity. The live cell

article

Thermodynamics of growth. Non-equilibrium thermodynamics of bacterial growth. The phenomenological and the mosaic approach

scientific article published on December 1982

Time-dependent hierarchical regulation analysis: deciphering cellular adaptation

scientific article published in September 2006

Time-dependent regulation analysis dissects shifts between metabolic and gene-expression regulation during nitrogen starvation in baker’s yeast

article

Time-dependent regulation of yeast glycolysis upon nitrogen starvation depends on cell history

scientific article published on 01 March 2010

Towards building the silicon cell: a modular approach

scientific article published on 19 October 2005

Tracing the molecular basis of transcriptional dynamics in noisy data by using an experiment-based mathematical model.

scientific article

Trade-off of dynamic fragility but not of robustness in metabolic pathways in silico.

scientific article published on 7 December 2012

Training of yeast cell dynamics.

scientific article published in April 2005

Transcription regulation of the nir gene cluster encoding nitrite reductase of Paracoccus denitrificans involves NNR and NirI, a novel type of membrane protein.

scientific article published in October 1999

Transcriptome meets metabolome: hierarchical and metabolic regulation of the glycolytic pathway

scientific article published in July 2001

Transduction of intracellular and intercellular dynamics in yeast glycolytic oscillations

scientific article published on March 2000

Two (completely) rate-limiting steps in one metabolic pathway? The resolution of a paradox using bacteriorhodopsin liposomes and the control theory

scientific article published on 01 January 1984

Understanding Dupuytren's Disease Using Systems Biology: A Move Away from Reductionism

scientific article published on 9 August 2012

Understanding complexity in neurodegenerative diseases: in silico reconstruction of emergence

scientific article published on 23 July 2012

Understanding glucose transport by the bacterial phosphoenolpyruvate:glycose phosphotransferase system on the basis of kinetic measurements in vitro

scientific article published in November 2000

Unraveling the complexity of flux regulation: a new method demonstrated for nutrient starvation in Saccharomyces cerevisiae

scholarly article

Untangling the wires: a strategy to trace functional interactions in signaling and gene networks

scientific article

Variation of efficiency with free-energy dissipation in models of biological energy transduction

scientific article published in October 1987

What Controls Glycolysis in Bloodstream FormTrypanosoma brucei?

scientific article published in Journal of Biological Chemistry

What bio technologists knew all along...?

scientific article published in October 1996

What it takes to understand and cure a living system: computational systems biology and a systems biology-driven pharmacokinetics-pharmacodynamics platform

scientific article published on 8 December 2010

What makes biochemical networks tick?

scientific article published in October 2004

Why and when channelling can decrease pool size at constant net flux in a simple dynamic channel

scientific article published in March 1996

Why cytoplasmic signalling proteins should be recruited to cell membranes.

scientific article

Why does yeast ferment? A flux balance analysis study

scientific article published on October 2010

Why in vivo may not equal in vitro - new effectors revealed by measurement of enzymatic activities under the same in vivo-like assay conditions

scientific article published on 12 October 2012

Why the phosphotransferase system of Escherichia coli escapes diffusion limitation

scientific article published on July 2003

Yeast cells with a specific cellular make-up and an environment that removes acetaldehyde are prone to sustained glycolytic oscillations

scientific article published on 01 March 1994

Yeast glycolytic oscillations that are not controlled by a single oscillophore: a new definition of oscillophore strength.

scientific article published in February 2005

‘Channelled’ pathways can be more sensitive to specific regulatory signals

scientific article published on 01 March 1993

‘Domino’ systems biology and the ‘A’ of ATP

scientific article published on 29 September 2012

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