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List of works by Jeffrey Esko

A Golgi-on-a-chip for glycan synthesis.

scientific article published in September 2009

A disaccharide precursor of sialyl Lewis X inhibits metastatic potential of tumor cells.

scientific article

A disaccharide-based inhibitor of glycosylation attenuates metastatic tumor cell dissemination

scientific article published on May 2006

A genetic model of substrate reduction therapy for mucopolysaccharidosis

scientific article

A mutant-cell library for systematic analysis of heparan sulfate structure-function relationships

scientific article published on 30 October 2018

A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia

scientific article published on 26 November 2020

Aggregation-Mediated Macromolecular Uptake by a Molecular Transporter ⬇️

scientific article published on April 26, 2013

Altered heparan sulfate structure in mice with deleted NDST3 gene function.

scientific article

ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance

scientific article published on 14 May 2019

ApoC-III Glycoforms Are Differentially Cleared by Hepatic TRL (Triglyceride-Rich Lipoprotein) Receptors

scientific article published on 08 August 2019

ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors.

scientific article published on 11 July 2016

Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans

scientific article published on 8 May 2013

Arylsulfatase G inactivation causes loss of heparan sulfate 3- O -sulfatase activity and mucopolysaccharidosis in mice ⬇️

scientific article published on June 11, 2012

Arylsulfatase K inactivation causes mucopolysaccharidosis due to deficient glucuronate desulfation of heparan and chondroitin sulfate

scientific article published on 28 August 2020

Arylsulfatase K is the Lysosomal 2-Sulfoglucuronate Sulfatase.

scientific article published on 5 January 2017

Author Correction: Downstream Products are Potent Inhibitors of the Heparan Sulfate 2-O-Sulfotransferase

scientific article published on 09 June 2020

Bacterial and Viral Infections

scientific article published on 20 March 2010

Bacterial modification of the host glycosaminoglycan heparan sulfate modulates SARS-CoV-2 infectivity

scientific article published on 18 August 2020

Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development.

scientific article

Bud specific N-sulfation of heparan sulfate regulates Shp2-dependent FGF signaling during lacrimal gland induction

scientific article published on 12 December 2007

CHO glycosylation mutants: proteoglycans

scientific article published on January 2006

Carriers of loss-of-function mutations in EXT display impaired pancreatic beta-cell reserve due to smaller pancreas volume

scientific article

Cell surface heparan sulfate promotes replication of Toxoplasma gondii

scientific article

Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type

scientific article

Cerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene function

scientific journal article

Clofazimine broadly inhibits coronaviruses including SARS-CoV-2

Compound heterozygous loss of Ext1 and Ext2 is sufficient for formation of multiple exostoses in mouse ribs and long bones ⬇️

scientific article published on February 15, 2011

Cooperative, Heparan Sulfate‐Dependent Cellular Uptake of Dimeric Guanidinoglycosides ⬇️

scientific article published on November 2, 2010

Correction: Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice

scientific article published on 01 March 2020

Correction: Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice

scientific article published on 01 July 2020

Corrigendum to "The heparan sulfate proteoglycan grip on hyperlipidemia and atherosclerosis" [Matrix Biol. 71-72 (2018) 262-282]

scientific article published on 03 March 2020

Corrigendum to: Triglyceride-rich lipoprotein binding and uptake by heparan sulfate proteoglycan receptors in a CRISPR/Cas9 library of Hep3B mutants

scientific article published on 24 February 2020

Deficiency of endothelial heparan sulfates attenuates allergic airway inflammation

scientific article

Delivery of Cargo to Lysosomes Using GNeosomes

scientific article published in January 2017

Delivery of an active lysosomal enzyme using GNeosomes

scientific article published on 17 August 2016

Demystifying heparan sulfate-protein interactions.

scientific article published on 06 March 2014

Dendrimer-like PEO glycopolymers exhibit anti-inflammatory properties

scientific article published on July 2005

Dendrimeric Guanidinoneomycin for Cellular Delivery of Bio-macromolecules

scientific article

Deoxygenated Disaccharide Analogs as Specific Inhibitors of  1-4-Galactosyltransferase 1 and Selectin-mediated Tumor Metastasis

scientific article

Differential Effects of Murine and Human Factor X on Adenovirus Transduction via Cell-surface Heparan Sulfate ⬇️

scientific article published on May 19, 2011

Differentiation of 3-O-sulfated heparin disaccharide isomers: identification of structural aspects of the heparin CCL2 binding motif

scientific article published on 09 December 2008

Disaccharide structure code for the easy representation of constituent oligosaccharides from glycosaminoglycans

scientific article published in April 2008

Discovery and Classification of Glycan-Binding Proteins

scientific article published on 20 March 2010

Disease-specific non-reducing end carbohydrate biomarkers for mucopolysaccharidoses

scientific article published on 8 January 2012

Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates

scientific article published on 22 December 2021

Downstream Products are Potent Inhibitors of the Heparan Sulfate 2-O-Sulfotransferase

scientific article published in Scientific Reports

Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis

scientific article published on 01 March 2021

Endothelial Heparan Sulfate Mediates Hepatic Neutrophil Trafficking and Injury during Staphylococcus aureus Sepsis

scientific article published on 21 September 2021

Endothelial and leukocyte heparan sulfates regulate the development of allergen-induced airway remodeling in a mouse model

scientific article

Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses

scientific article

Essential alterations of heparan sulfate during the differentiation of embryonic stem cells to Sox1-enhanced green fluorescent protein-expressing neural progenitor cells

scientific article published on 26 April 2007

Evolutionary differences in glycosaminoglycan fine structure detected by quantitative glycan reductive isotope labeling

scientific article published on 24 September 2008

Expanding the 3-O-Sulfate Proteome--Enhanced Binding of Neuropilin-1 to 3-O-Sulfated Heparan Sulfate Modulates Its Activity

scientific article

Expression patterns of alpha 2,3-sialyltransferases and alpha 1,3-fucosyltransferases determine the mode of sialyl Lewis X inhibition by disaccharide decoys.

scientific article

GNeosomes: Highly Lysosomotropic Nanoassemblies for Lysosomal Delivery

scientific article

Genetic alteration of endothelial heparan sulfate selectively inhibits tumor angiogenesis

scientific article

Glycan antagonists and inhibitors: a fount for drug discovery

scientific article

Glycan-based biomarkers for mucopolysaccharidoses ⬇️

scientific article published on July 29, 2013

Glycosaminoglycan binding facilitates entry of a bacterial pathogen into central nervous systems

scientific article

Growth factor-dependent branching of the ureteric bud is modulated by selective 6-O sulfation of heparan sulfate ⬇️

scientific article published on May 11, 2011

Guanidinylated Neomycin Conjugation Enhances Intranasal Enzyme Replacement in the Brain.

scientific article published on 12 August 2017

Guanidinylated neomycin delivers large, bioactive cargo into cells through a heparan sulfate-dependent pathway

scientific article

Guanidinylated neomycin mediates heparan sulfate-dependent transport of active enzymes to lysosomes

scientific article

Heparan Sulfate Modulates Neutrophil and Endothelial Function in Antibacterial Innate Immunity

scientific article

Heparan sulfate 3-O-sulfation: a rare modification in search of a function.

scientific article

Heparan sulfate Ndst1 gene function variably regulates multiple signaling pathways during mouse development

scientific article published on February 2007

Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development

scientific article published on 15 November 2006

Heparan sulfate expression in the neural crest is essential for mouse cardiogenesis

scientific article

Heparan sulfate is essential for high mobility group protein 1 (HMGB1) signaling by the receptor for advanced glycation end products (RAGE).

scientific article published on 11 October 2011

Heparan sulfate proteoglycans

scientific article

Heparan sulfate proteoglycans and triglyceride-rich lipoprotein metabolism

scientific article published on June 2008

Heparan sulfate proteoglycans fine-tune macrophage inflammation via IFN-β.

scientific article published on 5 January 2015

Heparan sulfate proteoglycans provide a signal to Plasmodium sporozoites to stop migrating and productively invade host cells

scientific article

Heparan sulfate regulates VEGF165- and VEGF121-mediated vascular hyperpermeability.

scientific article

Heparin's anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins

scientific article

Hepatic Heparan Sulfate Proteoglycans and Endocytic Clearance of Triglyceride-Rich Lipoproteins

scientific article published on January 1, 2010

Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice

scientific article published on 17 July 2019

Hepatic remnant lipoprotein clearance by heparan sulfate proteoglycans and low-density lipoprotein receptors depend on dietary conditions in mice

scientific article published on 11 July 2013

Hepatocyte Heparan Sulfate Is Required for Adeno-Associated Virus 2 but Dispensable for Adenovirus 5 Liver Transduction In Vivo

scientific article

Hs2st mediated kidney mesenchyme induction regulates early ureteric bud branching

scientific article

Immune-Mediated Inflammation May Contribute to the Pathogenesis of Cardiovascular Disease in Mucopolysaccharidosis Type I

scientific article

Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice.

scientific article

Inhibitory peptides of the sulfotransferase domain of the heparan sulfate enzyme, N-deacetylase-N-sulfotransferase-1.

scientific article

Insulin-dependent diabetes mellitus in mice does not alter liver heparan sulfate

scientific article

Intra-articular enzyme replacement therapy with rhIDUA is safe, well-tolerated, and reduces articular GAG storage in the canine model of mucopolysaccharidosis type I.

scientific article

Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis.

scientific article published in November 2004

Loss of corneal epithelial heparan sulfate leads to corneal degeneration and impaired wound healing.

scientific article published on May 2015

Loss of the heparan sulfate sulfotransferase, Ndst1, in mammary epithelial cells selectively blocks lobuloalveolar development in mice

scientific article

Macromolecular uptake of alkyl-chain-modified guanidinoglycoside molecular transporters

scientific article

Metabolism of vertebrate amino sugars with N-glycolyl groups: incorporation of N-glycolylhexosamines into mammalian glycans by feeding N-glycolylgalactosamine

scientific article

Modulation of heparan sulfate in the glomerular endothelial glycocalyx decreases leukocyte influx during experimental glomerulonephritis

scientific article published on 23 April 2014

N-Sulfation of Heparan Sulfate Regulates Early Branching Events in the Developing Mammary Gland ⬇️

scientific article published on October 11, 2012

Neurodevelopmental Changes in Excitatory Synaptic Structure and Function in the Cerebral Cortex of Sanfilippo Syndrome IIIA Mice

scientific article

PinAPL-Py: A comprehensive web-application for the analysis of CRISPR/Cas9 screens

scientific article

Polymyxins Facilitate Entry into Mammalian Cells

scientific article published on 25 April 2016

Proteomic atlas of organ vasculopathies triggered by Staphylococcus aureus sepsis

scientific article published on 11 October 2019

Proteomics-based screening of the endothelial heparan sulfate interactome reveals that C-type lectin 14a (CLEC14A) is a heparin-binding protein

scientific article published on 21 January 2020

Regulated translation of heparan sulfate N-acetylglucosamine N-deacetylase/n-sulfotransferase isozymes by structured 5'-untranslated regions and internal ribosome entry sites

scientific article published on 17 June 2002

Regulation of eosinophil recruitment and allergic airway inflammation by heparan sulfate proteoglycan (HSPG) modifying enzymes

scientific article published on 01 March 2018

Resistance to a bacterial toxin is mediated by removal of a conserved glycosylation pathway required for toxin-host interactions

scientific article

Role of the endothelial surface layer in neutrophil recruitment

scientific article

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

scientific article published on 14 July 2020

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

scientific article published on 14 September 2020

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

scientific article

Secondary storage of dermatan sulfate in Sanfilippo disease

scientific article

Shedding of Syndecan–1 From Human Hepatocytes Alters Very Low Density Lipoprotein Clearance ⬇️

scientific article published on December 6, 2011

Small changes in lymphocyte development and activation in mice through tissue-specific alteration of heparan sulphate.

scientific article published on 9 May 2008

Small molecule antagonists of cell-surface heparan sulfate and heparin-protein interactions.

scientific article published on 29 July 2015

Stable RAGE-Heparan Sulfate Complexes Are Essential for Signal Transduction

scientific article

Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling.

scientific article

Surfen and oxalyl surfen decrease tau hyperphosphorylation and mitigate neuron deficits in vivo in a zebrafish model of tauopathy

scientific article published on 16 March 2018

Surfen, a small molecule antagonist of heparan sulfate

scholarly article

Synthesis of N-acetyllactosamine derivatives with variation in the aglycon moiety for the study of inhibition of sialyl Lewis x expression

scientific article published on September 2003

The elusive role of heparan sulfate in Toxoplasma gondii infection

scientific article published on 01 February 2005

The heparan sulfate proteoglycan grip on hyperlipidemia and atherosclerosis

scientific article published on 24 May 2018

Triglyceride-rich lipoprotein binding and uptake by heparan sulfate proteoglycan receptors in a CRISPR/Cas9 library of Hep3B mutants

scientific article published on 01 July 2019

Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling

scientific article published in November 2002

WITHDRAWN: Glycan-based biomarkers for mucopolysaccharidoses

retracted scientific article published on 8 February 2013

Whole-Genome Sequencing of Invasion-Resistant Cells Identifies Laminin α2 as a Host Factor for Bacterial Invasion

scientific article (publication date: 10 January 2017)

ZNF263 is a transcriptional regulator of heparin and heparan sulfate biosynthesis

scientific article published on 10 April 2020

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