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List of works by Heike Walles

'Human-on-a-chip' developments: a translational cutting-edge alternative to systemic safety assessment and efficiency evaluation of substances in laboratory animals and man?

scientific article published on October 2012

* An Injectable Recombinant Collagen I Peptide-Based Macroporous Microcarrier Allows Superior Expansion of C2C12 and Human Bone Marrow-Derived Mesenchymal Stromal Cells and Supports Deposition of Mineralized Matrix

scientific article published on 3 March 2017

A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds

scientific article published on 06 April 2016

A bioreactor system for interfacial culture and physiological perfusion of vascularized tissue equivalents

scientific article published on 9 November 2012

A coculture system composed of THP-1 cells and 3D reconstructed human epidermis to assess activation of dendritic cells by sensitizing chemicals after topical exposure

scientific article published on 14 February 2019

A combined tissue engineered / in silico signature tool for patient stratification in lung cancer.

scientific article

A comparative multi-parametric in vitro model identifies the power of test conditions to predict the fibrotic tendency of a biomaterial

scientific article

A first vascularized skin equivalent as an alternative to animal experimentation

scientific article published on 15 May 2016

A human in vitro model that mimics the renal proximal tubule

scientific article

A multifunctional bioreactor for three-dimensional cell (co)-culture

scientific article

A novel small-animal model for accelerated investigation of tissue-engineered aortic valve conduits

scientific article

A perfusion bioreactor system efficiently generates cell-loaded bone substitute materials for addressing critical size bone defects

scientific article published on 26 May 2015

A standardized method based on pigmented epidermal models evaluates sensitivity against UV-irradiation

scientific article published on 13 April 2018

A three-dimensional intestinal tissue model reveals factors and small regulatory RNAs important for colonization with Campylobacter jejuni

scientific article published on 18 February 2020

A versatile modular bioreactor platform for Tissue Engineering

scientific article published on 05 August 2016

Acellular Scaffold Implantation – No Alternative to Tissue Engineering ⬇️

scientific article published on 01 March 2003

Activation of Myenteric Glia during Acute Inflammation In Vitro and In Vivo

scientific article

Advanced Therapy Medicinal Products: A Guide for Bone Marrow-derived MSC Application in Bone and Cartilage Tissue Engineering

scientific article published on 7 October 2017

Altered pancreatic islet morphology and function in SGLT1 knockout mice on a glucose-deficient, fat-enriched diet.

scientific article published on 23 May 2018

Alternative methods for the replacement of eye irritation testing

scientific article

Ammonia plasma treatment of polystyrene surfaces enhances proliferation of primary human mesenchymal stem cells and human endothelial cells

scientific article published on 9 November 2012

An Advanced Human Intestinal Coculture Model Reveals Compartmentalized Host and Pathogen Strategies during Salmonella Infection

scientific article published on 18 February 2020

An adherent mucus layer attenuates the genotoxic effect of colibactin

scientific article

An engineered 3D human airway mucosa model based on an SIS scaffold

scientific article

An in vitro model mimics the contact of biomaterials to blood components and the reaction of surrounding soft tissue

scientific article published on 15 March 2019

Androgen and estrogen receptors in the human corpus cavernosum penis: immunohistochemical and cell culture results ⬇️

scientific article published on October 29, 2003

Applicability of second-generation upcyte® human hepatocytes for use in CYP inhibition and induction studies

scientific article published on 10 August 2015

Automated real-time monitoring of human pluripotent stem cell aggregation in stirred tank reactors

scientific article published on 23 August 2019

Biological vascularized matrix for bladder tissue engineering: matrix preparation, reseeding technique and short-term implantation in a porcine model

scientific article published in January 2005

Biomimetic Human Tissue Model for Long-Term Study of Neisseria gonorrhoeae Infection

scientific article published on 31 July 2019

Biomimetic in vitro test system for evaluation of dental implant materials

scientific article published on 13 June 2020

Bioreactors in tissue engineering - principles, applications and commercial constraints

scientific article

Bone tissue engineering in osteoporosis

scientific article published on 04 April 2013

Calcium fluoride based multifunctional nanoparticles for multimodal imaging

scientific article published on 18 July 2017

Ciclopirox olamine promotes the angiogenic response of endothelial cells and mesenchymal stem cells

scientific article published on 01 January 2019

Clinical application of tissue engineered human heart valves using autologous progenitor cells

scientific article published in July 2006

Commensal and pathogenic biofilms differently modulate peri-implant oral mucosa in an organotypic model

scientific article published on 17 July 2019

Connecting Cancer Pathways to Tumor Engines: A Stratification Tool for Colorectal Cancer Combining Human In Vitro Tissue Models with Boolean In Silico Models

scientific article published on 20 December 2019

Construction of autologous human heart valves based on an acellular allograft matrix.

scientific article

Corrigendum: Rapid Analysis of Cell-Nanoparticle Interactions using Single-Cell Raman Trapping Microscopy

scientific article published on 01 November 2018

Could 37 degrees C storage temperature extend homovital valve allograft viability?

scientific article published on 01 May 2004

Cross-linked Collagen Hydrogel Matrix Resisting Contraction To Facilitate Full-Thickness Skin Equivalents.

scientific article published on 30 May 2017

Cytotoxicity of different intracavernous vasoactive drugs on cultured endothelial cells of human corpus cavernosum penis

scientific article published in September 2004

Deformation strain is the main physical driver for skeletal precursors to undergo osteogenesis in earlier stages of osteogenic cell maturation

scientific article published on 5 September 2017

Development of 3D human intestinal equivalents for substance testing in microliter-scale on a multi-organ-chip

scientific article

Development of Human Salivary Gland-Like Tissue In Vitro.

scientific article published on 4 August 2017

Development of a bioreactor-system for pre-endothelialized cardiac patch generation with enhanced viscoelastic properties by combined collagen I compression and stromal cell culture

scientific article published on 06 September 2020

Development of an Advanced Primary Human In Vitro Model of the Small Intestine

scientific article published on August 2016

Differential Regulation of SOX9 Protein During Chondrogenesis of Induced Pluripotent Stem Cells Versus Mesenchymal Stromal Cells: A Shortcoming for Cartilage Formation

scientific article published on 24 February 2016

Dynamic cultivation of human stem cells under physiological conditions.

scientific article

EZH2 Inhibition in Ewing Sarcoma Upregulates GD2 Expression for Targeting with Gene-Modified T Cells

scientific article published on 23 February 2019

Editorial: Strategies in tissue engineering and regenerative medicine ⬇️

scientific article published on 01 March 2013

Electrospun poly(D/L-lactide-co-L-lactide) hybrid matrix: a novel scaffold material for soft tissue engineering

scientific article published on 17 July 2010

Engineered liver-like tissue on a capillarized matrix for applied research

scientific article published in November 2007

Engineering of a vascularized scaffold for artificial tissue and organ generation

scientific article published on November 2005

Establishment of a Human Blood-Brain Barrier Co-culture Model Mimicking the Neurovascular Unit Using Induced Pluri- and Multipotent Stem Cells.

scientific article published on 22 March 2017

Establishment of a human 3D lung cancer model based on a biological tissue matrix combined with a Boolean in silico model

scientific article published on 18 December 2013

Europe's advanced therapy medicinal products: chances and challenges

scientific article published on 01 March 2009

Evaluation of a Miniaturized Biologically Vascularized Scaffold in vitro and in vivo

scientific article published on 16 March 2018

Ex vivo culture platform for assessment of cartilage repair treatment strategies.

scientific article published on 21 October 2016

Expansion of chondrocytes in a three-dimensional matrix for tracheal tissue engineering

scientific article

Experimental generation of a tissue-engineered functional and vascularized trachea.

scientific article published on December 2004

Experimental tracheal patching using extracellular matrix scaffolds

scientific article published on 01 April 2009

Expression of epidermal growth-factor receptor in lymphangiomatosis: a new therapeutic target?

scientific article published in June 2004

Feasibility Study on a Microwave-Based Sensor for Measuring Hydration Level Using Human Skin Models

scientific article

First human transplantation of a bioengineered airway tissue

scientific article published in October 2004

Follistatin Effects in Migration, Vascularization, and Osteogenesis in vitro and Bone Repair in vivo

Functional neointima characterization of vascular prostheses in human

scientific article published in March 2004

Functional tissue engineering of autologous tunica albuginea: a possible graft for Peyronie's disease surgery

scientific article published in June 2004

Generation and transplantation of an autologous vascularized bioartificial human tissue

scientific article

Generation of a three-dimensional full thickness skin equivalent and automated wounding

scientific article published on 26 February 2015

Guided tissue regeneration: porcine matrix does not transmit PERV.

scientific article published in August 2004

Host-integration of a tissue-engineered airway patch: two-year follow-up in a single patient

scientific article published on 11 December 2014

Human Organotypic Lung Tumor Models: Suitable For Preclinical 18F-FDG PET-Imaging

scientific article

Human barrier models for the in vitro assessment of drug delivery

scientific article published on 22 August 2016

Human skin equivalent as an alternative to animal testing

scientific article

Impedance spectroscopy for the non-destructive evaluation of in vitro epidermal models

scientific article

In Vitro Generation of Functional Liver Organoid-Like Structures Using Adult Human Cells

scientific article published on 21 October 2015

In situ guided tissue regeneration in musculoskeletal diseases and aging : Implementing pathology into tailored tissue engineering strategies

scientific article published on 20 October 2011

In vitro chemotaxis and tissue remodeling assays quantitatively characterize foreign body reaction

scientific article

In vitro viability of human cavernosal endothelial and fibroblastic cells after exposure to papaverine/phentolamine and prostaglandin E1.

scientific article published in June 2005

In vivo model for cross-species porcine endogenous retrovirus transmission using tissue engineered pulmonary arteries

scientific article published in September 2003

In vivo repopulation of xenogeneic and allogeneic acellular valve matrix conduits in the pulmonary circulation.

scientific article

Inflammation-induced tissue damage mimicking GvHD in human skin models as test-platform for immunotherapeutics

scientific article published on 14 April 2020

Influence of scaffold thickness and scaffold composition on bioartificial graft survival

scientific article published on 01 March 2003

Inhibitor of Apoptosis Protein-1 Regulates Tumor Necrosis Factor-Mediated Destruction of Intestinal Epithelial Cells

scientific article published on 23 November 2016

Integrating biological vasculature into a multi-organ-chip microsystem

scientific article

Interactions of donor sources and media influence the histo-morphological quality of full-thickness skin models

scientific article published on 7 September 2016

Investigation of Migration and Differentiation of Human Mesenchymal Stem Cells on Five-Layered Collagenous Electrospun Scaffold Mimicking Native Cartilage Structure

scientific article published on 17 May 2016

Is chronic graft rejection the reason for degenerative changes in allogeneic and xenogeneic heart valve prostheses: immunohistochemical evaluation of inflammatory factors

scientific article published in October 2002

Isolation of primary endothelial and stromal cell cultures of the corpus cavernosum penis for basic research and tissue engineering

scientific article published in May 2005

Isotropic Versus Bipolar Functionalized Biomimetic Artificial Basement Membranes and Their Evaluation in Long-Term Human Cell Co-Culture

scientific article published on 10 June 2016

Linking two worlds in polymer chemistry: The influence of block uniformity and dispersity in amphiphilic block copolypeptoids on their self-assembly

scientific article published on 07 February 2019

Matrix decoded - A pancreatic extracellular matrix with organ specific cues guiding human iPSC differentiation

scientific article published on 06 March 2020

Mimicking Metastases Including Tumor Stroma: A New Technique to Generate a Three-Dimensional Colorectal Cancer Model Based on a Biological Decellularized Intestinal Scaffold

scientific article published on 03 May 2016

Nanotopographical Coatings Induce an Early Phenotype-Specific Response of Primary Material-Resident M1 and M2 Macrophages

scientific article published on 04 March 2020

Nell-1, HMGB1 and CCN2 enhance migration and vasculogenesis, but not osteogenic differentiation compared to BMP2.

scientific article published on 2 May 2017

Non-Coding RNAs in Lung Cancer: Contribution of Bioinformatics Analysis to the Development of Non-Invasive Diagnostic Tools

scientific article published on 26 December 2016

Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology.

scientific article

Non-contact, label-free monitoring of cells and extracellular matrix using Raman spectroscopy

scientific article

Obstructed defecation-an enteric neuropathy? An exploratory study of patient samples

scientific article published on 03 September 2018

Oligonucleotide and Parylene Surface Coating of Polystyrene and ePTFE for Improved Endothelial Cell Attachment and Hemocompatibility

scientific article published on 12 March 2012

Osteogenesis and mineralization of mesenchymal stem cells in collagen type I-based recombinant peptide scaffolds

scientific article

Physical contact between mesenchymal stem cells and endothelial precursors induces distinct signatures with relevance to the very early phase of regeneration

scientific article published on 13 August 2018

Porcine endogenous retrovirus released by a bioartificial liver infects primary human cells

scientific article

Preclinical Assessment of a Tissue-Engineered Vasomotive Human Small-Calibered Vessel Based on a Decellularized Xenogenic Matrix: Histological and Functional Characterization ⬇️

scholarly article by Jörg Heine et al published May 2011 in Tissue Engineering. Part A

Preparation of a Three-Dimensional Full Thickness Skin Equivalent

scientific article

ROR1-CAR T cells are effective against lung and breast cancer in advanced microphysiologic 3D tumor models

scientific article published on 19 September 2019

Raman Spectroscopy: A Noninvasive Analysis Tool for the Discrimination of Human Skin Cells

scientific article published on 20 July 2011

Raman spectroscopy as a tool for quality and sterility analysis for tissue engineering applications like cartilage transplants.

scientific article

Raman spectroscopy for the non-contact and non-destructive monitoring of collagen damage within tissues

scientific article published on 27 September 2011

Rapid Analysis of Cell-Nanoparticle Interactions using Single-Cell Raman Trapping Microscopy.

scientific article published on 23 February 2018

Recombinant Collagen I Peptide Microcarriers for Cell Expansion and Their Potential Use As Cell Delivery System in a Bioreactor Model

scientific article published on 7 February 2018

Reepithelialization in focus: Non-invasive monitoring of epidermal wound healing in vitro

scientific article published on 01 August 2019

Regulatory-Compliant Validation of a Highly Sensitive qPCR for Biodistribution Assessment of Hemophilia A Patient Cells

scientific article published on 01 June 2020

Replacement of the trachea with an autologous aortic graft

scientific article published on 01 September 2004

Replacing the Draize eye test: Impedance spectroscopy as a 3R method to discriminate between all GHS categories for eye irritation

scientific article published in Scientific Reports

Role of inflammation in allogeneic and xenogeneic heart valve degeneration: immunohistochemical evaluation of inflammatory endothelial cell activation

scientific article published in July 2003

Schedule-dependent antagonism of paclitaxel and cisplatin in human gastric and ovarian carcinoma cell Lines in vitro ⬇️

scientific article published on 01 January 1995

Screening Applications to Test Cellular Fitness in Transwell® Models After Nanoparticle Treatment

scientific article published in January 2017

Session 10: Biofilms Implant related infections

scientific article published on 01 February 2019

Session 9: Biomaterials -Elektrospinning

scientific article published on 01 February 2019

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

scientific article published on 29 March 2018

Spin echo based cardiac diffusion imaging at 7T: An ex vivo study of the porcine heart at 7T and 3T

scientific article published on 25 March 2019

Stem cell labeling with iron oxide nanoparticles: impact of 3D culture on cell labeling maintenance

scientific article published on 26 July 2016

Stem cell microenvironments--unveiling the secret of how stem cell fate is defined

scientific article

Stem cell- and growth factor-based regenerative therapies for avascular necrosis of the femoral head

scientific article published on 22 February 2012

Strategies and First Advances in the Development of Prevascularized Bone Implants

scientific article

Structure-Function relationships of equine menisci.

scientific article published on 9 March 2018

The physiological performance of a three-dimensional model that mimics the microenvironment of the small intestine

scientific article

The potential of bioartificial tissues in oncology research and treatment

scientific article published on 27 June 2007

Three-Dimensional Coculture of Meniscal Cells and Mesenchymal Stem Cells in Collagen Type I Hydrogel on a Small Intestinal Matrix-A Pilot Study Toward Equine Meniscus Tissue Engineering

scientific article published on 18 January 2017

Tissue Engineering Human Small‐Caliber Autologous Vessels Using a Xenogenous Decellularized Connective Tissue Matrix Approach: Preclinical Comparative Biomechanical Studies ⬇️

scientific article published on July 7, 2011

Tissue Mimicry in Morphology and Composition Promotes Hierarchical Matrix Remodeling of Invading Stem Cells in Osteochondral and Meniscus Scaffolds

scientific article published on 30 May 2018

Tissue engineering of a human 3D in vitro tumor test system

scientific article published on 06 August 2013

Tissue engineering of viable pulmonary arteries for surgical correction of congenital heart defects

scientific article published in April 2006

Tissue remodeling in a bioartificial fibromuscular patch following transplantation in a human

scientific article published in July 2005

Track I. Cellular-, Tissue- and Bioengineering

scientific article published on 01 September 2016

Upcyte® microvascular endothelial cells repopulate decellularized scaffold

scientific article

Vascularised human tissue models: a new approach for the refinement of biomedical research

scientific article published on 23 April 2010

[Differentiation potential of human stem cells--approaches to tissue engineering and to cell transplantation]

scientific article published on 01 July 2002

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