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List of works by Verena Dirsch

12(S)-HETE increases intracellular Ca(2+) in lymph-endothelial cells disrupting their barrier function in vitro; stabilization by clinical drugs impairing calcium supply

scientific article published on 4 July 2016

12/15-lipoxygenase contributes to platelet-derived growth factor-induced activation of signal transducer and activator of transcription 3

scientific article

2-(2,4-dihydroxyphenyl)-5-(E)-propenylbenzofuran promotes endothelial nitric oxide synthase activity in human endothelial cells.

scientific article published on 6 July 2012

6-Dihydroparadol, a Ginger Constituent, Enhances Cholesterol Efflux from THP-1-Derived Macrophages

A Maillard reaction product enhances eNOS activity in human endothelial cells.

scientific article

A eudesmane-type sesquiterpene isolated from Pluchea odorata (L.) Cass. combats three hallmarks of cancer cells: Unrestricted proliferation, escape from apoptosis and early metastatic outgrowth in vitro

scientific article published on 5 May 2015

A novel roscovitine derivative potently induces G1-phase arrest in platelet-derived growth factor-BB-activated vascular smooth muscle cells

scientific article

A trimeric propelargonidin from stem bark of Heisteria pallida

A two-step chemical and circular dichroic method for assigning the absolute configurations of sphingosines

article by Verena Dirsch et al published July 1995 in Tetrahedron Letters

AHR/CYP1A1 interplay triggers lymphatic barrier breaching in breast cancer spheroids by inducing 12(S)-HETE synthesis

scientific article published in November 2016

Activated AMPK boosts the Nrf2/HO-1 signaling axis--A role for the unfolded protein response

scientific article

Activation of endothelial nitric oxide synthase by red wine polyphenols: impact of grape cultivars, growing area and the vinification process

scientific article published on March 2007

Active NF-E2-related factor (Nrf2) contributes to keep endothelial NO synthase (eNOS) in the coupled state: role of reactive oxygen species (ROS), eNOS, and heme oxygenase (HO-1) levels.

scientific article published on 21 September 2009

Activity-guided isolation of NF-κB inhibitors and PPARγ agonists from the root bark of Lycium chinense Miller

scientific article

Ajoene, a compound of garlic, induces apoptosis in human promyeloleukemic cells, accompanied by generation of reactive oxygen species and activation of nuclear factor kappaB

article

Ajoene, an experimental anti-leukemic drug: mechanism of cell death

scientific article published on January 2002

Ajoene-induced cell death in human promyeloleukemic cells does not require JNK but is amplified by the inhibition of ERK.

scientific article

Allspice and Clove As Source of Triterpene Acids Activating the G Protein-Coupled Bile Acid Receptor TGR5

scientific article published on 17 July 2017

Anti-inflammatory activities of hypocretenolides from Leontodon hispidus

scientific article

Anti-inflammatory effects of a bioavailable compound, Artepillin C, in Brazilian propolis

scientific article published on 29 February 2008

Apoptosis signaling triggered by the marine alkaloid ascididemin is routed via caspase-2 and JNK to mitochondria

scientific article published on February 2004

Application of 4,5-diaminofluorescein to reliably measure nitric oxide released from endothelial cellsin vitro ⬇️

scientific article published on June 15, 2003

Ascorbate stimulates endothelial nitric oxide synthase enzyme activity by rapid modulation of its phosphorylation status.

scientific article published on 17 April 2012

Assessment of anti-inflammatory properties of extracts from Honeysuckle (Lonicera sp. L., Caprifoliaceae) by ATR-FTIR spectroscopy

scientific article

Bilirubin Decreases Macrophage Cholesterol Efflux and ATP-Binding Cassette Transporter A1 Protein Expression.

scientific article published on 28 April 2017

Bioactivity-guided isolation of 1,2,3,4,6-Penta-O-galloyl-D-glucopyranose from Paeonia lactiflora roots as a PTP1B inhibitor.

scientific article published on September 2010

Bioguided Isolation of (9Z)-Octadec-9-enoic Acid from Phellodendron amurense Rupr. and Identification of Fatty Acids as PTP1B Inhibitors

scientific article published on 28 November 2011

Biologically active oxidized lipids (phytoprostanes) in the plant diet and parenteral lipid nutrition

article

Bupleurum chinense Roots: a Bioactivity-Guided Approach toward Saponin-Type NF-κB Inhibitors.

scientific article published on 8 September 2017

C13 Megastigmane Derivatives From Epipremnum pinnatum: β-Damascenone Inhibits the Expression of Pro-Inflammatory Cytokines and Leukocyte Adhesion Molecules as Well as NF-κB Signaling

scientific article published on 28 November 2019

Caffeic acid phenethyl ester inhibits PDGF-induced proliferation of vascular smooth muscle cells via activation of p38 MAPK, HIF-1α, and heme oxygenase-1.

scientific article

Capsaicin from chili ( Capsicum spp.) inhibits vascular smooth muscle cell proliferation

scientific article

Cephalostatin 1 Inactivates Bcl-2 by Hyperphosphorylation Independent of M-Phase Arrest and DNA Damage

scientific article published on 09 February 2005

Cephalostatin 1 selectively triggers the release of Smac/DIABLO and subsequent apoptosis that is characterized by an increased density of the mitochondrial matrix

scientific article published on 01 December 2003

Characterization of Constituents with Potential Anti-Inflammatory Activity in Chinese Lonicera Species by UHPLC-HRMS Based Metabolite Profiling

scientific article published in 2022

Chronic treatment with resveratrol induces redox stress- and ataxia telangiectasia-mutated (ATM)-dependent senescence in p53-positive cancer cells.

scientific article

Computer-aided discovery, validation, and mechanistic characterization of novel neolignan activators of peroxisome proliferator-activated receptor gamma

scientific article

Constituents of Mediterranean Spices Counteracting Vascular Smooth Muscle Cell Proliferation: Identification and Characterization of Rosmarinic Acid Methyl Ester as a Novel Inhibitor

scientific article published on 5 February 2018

Cytotoxic sesquiterpene lactones mediate their death-inducing effect in leukemia T cells by triggering apoptosis

scientific article published in August 2001

Design and Synthesis of a Compound Library Exploiting 5-Methoxyleoligin as Potential Cholesterol Efflux Promoter

scientific article published on 04 February 2020

Discovery and resupply of pharmacologically active plant-derived natural products: A review ⬇️

scientific article

Discovery of a novel IKK-β inhibitor by ligand-based virtual screening techniques

scientific article

Discovery of new liver X receptor agonists by pharmacophore modeling and shape-based virtual screening

scientific article published on 6 February 2014

Dracoside, a New Steroidal Saponin fromHelleborus purpurascens

Drugs from nature targeting inflammation (DNTI): a successful Austrian interdisciplinary network project

scientific article

Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase.

scientific article published on August 1998

Effect of chronic GH overproduction on cardiac ANP expression and circulating ANP levels

scientific article published on 01 September 1998

Effect of garlic powder on C-reactive protein and plasma lipids in overweight and smoking subjects

scientific article published on 01 December 2006

Effect of resveratrol on endothelial cell function: Molecular mechanisms

scientific article published on September 2010

Effects of Scrophularia extracts on tumor cell proliferation, death and intravasation through lymphoendothelial cell barriers

scientific article

Erythrodiol, an Olive Oil Constituent, Increases the Half-Life of ABCA1 and Enhances Cholesterol Efflux from THP-1-Derived Macrophages.

scientific article

Ethnopharmacological in vitro studies on Austria's folk medicine--an unexplored lore in vitro anti-inflammatory activities of 71 Austrian traditional herbal drugs

scientific article

Eurycomalactone Inhibits Expression of Endothelial Adhesion Molecules at a Post-Transcriptional Level

scientific article published on 17 November 2017

Evaluation of Apricot, Bilberry, and Elderberry Pomace Constituents and Their Potential To Enhance the Endothelial Nitric Oxide Synthase (eNOS) Activity

Evaluation of the analgesic and anti-inflammatory effects of a Brazilian green propolis

scientific article published on 10 August 2006

Fenofibrate inhibits tumour intravasation by several independent mechanisms in a 3-dimensional co-culture model

scientific article published on 7 April 2017

Garlic (Allium sativum L.) modulates cytokine expression in lipopolysaccharide-activated human blood thereby inhibiting NF-kappaB activity

scientific article published on 01 July 2003

Garlic metabolites fail to inhibit the activation of the transcription factor NF-kappaB and subsequent expression of the adhesion molecule E-selectin in human endothelial cells

scientific article published on 6 January 2004

Glucose availability is a decisive factor for Nrf2-mediated gene expression

scientific journal article

Glycolytic switch in response to betulinic acid in non-cancer cells

scientific article published on 22 December 2014

Helenalin bypasses Bcl-2-mediated cell death resistance by inhibiting NF-κB and promoting reactive oxygen species generation

scientific article published on 2 June 2011

Helenalin triggers a CD95 death receptor-independent apoptosis that is not affected by overexpression of Bcl-x(L) or Bcl-2.

scientific article published in August 2001

Honokiol: a non-adipogenic PPARγ agonist from nature

scientific article

Identification and characterization of [6]-shogaol from ginger as inhibitor of vascular smooth muscle cell proliferation

scientific article

Identification of chromomoric acid C-I as an Nrf2 activator in Chromolaena odorata

scientific article

Identification of isosilybin a from milk thistle seeds as an agonist of peroxisome proliferator-activated receptor gamma

scientific article

Identification of ostruthin from Peucedanum ostruthium rhizomes as an inhibitor of vascular smooth muscle cell proliferation ⬇️

scientific article

Identification of plumericin as a potent new inhibitor of the NF-κB pathway with anti-inflammatory activity in vitro and in vivo

scientific article

Ikarugamycin induces DNA damage, intracellular calcium increase, p38 MAP kinase activation and apoptosis in HL-60 human promyelocytic leukemia cells.

scientific article published on 12 March 2011

Imbricaric acid and perlatolic acid: multi-targeting anti-inflammatory depsides from Cetrelia monachorum ⬇️

scientific article published in 2013

Impact of natural products on the cholesterol transporter ABCA1

scientific article published on 02 December 2019

Impact of trans-resveratrol-sulfates and -glucuronides on endothelial nitric oxide synthase activity, nitric oxide release and intracellular reactive oxygen species

scientific article

In Silico Workflow for the Discovery of Natural Products Activating the G Protein-Coupled Bile Acid Receptor 1.

scientific article published on 2 July 2018

In vitro characterisation of the anti-intravasative properties of the marine product heteronemin.

scientific article published on 30 March 2013

In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen.

scientific article published on 8 January 2013

Increased aerobic glycolysis is important for the motility of activated VSMC and inhibited by indirubin-3'-monoxime

scientific article published on 14 May 2016

Indirubin and Indirubin Derivatives for Counteracting Proliferative Diseases

scientific article

Indirubin-3'-monoxime blocks vascular smooth muscle cell proliferation by inhibition of signal transducer and activator of transcription 3 signaling and reduces neointima formation in vivo

scientific article published on 16 September 2010

Indirubin-3'-monoxime exerts a dual mode of inhibition towards leukotriene-mediated vascular smooth muscle cell migration

scientific article

Inhibition of growth factor mediated Akt phosphorylation in vascular smooth muscle cells by resveratrol: the contribution of SH2 domain containing phosphatase 2 and reactive oxygen species

Inhibition of tumour spheroid-induced prometastatic intravasation gates in the lymph endothelial cell barrier by carbamazepine: drug testing in a 3D model

scientific article published on 19 December 2013

Interference with platelet-derived growth factor-induced signalling in vascular smooth muscle cells by roscovitine.

scientific article published on 5 November 2008

Intravasation of SW620 colon cancer cell spheroids through the blood endothelial barrier is inhibited by clinical drugs and flavonoids in vitro.

scientific article

Leoligin, the Major Lignan from Edelweiss (Leontopodium nivale subsp. alpinum), Promotes Cholesterol Efflux from THP-1 Macrophages.

scientific article published on 24 May 2016

Leoligin, the major lignan from Edelweiss, inhibits intimal hyperplasia of venous bypass grafts.

scientific article published on 19 February 2009

Leoligin-inspired synthetic lignans with selectivity for cell-type and bioactivity relevant for cardiovascular disease

scientific article published on 14 May 2019

Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro ⬇️

scientific article

Linked magnolol dimer as a selective PPARγ agonist - Structure-based rational design, synthesis, and bioactivity evaluation

scientific article

Lobatin B inhibits NPM/ALK and NF-κB attenuating anaplastic-large-cell-lymphomagenesis and lymphendothelial tumour intravasation.

scientific article published on 15 November 2014

Magnolol dimer-derived fragments as PPARγ-selective probes

scientific article published on 01 October 2018

Modulation of Nrf2-dependent gene transcription by bilberry anthocyanins in vivo

scientific article

Modulation of bacterial ghosts--induced nitric oxide production in macrophages by bacterial ghost-delivered resveratrol

scientific article

Modulation of endothelial nitric oxide by plant-derived products.

scientific article published on 2 June 2009

NADPH oxidases 1 and 4 mediate cellular senescence induced by resveratrol in human endothelial cells.

scientific article

NF-κB inhibitors from Eurycoma longifolia ⬇️

scientific article published on 27 January 2014

Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review

scientific article

Natural products as modulators of retinoic acid receptor-related orphan receptors (RORs)

scientific article published on 29 October 2020

Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR

scientific article published on 13 March 2018

Natural products in drug discovery: advances and opportunities

scientific article

No evidence for modulation of endothelial nitric oxide synthase by the olive oil polyphenol hydroxytyrosol in human endothelial cells.

scientific article published on 30 March 2007

Nonprenylated Xanthones from Gentiana lutea, Frasera caroliniensis, and Centaurium erythraea as Novel Inhibitors of Vascular Smooth Muscle Cell Proliferation.

scientific article published on 13 November 2015

Norfuraneol dephosphorylates eNOS at threonine 495 and enhances eNOS activity in human endothelial cells.

scientific article published on 26 November 2008

Novel interactomics approach identifies ABCA1 as direct target of evodiamine, which increases macrophage cholesterol efflux

scientific article published in Scientific Reports

Picomole scale stereochemical analysis of sphingosines and dihydrosphingosines

scientific article published on 01 July 1996

Piperine Congeners as Inhibitors of Vascular Smooth Muscle Cell Proliferation

scientific article published on 01 July 2015

Piperine inhibits ABCA1 degradation and promotes cholesterol efflux from THP-1-derived macrophages

scientific article

Plumericin inhibits proliferation of vascular smooth muscle cells by blocking STAT3 signaling via S-glutathionylation

scientific article published on 09 February 2016

Polyacetylenes from Notopterygium incisum--new selective partial agonists of peroxisome proliferator-activated receptor-gamma ⬇️

scientific article published on 22 April 2013

Polyacetylenes from Oplopanax horridus and Panax ginseng: Relationship between Structure and PPARγ Activation

scientific article published on 04 March 2020

Polyyne hybrid compounds from Notopterygium incisum with peroxisome proliferator-activated receptor gamma agonistic effects

scientific article published on 21 October 2014

Quantitation of phenylpropanoids and iridoids in insulin-sensitising extracts of Leonurus sibiricus L. (Lamiaceae).

scientific article published on 2 September 2015

Ratanhiaphenol III from Ratanhiae radix is a PTP1B inhibitor.

scientific article published on 3 February 2012

Red wine polyphenols enhance endothelial nitric oxide synthase expression and subsequent nitric oxide release from endothelial cells

scientific article published on September 2002

Regulation of eNOS enzyme activity by posttranslational modification.

scientific article published on January 2014

Reliable in vitro measurement of nitric oxide released from endothelial cells using low concentrations of the fluorescent probe 4,5-diaminofluorescein

scientific article

Resveratrol blocks Akt activation in angiotensin II- or EGF-stimulated vascular smooth muscle cells in a redox-independent manner.

scientific article published on 10 November 2010

Resveratrol increases serine15-phosphorylated but transcriptionally impaired p53 and induces a reversible DNA replication block in serum-activated vascular smooth muscle cells

scientific article published in April 2003

Resveratrol inhibits angiotensin II- and epidermal growth factor-mediated Akt activation: role of Gab1 and Shp2.

scientific article

Resveratrol inhibits migration and Rac1 activation in EGF‐ but not PDGF‐activated vascular smooth muscle cells ⬇️

scientific article published on July 5, 2011

Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity

scientific article

Resveratrol suppresses angiotensin II-induced Akt/protein kinase B and p70 S6 kinase phosphorylation and subsequent hypertrophy in rat aortic smooth muscle cells

scientific article published in October 2002

Role of Smac in cephalostatin-induced cell death

scientific article published on 19 September 2008

Screening of Vietnamese medicinal plants for NF-κB signaling inhibitors: assessing the activity of flavonoids from the stem bark of Oroxylum indicum.

scientific article

Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARα and PPARγ and the Respective Bioactive Compounds

scientific article

Sesquiterpene lactones induce distinct forms of cell death that modulate human monocyte-derived macrophage responses

scientific article published on January 2007

Silymarin Constituents Enhance ABCA1 Expression in THP-1 Macrophages.

scientific article

Structural Features Defining NF-κB Inhibition by Lignan-Inspired Benzofurans and Benzothiophenes

scientific article published on 31 July 2020

Structural requirements of sesquiterpene lactones to inhibit LPS-induced nitric oxide synthesis in RAW 264.7 macrophages

scientific article

Synergy study of the inhibitory potential of red wine polyphenols on vascular smooth muscle cell proliferation.

scientific article

Synthetic cryptolepine inhibits DNA binding of NF-kappaB.

scientific article published on 24 October 2006

The Dietary Constituent Falcarindiol Promotes Cholesterol Efflux from THP-1 Macrophages by Increasing ABCA1 Gene Transcription and Protein Stability

scientific article

The Griess assay: suitable for a bio-guided fractionation of anti-inflammatory plant extracts?

article

The Herbal DrugMelampyrum pratenseL. (Koch): Isolation and Identification of Its Bioactive Compounds Targeting Mediators of Inflammation ⬇️

scientific article published on February 26, 2013

The Marine Product Cephalostatin 1 Activates an Endoplasmic Reticulum Stress-specific and Apoptosome-independent Apoptotic Signaling Pathway

scientific article published in Journal of Biological Chemistry

The germacranolide sesquiterpene lactone neurolenin B of the medicinal plant Neurolaena lobata (L.) R.Br. ex Cass inhibits NPM/ALK-driven cell expansion and NF-κB-driven tumour intravasation

scientific article published on 26 June 2015

The triterpenoid quinonemethide pristimerin inhibits induction of inducible nitric oxide synthase in murine macrophages

scientific article

Triterpenoic Acids from Apple Pomace Enhance the Activity of the Endothelial Nitric Oxide Synthase (eNOS).

scientific article published on 18 December 2015

Trophosome of the Deep-Sea Tubeworm Riftia pachyptila Inhibits Bacterial Growth

scientific article

Tylophorine reduces protein biosynthesis and rapidly decreases cyclin D1, inhibiting vascular smooth muscle cell proliferation in vitro and in organ culture

scientific article published on 23 April 2019

Walnut leaf extract inhibits PTP1B and enhances glucose-uptake in vitro.

scientific article

Xanthohumol Blocks Proliferation and Migration of Vascular Smooth Muscle Cells in Vitro and Reduces Neointima Formation in Vivo

scientific article

Xanthohumol attenuates tumour cell-mediated breaching of the lymphendothelial barrier and prevents intravasation and metastasis

scientific article published on 17 March 2013

[On asthma and allergic reactions. Omalizumab: from IgE to anti-IgE].

scientific article published in January 2004

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