List of works - Maureen Murphy

A conserved domain in exon 2 coding for the human and murine ARF tumor suppressor protein is required for autophagy induction.

scientific article

A functionally significant SNP in TP53 and breast cancer risk in African-American women

scientific article

A modified HSP70 inhibitor shows broad activity as an anticancer agent

scientific article

A novel cancer therapy approach targeting microtubule function.

scientific article published on 20 December 2006

A novel inhibitor of HSP70 induces mitochondrial toxicity and immune cell recruitment in tumors

scientific article published on 06 October 2020

A physician responds

scientific article published on 01 January 2002

A rare TP53 mutation predominant in Ashkenazi Jews confers risk of multiple cancers

scientific article published on 16 July 2020

A small molecule inhibitor of inducible heat shock protein 70.

scientific article published on October 2009

A unified approach to targeting the lysosome's degradative and growth signaling roles.

scientific article published on 12 September 2017

ARF induces autophagy by virtue of interaction with Bcl-xl.

scientific article published on 02 December 2008

ARF, autophagy and tumor suppression.

scientific article published on 07 April 2009

ATG5 Mediates a Positive Feedback Loop between Wnt Signaling and Autophagy in Melanoma

scientific article

Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53.

scientific article published on 03 June 2009

Activation of cancer-specific gene expression by the survivin promoter

scientific article published on April 2002

Addition-substitution reactions of 2-thio-3-chloroacrylamides with carbon, nitrogen, oxygen, sulfur and selenium nucleophiles ⬇️

scientific article published on February 21, 2011

African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin

scientific article published on 24 January 2020

An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model

scientific article

An assessment of attitudes toward gender inequitable sexual and reproductive health norms in South Sudan: a community-based participatory research approach

scientific article

An assessment of gender inequitable norms and gender-based violence in South Sudan: a community-based participatory research approach

scientific article

Author Correction: African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin

scientific article published on 19 March 2020

Autophagy in tumor suppression and cancer therapy

scientific article published on January 1, 2011

Autophagy researchers

BID regulation by p53 contributes to chemosensitivity

scientific article (publication date: November 2002)

Biochemical changes associated with a multidrug-resistant phenotype of a human glioma cell line with temozolomide-acquired resistance

scientific article

C-Glycosylation of Oxygenated Naphthols with 3-Dimethylamino-2,3,6-trideoxy-L-arabino-hexopyranose and 3-Azido-2,3,6-trideoxy-D-arabino-hexopyranose

scientific article published in 2003

CSF1 is a novel p53 target gene whose protein product functions in a feed-forward manner to suppress apoptosis and enhance p53-mediated growth arrest

scientific article

Cardiac dysfunction in the trastuzumab clinical trials experience

scientific article (publication date: March 2002)

Common genetic variants in the TP53 pathway and their impact on cancer

scientific article published on 01 July 2019

Common tumour p53 mutations in immortalized cells from Hupki mice heterozygous at codon 72.

scientific article published on 12 November 2007

Comparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 inhibition.

scientific article

Correction: CSF1 Is a Novel p53 Target Gene Whose Protein Product Functions in a Feed-Forward Manner to Suppress Apoptosis and Enhance p53-Mediated Growth Arrest.

scientific article published on 17 September 2013

Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrate

scientific article published in 2014

Design, Synthesis and Biological Evaluation of β-Carboline Dimers Based on the Structure of Neokauluamine

scientific article published on June 2015

Differential Display Techniques to Identify Tumor Suppressor Gene Pathways

scientific article published on 01 January 2003

Down-regulation of the stathmin/Op18 and FKBP25 genes following p53 induction.

scientific article

Editorial: Double-Edged Swords: Genetic Factors That Influence the Pathogenesis of Both Metabolic Disease and Cancer

scientific article published on 03 July 2019

Effects on quality of life of combined trastuzumab and chemotherapy in women with metastatic breast cancer.

scientific article published in July 2002

Efficacy of the HSP70 inhibitor PET-16 in multiple myeloma

scientific article published on 15 July 2015

Elevated telomere dysfunction in cells containing the African-centric Pro47Ser cancer-risk variant of TP53.

scientific article published on 4 June 2019

Establishment and characterization of a human leptomeningeal cell line.

scientific article published on November 1991

Exploiting TERT dependency as a therapeutic strategy for NRAS-mutant melanoma

scientific article published on 26 April 2018

Fatty acid transport protein 2 reprograms neutrophils in cancer

scientific article published on 17 April 2019

Functional interplay among thiol-based redox signaling, metabolism, and ferroptosis unveiled by a genetic variant of TP53

scientific article published on 14 October 2020

Gender Equitable Men Scale--Modified Version

Genetic Modifiers of the p53 Pathway

scientific article published on April 2016

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors

scientific article published on 16 March 2016

HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells

scientific article

Heat shock proteins regulate activation-induced proteasomal degradation of the mature phosphorylated form of protein kinase C.

scientific article published on 30 July 2013

Identification and characterization of small molecule human papillomavirus E6 inhibitors

scientific article

Identification of Mubritinib (TAK 165) as an inhibitor of KSHV driven primary effusion lymphoma via disruption of mitochondrial OXPHOS metabolism

scientific article published on 17 November 2020

Identification of TRIML2, a novel p53 target, that enhances p53 SUMOylation and regulates the transactivation of proapoptotic genes

scientific article published on 25 September 2014

Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

scientific article published on 10 November 2020

Influences of sex, age and education on attitudes towards gender inequitable norms and practices in South Sudan

scientific article

Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function

scientific article published on 21 April 2017

Interaction of the ARF tumor suppressor with cytosolic HSP70 contributes to its autophagy function

scientific article published on 15 September 2011

Investigation of the reaction of α-thioamides, α-esters and α-nitriles with N-halosuccinimides

Investigation of the synthetic and mechanistic aspects of the highly stereoselective transformation of α-thioamides to α-thio-β-chloroacrylamides

Ironing out how p53 regulates ferroptosis

scientific article published on 17 October 2016

Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer

scientific article

Loss of chromosome 8p sequences in human breast carcinoma cell lines

scientific article published in August 1994

Low risk HPV-E6 traps p53 in the cytoplasm and induces p53-dependent apoptosis

scientific article published on December 2008

Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53

scientific article published on 08 April 2019

Methods to study p53-repressed promoters

scientific article published on 01 January 2003

Microarray Expression Profiling of p53-Dependent Transcriptional Changes in an Immortalized Mouse Embryo Fibroblast Cell Line

scientific article published on 20 July 2003

Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

scientific article

Mutant p53 controls tumor metabolism and metastasis by regulating PGC-1α.

scientific article published on 20 February 2018

Oligomerization of BAK by p53 utilizes conserved residues of the p53 DNA binding domain

scientific article published on 4 June 2008

Oncogenes and Tumor Suppressor Genes in Autophagy

scientific article published in 2013

P53 represses pyrimidine catabolic gene dihydropyrimidine dehydrogenase (DPYD) expression in response to thymidylate synthase (TS) targeting.

scientific article published on 29 August 2017

PUMA-dependent apoptosis in NSCLC cancer cells by a dimeric β-carboline.

scientific article published on 13 September 2016

Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma

scientific article published on 01 February 2020

Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma

scientific article published on 11 December 2019

Polymorphic variants in the p53 pathway.

scientific article

Polymorphisms in the p53 pathway.

scientific article

Polyunsaturated Fatty Acids from Astrocytes Activate PPARγ Signaling in Cancer Cells to Promote Brain Metastasis

scientific article published on 02 October 2019

Regulation of cell death in oncogenesis.

scientific article

Regulation of female reproduction by p53 and its family members

scientific article

Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.

scientific article

Safety of treatment of metastatic breast cancer with trastuzumab beyond disease progression

scientific article published in March 2004

Selective β-oxidation of α-sulfanyl amides

Single step stereospecific transformation of 2-phenylthio secondary amides into (Z)-3-chloro-2-phenylthio acrylamides

Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans

scientific article

Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis

scientific article published on 27 August 2015

Structural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocket

scientific article (publication date: 21 November 2014)

Subtelomeric p53 binding prevents accumulation of DNA damage at human telomeres.

scientific article

Synthesis and stereoselective oxidation of α-thio-β-chloropropenyloxazolidin-2-ones

Synthesis of 3-azido-2,3,6-trideoxy-beta-D-arabino-hexopyranosyl pyranonaphthoquinone analogues of medermycin

scientific article published in May 2003

Tailoring Chemotherapy for the African-Centric S47 Variant of TP53

scientific article published on 16 August 2018

The ARF tumor suppressor can promote the progression of some tumors.

scientific article published on December 2008

The ARF/oncogene pathway activates p53 acetylation within the DNA binding domain

scientific article published on 24 June 2007

The African-specific S47 polymorphism of p53 alters chemosensitivity

scientific article published on 2 August 2016

The Codon 72 TP53 Polymorphism Contributes to TSC Tumorigenesis through the Notch-Nodal Axis

scientific article published on 14 May 2019

The HSP70 family and cancer

scientific article published on 4 April 2013

The Hsp70 Family of Heat Shock Proteins in Tumorigenesis: From Molecular Mechanisms to Therapeutic Opportunities

scientific article published on 14 October 2014

The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction

scientific article published on 02 March 2016

The Thousand Doors that Lead to Death: p53-Dependent Repression and Apoptosis

scientific article published on 20 July 2003

The codon 47 polymorphism in p53 is functionally significant.

scientific article published on 25 April 2005

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

scientific article published on 3 February 2003

The codon 72 polymorphism of p53 influences cell fate following nutrient deprivation

scientific article published on 5 May 2017

The codon 72 polymorphism of p53 regulates interaction with NF-{kappa}B and transactivation of genes involved in immunity and inflammation

scientific article

The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation

scientific article

The methionine salvage pathway compound 4-methylthio-2-oxobutanate causes apoptosis independent of down-regulation of ornithine decarboxylase.

scientific article published on 25 July 2006

The neurofibromatosis 2 (NF2) tumor suppressor gene encodes multiple alternatively spliced transcripts.

scientific article published on April 1994

The p53 Codon 72 Polymorphism Modifies the Cellular Response to Inflammatory Challenge in the Liver

scientific article published on January 2013

The p53 Tumor Suppressor in the Control of Metabolism and Ferroptosis

scientific article published on 11 April 2018

The p53 family and programmed cell death

scientific article published on October 2008

The role of the p53 tumor suppressor in metabolism and diabetes

scientific article

The tetramerization domain of p53 is required for efficient BAK oligomerization

scientific article

The transcription-independent mitochondrial cell death pathway is defective in non-transformed cells containing the Pro47Ser variant of p53

scientific article published in 2018

Tissue-specific apoptotic effects of the p53 codon 72 polymorphism in a mouse model.

scientific article

Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a.

scientific article

Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.

scientific article published on 19 November 2001

Tumor cells containing the African-Centric S47 variant of show increased Warburg metabolism

article published in 2019

Wild-type and Hupki (human p53 knock-in) murine embryonic fibroblasts: p53/ARF pathway disruption in spontaneous escape from senescence

scientific article

Wild-type and mutant p53 proteins interact with mitochondrial caspase-3

scientific article published on 15 April 2011

Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells

scientific article

p53 and ARF: unexpected players in autophagy

scientific article

p53 differentially inhibits cell growth depending on the mechanism of telomere maintenance

scientific article published on July 2004

p53 family members regulate cancer stem cells

scientific article published on 8 April 2016

p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression

scientific article

p53 moves to mitochondria: a turn on the path to apoptosis.

scientific article published on 4 July 2004

p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways.

scientific article published on 15 January 2018

p53, transcriptional, and drug sensitivity: fresh perspectives on an old activity.

scientific article published in November 2010

List of works by Maureen Murphy

A conserved domain in exon 2 coding for the human and murine ARF tumor suppressor protein is required for autophagy induction.

A functionally significant SNP in TP53 and breast cancer risk in African-American women

A modified HSP70 inhibitor shows broad activity as an anticancer agent

A novel cancer therapy approach targeting microtubule function.

A novel inhibitor of HSP70 induces mitochondrial toxicity and immune cell recruitment in tumors

A physician responds

A rare TP53 mutation predominant in Ashkenazi Jews confers risk of multiple cancers

A small molecule inhibitor of inducible heat shock protein 70.

A unified approach to targeting the lysosome's degradative and growth signaling roles.

ARF induces autophagy by virtue of interaction with Bcl-xl.

ARF, autophagy and tumor suppression.

ATG5 Mediates a Positive Feedback Loop between Wnt Signaling and Autophagy in Melanoma

Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53.

Activation of cancer-specific gene expression by the survivin promoter

Addition-substitution reactions of 2-thio-3-chloroacrylamides with carbon, nitrogen, oxygen, sulfur and selenium nucleophiles ⬇️

African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin

An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model

An assessment of attitudes toward gender inequitable sexual and reproductive health norms in South Sudan: a community-based participatory research approach

An assessment of gender inequitable norms and gender-based violence in South Sudan: a community-based participatory research approach

Author Correction: African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin

Autophagy in tumor suppression and cancer therapy

Autophagy researchers

BID regulation by p53 contributes to chemosensitivity

Biochemical changes associated with a multidrug-resistant phenotype of a human glioma cell line with temozolomide-acquired resistance

C-Glycosylation of Oxygenated Naphthols with 3-Dimethylamino-2,3,6-trideoxy-L-arabino-hexopyranose and 3-Azido-2,3,6-trideoxy-D-arabino-hexopyranose

CSF1 is a novel p53 target gene whose protein product functions in a feed-forward manner to suppress apoptosis and enhance p53-mediated growth arrest

Cardiac dysfunction in the trastuzumab clinical trials experience

Common genetic variants in the TP53 pathway and their impact on cancer

Common tumour p53 mutations in immortalized cells from Hupki mice heterozygous at codon 72.

Comparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 inhibition.

Correction: CSF1 Is a Novel p53 Target Gene Whose Protein Product Functions in a Feed-Forward Manner to Suppress Apoptosis and Enhance p53-Mediated Growth Arrest.

Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrate

Design, Synthesis and Biological Evaluation of β-Carboline Dimers Based on the Structure of Neokauluamine

Differential Display Techniques to Identify Tumor Suppressor Gene Pathways

Down-regulation of the stathmin/Op18 and FKBP25 genes following p53 induction.

Editorial: Double-Edged Swords: Genetic Factors That Influence the Pathogenesis of Both Metabolic Disease and Cancer

Effects on quality of life of combined trastuzumab and chemotherapy in women with metastatic breast cancer.

Efficacy of the HSP70 inhibitor PET-16 in multiple myeloma

Elevated telomere dysfunction in cells containing the African-centric Pro47Ser cancer-risk variant of TP53.

Establishment and characterization of a human leptomeningeal cell line.

Exploiting TERT dependency as a therapeutic strategy for NRAS-mutant melanoma

Fatty acid transport protein 2 reprograms neutrophils in cancer

Functional interplay among thiol-based redox signaling, metabolism, and ferroptosis unveiled by a genetic variant of TP53

Gender Equitable Men Scale--Modified Version

Genetic Modifiers of the p53 Pathway

Guidelines for the use and interpretation of assays for monitoring autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors

HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells

Heat shock proteins regulate activation-induced proteasomal degradation of the mature phosphorylated form of protein kinase C.

Identification and characterization of small molecule human papillomavirus E6 inhibitors

Identification of Mubritinib (TAK 165) as an inhibitor of KSHV driven primary effusion lymphoma via disruption of mitochondrial OXPHOS metabolism

Identification of TRIML2, a novel p53 target, that enhances p53 SUMOylation and regulates the transactivation of proapoptotic genes

Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

Influences of sex, age and education on attitudes towards gender inequitable norms and practices in South Sudan

Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function

Interaction of the ARF tumor suppressor with cytosolic HSP70 contributes to its autophagy function

Investigation of the reaction of α-thioamides, α-esters and α-nitriles with N-halosuccinimides

Investigation of the synthetic and mechanistic aspects of the highly stereoselective transformation of α-thioamides to α-thio-β-chloroacrylamides

Ironing out how p53 regulates ferroptosis

Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer

Loss of chromosome 8p sequences in human breast carcinoma cell lines

Low risk HPV-E6 traps p53 in the cytoplasm and induces p53-dependent apoptosis

Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53

Methods to study p53-repressed promoters

Microarray Expression Profiling of p53-Dependent Transcriptional Changes in an Immortalized Mouse Embryo Fibroblast Cell Line

Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

Mutant p53 controls tumor metabolism and metastasis by regulating PGC-1α.

Oligomerization of BAK by p53 utilizes conserved residues of the p53 DNA binding domain

Oncogenes and Tumor Suppressor Genes in Autophagy

P53 represses pyrimidine catabolic gene dihydropyrimidine dehydrogenase (DPYD) expression in response to thymidylate synthase (TS) targeting.

PUMA-dependent apoptosis in NSCLC cancer cells by a dimeric β-carboline.

Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma

Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma

Polymorphic variants in the p53 pathway.

Polymorphisms in the p53 pathway.

Polyunsaturated Fatty Acids from Astrocytes Activate PPARγ Signaling in Cancer Cells to Promote Brain Metastasis

Regulation of cell death in oncogenesis.

Regulation of female reproduction by p53 and its family members