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List of works by Jan Hoeijmakers

2-Acetylaminofluorene-modified probes for the indirect hybridocytochemical detection of specific nucleic acid sequences ⬇️

scientific article published on 01 July 1984

A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription

scientific article

A Mouse Model for the Basal Transcription/DNA Repair Syndrome Trichothiodystrophy ⬇️

scientific article published on June 1, 1998

A human and mouse homolog of the Schizosaccharomyces pombe rad1+ cell cycle checkpoint control gene

scientific article

A long-range restriction map of the human chromosome 19q13 region: close physical linkage between CKMM and the ERCC1 and ERCC2 genes

scientific article

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

scientific article

A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A

scientific article

A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein

scientific article

A presumed DNA helicase encoded by ERCC-3 is involved in the human repair disorders xeroderma pigmentosum and Cockayne's syndrome

scientific article

A variant surface glycoprotein of Trypanosoma brucei synthesized with a C-terminal hydrophobic 'tail' absent from purified glycoprotein.

scientific article published in December 1980

ATP-dependent chromatin remodeling by the Cockayne syndrome B DNA repair-transcription-coupling factor.

scientific article

Adaptive stress response in segmental progeria resembles long-lived dwarfism and calorie restriction in mice

scientific article

Age-related skeletal dynamics and decrease in bone strength in DNA repair deficient male trichothiodystrophy mice

scientific article (publication date: 2012)

Aging and genome maintenance: lessons from the mouse?

scientific article (publication date: 28 February 2003)

Altered lipid metabolism in the aging kidney identified by three layered omic analysis

scientific article

Augmentation of protein production by a combination of the T7 RNA polymerase system and ubiquitin fusion: overproduction of the human DNA repair protein, ERCC1, as a ubiquitin fusion protein in Escherichia coli.

scientific article published on September 1993

Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase.

scientific article published on November 1997

Biochemical and biological characterization of wild-type and ATPase-deficient Cockayne syndrome B repair protein.

scientific article published in May 1998

Ca2+ toxicity due to reverse Na+/Ca2+ exchange contributes to degeneration of neurites of DRG neurons induced by a neuropathy-associated Nav1.7 mutation

scientific article

Cell type-specific hypersensitivity to oxidative damage in CSB and XPA mice

scientific journal article

Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency

scientific article (publication date: October 2014)

Characterization of kinetoplast DNA networks from the insect trypanosome Crithidia luciliae

scientific article published on September 20, 1977

Characterization of mRAD18Sc, a mouse homolog of the yeast postreplication repair gene RAD18

scientific journal article

Characterization of the mouse homolog of the XPBC/ERCC-3 gene implicated in xeroderma pigmentosum and Cockayne's syndrome

scientific journal article

Chromosomal stability and the DNA double-stranded break connection

scientific article (publication date: March 2001)

Clinical heterogeneity within xeroderma pigmentosum associated with mutations in the DNA repair and transcription gene ERCC3

scientific article

Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH

scientific article

Cloning and characterization of the Drosophila homolog of the xeroderma pigmentosum complementation-group B correcting gene, ERCC3.

scientific article published on November 1992

Cloning of a human homolog of the yeast nucleotide excision repair gene MMS19 and interaction with transcription repair factor TFIIH via the XPB and XPD helicases

scientific article

Cloning of human and mouse genes homologous to RAD52, a yeast gene involved in DNA repair and recombination

scientific article

Cloning, comparative mapping, and RNA expression of the mouse homologues of the Saccharomyces cerevisiae nucleotide excision repair gene RAD23

scientific journal article

Cockayne syndrome: defective repair of transcription? ⬇️

scientific article published on July 16, 1997

Complementation group assignments of moderately UV-sensitive CHO mutants isolated by large-scale screening (FAECB)

scientific article published on 01 July 1994

Conserved pattern of antisense overlapping transcription in the homologous human ERCC-1 and yeast RAD10 DNA repair gene regions

scientific article

Correction of the DNA repair defect in xeroderma pigmentosum group E by injection of a DNA damage-binding protein

scientific article

Correction of xeroderma pigmentosum repair defect by basal transcription factor BTF2 (TFIIH)

scientific article

DNA Damage, Aging, and Cancer

scientific article

DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A

scientific article

DNA damage-induced histone H1 ubiquitylation is mediated by HUWE1 and stimulates the RNF8-RNF168 pathway.

scientific article published on 10 November 2017

DNA rearrangements involving the genes for variant antigens in Trypanosoma brucei

scientific article published on 01 January 1981

DNA repair and ultraviolet mutagenesis in cells from a new patient with xeroderma pigmentosum group G and cockayne syndrome resemble xeroderma pigmentosum cells

scientific article published on October 1996

DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents

scientific article published on 01 May 1999

DNA structural elements required for ERCC1-XPF endonuclease activity.

scientific article published on April 1998

DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair ⬇️

scientific article published on August 15, 1998

Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition

scientific journal article

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

scientific journal article

Delayed and accelerated aging share common longevity assurance mechanisms

scientific article

Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions

scientific journal article

Developmental defects and male sterility in mice lacking the ubiquitin-like DNA repair gene mHR23B

scientific article

Dhr6, a Drosophila homolog of the yeast DNA-repair gene RAD6.

scientific article published on May 1991

Differences between rodent and human cell lines in the amount of integrated DNA after transfection

scientific article published on 01 March 1987

Different effects of CSA and CSB deficiency on sensitivity to oxidative DNA damage

scientific journal article

Differential role of basal keratinocytes in UV-induced immunosuppression and skin cancer

scientific article

Differentiation driven changes in the dynamic organization of Basal transcription initiation

scientific article

Dimerization and nuclear entry of mPER proteins in mammalian cells

scientific article

Disruption of TTDA results in complete nucleotide excision repair deficiency and embryonic lethality

scientific article

Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence

scientific journal article

Disruption of mouse SNM1 causes increased sensitivity to the DNA interstrand cross-linking agent mitomycin C

scientific article

Dynamic interaction of TTDA with TFIIH is stabilized by nucleotide excision repair in living cells

scientific article

ERCC1-XPF endonuclease facilitates DNA double-strand break repair

scientific article

ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes

scientific article

ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne's syndrome and preferential repair of active genes

scientific article (publication date: 11 December 1992)

Early postnatal ataxia and abnormal cerebellar development in mice lacking Xeroderma pigmentosum Group A and Cockayne syndrome Group B DNA repair genes

scientific article

Efficient cDNA cloning by direct phenotypic correction of a mutant human cell line (HPRT−) using an Epstein - Barr virus-derived cDNA expression vector ⬇️

scientific article published on September 25, 1991

Evolution and mutagenesis of the mammalian excision repair gene ERCC-1

scientific article

Expression of the ubiquitin-conjugating DNA repair enzymes HHR6A and B suggests a role in spermatogenesis and chromatin modification.

scientific article

First reported patient with human ERCC1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure

scientific article

Fluorescence correlation spectroscopy of the binding of nucleotide excision repair protein XPC-hHr23B with DNA substrates

scientific article published on 24 June 2008

From xeroderma pigmentosum to the biological clock contributions of Dirk Bootsma to human genetics

scientific article published in February 2001

Genome maintenance mechanisms for preventing cancer

scientific article (publication date: 17 May 2001)

Genomic characterization of the human DNA excision repair gene ERCC-1

scientific article

Histone ubiquitination and chromatin remodeling in mouse spermatogenesis

scientific article published in March 1999

Homeostatic imbalance between apoptosis and cell renewal in the liver of premature aging Xpd mice

scientific journal article

Homologous and non-homologous recombination differentially affect DNA damage repair in mice

scientific article

How Relevant is the Escherichia coli UvrABC Model for Excision Repair in Eukaryotes? ⬇️

scientific article published on December 1, 1991

Human RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaks

scientific article

Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: evidence for functional conservation

scientific article

Human and mouse homologs of the Schizosaccharomyces pombe rad17+ cell cycle checkpoint control gene

scientific article

Hybridocytochemistry with 2-acetylaminofluorene-modified probes

scientific article published on 01 March 1984

Inactivation of the HR6B ubiquitin-conjugating DNA repair enzyme in mice causes male sterility associated with chromatin modification.

scientific article published in September 1996

Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome

scientific article

Involvement of global genome repair, transcription coupled repair, and chromatin remodeling in UV DNA damage response changes during development

scientific article

Isolation and characterization of kinetoplast DNA from bloodstream form of Trypanosoma brucei

scientific article

Kinetoplast DNA ⬇️

scientific article published on January 1, 1979

Kinetoplast DNA in the insect trypanosomes Crithidia luciliae and Crithidia fasciculata. I. Sequence evolution and transcription of the maxicircle

scientific article published on 01 May 1982

Knockout mouse model and gametogenic failure

scientific journal article

Localization of the nucleotide excision repair gene ERCC6 to human chromosome 10q11-q21

scientific article (publication date: April 1992)

Localization of the xeroderma pigmentosum group B-correcting gene ERCC3 to human chromosome 2q21

scientific article

Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31

scientific article published on March 1, 1992

Loss of HR6B ubiquitin-conjugating activity results in damaged synaptonemal complex structure and increased crossing-over frequency during the male meiotic prophase

scientific article

MARK-AGE biomarkers of ageing

scientific article

Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms

scientific journal article

Mammalian nucleotide excision repair

scientific article published on December 1995

Mapping of interaction domains between human repair proteins ERCC1 and XPF

scientific article

Maxi-circles and mini-circles in kinetoplast DNA from trypanosoma cruzi

scientific article published on 01 April 1980

Meningococcal disease in The Netherlands, 1959-1981: the occurrence of serogroups and serotypes 2a and 2b of Neisseria meningitidis

scientific article published on 01 March 1986

Microinjected photoreactivating enzymes from Anacystis and Saccharomyces monomerize dimers in chromatin of human cells

scientific article published on 01 July 1985

Microinjection of Micrococcus luteus UV-endonuclease restores UV-induced unscheduled DNA synthesis in cells of 9 xeroderma pigmentosum complementation groups

scientific article published on 01 June 1985

Microinjection of human cell extracts corrects xeroderma pigmentosum defect ⬇️

scientific article published on January 1, 1983

Molecular and cellular analysis of the DNA repair defect in a patient in xeroderma pigmentosum complementation group D who has the clinical features of xeroderma pigmentosum and Cockayne syndrome

scientific article

Molecular and functional analysis of theXPBC/ERCC-3promoter: transcription activity is dependent on the integrity of an Sp1-binding site ⬇️

scientific article published on January 25, 1992

Molecular basis of DNA repair mechanisms and syndromes

scientific article

Molecular characterization of the human excision repair gene ERCC-1: cDNA cloning and amino acid homology with the yeast DNA repair gene RAD10.

scientific article

Molecular cloning and biological characterization of the human excision repair gene ERCC-3

scientific article

Molecular cloning of a human DNA repair gene

scientific article

Molecular cloning of the human DNA excision repair gene ERCC-6

scientific article

Molecular mechanism of nucleotide excision repair.

scientific article

Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination

scientific journal article

Mutational analysis of the human nucleotide excision repair gene ERCC1

scientific article

Novel expression-linked copies of the genes for variant surface antigens in trypanosomes

scientific article published in Nature

Novel functional interactions between nucleotide excision DNA repair proteins influencing the enzymatic activities of TFIIH, XPG, and ERCC1-XPF

scientific journal article

Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein

scientific article

Phenotypic heterogeneity in nucleotide excision repair mutants of rodent complementation groups 1 and 4

scientific article published on 01 March 1997

Photic induction of mPer1 and mPer2 in cry-deficient mice lacking a biological clock

scientific article published on 01 December 1999

Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks

scientific article

Premature aging in mice deficient in DNA repair and transcription

scientific journal article

RAD25 (SSL2), the yeast homolog of the human xeroderma pigmentosum group B DNA repair gene, is essential for viability ⬇️

scientific article published on December 1, 1992

RNA from the insect trypanosome Crithidia luciliae contains transcripts of the maxi-circle and not of the mini-circle component of kinetoplast DNA.

scientific article published in November 1978

Rec8p, a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fission yeast to humans

scientific article

Recombination and joining: different means to the same ends ⬇️

scientific article published on 01 June 1997

Reduced hematopoietic reserves in DNA interstrand crosslink repair-deficient Ercc1-/- mice

scientific journal article

Rescue of progeria in trichothiodystrophy by homozygous lethal Xpd alleles

scientific article

Retinal degeneration and ionizing radiation hypersensitivity in a mouse model for Cockayne syndrome

scientific journal article

Sequence conservation of the rad21 Schizosaccharomyces pombe DNA double-strand break repair gene in human and mouse

scientific article

Sequential assembly of the nucleotide excision repair factors in vivo

scientific journal article

Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis

scientific journal article

Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6

scientific article

Structure and expression of the excision repair gene ERCC6, involved in the human disorder Cockayne's syndrome group B

scientific article

Structure and expression of the human XPBC/ERCC-3 gene involved in DNA repair disorders xeroderma pigmentosum and Cockayne's syndrome

scientific article

Structure of the nuclear pore complex in mammalian cells Two annular components ⬇️

scientific article published on 01 July 1974

Sublimiting concentration of TFIIH transcription/DNA repair factor causes TTD-A trichothiodystrophy disorder

scientific article (publication date: November 2000)

TFIIH with inactive XPD helicase functions in transcription initiation but is defective in DNA repair.

scientific article

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

scientific article (publication date: 20 April 2000)

The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor

scientific article

The HhH domain of the human DNA repair protein XPF forms stable homodimers

scientific article

The Human Rad54 Recombinational DNA Repair Protein Is a Double-stranded DNA-dependent ATPase ⬇️

scientific article published on October 23, 1998

The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway

scientific article

The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor

scientific article

The cloned human DNA excision repair gene ERCC-1 fails to correct xeroderma pigmentosum complementation groups A through I

scientific article published on 01 March 1989

The genes for variant antigens in trypanosomes

scientific article published on 01 September 1980

The isolation of plasmids containing DNA complementary to messenger RNA for variant surface glycoproteins of Trypanosoma brucei

scientific article published on 01 March 1980

The kinetoplast DNA of Trypanosoma equiperdum

scientific article published on 01 May 1980

The major transcripts of the kinetoplast DNA of Trypanosoma brucei are very small ribosomal RNAs.

scientific article published in January 1983

The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency

scientific article published in 2014

The rhp6+ gene of Schizosaccharomyces pombe: a structural and functional homolog of the RAD6 gene from the distantly related yeast Saccharomyces cerevisiae

scientific article

The structure of the XPF-ssDNA complex underscores the distinct roles of the XPF and ERCC1 helix- hairpin-helix domains in ss/ds DNA recognition

scientific article

The structure-specific endonuclease Ercc1-Xpf is required for targeted gene replacement in embryonic stem cells

scientific article

The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks

scientific journal article

The ubiquitin-conjugating DNA repair enzyme HR6A is a maternal factor essential for early embryonic development in mice

scientific article

Transcription of kinetoplast DNA in Trypanosoma brucei bloodstream and culture forms ⬇️

scientific article published on May 1, 1981

Transcription-coupled and global genome repair differentially influence UV-B-induced acute skin effects and systemic immunosuppression

scientific journal article

Transcription-coupled repair and premature ageing

scientific article

Transfection of the cloned human excision repair gene ERCC-1 to UV-sensitive CHO mutants only corrects the repair defect in complementation group-2 mutants

scientific article published on 01 March 1988

Transient correction of excision repair defects in fibroblasts of 9 xeroderma pigmentosum complementation groups by microinjection of crude human cell extracts

scientific article published on 01 May 1986

Translocation of Cockayne syndrome group A protein to the nuclear matrix: possible relevance to transcription-coupled DNA repair

scientific article

Two Human Homologs of Rad23 Are Functionally Interchangeable in Complex Formation and Stimulation of XPC Repair Activity ⬇️

scientific article published on December 1, 1997

UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair

scientific article

Ubiquitin ligase Rad18Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase

scientific journal article

Variations in maxi-circle and mini-circle sequences in kinetoplast DNAs from different Trypanosoma brucei strains ⬇️

scientific article published on December 11, 1980

Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC

scientific article

Workshop on DNA repair

scientific article published on 01 January 1992

XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription

scientific article

XPC and human homologs of RAD23: intracellular localization and relationship to other nucleotide excision repair complexes

scientific article

Xeroderma Pigmentosum Group C Protein Complex Is the Initiator of Global Genome Nucleotide Excision Repair ⬇️

scientific article published on August 1, 1998

Xeroderma pigmentosum complementation group H falls into complementation group D

scientific article published on 01 September 1991

Xeroderma pigmentosum group A correcting protein from calf thymus

scientific article published on 01 September 1992

Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease

scientific article

p44 and p34 subunits of the BTF2/TFIIH transcription factor have homologies with SSL1, a yeast protein involved in DNA repair

scientific article

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