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List of works by Hans Clevers

5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation

scientific article published on 21 October 2020

A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses

A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening

scientific article published on 18 October 2018

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity.

scientific article

A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche

scientific article published in December 2017

A Versatile Biosynthetic Hydrogel Platform for Engineering of Tissue Analogues

scientific article published on 12 August 2019

A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis

scientific article published on 28 January 2019

A comprehensive model of the spatio-temporal stem cell and tissue organisation in the intestinal crypt

scientific article

A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal

scientific article

A functional CFTR assay using primary cystic fibrosis intestinal organoids

scientific article

A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development

scientific journal article

A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta

scientific article

A promoter-level mammalian expression atlas

scientific article

A rectal cancer organoid platform to study individual responses to chemoradiation

scientific article published on 07 October 2019

A20 controls intestinal homeostasis through cell-specific activities

scientific article published on 30 September 2014

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

scientific journal article

AU-rich elements and alternative splicing in the beta-catenin 3'UTR can influence the human beta-catenin mRNA stability

scientific article published on 15 April 2006

Aberrant polycystin-1 expression results in modification of activator protein-1 activity, whereas Wnt signaling remains unaffected

scientific article published on 15 April 2004

Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins.

scientific article published on 27 December 2016

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

scientific article

Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth

scientific article

Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins

scientific article

Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins.

scientific article

Adult stem cells in the small intestine are intrinsically programmed with their location-specific function

scientific article

Advancing lung organoids for COVID-19 research

scientific article published in June 2021

Airway organoids as models of human disease

scientific article published on 29 April 2020

Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type.

scientific article

An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth

scientific article

An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance

scientific article published on 19 February 2019

An Organoid-derived Bronchioalveolar Model for SARS-CoV-2 Infection of Human Alveolar-type II-like Cells

scientific article published on 06 December 2020

An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking

scientific article

An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity

scientific article published on 11 March 2020

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

scientific article published on 22 April 2019

Analysis of neural crest-derived clones reveals novel aspects of facial development

scientific article

Analysis of the glyco-code in pancreatic ductal adenocarcinoma identifies glycan-mediated immune regulatory circuits

scientific article published on 11 January 2022

Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer

scientific article published on June 2015

Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts

scientific article

Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells

scientific article published on 20 February 2020

Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids

scientific article published on 27 May 2020

Author Correction: Fasting-mimicking diet and hormone therapy induce breast cancer regression

scientific article published on 04 December 2020

Automated brightfield morphometry of 3D organoid populations by OrganoSeg.

scientific article

BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance

scientific article

Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB

scientific journal article

Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation

scientific article published in December 2003

Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion.

scientific article

Bioengineered bile ducts recapitulate key cholangiocyte functions

scientific article published on 12 June 2018

CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank

scientific article published on 20 February 2020

CRISPR-Cas Tools and Their Application in Genetic Engineering of Human Stem Cells and Organoids

scientific article published on 01 November 2020

CRISPR-Induced TMPRSS2-ERG Gene Fusions in Mouse Prostate Organoids.

scientific article published on 28 March 2017

CRISPR/Cas 9 genome editing and its applications in organoids

scientific article published on 26 January 2017

CRISPR/Cas9-Mediated Genome Editing of Mouse Small Intestinal Organoids

scientific article published in January 2016

Cancer modeling meets human organoid technology

scientific article published on 06 June 2019

Cancer stem cells revisited

scientific article published in October 2017

Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation

scientific journal article

Canonical Wnt signals are essential for homeostasis of the intestinal epithelium

scientific article

Cdx2 determines the fate of postnatal intestinal endoderm

scientific journal article

Cell fate specification and differentiation in the adult mammalian intestine

scientific article published on 21 September 2020

Challenges in Establishing Pure Lung Cancer Organoids Limit Their Utility for Personalized Medicine

scientific article published on 01 May 2020

Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis

scientific article

Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis ⬇️

scientific article published on November 16, 2010

Cloning and characterization of hELD/OSA1, a novel BRG1 interacting protein

scientific article

Concise review: the yin and yang of intestinal (cancer) stem cells and their progenitors

scientific article

Consensus molecular subtypes of colorectal cancer are recapitulated in in vitro and in vivo models

scientific article published on 5 January 2018

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

scientific article

Controlled gene expression in primary Lgr5 organoid cultures

scientific article

Converging biofabrication and organoid technologies: the next frontier in hepatic and intestinal tissue engineering?

scientific article published on 17 February 2017

Conversion of mature human β-cells into glucagon-producing α-cells.

scientific article published on 8 April 2013

Conversion of metaplastic Barrett's epithelium into post-mitotic goblet cells by gamma-secretase inhibition

scientific article

Correction for Muncan et al., "Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c-"

article

Correction: The Leukemia-Associated Mllt10/Af10-Dot1l Are Tcf4/β-Catenin Coactivators Essential for Intestinal Homeostasis

scientific article published on 7 February 2017

Corrigendum: Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors

scientific article published in November 2017

Crypt stem cells as the cells-of-origin of intestinal cancer

scientific article

Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation

scientific article published on 25 August 2016

Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine

scientific article published on 9 June 2005

Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss

scientific article published on 24 August 2010

Cysteamine-bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis

scientific article published on 24 June 2021

De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data

scientific article

De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine

scientific article published in March 2004

Deficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss

scientific article published on 09 September 2020

Defining Adult Stem Cell Function at Its Simplest: The Ability to Replace Lost Cells through Mitosis

scientific article published on 01 August 2019

Defining Adult Stem Cells by Function, Not by Phenotype.

scientific article published in March 2018

Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells

scientific article published on 15 August 2019

Designer matrices for intestinal stem cell and organoid culture

scientific article published on 16 November 2016

Development and application of human adult stem or progenitor cell organoids

scientific article published on 28 July 2015

Developmental stage‐specific contribution of LGR5+ cells to basal and luminal epithelial lineages in the postnatal mammary gland ⬇️

scientific article published on November 1, 2012

Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand

scientific journal article

Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment

scientific article (publication date: November 2003)

Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium

scientific article

Differentiated human airway organoids to assess infectivity of emerging influenza virus

article published in the Proceedings of the National Academy of Sciences of the United States of America

Differentiated human colorectal cancer cells protect tumor-initiating cells from irinotecan

scientific article published on 01 April 2011

Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids

scientific article published on 6 October 2015

Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. ⬇️

scientific article

Distinct Cellular Basis for Early Cardiac Arrhythmias, the Cardinal Manifestation of Arrhythmogenic Cardiomyopathy, and the Skin Phenotype of Cardiocutaneous Syndromes

scientific article

Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines

scientific article

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer.

scientific article published on 23 February 2017

Dll1+ secretory progenitor cells revert to stem cells upon crypt damage

scientific article published on 23 September 2012

Down-regulation of Rap1 activity is involved in ephrinB1-induced cell contraction.

scientific article published on July 2005

Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation.

scientific article published on 9 March 2016

Dynamics of Lgr6⁺ Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis

scientific article

ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response

scientific article published on 28 March 2013

Efficient double fragmentation ChIP-seq provides nucleotide resolution protein-DNA binding profiles

scientific article

Efficient intracellular delivery of native proteins

scientific article published on 01 April 2015

Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion

scientific article published on 16 December 2019

Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient

scientific article published on 23 July 2018

Enteroendocrine dynamics - New tools reveal hormonal plasticity in the gut

scientific article published on 12 June 2020

Enterovirus 71 infection of human airway organoids reveals VP1-145 as a viral infectivity determinant.

scientific article

EphB receptor activity suppresses colorectal cancer progression

scientific article published on June 2005

EphB/EphrinB receptors and Wnt signaling in colorectal cancer

scientific article

Erratum: EphB receptor activity suppresses colorectal cancer progression

scholarly article published in Nature

Establishment and Culture of Human Intestinal Organoids Derived from Adult Stem Cells

scientific article published on 01 September 2020

Establishment and characterization of a canine keratinocyte organoid culture system

scientific article published on 02 July 2018

Establishment of Pancreatic Organoids from Normal Tissue and Tumors

scientific article published on 04 December 2020

Establishment of human fetal hepatocyte organoids and CRISPR-Cas9-based gene knockin and knockout in organoid cultures from human liver

scientific article published on 27 November 2020

Establishment of patient-derived cancer organoids for drug-screening applications

scientific article published on 14 September 2020

Everything has its time: Id2 clocks embryonic specification of Lgr5+ gut stem cells

scientific article published on 15 March 2017

Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential.

scientific article published in March 2018

Expression pattern of Wnt signaling components in the adult intestine

scientific article published in August 2005

Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture

scientific article published on 11 December 2019

FANTOM5 CAGE profiles of human and mouse samples

scientific article published on 29 August 2017

Fast and efficient generation of knock-in human organoids using homology-independent CRISPR-Cas9 precision genome editing

scientific article published on 02 March 2020

Fasting-mimicking diet and hormone therapy induce breast cancer regression

scientific article published on 15 July 2020

Fishing for intestinal cancer models: unraveling gastrointestinal homeostasis and tumorigenesis in zebrafish

scientific article published in December 2009

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.

scientific article published on August 2010

Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients

scientific article published on 11 February 2017

Forskolin-induced swelling of intestinal organoids correlates with disease severity in adults with cystic fibrosis and homozygous F508del mutations

scientific article published on 14 November 2019

FoxM1 is required for execution of the mitotic programme and chromosome stability

scientific article

Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cells

scientific article

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell

scientific article published on 11 March 2012

Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients

scientific article

Generation and analysis of mouse intestinal tumors and organoids harboring APC and K-Ras mutations

scientific article

Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure

scientific article published on 26 February 2016

Generation of BAC transgenic epithelial organoids

scientific article

Generation of L cells in mouse and human small intestine organoids

scientific article

Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids

scientific article published on 09 August 2018

Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research

scientific article published on 05 October 2016

Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids

scientific article published on 07 March 2017

Genome sequencing of normal cells reveals developmental lineages and mutational processes

scientific article published on 29 June 2014

Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance

scientific article published on 01 March 2020

Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors

scientific article published on 21 November 2016

Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells

scientific article published on 11 February 2008

Germline deletions in the tumour suppressor gene FOCAD are associated with polyposis and colorectal cancer development.

scientific article published on 26 March 2015

Giving APCmin tumours a SPARC.

scientific article published on 19 April 2007

Glial origin of mesenchymal stem cells in a tooth model system

scientific article published on 27 July 2014

Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications

scientific article published on June 2013

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction

scientific journal article

Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice.

scientific article

Hepatocyte growth factor/MET and CD44 in colorectal cancer: partners in tumorigenesis and therapy resistance

scientific article published on 22 September 2020

High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells

scientific article published on 01 August 2020

High-resolution 3D imaging of fixed and cleared organoids

scientific article published on 03 May 2019

Highly sensitive proteome analysis of FACS-sorted adult colon stem cells

scientific article

Hindgut defects and transformation of the gastro-intestinal tract in Tcf4(-/-)/Tcf1(-/-) embryos

scientific journal article

Homeostatic mini-intestines through scaffold-guided organoid morphogenesis

scientific article published on 16 September 2020

How the Gut Feels, Smells, and Talks

scientific article published in June 2017

Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease

scientific article published on 14 December 2020

Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells

scientific article

Human-Derived Model Systems in Gynecological Cancer Research

scientific article published on 24 August 2020

IFN-γ: The T cell's license to kill stem cells in the inflamed intestine

scientific article published on 01 December 2019

Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping

scientific article published on 31 January 2019

Identification of a clonally expanding haematopoietic compartment in bone marrow

scientific article published on 27 November 2012

Identification of stem cells in small intestine and colon by marker gene Lgr5

scientific article (publication date: 25 October 2007)

Identification of two novel regulated serines in the N terminus of beta-catenin

scientific article published in June 2002

Identifying the Stem Cell of the Intestinal Crypt: Strategies and Pitfalls ⬇️

scientific article published on October 5, 2012

Illegitimate WNT signaling promotes proliferation of multiple myeloma cells

scientific article

In Situ Hybridization to Identify Gut Stem Cells.

scientific article published on 3 August 2015

In situ hybridization to identify gut stem cells

scientific article published in January 2010

In vitro expansion and transplantation of intestinal crypt stem cells

scientific article published on 18 May 2012

In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection

scientific article

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. ⬇️

scientific article published on 27 January 2013

Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency.

scientific article

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

scientific article published on 25 August 2016

Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer

scientific article published on 01 June 2019

Indian hedgehog regulates intestinal stem cell fate through epithelial-mesenchymal interactions during development.

scientific article published on 11 June 2010

Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells.

scientific article published on 17 November 2016

Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition

scientific article

Inflammatory Bowel Disease, Stress, and the Endoplasmic Reticulum

scientific article

Integrated genome-wide analysis of transcription factor occupancy, RNA polymerase II binding and steady-state RNA levels identify differentially regulated functional gene classes

scientific article published on 13 September 2011

Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency

scientific article published on 26 September 2018

Intestinal Regeneration: Regulation by the Microenvironment

scientific article published on 01 August 2020

Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

scientific article (publication date: October 2010)

Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging.

scientific article

Intestinal epithelial organoids fuse to form self-organizing tubes in floating collagen gels.

scientific article published in March 2017

Intestinal regeneration: YAP-tumor suppressor and oncoprotein?

scientific article published in February 2013

Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors.

scientific article published on 17 May 2010

Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties

scientific article

Intra-tumour diversification in colorectal cancer at the single-cell level

scientific article published in Nature

Isolation and in vitro expansion of human colonic stem cells.

scientific article

KLF5 regulates the integrity and oncogenicity of intestinal stem cells

scientific article published on 13 March 2014

Kidney Organoids and Tubuloids

scientific article published on 26 May 2020

LGR5 positivity defines stem-like cells in colorectal cancer

scientific article

LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism

scientific article published on July 2009

LKB1 tumor suppressor protein: PARtaker in cell polarity

scientific article

Large-Scale Production of LGR5-Positive Bipotential Human Liver Stem Cells

scientific article published on 12 November 2019

Leucine-rich repeat-containing G-protein-coupled Receptor 5 marks short-term hematopoietic stem and progenitor cells during mouse embryonic development

scientific article

Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells

scientific article

Lgr proteins in epithelial stem cell biology

scientific article published on June 2013

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

scientific article

Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes ⬇️

scientific article published on February 4, 2011

Lgr5 marks cycling, yet long-lived, hair follicle stem cells.

scientific article published on 12 October 2008

Lgr5(+) liver stem cells, hepatic organoids and regenerative medicine.

scientific article

Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development.

scientific article

Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

scientific article published on 01 March 2010

LifeTime and improving European healthcare through cell-based interceptive medicine

scientific article published on 07 September 2020

Lineage tracing in the intestinal epithelium

scientific article published in May 2010

Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas

scientific article

Lineage-dependent spatial and functional organization of the mammalian enteric nervous system.

scientific article published in May 2017

Lipid-mediated Wnt protein stabilization enables serum-free culture of human organ stem cells.

scientific article published on 6 March 2017

Live and let die in the intestinal epithelium

scientific article published on December 2003

Live and let die in the intestinal epithelium [Curr. Opin. Cell Biol. 15 (2003) 763]

article by Elena Sancho et al published February 2004 in Current Opinion in Cell Biology

Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation.

scientific article

Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis

scientific article

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids

scientific article published on 01 November 2018

Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals

scientific article published on 22 December 2015

Long-Term Survival of Transplanted Autologous Canine Liver Organoids in a COMMD1-Deficient Dog Model of Metabolic Liver Disease

scientific article published on 11 February 2020

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

scientific article published on 02 September 2011

Long-term culture of genome-stable bipotent stem cells from adult human liver

scientific article

Long-term culture, genetic manipulation and xenotransplantation of human normal and breast cancer organoids

scientific article published on 10 March 2021

Long-term expanding human airway organoids for disease modeling

scientific article published on 14 January 2019

Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures

scientific article published on 28 June 2019

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

scientific journal article

Loss of syntaxin 3 causes variant microvillus inclusion disease

scientific article

Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo

scientific article published on 09 June 2017

Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl

scientific article

Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling

scientific article

MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway.

scientific article

MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms

scientific article published on 14 July 2017

MET Signaling Overcomes Epidermal Growth Factor Receptor Inhibition in Normal and Colorectal Cancer Stem Cells Causing Drug Resistance

scientific article published on 27 June 2019

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

scientific article

Many inflammatory bowel disease risk loci include regions that regulate gene expression in immune cells and the intestinal epithelium.

scientific article published on 12 December 2013

Mapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67-RFP allele

scientific article

Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE

scientific article published on February 2007

Measuring mutation accumulation in single human adult stem cells by whole-genome sequencing of organoid cultures

scientific article published on 7 December 2017

Microbiota controls the homeostasis of glial cells in the gut lamina propria

scientific article

Model organoids provide new research opportunities for ductal pancreatic cancer

scientific article published on 23 February 2015

Modeling Development and Disease with Organoids

scientific article

Modeling Human Digestive Diseases With CRISPR-Cas9-Modified Organoids

scientific article published on 23 November 2018

Modeling pancreatic cancer with organoids

scientific article published on April 2016

Modelling Cryptosporidium infection in human small intestinal and lung organoids

scientific article published on 25 June 2018

Modelling cancer immunomodulation using epithelial organoid cultures

article

Modelling of primary ciliary dyskinesia using patient-derived airway organoids ⬇️

scientific article published on 25 October 2021

Monoclonal Antibodies Against Lgr5 Identify Human Colorectal Cancer Stem Cells ⬇️

scientific article published on 01 November 2012

Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations.

scientific article

Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex

scientific article

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation

scientific article published on 11 May 2016

Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli

scientific article published on 27 February 2020

Myc deletion rescues Apc deficiency in the small intestine

scientific journal article

Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors

scientific article

Neural stem cells for diabetes cell‐based therapy ⬇️

scientific article published on December 1, 2011

Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo

scientific article published on 14 August 2020

Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny

scientific article published on December 2013

Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche

scientific article published on 17 May 2018

OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells

scientific article

On the biomechanics of stem cell niche formation in the gut--modelling growing organoids

scientific article

Oncogene-inducible organoids as a miniature platform to assess cancer characteristics

scientific article

Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

scientific article published on 29 April 2019

Optimality in the development of intestinal crypts

scientific article published on February 2012

Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy

scientific article published on 03 May 2019

Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer

article

Organoid culture systems for prostate epithelial and cancer tissue.

scientific article published on 21 January 2016

Organoid cultures derived from patients with advanced prostate cancer

scientific article

Organoid cultures for the analysis of cancer phenotypes

scientific article published on 31 December 2013

Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages

scientific article published on 06 April 2020

Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles

scientific article published on 26 March 2020

Organoid models of human and mouse ductal pancreatic cancer

scientific article

Organoids as Model for Infectious Diseases: Culture of Human and Murine Stomach Organoids and Microinjection of Helicobacter Pylori.

scientific article

Organoids in immunological research

scientific article published on 18 December 2019

Organoids: Modeling Development and the Stem Cell Niche in a Dish.

scientific article published on September 2016

Origins of lymphatic and distant metastases in human colorectal cancer.

scientific article

PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation

scientific article published on 01 October 2018

Pancreatic cancer organoids recapitulate disease and allow personalized drug screening

scientific article published on 09 December 2019

Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling

scientific article published on 01 August 2018

Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell-derived IFN-γ.

scientific article

Paneth cells

scientific article

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

scientific article

Patient-Derived Head and Neck Cancer Organoids Recapitulate EGFR Expression Levels of Respective Tissues and Are Responsive to EGFR-Targeted Photodynamic Therapy

scientific article published on 05 November 2019

Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses

scientific article published on 01 June 2020

Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients

scientific article published on 01 October 2019

Patient-derived pancreatic tumour organoids identify therapeutic responses to oncolytic adenoviruses

scientific article published on 24 May 2020

Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer

scientific article published on January 2017

Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts".

scientific article published on 9 July 2012

Phosphatidylinositol 3-kinase signaling does not activate the wnt cascade

scientific article published on December 2009

Plasticity within stem cell hierarchies in mammalian epithelia

scientific article

Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia

scientific article published on 28 May 2015

Preclinical models of pancreatic ductal adenocarcinoma

scientific article

Premigratory and migratory neural crest cells are multipotent in vivo

scientific article

Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases

scientific article

Primary Intestinal Epithelial Organoid Culture

scientific article published on 01 January 2020

Primary Mouse Small Intestinal Epithelial Cell Cultures ⬇️

scientific article published on January 1, 2013

Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids

scientific article published on 23 May 2019

Profiling proliferative cells and their progeny in damaged murine hearts

article published in the Proceedings of the National Academy of Sciences of the United States of America

Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine

scientific article published on 24 March 2009

Prospective derivation of a living organoid biobank of colorectal cancer patients.

scientific article published on May 2015

Proteome changes induced by knock-down of the deubiquitylating enzyme HAUSP/USP7.

scientific article published on 10 October 2007

Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine

scientific article published on 17 March 2021

RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation

scientific article published on 21 June 2016

ROCKin' Intestinal Cell Fate: A Potential Avenue to Improve Glucose Sensitivity

scientific article published on 08 September 2018

Rap2A links intestinal cell polarity to brush border formation

scientific article

Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc

scientific article published on 5 September 2006

Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells

scientific article published on 23 August 2012

Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon

scientific article published on 29 August 2016

Regulation and plasticity of intestinal stem cells during homeostasis and regeneration

scientific article published on October 2016

Regulation of stem cell therapies under attack in Europe: for whom the bell tolls

scientific article published on 3 May 2013

Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters

scientific article published on 27 January 2016

Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression

scientific article published on 24 June 2011

Retroviral gene expression control in primary organoid cultures

scientific article published on 13 November 2013

Robust cre-mediated recombination in small intestinal stem cells utilizing the olfm4 locus

scientific article published on 26 June 2014

SARS-CoV-2 Productively Infects Human Gut Enterocytes

scientific article published on 26 April 2020

SARS-CoV-2 infection and replication in human gastric organoids

scientific article published on 16 November 2021

SARS-CoV-2 productively infects human gut enterocytes

scientific article

SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes

scientific article

SOX9 is required for the differentiation of paneth cells in the intestinal epithelium

scientific journal article

SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production

scientific journal article

STRAD pseudokinases regulate axogenesis and LKB1 stability

scientific article

Selection of personalized patient therapy through the use of knowledge-based computational models that identify tumor-driving signal transduction pathways.

scientific article published on 2 April 2014

Sequencing metabolically labeled transcripts in single cells reveals mRNA turnover strategies

scientific article

Sequential cancer mutations in cultured human intestinal stem cells

scientific article published on 29 April 2015

Signaling pathways in intestinal development and cancer

scientific article published in January 2004

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

scientific article (publication date: 14 May 2009)

Single-cell derived tumor organoids display diversity in HLA class I peptide presentation

scientific article published on 21 October 2020

Single-cell dissection of transcriptional heterogeneity in human colon tumors

scientific article

Single-cell messenger RNA sequencing reveals rare intestinal cell types

scientific article

Single-molecule transcript counting of stem-cell markers in the mouse intestine

scientific article published on 27 November 2011

Slide preparation for single-cell-resolution imaging of fluorescent proteins in their three-dimensional near-native environment

scientific article published on 28 July 2011

Snake Venom Gland Organoids

scientific article published on 01 January 2020

SnapShot: Growing Organoids from Stem Cells

scientific article published on 01 June 2015

SnapShot: The Intestinal Crypt

scientific article published on 01 February 2013

Sox9 marks adult organ progenitors

scientific article published on 01 January 2011

Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector

scientific article

Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue.

scientific article published in February 2010

Stem Cells in Repair of Gastrointestinal Epithelia

scientific article

Stem cell self-renewal in intestinal crypt

scientific article published on 20 July 2011

Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control

scientific article

Stem cell-derived organoids and their application for medical research and patient treatment

scientific article published on 8 April 2017

Stem cells and cancer of the stomach and intestine

scientific article published on 08 June 2010

Stem cells marked by the R-spondin receptor LGR5.

scientific article published on 21 May 2014

Stem cells, self-renewal, and differentiation in the intestinal epithelium

scientific article

Strategies for homeostatic stem cell self-renewal in adult tissues

scientific article published on June 2011

Stratifying infants with cystic fibrosis for disease severity using intestinal organoid swelling as a biomarker of CFTR function

scientific article published on 17 September 2018

Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5

scientific article

Structures of Wnt-Antagonist ZNRF3 and Its Complex with R-Spondin 1 and Implications for Signaling

scientific article

Studying cellular heterogeneity and drug sensitivity in colorectal cancer using organoid technology

scientific article published on 24 September 2018

Sumoylation by Ubc9 Regulates the Stem Cell Compartment and Structure and Function of the Intestinal Epithelium in Mice ⬇️

scientific article published on October 14, 2010

Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling.

scientific article published on 3 May 2017

Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins

scientific article published on 6 December 2017

T-cell factor 4 (Tcf7l2) maintains proliferative compartments in zebrafish intestine

scientific article

T-cell factor 4 (tcf7l2) is the main effector of Wnt signaling during zebrafish intestine organogenesis

scientific article published in March 2009

T-cell factors: turn-ons and turn-offs

scientific article

TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions

scientific article

TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling

scientific article

TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype

scientific article

Tales from the crypt: new insights into intestinal stem cells

scientific article published on 01 January 2019

Targeting development of incretin-producing cells increases insulin secretion

scientific article published on 15 December 2014

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening

scientific article

The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis

scientific article published in 2011

The Generation of Organoids for Studying Wnt Signaling

scientific article published on January 2016

The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas

scientific journal article

The Human Cell Atlas

scientific article

The Human Cell Atlas

The Human Cell Atlas White Paper ⬇️

journal article from 'arXiv:1810.05192 [q-bio]' published in 2018

The Intestinal Wnt/TCF Signature.

scientific article published on 18 August 2006

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers

scientific article published on 12 June 2012

The Myofibroblasts' War on Drugs

scientific article published on 01 September 2018

The Organoid Cell Atlas

scientific article

The Organoid Cell Atlas: A Rosetta Stone for Biomedical Discovery and Regenerative Therapy ⬇️

journal article published in 2020

The R-spondin protein family

scientific article

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

scientific article published on February 2014

The Wnt/beta-catenin pathway regulates cardiac valve formation

scientific article published in October 2003

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

scientific article

The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice

scientific article

The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium

scientific journal article

The gut microbiota keeps enteric glial cells on the move; prospective roles of the gut epithelium and immune system

scientific article published on 11 November 2015

The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus

scientific article

The intestinal stem cell

scientific article published on July 2008

The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse

scientific article

The kinase TNIK is an essential activator of Wnt target genes

scientific article

The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis

scientific article

The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development.

scientific article published on 25 October 2005

The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish ⬇️

scientific article published on March 15, 2011

Three-dimensional single-cell imaging for the analysis of RNA and protein expression in intact tumour biopsies

scientific article published on 29 June 2020

Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors

scientific article published on 01 March 2019

Tissue-Engineering the Intestine: The Trials before the Trials

scientific article published on 01 June 2019

Tissue-resident adult stem cell populations of rapidly self-renewing organs

scientific article published on December 2010

Tissue-specific mutation accumulation in human adult stem cells during life

scientific article published on 3 October 2016

Tracking adult stem cells.

scientific article

Tracking down the stem cells of the intestine: strategies to identify adult stem cells

scientific article published in December 2007

Transcription factor achaete scute-like 2 controls intestinal stem cell fate

scientific journal article

Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development

scientific article

Transcription factor target practice

scientific article

Transcriptome profile of human colorectal adenomas.

scientific article published in December 2007

Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2.

scientific article

Translation and Replication Dynamics of Single RNA Viruses

scientific article published on 06 November 2020

Translational applications of adult stem cell-derived organoids.

scientific article published on March 2017

Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy

scientific article

Troy/TNFRSF19 marks epithelial progenitor cells during mouse kidney development that continue to contribute to turnover in adult kidney

scientific article published on 13 December 2017

Tubuloids derived from human adult kidney and urine for personalized disease modeling

scientific article published on 04 March 2019

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

scientific article published on 30 August 2012

Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation

scientific article published on 26 October 2023

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

scientific article

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer.

scientific article

Very Early Onset Inflammatory Bowel Disease: A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies

scientific article published on 03 December 2019

Visualization of a short-range Wnt gradient in the intestinal stem-cell niche.

scientific article published on 10 February 2016

WNT signaling and lymphocyte development

scientific article

WNT signaling in the normal intestine and colorectal cancer

scientific article published on January 2007

WNT signalling events near the cell membrane and their pharmacological targeting for the treatment of cancer.

scientific article published on 28 February 2017

What Is Your Conceptual Definition of "Cell Type" in the Context of a Mature Organism? ⬇️

scientific article published on 01 March 2017

What does the concept of the stem cell niche really mean today?

scientific article

Who Is in the Driver's Seat: Tracing Cancer Genes Using CRISPR-Barcoding

scientific article published in August 2016

Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer.

scientific article published on 11 May 2014

Wnt activates the Tak1/Nemo-like kinase pathway

scientific article (publication date: 23 April 2004)

Wnt control of stem cells and differentiation in the intestinal epithelium

scientific article

Wnt signaling controls the phosphorylation status of beta-catenin.

scientific article published on 7 February 2002

Wnt signaling in the intestinal epithelium: from endoderm to cancer

scientific article

Wnt signaling mediates regional specification in the vertebrate face

scientific journal article

Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer

scientific article published in September 2002

Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex

scientific article

Wnt signaling, lgr5, and stem cells in the intestine and skin

scientific article

Wnt signalling induces maturation of Paneth cells in intestinal crypts

scientific journal article

Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin

scientific article

Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF.

scientific article published on 10 January 2014

Wnt/beta-catenin signaling in development and disease

scientific article (publication date: 3 November 2006)

Wnt/β-Catenin Signaling and Disease ⬇️

scientific article published on June 8, 2012

Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

scientific article published on June 2017

Wnt/β-catenin signaling in adult mammalian epithelial stem cells

scientific article

Xenograft and organoid model systems in cancer research

scientific article published on 08 July 2019

You Wnt some, you lose some: oncogenes in the Wnt signaling pathway

scientific article

ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling.

scientific article published on 7 May 2018

c-Myb is required for progenitor cell homeostasis in colonic crypts.

scholarly article

p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium

scientific article

p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice

article published in 2009

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