Search filters

List of works by Frank Kirchhoff

90K, an interferon-stimulated gene product, reduces the infectivity of HIV-1.

scientific article published on 24 October 2013

A Highly Conserved Residue of the HIV-1 gp120 Inner Domain Is Important for Antibody-Dependent Cellular Cytotoxicity Responses Mediated by Anti-cluster A Antibodies

scientific article

A flow cytometry-based FRET assay to identify and analyse protein-protein interactions in living cells

scientific article

A molecular tweezer antagonizes seminal amyloids and HIV infection.

scientific article

A naturally occurring variation in the proline-rich region does not attenuate human immunodeficiency virus type 1 nef function

scientific article published on September 2004

A rare missense variant abrogates the signaling activity of tetherin/BST-2 without affecting its effect on virus release

scientific article

A simian immunodeficiency virus V3 loop mutant that does not efficiently use CCR5 or common alternative coreceptors is moderately attenuated in vivo

scientific article published on 28 November 2006

Alterations in HIV-1 LTR promoter activity during AIDS progression

scientific article published on December 2003

Amino acid 324 in the simian immunodeficiency virus SIVmac V3 loop can confer CD4 independence and modulate the interaction with CCR5 and alternative coreceptors

scientific article published on April 2004

Aminoquinoline surfen inhibits the action of SEVI (semen-derived enhancer of viral infection).

scientific article

An optimized MM/PBSA virtual screening approach applied to an HIV-1 gp41 fusion peptide inhibitor.

scientific article

Ancient origin of a deletion in human BST2/Tetherin that confers protection against viral zoonoses

scientific article published on 11 August 2011

Association of Nef with p21-activated kinase 2 is dispensable for efficient human immunodeficiency virus type 1 replication and cytopathicity in ex vivo-infected human lymphoid tissue

scientific article

Association of simian immunodeficiency virus Nef with cellular serine/threonine kinases is dispensable for the development of AIDS in rhesus macaques ⬇️

scientific article published on August 1, 1997

BST-2 Expression Modulates Small CD4-Mimetic Sensitization of HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity

scientific article published on 22 March 2017

CD4 binding affinity determines human immunodeficiency virus type 1-induced alpha interferon production in plasmacytoid dendritic cells

scientific article published on 25 June 2008

CD4+ T cell-derived IL-21 and deprivation of CD40 signaling favor the in vivo development of granzyme B-expressing regulatory B cells in HIV patients

scientific article published on 16 March 2015

CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling

scientific article published on June 2009

CL-385319 inhibits H5N1 avian influenza A virus infection by blocking viral entry

scientific article published on 22 April 2011

Circulating Nef induces dyslipidemia in simian immunodeficiency virus-infected macaques by suppressing cholesterol efflux

scientific article

Comprehensive analysis of nef functions selected in simian immunodeficiency virus-infected macaques

scientific article

Conservation of Nef function across highly diverse lineages of SIVsmm

scientific article published on 09 April 2009

Conserved residue Lys574 in the cavity of HIV-1 Gp41 coiled-coil domain is critical for six-helix bundle stability and virus entry.

scientific article published on 6 July 2007

Contribution of Vpu, Env, and Nef to CD4 down-modulation and resistance of human immunodeficiency virus type 1-infected T cells to superinfection

scientific article published on August 2006

Control of TLR7-mediated type I IFN signaling in pDCs through CXCR4 engagement-A new target for lupus treatment

scientific article published on 10 July 2019

Counteraction of HLA-C-mediated immune control of HIV-1 by Nef.

scientific article

Differential Control of BST2 Restriction and Plasmacytoid Dendritic Cell Antiviral Response by Antagonists Encoded by HIV-1 Group M and O Strains

scientific article

Differential regulation of NF-κB-mediated proviral and antiviral host gene expression by primate lentiviral Nef and Vpu proteins

scientific article published on 22 January 2015

Differential regulation of human immunodeficiency virus type 2 and simian immunodeficiency virus promoter activity

scientific article published in July 2004

Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen.

scientific article

Discovery and characterization of an endogenous CXCR4 antagonist

scientific article

Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide

scientific article

Discovery of modulators of HIV-1 infection from the human peptidome

scientific article

Down-Modulation of CD8αβ Is a Fundamental Activity of Primate Lentiviral Nef Proteins ⬇️

scientific article published on October 19, 2011

Down-modulation of mature major histocompatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles.

scientific article published on October 2003

EPI-X4, a novel endogenous antagonist of CXCR4

scientific article published on 8 October 2015

Early Vertebrate Evolution of the Host Restriction Factor Tetherin

scientific article

Effect of R77Q, R77A and R80A changes in Vpr on HIV-1 replication and CD4 T cell depletion in human lymphoid tissue ex vivo

scientific article

Effect of naturally-occurring gp41 HR1 variations on susceptibility of HIV-1 to fusion inhibitors

scientific article published in September 2005

Effect of semen and seminal amyloid on vaginal transmission of simian immunodeficiency virus

scientific article

Efficient Nef-mediated downmodulation of TCR-CD3 and CD28 is associated with high CD4+ T cell counts in viremic HIV-2 infection

scientific article

Efficient SIVcpz replication in human lymphoid tissue requires viral matrix protein adaptation

scientific article

Efficient Vpu-Mediated Tetherin Antagonism by an HIV-1 Group O Strain

scientific article

Emerging Role of PYHIN Proteins as Antiviral Restriction Factors

scientific article published on 18 December 2020

Emerging role of the host restriction factor tetherin in viral immune sensing

scientific article published on 26 September 2013

Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3.

scientific article published on 5 September 2017

Endogenous TRIM5α Function Is Regulated by SUMOylation and Nuclear Sequestration for Efficient Innate Sensing in Dendritic Cells

scientific article

Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased Env incorporation and viral replication

scientific article published on 19 June 2003

Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein

scientific article

Exploiting the human peptidome for novel antimicrobial and anticancer agents

scientific article published on 31 October 2017

Fibrils of prostatic acid phosphatase fragments boost infections with XMRV (xenotropic murine leukemia virus-related virus), a human retrovirus associated with prostate cancer

scientific article

First steps toward a globally effective HIV/AIDS vaccine.

scientific article published on 24 October 2013

Frequencies of lymphoid T-follicular helper cells obtained longitudinally by lymph node fine-needle aspiration correlate significantly with viral load in SIV-infected rhesus monkeys

scientific article published on 31 July 2015

Generation and Characterization of Virus-Enhancing Peptide Nanofibrils Functionalized with Fluorescent Labels

scientific article published on 16 March 2017

Genetic identity and biological phenotype of a transmitted/founder virus representative of nonpathogenic simian immunodeficiency virus infection in African green monkeys

scientific article

Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 Infectivity

scientific article published on 15 March 2016

Guanylate binding protein 5: Impairing virion infectivity by targeting retroviral envelope glycoproteins

scientific article published on 8 June 2016

HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4+ T Cells

scientific article published on October 2016

HIV infection in a patient with alpha-1 antitrypsin deficiency: a detrimental combination?

article

HIV replication: a game of hide and sense.

scientific article

HIV-1 Group P is unable to antagonize human tetherin by Vpu, Env or Nef.

scientific article

HIV-1 Vpu Does Not Degrade Interferon Regulatory Factor 3 ⬇️

scientific article published on April 3, 2013

HIV-1 Vpu affects the anterograde transport and the glycosylation pattern of NTB-A.

scientific article published on 22 March 2013

HIV-1 accessory proteins: Nef.

scientific article published on January 2014

HIV-1-Mediated Downmodulation of HLA-C Impacts Target Cell Recognition and Antiviral Activity of NK Cells

scientific article published on July 2017

Hemofiltrate CC chemokine 1[9-74] causes effective internalization of CCR5 and is a potent inhibitor of R5-tropic human immunodeficiency virus type 1 strains in primary T cells and macrophages

scientific article

Host proteins involved in HIV infection: new therapeutic targets.

scientific article published on 16 December 2009

Human immunodeficiency virus type 1 inhibits DNA damage-triggered apoptosis by a Nef-independent mechanism

scientific article

Human immunodeficiency virus type 1 nef expression prevents AP-2-mediated internalization of the major histocompatibility complex class II-associated invariant chain.

scientific article

Human immunodeficiency virus type 1 variants resistant to first- and second-version fusion inhibitors and cytopathic in ex vivo human lymphoid tissue

scientific article published on 11 April 2007

Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein

scientific article

Human-Specific Adaptations in Vpu Conferring Anti-tetherin Activity Are Critical for Efficient Early HIV-1 Replication In Vivo

scientific article published in January 2018

IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro

scientific article published on 28 July 2021

IFITM proteins promote SARS-CoV-2 infection of human lung cells

IFITMs: Important Factors In Trans-Mission of HIV-1.

scientific article published on October 2016

Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses

scientific article published on 16 May 2015

Identification of the first nonpeptidergic inverse agonist for a constitutively active viral-encoded G protein-coupled receptor

scientific article published on 26 November 2002

Immune evasion activities of accessory proteins Vpu, Nef and Vif are conserved in acute and chronic HIV-1 infection.

scientific article published on 30 March 2015

Immune evasion and counteraction of restriction factors by HIV-1 and other primate lentiviruses

scientific article

Implications of Nef: host cell interactions in viral persistence and progression to AIDS.

scientific article published on January 2009

Importance of the N-distal AP-2 binding element in Nef for simian immunodeficiency virus replication and pathogenicity in rhesus macaques

scientific article published on May 2006

Increased susceptibility of CD4+ T cells from elderly individuals to HIV-1 infection and apoptosis is associated with reduced CD4 and enhanced CXCR4 and FAS surface expression levels

scientific article

Inefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+T cells in natural SIV infection

scientific article

Influenza A virus does not encode a tetherin antagonist with Vpu-like activity and induces IFN-dependent tetherin expression in infected cells

scientific article

Inhibition of HIV-1 group M and O isolates by fusion inhibitors

scientific article

Interferons and beyond: Induction of antiretroviral restriction factors

scientific article published on 15 December 2017

Involvement of a C-terminal motif in the interference of primate lentiviral Vpu proteins with CD1d-mediated antigen presentation

scientific article

Is Nef the elusive cause of HIV-associated hematopoietic dysfunction?

scientific article published on May 2008

Is the high virulence of HIV-1 an unfortunate coincidence of primate lentiviral evolution?

scientific article

LSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirus

scientific article

Lentiviral Nef proteins manipulate T cells in a subset-specific manner

scientific article

Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals

scientific article

Link between primate lentiviral coreceptor usage and Nef function

scientific article

Liquefaction of semen generates and later degrades a conserved semenogelin peptide that enhances HIV infection

scientific article

Loss of Nef-mediated CD3 down-regulation in the HIV-1 lineage increases viral infectivity and spread

scientific article published on 16 March 2020

Low levels of SIV infection in sooty mangabey central memory CD⁴⁺ T cells are associated with limited CCR5 expression

scientific article published on 26 June 2011

Modest attenuation of HIV-1 Vpu alleles derived from elite controller plasma

scientific article published on 20 March 2015

Molecular Control of HIV and SIV Latency

scientific article

Monkeypox: A New Threat?

scientific article published on 18 July 2022

Multilayered and versatile inhibition of cellular antiviral factors by HIV and SIV accessory proteins.

scientific article

Mutation of a diacidic motif in SIV-PBj Nef impairs T-cell activation and enteropathic disease

scientific article published on 2 March 2011

Mutations in the C3 region of human and simian immunodeficiency virus envelope have differential effects on viral infectivity, replication, and CD4-dependency

scientific article published on October 2003

Naturally occurring fragments from two distinct regions of the prostatic acid phosphatase form amyloidogenic enhancers of HIV infection

scientific article published on 16 November 2011

Nef alleles from children with non-progressive HIV-1 infection modulate MHC-II expression more efficiently than those from rapid progressors.

scientific article published in May 2007

Nef associates with p21-activated kinase 2 in a p21-GTPase-dependent dynamic activation complex within lipid rafts.

scientific article published on December 2004

Nef enhances human immunodeficiency virus type 1 infectivity and replication independently of viral coreceptor tropism

scientific article

Nef induces multiple genes involved in cholesterol synthesis and uptake in human immunodeficiency virus type 1-infected T cells

scientific article

Nef proteins from diverse groups of primate lentiviruses downmodulate CXCR4 to inhibit migration to the chemokine stromal derived factor 1.

scientific article

Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors

scientific article

Nef proteins from simian immunodeficiency viruses are tetherin antagonists.

scientific article

Nef proteins of epidemic HIV-1 group O strains antagonize human tetherin

scientific article

Nef-Mediated Suppression of T Cell Activation Was Lost in a Lentiviral Lineage that Gave Rise to HIV-1

scientific article

Nef-mediated enhancement of virion infectivity and stimulation of viral replication are fundamental properties of primate lentiviruses

scientific article

Normal immune function and inability to isolate virus in culture in an individual with long-term human immunodeficiency virus type 1 infection.

scientific article published in April 1994

Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells

scientific article published on 06 August 2020

Osteopontin regulates and attenuates aging-associated phenotypes of HSCS

scholarly article by Novella Guidi published in September 2016

Peptide nanofibrils as enhancers of retroviral gene transfer

scientific article published on 28 May 2014

Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses.

scientific article published on 20 January 2013

Peptides released by physiological cleavage of semen coagulum proteins form amyloids that enhance HIV infection

scientific article published on December 2011

Preadaptation of Simian Immunodeficiency Virus SIVsmm Facilitated Env-Mediated Counteraction of Human Tetherin by Human Immunodeficiency Virus Type 2

scholarly article by Elena Heusinger published in September 2018

Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing

scientific article

Primary human immunodeficiency virus type 1 nef alleles show major differences in pathogenicity in transgenic mice

scientific article published on 21 February 2007

Primary sooty mangabey simian immunodeficiency virus and human immunodeficiency virus type 2 nef alleles modulate cell surface expression of various human receptors and enhance viral infectivity and replication.

scientific article

Primate Lentiviruses Modulate NF-κB Activity by Multiple Mechanisms to Fine-Tune Viral and Cellular Gene Expression

scientific article published on 14 February 2017

Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms

scientific article

Primate lentiviruses use at least three alternative strategies to suppress NF-κB-mediated immune activation

scientific article published on 31 August 2017

Proceedings of the Frontiers of Retrovirology Conference 2016.

scientific article published on 26 September 2016

Proline 35 of human immunodeficiency virus type 1 (HIV-1) Vpr regulates the integrity of the N-terminal helix and the incorporation of Vpr into virus particles and supports the replication of R5-tropic HIV-1 in human lymphoid tissue ex vivo

scientific article published on 6 June 2007

Properties of Human and Simian Immunodeficiency Viruses

Reacquisition of Nef-mediated tetherin antagonism in a single in vivo passage of HIV-1 through its original chimpanzee host

scientific article

Reduced Susceptibility to VIRIP-Based HIV-1 Entry Inhibitors Has a High Genetic Barrier and Severe Fitness Costs

article

Resistance of Major Histocompatibility Complex Class B (MHC-B) to Nef-Mediated Downregulation Relative to that of MHC-A Is Conserved among Primate Lentiviruses and Influences Antiviral T Cell Responses in HIV-1-Infected Individuals

scientific article published on 18 October 2017

SARS-CoV-2 Is Restricted by Zinc Finger Antiviral Protein despite Preadaptation to the Low-CpG Environment in Humans

scientific article published on 16 October 2020

SEVI and Semen Impair the Anti-HIV-1 Activity of Drugs and Microbicides

article

SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity

scientific article published on 24 February 2021

SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue

article

Sandwich enzyme-linked immunosorbent assay for the quantification of human serum albumin fragment 408-423 in bodily fluids

scientific article published on 4 February 2015

Selective downmodulation of HLA-A and -B by Nef alleles from different groups of primate lentiviruses

scientific article published on 21 December 2007

Selective downregulation of rhesus macaque and sooty mangabey major histocompatibility complex class I molecules by Nef alleles of simian immunodeficiency virus and human immunodeficiency virus type 2.

scientific article

Semen enhances HIV infectivity and impairs the antiviral efficacy of microbicides

scientific article

Semen-derived amyloid fibrils drastically enhance HIV infection

scientific article

Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI.

scientific article

Sequences Just Upstream of the Simian Immunodeficiency Virus Core Enhancer Allow Efficient Replication in the Absence of NF-κB and Sp1 Binding Elements ⬇️

scientific article published on July 1, 1998

Short-term monotherapy in HIV-infected patients with a virus entry inhibitor against the gp41 fusion peptide

scientific article

Silencing HIV-1 In Vivo

article

Single-Cell Characterization of Endothelin System Gene Expression in the Cerebellum In Situ ⬇️

scientific article published on January 1, 1998

Single-cell transcriptomics identifies prothymosin α restriction of HIV-1 in vivo

scientific article published on 02 August 2023

SnapShot: antiviral restriction factors

scientific article published on 22 October 2015

Sooty mangabey genome sequence provides insight into AIDS resistance in a natural SIV host

scientific article published in January 2018

Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity

scientific article published on 10 April 2018

Spike residue 403 affects binding of coronavirus spikes to human ACE2

scientific article published on 25 November 2021

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

scientific article

Synthesis of Peptide-Functionalized Poly(bis-sulfone) Copolymers Regulating HIV-1 Entry and Cancer Stem Cell Migration

article

T-cell receptor:CD3 down-regulation is a selected in vivo function of simian immunodeficiency virus Nef but is not sufficient for effective viral replication in rhesus macaques

scientific article

TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition

scientific article

Tetherin antagonism by HIV-1 and its SIV precursors.

scientific article published on 3 October 2011

Tetherin antagonism by primate lentiviral nef proteins.

scientific article

Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains.

scientific article

Tetherin: Holding On and Letting Go

scientific article published on 01 April 2010

The Antiviral Activity of the Cellular Glycoprotein LGALS3BP/90K is Species-Specific.

scientific article

The Potency of Nef-Mediated SERINC5 Antagonism Correlates with the Prevalence of Primate Lentiviruses in the Wild

scientific article published on September 2016

The cationic properties of SEVI underlie its ability to enhance human immunodeficiency virus infection

scientific article published on 22 October 2008

The efficiency of Vpx-mediated SAMHD1 antagonism does not correlate with the potency of viral control in HIV-2-infected individuals

scientific article published on 5 March 2013

The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses.

scientific article published on 14 September 2009

The most frequent naturally occurring length polymorphism in the HIV-1 LTR has little effect on proviral transcription and viral replication

scientific article published on January 2002

The negative (?) factor of HIV and SIV

scientific article published on January 1, 1992

The presence of a vpu gene and the lack of Nef-mediated downmodulation of T cell receptor-CD3 are not always linked in primate lentiviruses

scientific article

The role of upstream U3 sequences in HIV-1 replication and CD4+ T cell depletion in human lymphoid tissue ex vivo

scientific article published on 15 August 2005

The transmembrane domain of HIV-1 Vpu is sufficient to confer anti-tetherin activity to SIVcpz and SIVgor Vpu proteins: cytoplasmic determinants of Vpu function

scientific article

Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts

scientific article

Uninfected Bystander Cells Impact the Measurement of HIV-Specific Antibody-Dependent Cellular Cytotoxicity Responses.

scientific article

Viremic long-term nonprogressive HIV-1 infection is not associated with abnormalities in known Nef functions

scientific article published on 04 February 2014

Vpr and Vpu are important for efficient human immunodeficiency virus type 1 replication and CD4+ T-cell depletion in human lymphoid tissue ex vivo

scientific article published in November 2004

Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1

scientific article published on 20 July 2020

Vpu serine 52 dependent counteraction of tetherin is required for HIV-1 replication in macrophages, but not in ex vivo human lymphoid tissue

scientific article

Vpu-Mediated Counteraction of Tetherin Is a Major Determinant of HIV-1 Interferon Resistance

scientific article

Paulina is supported by:

About Paulina

Help