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List of works by Gregg L. Semenza

'The metabolism of tumours': 70 years later

scientific article

151 years Berliner Klinische Wochenschrift and the 20th anniversary of the Journal of Molecular Medicine

scientific article published on 11 August 2015

A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension

scientific article published on 13 May 2019

A Simplified Procedure for the Isolation of the Sucrase . Isomaltase Complex from Rabbit Intestine Its Amino-Acid and Sugar Composition ⬇️

scientific article published on October 17, 1972

A chemical procedure for determining the sidedness of the NH2 terminus in a membrane protein. The small intestinal sucrase-isomaltase

scientific article published on 01 December 1983

A compendium of proteins that interact with HIF-1α.

scientific article published on 20 March 2017

A fully active, two-active-site, single-chain sucrase.isomaltase from pig small intestine. Implications for the biosynthesis of a mammalian integral stalked membrane protein

scientific article

A genetic mechanism for Tibetan high-altitude adaptation

scientific article

A new weapon for attacking tumor blood vessels

scientific article

A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication

scientific article

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

scientific article

A physical sciences network characterization of non-tumorigenic and metastatic cells

scientific article published on January 2013

A probable oxocarbonium ion in the reaction mechanism of small intestinal sucrase and isomaltase ⬇️

scientific article published on October 10, 1975

A return to cancer metabolism

scientific article published on 08 February 2011

A two-active site one-polypeptide enzyme: the isomaltase from sea lion small intestinal brush-border membrane. Its possible phylogenetic relationship with sucrase-isomaltase

scientific article

AJP-Cell Theme: Cellular Responses to Hypoxia.

scientific article published in September 2015

Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice

scientific article

Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

scientific article

Activation of hypoxia-inducible factor 1 during macrophage differentiation

scientific article published on 15 February 2006

Activation of hypoxia-inducible factor 1 in human T-cell leukaemia virus type 1-infected cell lines and primary adult T-cell leukaemia cells

scientific article

Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1.

scientific article published on 15 February 2013

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

scientific article

Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2.

scientific article published on July 2012

Adenoviral transfer of HIF-1alpha enhances vascular responses to critical limb ischemia in diabetic mice

scientific article published on 19 October 2009

Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection

scientific article

Advances in cancer biology and therapy

scientific article published on 01 April 2013

Affinity labeling of the active sites in the sucrase-isomaltase complex from small intestine.

scientific article published in October 1974

Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity

scientific article published on 01 September 2000

Age-dependent impairment of HIF-1alpha expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells

scientific article

Aging impairs the mobilization and homing of bone marrow-derived angiogenic cells to burn wounds

scientific article published on 16 April 2011

Altered hypoxia-inducible factor-1 alpha expression levels correlate with coronary vessel anomalies

scientific article published on October 2009

Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1alpha

scientific article published on 28 February 2006

American Journal of Physiology-Cell Physiology theme: hypoxia ⬇️

scientific article published on November 17, 2010

An Xba I polymorphism 3' to the human erythropoietin (EPO) gene

scientific article

An essential role for chaperone-mediated autophagy in cell cycle progression

scientific article published on January 2015

Analysis of hypoxia-induced metabolic reprogramming

scientific article published on January 2014

Analysis of hypoxia-inducible factor 1alpha expression and its effects on invasion and metastasis

scientific article published in January 2007

Angiogenesis in ischemic and neoplastic disorders

scientific article

Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy

scientific article

Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells

retracted scientific article

Anthracyclines suppress pheochromocytoma cell characteristics, including metastasis, through inhibition of the hypoxia signaling pathway

scientific article

Assignment of the hypoxia-inducible factor 1alpha gene to a region of conserved synteny on mouse chromosome 12 and human chromosome 14q

scientific article

Association of increasing burn severity in mice with delayed mobilization of circulating angiogenic cells

scientific article

BIRC2 Expression Impairs Anti-Cancer Immunity and Immunotherapy Efficacy

scientific article published on 01 August 2020

Baffled by bafilomycin: an anticancer agent that induces hypoxia-inducible factor-1alpha expression

scientific article published on 25 September 2006

Biologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography

scientific article published in January 2002

Biosynthesis and assembly of the largest and major intrinsic polypeptide of the small intestinal brush borders.

scientific article published on January 1983

Biosynthesis of sucrase-isomaltase. Purification and NH2-terminal amino acid sequence of the rat sucrase-isomaltase precursor (pro-sucrase-isomaltase) from fetal intestinal transplants

scientific journal article

Blood vessels, disease pathogenesis, and novel therapies

scientific article published in March 2013

Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia

scientific article published on 29 November 2004

Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization

scientific article published on 26 October 2007

Cancer-stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis

scientific article

Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5' enhancer

scientific article published in June 1998

Carboxyl Groups at the Two Active Centers of Sucrase-Isomaltase from Rabbit Small Intestine ⬇️

scientific article published on March 1, 1977

Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1

scientific article published on 01 March 1998

Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1.

scientific article published on 23 October 2003

Cell-free synthesis, membrane integration, and glycosylation of pro-sucrase-isomaltase

scientific article published on 01 June 1986

Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice

scientific article published on October 1991

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

scientific article

Cellular and molecular dissection of reperfusion injury: ROS within and without

scientific article published on 01 February 2000

Cell‐free synthesis of the one‐chain precursor of a major intrinsic protein complex of the small‐intestinal brush border membrane (pro‐sucrase—isomaltase) ⬇️

scientific article published on December 28, 1981

Chairman's summary: mechanisms of oxygen homeostasis, circa 1999.

scientific article

Changing the editorial process at JCI and JCI Insight in response to the COVID-19 pandemic

scientific article published on 23 March 2020

Chaperone-mediated autophagy targets hypoxia-inducible factor-1α (HIF-1α) for lysosomal degradation

scientific article published on March 2013

Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.

scientific article published on October 1993

Chemotherapy induces enrichment of CD47+/CD73+/PDL1+ immune evasive triple-negative breast cancer cells

scientific article published on 24 January 2018

Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype

scientific article

Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell Enrichment

scientific article published in February 2017

Chemotherapy-Induced Ca<sup>2+</sup> Release Stimulates Breast Cancer Stem Cell Enrichment

scientific article published on 01 January 2021

Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness

scientific article published on 19 May 2020

Chronic cold exposure results in subcutaneous adipose tissue browning and altered global metabolism in Qinghai-Tibetan plateau pika (Ochotona curzoniae)

scientific article published on 13 April 2018

Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4.

scientific article published on July 2013

Collagen prolyl hydroxylases are essential for breast cancer metastasis

scientific article published on 28 March 2013

Combination of HIF-1α gene transfection and HIF-1-activated bone marrow-derived angiogenic cell infusion improves burn wound healing in aged mice.

scientific article published on 20 June 2013

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer

scientific article published on 24 August 2016

Complementary roles of gasotransmitters CO and H2S in sleep apnea

scientific article published on 23 January 2017

Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha

scientific article published on 11 October 2007

Complete primary structure of human and rabbit lactase-phlorizin hydrolase: implications for biosynthesis, membrane anchoring and evolution of the enzyme

scientific article

Constitutively active HIF-1alpha improves perfusion and arterial remodeling in an endovascular model of limb ischemia

scientific article published on 01 October 2005

Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1

scientific article

Control of lactase in human adult-type hypolactasia and in weaning rabbits and rats

scientific article published on October 1989

Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression

scientific article

DNA binding and transcriptional properties of wild-type and mutant forms of the homeodomain protein Msx2

scientific article

DNA methylation in the central and efferent limbs of the chemo reflex requires carotid body neural activity

scientific article

Decreased expression of cystathionine β-synthase promotes glioma tumorigenesis

scientific article

Decreased lymphatic HIF-2α accentuates lymphatic remodeling in lymphedema

scientific article published on 16 July 2020

Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha

scientific journal article

Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death

scientific journal article

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

scientific article (publication date: 4 February 2010)

Desferrioxamine induces erythropoietin gene expression and hypoxia- inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction

scientific article published on 15 December 1993

Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction

scientific article published on December 1993

Detection of a novel DNA polymorphism in the beta-globin gene cluster ⬇️

scientific article published on May 25, 1984

Development of novel therapeutic strategies that target HIF-1.

scientific article

Differentiation stage-specific requirement in hypoxia-inducible factor-1alpha-regulated glycolytic pathway during murine B cell development in bone marrow

scientific article

Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth

scientific article

Digoxin inhibits development of hypoxic pulmonary hypertension in mice

scientific article published on 9 January 2012

Digoxin inhibits retinal ischemia-induced HIF-1alpha expression and ocular neovascularization

scientific article

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

scientific article

Disposition of the carboxy-terminus tail of rabbit lactase-phlorizin hydrolase elucidated by phosphorylation with protein kinase A in vitro and in tissue culture

scientific article published on 01 July 1995

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

scientific article

Dissociation of Small-Intestinal Sucrase. Isomaltase Complex into Enzymatically Active Subunits ⬇️

scientific article published on April 1, 1975

Do pancreatic proteases play a role in processing prolactase and/or in the postweaning decline of lactase?

scientific article published on 01 January 1995

Does loss of CD151 expression promote the metastasis of hypoxic colon cancer cells?

scientific article published on 01 December 2008

Dynamic regulation of stem cell specification and maintenance by hypoxia-inducible factors

scientific article

Effect of altered redox states on expression and DNA-binding activity of hypoxia-inducible factor 1.

scientific article published on July 1995

Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1.

scientific article published on November 1995

Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia

scientific article published on 11 October 2007

Emerging roles of PKM2 in cell metabolism and cancer progression

scientific article

Endothelial HIF-2α as a Key Endogenous Mediator Preventing Emphysema

scientific article published on 09 June 2020

Endothelial Hypoxia-Inducible Factor-2α Is Required for the Maintenance of Airway Microvasculature

scientific article published on 01 January 2019

Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-β signaling

scientific article published on 8 March 2012

Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes

scientific article published on 7 December 2007

Enhanced bone regeneration associated with decreased apoptosis in mice with partial HIF-1alpha deficiency

scientific journal article

Enhanced interferon-gamma gene expression in T Cells and reduced ovalbumin-dependent lung eosinophilia in hypoxia-inducible factor-1-alpha-deficient mice

scientific article

Epigenetic changes by DNA methylation in chronic and intermittent hypoxia

scientific article published on 24 August 2017

Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis

scientific article published on 9 January 2012

Epigenetic regulation of redox state mediates persistent cardiorespiratory abnormalities after long-term intermittent hypoxia

scientific article published on 9 August 2016

Erythropoietin gene expression in transgenic mice and human hepatoma cells

scientific article published on April 1994

Ethanol selectively affects Na+-gradient dependent intestinal transport systems

scientific article published in January 1986

Evaluation of HIF-1 inhibitors as anticancer agents

scientific article

Evidence for H(+)-induced insertion of influenza hemagglutinin HA2 N-terminal segment into viral membrane

scientific article published on 01 July 1994

Expression Pattern of HIF-1α and VEGF Supports Circumferential Application of Scatter Laser for Proliferative Sickle Retinopathy

scientific article

Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis

scientific article published on 01 October 2001

Expression of hypoxia-inducible factor 1: mechanisms and consequences

scientific article

Expression of hypoxia-inducible factor 1? in brain tumors

scientific article (publication date: June 2000)

Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression

scientific article (publication date: June 2000)

Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer

scientific article (publication date: April 2001)

Expression of the angiogenic mediator, angiopoietin-like 4, in the eyes of patients with proliferative sickle retinopathy

scientific article published on 23 August 2017

Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1.

scientific article

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

scientific article

Familial Polycythemia ⬇️

scientific article published on June 30, 1995

Fostering trust-- Mol Med's scientific integrity policy

scientific article published on 01 January 2009

Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1

scientific article published on 4 January 2012

Functional analysis of the role of hypoxia-inducible factor 1 in the pathogenesis of hypoxic pulmonary hypertension.

scientific article published in January 2004

Furin, PC1/3, and/or PC6A Process Rabbit, but Not Human, Pro-lactase-phlorizin Hydrolase to the 180-kDa Intermediate ⬇️

scientific article published on October 27, 1995

G-rich oligonucleotides inhibit HIF-1alpha and HIF-2alpha and block tumor growth

scientific article

Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer

scientific article

Gas biology: small molecular medicine

scientific article published on 01 March 2012

Gaseous messengers in oxygen sensing

scientific article published on 16 February 2012

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia

scientific article

Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization

scholarly article by Lisha Xiang et al published 17 January 2019 in Cell Death and Disease

Graft microvascular disease in solid organ transplantation

scientific article published on June 2014

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea

scientific article

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

scientific article

HIF and the lung: role of hypoxia-inducible factors in pulmonary development and disease

scientific article published on January 2011

HIF-1 and human disease: one highly involved factor

scientific article (publication date: 15 August 2000)

HIF-1 and mechanisms of hypoxia sensing

scientific article

HIF-1 and tumor progression: pathophysiology and therapeutics

scientific article (publication date: 2002)

HIF-1 inhibitors for cancer therapy: from gene expression to drug discovery

scientific article published on January 2009

HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

scientific article published on May 2007

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

scientific article published on 03 September 2013

HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury ⬇️

scientific article published on August 5, 2010

HIF-1 mediates the Warburg effect in clear cell renal carcinoma

scientific article published on June 2007

HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells

scientific article

HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells

scientific article

HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes.

scientific article

HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus

scientific article (publication date: 5 October 2001)

HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

scientific article published on 22 August 2011

HIF-1-dependent respiratory, cardiovascular, and redox responses to chronic intermittent hypoxia

scientific article published on September 2007

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

scientific article

HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression.

scientific article published on 18 September 2014

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

scientific article (publication date: April 2000)

HIF-1: upstream and downstream of cancer metabolism

scientific article

HIF-1: using two hands to flip the angiogenic switch

scientific article

HIF-1A, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors

scientific article published in December 2002

HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas.

scientific article published on April 2005

HIF-1alpha-targeted pathways are activated by heat acclimation and contribute to acclimation-ischemic cross-tolerance in the heart.

scientific article

HIF-1beta determines ABCA1 expression under hypoxia in human macrophages

scientific article published on 12 October 2009

HIF-1α activation by intermittent hypoxia requires NADPH oxidase stimulation by xanthine oxidase

scientific article

HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells

scientific article published in May 2015

HIF-1α is required for development of the sympathetic nervous system

scientific article published on 13 June 2019

HIF-dependent antitumorigenic effect of antioxidants in vivo

scientific article published on September 2007

Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury

scientific article

Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia

scientific article published on 14 September 2006

High-affinity phlorizin binding to brush border membranes from small intestine: Identity with (a part of) the glucose transport system, dependence on the Na+-gradient, partial purification ⬇️

scientific article published on 01 January 1977

Hinf I polymorphism 3' to the human beta-globin gene detected by the polymerase chain reaction (PCR).

scientific article

Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization

scientific article published on 27 August 2021

Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression

scientific article

Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha

scientific article

Human erythropoietin gene expression in transgenic mice: multiple transcription initiation sites and cis-acting regulatory elements

scientific article published on March 1990

Hydrodynamic properties of phospholipid vesicles and of sucrase isomaltase-phospholipid vesicles.

scientific article published in September 1981

Hydrophobic binding of the ectodomain of influenza hemagglutinin to membranes occurs through the "fusion peptide"

scientific article published on 01 April 1989

Hydrophobic labeling, isolation, and partial characterization of the NH2-terminal membranous segment of sucrase-isomaltase complex

scientific article published in Journal of Biological Chemistry

Hydrophobic photolabeling identifies BHA2 as the subunit mediating the interaction of bromelain-solubilized influenza virus hemagglutinin with liposomes at low pH.

scientific article

Hydroxylation of HIF-1: oxygen sensing at the molecular level

scientific article

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

article

Hypoxia Selectively Enhances Integrin α5β1 Receptor Expression in Breast Cancer to Promote Metastasis

scientific article published on 17 February 2017

Hypoxia and cancer

scientific article published on 01 June 2007

Hypoxia and human disease-and the Journal of Molecular Medicine

scientific article

Hypoxia and the extracellular matrix: drivers of tumour metastasis

scientific article

Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m⁶A-demethylation of NANOG mRNA.

scientific article

Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1

scientific article

Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca2+ in pulmonary arterial smooth muscle cells

scientific article

Hypoxia inducible factor-1 mediates pancreatic β-cell dysfunction by intermittent hypoxia

scientific article published on 16 September 2020

Hypoxia inducible factor-1-dependent up-regulation of BMP4 mediates hypoxia-induced increase of TRPC expression in PASMCs

scientific article

Hypoxia inducible factor-1alpha is increased in ischemic retina: temporal and spatial correlation with VEGF expression

scientific article

Hypoxia inhibits G1/S transition through regulation of p27 expression

scientific article published on 08 December 2000

Hypoxia pathway linked to kidney failure

scientific article published on 01 September 2006

Hypoxia regulates CD44 and its variant isoforms through HIF-1α in triple negative breast cancer

scientific article

Hypoxia, HIF-1, and the pathophysiology of common human diseases.

scientific article

Hypoxia, clonal selection, and the role of HIF-1 in tumor progression

scientific article

Hypoxia-Inducible Factor 1α Is a Critical Downstream Mediator for Hypoxia-Induced Mitogenic Factor (FIZZ1/RELMα)-Induced Pulmonary Hypertension

scientific article

Hypoxia-Inducible Factor-Dependent Expression of Angiopoietin-Like 4 by Conjunctival Epithelial Cells Promotes the Angiogenic Phenotype of Pterygia

scientific article published on September 2017

Hypoxia-Inducible Factors: Master Regulators of Cancer Progression

scientific article published on 16 November 2016

Hypoxia-induced resistance to anticancer drugs is associated with decreased senescence and requires hypoxia-inducible factor-1 activity

scientific article

Hypoxia-induced suppression of alternative splicing of MBD2 promotes breast cancer metastasis via activation of FZD1

scientific article published on 05 January 2021

Hypoxia-inducible Factor-1 Mediates Transcriptional Activation of the Heme Oxygenase-1 Gene in Response to Hypoxia

article

Hypoxia-inducible factor 1 (HIF-1) pathway

scientific article published on 09 October 2007

Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts

scientific article published on 19 February 2013

Hypoxia-inducible factor 1 and breast cancer metastasis

scientific article

Hypoxia-inducible factor 1 and cancer pathogenesis

scientific article published on September 2008

Hypoxia-inducible factor 1 and cardiovascular disease

scientific article

Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1

scientific article

Hypoxia-inducible factor 1 and the molecular physiology of oxygen homeostasis

scientific article published on March 1998

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

scientific article

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

scientific article

Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart

scientific article published on 07 October 2013

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

scientific article published on 01 October 1996

Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype

scientific article

Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia

scientific journal article

Hypoxia-inducible factor 1 regulates vascular endothelial growth factor expression in human pancreatic cancer

scientific article published on January 2003

Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning

scientific article

Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma

scientific article published on 09 January 2016

Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment

article published in the Proceedings of the National Academy of Sciences of the United States of America

Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells

scientific article

Hypoxia-inducible factor 1: Regulator of mitochondrial metabolism and mediator of ischemic preconditioning ⬇️

scientific article published on August 21, 2010

Hypoxia-inducible factor 1: control of oxygen homeostasis in health and disease

scientific article

Hypoxia-inducible factor 1: from molecular biology to cardiopulmonary physiology

scientific article

Hypoxia-inducible factor 1: master regulator of O2 homeostasis

scientific article published on 01 October 1998

Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology

scientific article

Hypoxia-inducible factor 1alpha polymorphism and coronary collaterals in patients with ischemic heart disease

scientific article published in August 2005

Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations

scholarly article

Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension

scientific article

Hypoxia-inducible factor plays a gut-injurious role in intestinal ischemia reperfusion injury

scientific article

Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development

scientific journal article

Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia

article by P J Lee et al published 1 February 1997 in Journal of Biological Chemistry

Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling

scientific article published on 17 February 2010

Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.

scientific article published in March 2006

Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis

scientific article

Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment

scientific article

Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis

scientific article

Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells

retracted scientific article

Hypoxia-inducible factors enhance glutamate signaling in cancer cells

scientific article

Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells

retracted scientific article

Hypoxia-inducible factors promote breast cancer stem cell specification and maintenance in response to hypoxia or cytotoxic chemotherapy

scientific article published on 19 December 2018

Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression

scientific article published on March 2014

Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells

scientific article published on 31 August 2016

Hypoxia-inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype

scientific article published on 22 December 2016

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

scientific article

Hypoxia-inducible factor–dependent breastcancer–mesenchymal stem cell bidirectional signaling promotesmetastasis.

scientific article published in March 2013

Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene

scientific article published on July 1991

Hypoxia. Cross talk between oxygen sensing and the cell cycle machinery

scientific article

Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy

scientific article published on October 2006

Hypoxic retinal Muller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4.

scientific article published on 19 August 2013

Identification of chemical compounds that induce HIF-1alpha activity

scientific article

Impaired angiogenesis and mobilization of circulating angiogenic cells in HIF-1alpha heterozygous-null mice after burn wounding

scientific article

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha

scientific journal article

In Vitro Assays of Breast Cancer Stem Cells

scientific article published in January 2018

In vivo expression of mRNAs encoding hypoxia-inducible factor 1

scientific article

Incorporation of hydrophobic aminopeptidase from hog kidney into egg lecithin liposomes: number and orientation of aminopeptidase molecules in the lecithin vesicles

scientific article

Increased expression of hypoxia inducible factor-1alpha in rat and human prostate cancer

scientific article published on 01 December 1998

Increased size of solid organs in patients with Chuvash polycythemia and in mice with altered expression of HIF-1alpha and HIF-2alpha

scientific article

Increased susceptibility of HIF-1α heterozygous-null mice to cardiovascular malformations associated with maternal diabetes

scientific article published on 22 April 2013

Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR.

scientific article published on December 2008

Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling

scientific article published on 26 July 2004

Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain

scientific article published on December 1999

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

scientific article

Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis

scientific article

Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation

scientific article published on 26 December 2017

Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway

scientific article

Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells

scientific article published on 30 July 2002

Intestinal lactase-phlorizin hydrolase (LPH): the two catalytic sites; the role of the pancreas in pro-LPH maturation.

scientific article

Intratumoral hypoxia, radiation resistance, and HIF-1.

scientific article

Introduction to tumor microenvironment regulation of cancer cell survival, metastasis, inflammation, and immune surveillance.

scientific article

Involvement of hypoxia-inducible factor 1 in human cancer

scientific article published in February 2002

Involvement of hypoxia-inducible factor 1 in pulmonary pathophysiology

scientific article

Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis

scientific article published on 03 June 2009

Is 15-min ischemia too lethal to be an ischemic preconditioning stimulus?

scientific article published on 01 November 2006

Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis

scientific article published on 4 August 2011

KSHV induces aerobic glycolysis and angiogenesis through HIF-1-dependent upregulation of pyruvate kinase 2 in Kaposi's sarcoma

scientific article

LPS induces hypoxia-inducible factor 1 activation in macrophage-differentiated cells in a reactive oxygen species-dependent manner

scientific article published on May 2008

Lack of Evidence for Vasoactive and Inflammatory Mediators in the Promotion of Macular Edema Associated with Epiretinal Membranes

scientific article published on 6 September 2017

Lack of some intestinal maltases in a human disease transmitted by a single genetic factor

scientific article published in August 1965

Lactase persistence versus decline in human adults: multifactorial events are involved in down-regulation after weaning.

scientific article published on May 1997

Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis

scientific article (publication date: 21 February 2001)

Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma

scientific article (publication date: 15 March 2003)

Life with oxygen

scientific article published in October 2007

Localization of cells producing erythropoietin in murine liver by in situ hybridization

scientific article published on 01 June 1991

Location of the two catalytic sites in intestinal lactase-phlorizin hydrolase. Comparison with sucrase-isomaltase and with other glycosidases, the membrane anchor of lactase-phlorizin hydrolase ⬇️

scientific article published on September 15, 1992

MCM proteins are negative regulators of hypoxia-inducible factor 1.

scientific article published on June 2011

Macrophage migration inhibitory factor activates hypoxia-inducible factor in a p53-dependent manner

scientific article

Maintenance of redox homeostasis by hypoxia-inducible factors

scientific article

Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors.

scientific article published on 5 June 2012

Meeting report: exploiting the tumor microenvironment for therapeutics

scientific article published on 01 May 2006

Membrane topology of light-harvesting protein B870-alpha of Rhodospirillum rubrum G-9+. Amino acid residues in contact with the lipid bilayer as inferred from labeling with photogenerated carbenes

scientific article published on December 1985

Messenger RNAs expressed in intestine of adult but not baby rabbits. Isolation of cognate cDNAs and characterization of a novel brush border protein with esterase and phospholipase activity

scientific article

Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors

scientific article published on 11 July 2018

Metabolic reprogramming by HIF-1 promotes the survival of bone marrow-derived angiogenic cells in ischemic tissue

scientific article

Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration

scientific article published on 01 July 2018

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

scientific journal article

Mitochondrial autophagy: life and breath of the cell

scientific article published on 25 March 2008

Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics

scientific article (publication date: 15 March 2000)

Molecular basis of hypoxia-induced erythropoietin expression.

scientific article published on March 1996

Molecular cytogenetic characterization of a subtle interstitial del(3)(p25.3p26.2) in a patient with deletion 3p syndrome

scientific article published on April 2002

Molecular events implicated in brain tumor angiogenesis and invasion

scientific article

Molecular mechanisms mediating metastasis of hypoxic breast cancer cells

scientific article

Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis

retracted scientific article published on 22 April 2013

N-terminal sequences of pig intestinal sucrase-isomaltase and pro-sucrase-isomaltase

article

Na+-dependent, electroneutral L-ascorbate transport across brush border membrane vesicles from human small intestine ⬇️

scientific article published on December 15, 1979

Na+-dependent, electroneutral l-ascorbate transport across brush border membrane vesicles from guinea pig small intestine ⬇️

scientific article published on March 23, 1979

Na+-dependent, potential-sensitive l-ascorbate transport across brush border membrane vesicles from kidney cortex ⬇️

scientific article published on 01 September 1981

Negative regulation of hypoxic responses via induced Reptin methylation.

scientific article

Neural regulation of hypoxia-inducible factors and redox state drives the pathogenesis of hypertension in a rodent model of sleep apnea

scientific article published on 7 May 2015

New insights into nNOS regulation of vascular homeostasis

scientific article

Next-gen cancer research

scientific article published on 01 August 2017

Nitric Oxide Induces Hypoxia-inducible Factor 1 Activation That Is Dependent on MAPK and Phosphatidylinositol 3-Kinase Signaling ⬇️

scientific article published on November 4, 2003

Nitric oxide prevents axonal degeneration by inducing HIF-1-dependent expression of erythropoietin

scientific article

Novel strategies for cancer therapy

scientific article

O2 sensing: only skin deep?

scientific article

O2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1.

scientific article

OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha

scientific article

On the efficiency of energy conversion in sodium-driven D-glucose transport across small intestinal brush border membrane vesicles: an estimation ⬇️

scientific article published on 01 December 1979

On the primary site of control in the spontaneous development of small-intestinal sucrase-isomaltase after birth

article

Oncogenic alterations of metabolism

scientific article

Orientation and motion of spin-labels in rabbit small intestinal brush border vesicle membranes

scientific article published on 01 October 1982

Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases

scientific article (publication date: 15 November 1999)

Oxygen Sensing and Homeostasis

scientific article

Oxygen homeostasis

scientific article published on May 2010

Oxygen sensing and response to hypoxia by mammalian cells

scientific article

Oxygen sensing in the body

scientific article

Oxygen sensing, homeostasis, and disease

scientific article published on August 2011

Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology

scientific article published on 07 August 2013

Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1.

scientific article published on July 2007

Oxygen-independent upregulation of vascular endothelial growth factor and vascular barrier dysfunction during ventilated pulmonary ischemia in isolated ferret lungs

scientific article published on 01 March 2000

Oxygen-regulated transcription factors and their role in pulmonary disease

scientific article

PHD3-mediated prolyl hydroxylation of nonmuscle actin impairs polymerization and cell motility

scientific article

PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis

scientific article published on 8 June 2016

PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia

scientific article published on 2 February 2016

PTEN activity is modulated during ischemia and reperfusion: involvement in the induction and decay of preconditioning

scientific article

Partial HIF-1alpha deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia

scientific article published on 01 July 2001

Partial amino acid sequences around the essential carboxylate in the active sites of the intestinal sucrase-isomaltase complex

scientific article published on 01 June 1976

Partial rescue of defects in Cited2-deficient embryos by HIF-1alpha heterozygosity.

scientific article

Pathways for Oxygen Regulation and Homeostasis: The 2016 Albert Lasker Basic Medical Research Award

scientific article

Perinatal lethality and multiple craniofacial malformations in MSX2 transgenic mice.

scientific article published in March 1997

Perspectives on oxygen sensing

scientific article

Pharmacologic Targeting of Hypoxia-Inducible Factors

scientific article published on 01 January 2019

Phlorizin as a probe of the small-intestinal Na+,D-glucose cotransporter. A model

scientific article published on 01 June 1982

Phosphatidylcholine exchange between brush border membrane vesicles and sonicated liposomes

scientific article published on 01 June 1980

Phosphatidylinositol-3-kinase signaling is required for erythropoietin-mediated acute protection against myocardial ischemia/reperfusion injury

scientific article published on 26 April 2004

Phospholipid topology and flip-flop in intestinal brush-border membrane

article

Physiology meets biophysics: visualizing the interaction of hypoxia-inducible factor 1 alpha with p300 and CBP

scientific article

Polycythemia in transgenic mice expressing the human erythropoietin gene ⬇️

scientific article

Primary familial polycythemia: a frameshift mutation in the erythropoietin receptor gene and increased sensitivity of erythroid progenitors to erythropoietin

scientific article

Proceedings of the Oxygen Homeostasis/Hypoxia Meeting

scientific article published in May 2004

Processing of human intestinal prolactase to an intermediate form by furin or by a furin-like proprotein convertase

scientific article published on 01 November 1998

Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis

scientific article published on February 2013

Promotion of airway anastomotic microvascular regeneration and alleviation of airway ischemia by deferoxamine nanoparticles

scientific article

Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, [...]

scientific article

Protein kinase A-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1.

scientific article published on 31 May 2016

Protein kinase G-regulated production of H2S governs oxygen sensing

scientific article published on 21 April 2015

Pulmonary vascular responses to chronic hypoxia mediated by hypoxia-inducible factor 1.

scientific article

Purification and characterization of hypoxia-inducible factor 1

scientific journal article

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

scientific article

Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells

scientific article published on July 2011

RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha

scientific article published on January 2007

RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization

scientific article published on 7 March 2007

ROS signaling in systemic and cellular responses to chronic intermittent hypoxia

scientific article published on September 2007

Rabbit small intestinal trehalase. Purification, cDNA cloning, expression, and verification of glycosylphosphatidylinositol anchoring ⬇️

scientific article published on September 5, 1990

Rac1 activity is required for the activation of hypoxia-inducible factor 1.

scientific article published on 30 March 2001

Recent advances in vascular biology and their clinical relevance

scientific article published on 17 May 2009

Reciprocal Regulation of DUSP9 and DUSP16 Expression by HIF-1 Controls ERK and p38 MAP Kinase Activity and Mediates Chemotherapy-Induced Breast Cancer Stem Cell Enrichment.

scientific article

Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2.

scientific article published on August 1999

Reducing bias: accounting for the order of co-first authors

scientific article published on 29 April 2019

Region-specific expression of multiple lactase-phlorizin hydrolase genes in intestine of rabbit

scientific article published in December 1993

Regulation of angiogenesis by hypoxia-inducible factor 1.

scientific article

Regulation of cancer cell metabolism by hypoxia-inducible factor 1.

scientific article published on 09 December 2008

Regulation of cardiovascular development and physiology by hypoxia-inducible factor 1.

scientific article

Regulation of carotid body oxygen sensing by hypoxia-inducible factors

scientific article published on 13 August 2015

Regulation of cell proliferation by hypoxia-inducible factors

scientific article

Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1.

scientific article published in March 2003

Regulation of erythropoietin production. New insights into molecular mechanisms of oxygen homeostasis.

scientific article published on October 1994

Regulation of gene expression by HIF-1.

scientific article

Regulation of hypoxia-induced angiogenesis: a chaperone escorts VEGF to the dance

scientific article

Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases

scientific article

Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer

scientific article published on September 2003

Regulation of hypoxia-inducible factor-α isoforms and redox state by carotid body neural activity in rats

scientific article published on 27 June 2014

Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

scientific article (publication date: 1999)

Regulation of metabolism by hypoxia-inducible factor 1.

scientific article published on 22 July 2011

Regulation of osteogenesis-angiogenesis coupling by HIFs and VEGF

scientific article published on August 2009

Regulation of oxygen homeostasis by hypoxia-inducible factor 1.

scientific article published on April 2009

Regulation of physiological responses to continuous and intermittent hypoxia by hypoxia-inducible factor 1.

scientific article

Regulation of the breast cancer stem cell phenotype by hypoxia-inducible factors

scientific article published on December 2015

Regulation of tissue perfusion in mammals by hypoxia-inducible factor 1.

scientific article published on 24 August 2007

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha

scientific article

Regulation of vascularization by hypoxia-inducible factor 1

scientific article published on 01 October 2009

Reply to Lopez-Lazaro: Evidence that digoxin inhibits human cancer.

scholarly article

Respiratory complications of mucopolysaccharide storage disorders.

scientific article published in July 1988

Reversible inhibition of hypoxia-inducible factor 1 activation by exposure of hypoxic cells to the volatile anesthetic halothane

scientific article

Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation

scientific article published on June 2004

Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain

scientific article published on 01 September 2000

Role of hypoxia-inducible factors in breast cancer metastasis

scientific article

SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1 alpha ubiquitination and degradation

scientific article published on 10 September 2007

Segregation of a familial balanced (12;10) insertion resulting in Dup(10)(q21.2q22.1) and Del(10)(q21.2q22.1) in first cousins

scientific article published on March 1997

Segregation of a familial balanced (12;10) insertion resulting in dup(10)(q21.2q22.1) and del(10)(q21.2q22.1) in first cousins

Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways

scientific article

Selective killing of hypoxia-inducible factor-1-active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer

scientific article published on 5 May 2009

Selective labeling of the hydrophobic core of membranes with 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine, a carbene-generating reagent

scientific article published in December 1981

Serendipity, Generosity, and Inspiration

scientific article

Series introduction: tissue ischemia: pathophysiology and therapeutics

scientific article

Serine Synthesis Helps Hypoxic Cancer Stem Cells Regulate Redox

scientific article published on 3 November 2016

Signal transduction to hypoxia-inducible factor 1

scientific article (publication date: September 2002)

Similarity in effects of Na+ gradients and membrane potentials on D-glucose transport by, and phlorizin binding to, vesicles derived from brush borders of rattit intestinal mucosal cells

scientific article published on May 3, 1978

Single amino acid substitutions can convert the uncleaved signal-anchor of sucrase-isomaltase to a cleaved signal sequence.

scientific article published in August 1992

Single bilayer lipid-protein vesicles formed from phosphatidylcholine and small intestinal sucrase.isomaltase ⬇️

scientific article published on October 25, 1978

Sirtuin-7 inhibits the activity of hypoxia-inducible factors

scientific article published on 09 June 2013

Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury

scientific article

Species differences in the sites of cleavage of pro-lactase to lactase supports lack of selective pressure

scientific article published on 01 November 1999

Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha

scientific article

Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha

scientific article

Spontaneous transformation of cultured mouse bone marrow-derived stromal cells

scientific article published in November 2006

Stereospecific ring opening of conduritol-B-epoxide by an active site aspartate residue of sucrase-isomaltase ⬇️

scientific article published on July 8, 1977

Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor

scientific article published on July 2005

Structural and functional analysis of hypoxia-inducible factor 1.

scientific article published on February 1997

Subunits of the Small-Intestinal Sucrase . Isomaltase Complex and Separation of Its Enzymatically Active Isomaltase Moiety ⬇️

scientific article published on February 15, 1973

Sucrase--isomaltase of the small-intestinal brush border membrane: assembly and biosynthesis

scientific article published on 01 January 1983

Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1

scientific article

Sustained delivery of a HIF-1 antagonist for ocular neovascularization

scientific article

Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia

scientific article

Systemic delivery of microencapsulated 3-bromopyruvate for the therapy of pancreatic cancer

scientific article

Systems biology of oxygen homeostasis

scientific article published on 21 February 2017

T-cell activation under hypoxic conditions enhances IFN-gamma secretion

scientific article

Targeting HIF-1 for cancer therapy

scientific article (publication date: October 2003)

Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways

scientific article published on August 2005

Targeting hypoxia-inducible factor 1 to stimulate tissue vascularization

scientific article published on 07 May 2015

Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung

scientific article published on 01 October 1998

The Genomics and Genetics of Oxygen Homeostasis

scientific article published on 07 April 2020

The HIF-1 antagonist acriflavine: visualization in retina and suppression of ocular neovascularization

scientific article published on 21 December 2016

The biguanide inhibition of d-glucose transport in membrane vesicles from small intestinal brush borders ⬇️

scientific article published on December 16, 1975

The biosynthesis of intestinal sucrase-isomaltase in human embryo is most likely controlled at the level of transcription

scientific article published on 01 December 1987

The electrogenic, Na+-dependent I- transport system in plasma membrane vesicles from thyroid glands

scientific article published on 01 January 1987

The expanding universe of hypoxia

scientific article published on 13 June 2008

The expression of lactase enzymatic activity and mRNA in human fetal jejunum. Effect of organ culture and of treatment with hydrocortisone.

scientific article published in April 1992

The human hypoxia-inducible factor 1alpha gene: HIF1A structure and evolutionary conservation

scientific article published in September 1998

The human lactase-phlorizin hydrolase gene is located on chromosome 2

scientific article published on 01 November 1988

The hydrophobic anchor of small-intestinal sucrase--isomaltase: N-terminal sequence of isomaltase subunit

scientific article published on December 1, 1978

The hypoxic tumor microenvironment: A driving force for breast cancer progression

scientific article

The inhibitory effect of sodium nitroprusside on HIF-1 activation is not dependent on nitric oxide-soluble guanylyl cyclase pathway

scientific article

The intravenous anesthetic propofol inhibits hypoxia-inducible factor 1 activity in an oxygen tension-dependent manner

scientific article

The levels of lactase and of sucrase-isomaltase along the rabbit small intestine are regulated both at the mRNA level and post-translationally

scientific article published on November 30, 1992

The mode of anchoring and precursor forms of sucrase-isomaltase and maltase-glucoamylase in chicken intestinal brush-border membrane. Phylogenetic implications

scientific article published in January 1987

The mode of association of the enzyme complex sucrase.isomaltase with the intestinal brush border membrane ⬇️

scientific article (publication date: 25 March 1979)

The role of hypoxia-inducible factors in carotid body (patho) physiology.

scientific article published on 23 January 2018

The role of hypoxia-inducible factors in oxygen sensing by the carotid body

scientific article published on January 2012

The silent carrier allele: beta thalassemia without a mutation in the beta-globin gene or its immediate flanking regions

scientific article published in November 1984

The small-intestinal Na+,d-glucose cotransporter: An asymmetric gated channel (or pore) responsive to ΔΨ ⬇️

scientific article published on January 1, 1983

The sucrase-isomaltase complex: primary structure, membrane-orientation, and evolution of a stalked, intrinsic brush border protein

scientific article

The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3

scientific journal article

The use of in situ hybridization to study erythropoietin gene expression in murine kidney and liver

scientific article

Therapeutic angiogenesis: another passing phase?

scientific article published on 01 May 2006

Tie2-dependent VHL knockdown promotes airway microvascular regeneration and attenuates invasive growth of Aspergillus fumigatus ⬇️

scientific article published on September 2013

Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells

scientific article published on 25 October 2011

Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

scientific article (publication date: August 1997)

Transcriptional regulation by hypoxia-inducible factor 1 molecular mechanisms of oxygen homeostasis

scientific article published on 01 July 1996

Transcriptional regulation of gene expression: mechanisms and pathophysiology

scientific article published on January 1994

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1

scientific article

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.

scientific article published on 16 September 2004

Transcriptional responses to intermittent hypoxia

scientific article

Tumor metabolism: cancer cells give and take lactate

scientific article

Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanisms

scientific article

Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1).

scientific article

Up-regulation of hypoxia-inducible factor 1alpha is an early event in prostate carcinogenesis

scientific article published in January 2004

V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression.

scientific article

VEGF secreted by hypoxic Müller cells induces MMP-2 expression and activity in endothelial cells to promote retinal neovascularization in proliferative diabetic retinopathy

scientific article published on 24 July 2013

VHL and p53: tumor suppressors team up to prevent cancer

scientific article

Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1 ⬇️

scientific article published on May 1, 2003

Vascular responses to hypoxia and ischemia

scientific article

Vasculogenesis, angiogenesis, and arteriogenesis: mechanisms of blood vessel formation and remodeling

scientific article published on November 2007

What is hypoxia-inducible factor-1 doing in the allergic lung?

scientific article published on 11 April 2011

n-Propyl gallate activates hypoxia-inducible factor 1 by modulating intracellular oxygen-sensing systems

scientific article published on April 2008

p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene

scientific article published on 01 October 1997

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