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List of works by Dieter Hoelzer

A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias

scientific article

AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor

scientific article (publication date: December 2002)

Acute leukemias of ambiguous lineage in adults: molecular and clinical characterization

scientific article published on 15 February 2013

Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapies

scientific article published on 22 March 2012

Adults with Philadelphia chromosome-like acute lymphoblastic leukemia frequently have IGH-CRLF2 and JAK2 mutations, persistence of minimal residual disease and poor prognosis

scientific article published on 25 August 2016

Altered apoptosis pathways in mantle cell lymphoma

scientific article published on January 2004

Alternating versus concurrent schedules of imatinib and chemotherapy as front-line therapy for Philadelphia-positive acute lymphoblastic leukemia (Ph+ALL)

scientific article published on 25 April 2006

Anti-CD19 BiTE Blinatumomab Induces High Complete Remission Rate In Adult Patients with Relapsed B-Precursor ALL: Updated Results of An Ongoing Phase II Trial ⬇️

scholarly article

Antifungal management and resource use in patients with acute myeloid leukaemia after chemotherapy--retrospective analysis of changes over 3 yr in a German hospital

scientific article published on 13 October 2011

Bendamustine in the treatment of non-Hodgkin's lymphoma: results and future perspectives

scientific article

Bendamustine plus rituximab is effective and has a favorable toxicity profile in the treatment of mantle cell and low-grade non-Hodgkin's lymphoma

scientific article

Bendamustine plus rituximab versus CHOP plus rituximab as first-line treatment for patients with indolent and mantle-cell lymphomas: an open-label, multicentre, randomised, phase 3 non-inferiority trial ⬇️

scientific article published on February 20, 2013

Blinatumomab vs historic standard-of-care treatment for minimal residual disease in adults with B-cell precursor acute lymphoblastic leukaemia

scientific article published on 24 January 2020

CD20 Expression and Response to Rituximab Treatment in B-Cell Precursor Lymphoblastic Leukemia - Results of the GMALL 08/2013 Trial ⬇️

scholarly article

CD4+ CD56+ neoplasia: clinical and biological features with emphasis on cytotoxic drug-induced apoptosis and expression of sialyl Lewis X.

scientific article

CD56 expression in T-cell acute lymphoblastic leukemia is associated with non-thymic phenotype and resistance to induction therapy but no inferior survival after risk-adapted therapy

scientific article published on 23 December 2008

Cell lineage assignment of cytogenetic findings in acute lymphoblastic leukemia using combined immunomagnetic cell separation and chromosome preparation ⬇️

scientific article published on 01 November 2003

Chemoimmunotherapy in acute lymphoblastic leukemia

scientific article published on 29 September 2011

Chromosomal organization and localization of the human histone deacetylase 9 gene (HDAC9)

scientific article (publication date: 26 April 2002)

Clinical features and prognostic implications of TCF3-PBX1 and ETV6-RUNX1 in adult acute lymphoblastic leukemia

scientific article

Clinical significance of minimal residual disease quantification in adult patients with standard-risk acute lymphoblastic leukemia.

scientific article

Clinical trial of valproic acid and all-trans retinoic acid in patients with poor-risk acute myeloid leukemia

scientific article

Cloning and chromosomal characterization of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 gene (PFKFB3, iPFK2)

scientific article (publication date: October 2003)

Comorbidities Are Frequent in Older Patients with De Novo Acute Lymphoblastic Leukemia (ALL) and Correlate with Induction Mortality: Analysis of More Than 1200 Patients from GMALL Data Bases ⬇️

scholarly article

Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.

scientific article

Dasatinib and low-intensity chemotherapy in elderly patients with Philadelphia chromosome-positive ALL

scientific article published on 27 April 2016

Developing a European network for adult ALL

scientific article published on 01 January 2004

Diagnosis, Prognostic Factors and Assessment of ALL in Adults: 2023 ELN Recommendations from a European Expert Panel

scholarly article

Dose-intensive chemotherapy including rituximab is highly effective but toxic in human immunodeficiency virus-infected patients with Burkitt lymphoma/leukemia: parallel study of 81 patients

scientific article published on 25 February 2014

Early Thymic Progenitor Leukemia (ETP-ALL) in Adults: A Distinct Molecular Entity, ⬇️

scholarly article

Early prediction of response in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) treated with imatinib

scientific article published on 23 October 2003

Epigenetic regulation of PAX5 expression in acute T-cell lymphoblastic leukemia

scientific article published on 14 December 2010

Erroneous class switching and false VDJ recombination: molecular dissection of t(8;14)/MYC-IGH translocations in Burkitt-type lymphoblastic leukemia/B-cell lymphoma

scientific article published on 25 April 2013

Exome Sequencing Identifies Recurring DNMT3A Mutations in Adult ETP-ALL ⬇️

scholarly article

Expression and function of prostate-apoptosis-response-gene-4 in lymphatic cells.

scientific article

Expression of IGFBP7 in acute leukemia is regulated by DNA methylation

scientific article published on 29 October 2010

Expression of interleukin 15 in primary adult acute lymphoblastic leukemia

scientific article published in January 2010

Expression of interleukin-18 receptor in fibroblast-like synoviocytes

scientific article

FLT3 mutations in early T-cell precursor ALL characterize a stem cell like leukemia and imply the clinical use of tyrosine kinase inhibitors

scientific article

Fine structure of translocation breakpoints within the major breakpoint region in BCR-ABL1-positive leukemias

scientific article published on 22 September 2011

GATA3 Silencing Defines a Distinct Subset of ETP-ALL. ⬇️

scholarly article

Genomic CDKN2A/2B deletions in adult Ph+ ALL are adverse despite allogeneic stem cell transplantation

scientific article published on 18 January 2018

Genomic Profiling Reveals Gain of Mutations in Histone Methylation Regulators in Relapsed Adult B Cell Precursor ALL ⬇️

scholarly article

Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease

scientific article

Germline variants in IKZF1, ARID5B, and CEBPE as risk factors for adult-onset acute lymphoblastic leukemia: an analysis from the GMALL study group

scientific article published on February 2014

Hematopoietic stem cell involvement in BCR-ABL1-positive ALL as potential mechanism of resistance to blinatumomab therapy.

scientific article

High BAALC expression predicts chemoresistance in adult B-precursor acute lymphoblastic leukemia

scientific article published on 11 January 2010

High Rate of FLT3 Mutations In Adult ETP-ALL. ⬇️

scholarly article

High Survival Rate in Adult Burkitt’s Lymphoma/Leukemia and Diffuse Large B-Cell Lymphoma with Mediastinal Involvement. ⬇️

scholarly article

High expression of the ETS transcription factor ERG predicts adverse outcome in acute T-lymphoblastic leukemia in adults

scientific article published on 5 September 2006

Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression

scientific article

Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell–engaging CD19/CD3-bispecific BiTE antibody blinatumomab ⬇️

scientific article published on May 16, 2012

Improved outcome of adult Burkitt lymphoma/leukemia with rituximab and chemotherapy: report of a large prospective multicenter trial

scientific article

Incidence and Prognostic Influence of DNMT3A Mutations in Acute Myeloid Leukemia ⬇️

scientific article published on June 13, 2011

Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy

scientific article published on 23 August 2011

Integrated analysis of relapsed B-cell precursor Acute Lymphoblastic Leukemia identifies subtype-specific cytokine and metabolic signatures

scientific article published on 12 March 2019

International reference analysis of outcomes in adults with B-precursor Ph-negative relapsed/refractory acute lymphoblastic leukemia

scientific article

Involvement of the MLL gene in adult T-lymphoblastic leukemia

scientific article published on 25 August 2012

Leading prognostic relevance of the BCR-ABL translocation in adult acute B-lineage lymphoblastic leukemia: a prospective study of the German Multicenter Trial Group and confirmed polymerase chain reaction analysis

scientific article published in March 2002

Leukemia research in Germany: the Competence Network Acute and Chronic Leukemias

scientific article published on 15 March 2016

Liposomal cytarabine is effective and tolerable in the treatment of central nervous system relapse of acute lymphoblastic leukemia and very aggressive lymphoma

scientific article

Loss-of-function but not dominant-negative intragenic IKZF1 deletions are associated with an adverse prognosis in adult BCR-ABL-negative acute lymphoblastic leukemia

scientific article published on 27 July 2017

Low ERG and BAALC expression identifies a new subgroup of adult acute T-lymphoblastic leukemia with a highly favorable outcome

scientific article

Low Expression Of BCL11B Predicts Poor Overall Survival In Adult Standard Risk T-ALL ⬇️

scholarly article

Low expression of T-cell transcription factor BCL11b predicts inferior survival in adult standard risk T-cell acute lymphoblastic leukemia patients

scientific article

MRD Kinetics in Adult Transplantation Recipients with Relapsed Acute Lymphoblastic Leukemia Depend on Initial Molecular Response to Front-Line Chemotherapy. ⬇️

scholarly article

Management of ALL in Adults: 2023 ELN Recommendations from a European Expert Panel

scholarly article

Mechanisms of resistance to STI571 (Imatinib) in Philadelphia-chromosome positive acute lymphoblastic leukemia

scientific article published on April 2004

MicroRNA Profiling Reveals Aberrant MicroRNA Expression in Adult ETP-ALL and Functional Studies Demonstrate a Role of Mir-222 in Acute Leukemia, ⬇️

scholarly article

MicroRNA profiling reveals aberrant microRNA expression in adult ETP-ALL and functional studies implicate a role for miR-222 in acute leukemia ⬇️

scientific article published on March 20, 2013

Minimal residual disease level predicts outcome in adults with Ph-negative B-precursor acute lymphoblastic leukemia

scientific article published on 01 December 2019

Molecular analysis of the t(2;8)/MYC-IGK translocation in high-grade lymphoma/leukemia by long-distance inverse PCR.

scientific article published on 25 November 2011

Molecular relapse in adult standard-risk ALL patients detected by prospective MRD monitoring during and after maintenance treatment: data from the GMALL 06/99 and 07/03 trials

scientific article

Monitoring of the Clonal Architecture of B-Cell Precursor ALL during Induction Chemoimmunotherapy ⬇️

scholarly article

Multi-Genomics of Relapsed B-Cell Precursor Acute Lymphoblastic Leukemia Reveals Three Distinct Genetic Clusters Characterized By Different Alterations ⬇️

scholarly article

Multidrug resistance-associated protein 4 (MRP4) gene polymorphisms and treatment response in adult acute lymphoblastic leukemia

scientific article

Mutational spectrum of adult T-ALL

scientific article published on February 2015

NUP214-ABL1 in adult T-ALL: the GMALL study group experience.

scientific article published on 27 July 2006

New Definition of Treatment Response in Adult Acute Lymphoblastic Leukemia (ALL): Use of Molecular Markers for Minimal Residual Disease (MRD). ⬇️

scholarly article

Next-Generation Sequencing and Real-Time Quantitative PCR For Quantification Of Low-Level Minimal Residual Disease In Acute Lymphoblastic Leukemia Of Adults ⬇️

scholarly article

Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL

scientific article (publication date: 15 June 2006)

No genetic evidence for involvement of Deltaretroviruses in adult patients with precursor and mature T-cell neoplasms

scientific article

Non-Functional ("haploinsufficient"), but Not Dominant Negative Clonal IKZF1 Deletions Confer an Adverse Prognosis in Adult BCR-ABL-Negative Acute Lymphoblastic Leukemia ⬇️

scholarly article

Novel agents aiming at specific molecular targets increase chemosensitivity and overcome chemoresistance in hematopoietic malignancies

scientific article

Novel antibody-based therapy for acute lymphoblastic leukaemia

scientific article published on January 2006

Outcome of adult patients with T-lymphoblastic lymphoma treated according to protocols for acute lymphoblastic leukemia

scientific article published in June 2002

Outcome of relapsed adult lymphoblastic leukemia depends on response to salvage chemotherapy, prognostic factors, and performance of stem cell transplantation.

scientific article

Outcomes of patients with Burkitt lymphoma older than age 40 treated with intensive chemotherapeutic regimens

scientific article

Overall Outcome of Relapsed Acute Lymphoblastic Leukemia Can Be Improved by Stem Cell Transplantation and Early Treatment in Stage of Molecular Relapse ⬇️

scholarly article

Overexpression of LEF1 predicts unfavorable outcome in adult patients with B-precursor acute lymphoblastic leukemia

scientific article published on 18 October 2011

Phase II trial of the anti-CD19 bispecific T cell-engager blinatumomab shows hematologic and molecular remissions in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia

scientific article published on 10 November 2014

Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia

scientific article

Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemia

scientific article published on October 2009

Prognostic implications of mutations and expression of the Wilms tumor 1 (WT1) gene in adult acute T-lymphoblastic leukemia

scientific article

Risk-adapted treatment according to minimal residual disease in adult ALL.

scientific article

Secondary acute myeloid leukaemia with monosomy 7 in identical adult twins

scientific article

Subclonal IKZF1 Deletions Indicate a Multiclonal Evolution In BCR-ABL1-Positive B-Cell Precursor ALL ⬇️

scholarly article

Successful Subtype Oriented Treatment Strategies in Adult T-All; Results of 744 Patients Treated in Three Consecutive GMALL Studies. ⬇️

scholarly article

T-cell lymphoblastic lymphoma and T-cell acute lymphoblastic leukemia: a separate entity?

scientific article published on January 2009

Targeted therapies in the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia

scientific article

Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival

scientific article published on 16 May 2011

The ABL tyrosine kinase inhibitor STI571 (Glivec) in Philadelphia positive acute lymphoblastic leukemia - promises, pitfalls and possibilities

scientific article

The European LeukemiaNet: achievements and perspectives

scientific article

The Hematopoietic Growth Factors in Acute Leukemia: A European Perspective ⬇️

scientific article published on January 1, 2011

The MLL recombinome of adult CD10-negative B-cell precursor acute lymphoblastic leukemia: results from the GMALL study group

scientific article published on 14 January 2009

The molecular biology of TRAIL-mediated signaling and its potential therapeutic exploitation in hematopoietic malignancies

scientific article published on January 2006

The role of high-dose cytarabine in induction therapy for adult ALL.

scientific article published in May 2002

The role of microRNA-196a and microRNA-196b as ERG regulators in acute myeloid leukemia and acute T-lymphoblastic leukemia

scientific article published on 8 June 2010

Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI)

scientific article (publication date: 10 December 2002)

Treatment of adult acute lymphoblastic leukemia

scientific article published on January 2006

Treatment of indolent non-Hodgkin's lymphoma with cladribine as single-agent therapy and in combination with mitoxantrone

scientific article published in May 2004

Treatment with monoclonal antibodies in acute lymphoblastic leukemia: current knowledge and future prospects

scientific article published on 26 November 2003

Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutations

scientific article published on 19 April 2013

Wilms' tumor gene 1 (WT1) expression in subtypes of acute lymphoblastic leukemia (ALL) of adults and impact on clinical outcome

scientific article published on 29 April 2009

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