List of works - Hartmuth C. Kolb

"On water": unique reactivity of organic compounds in aqueous suspension

scientific article

A highly selective and specific PET tracer for imaging of tau pathologies

scientific article

A new class of highly potent matrix metalloproteinase inhibitors based on triazole-substituted hydroxamates: (radio)synthesis and in vitro and first in vivo evaluation.

scientific article published on 16 May 2012

An integrated microfluidic device for large-scale in situ click chemistry screening

scientific article

Atherosclerotic plaque uptake of a novel integrin tracer ¹⁸F-Flotegatide in a mouse model of atherosclerosis

scientific article

Batch-reactor microfluidic device: first human use of a microfluidically produced PET radiotracer

scientific article

Biodistribution and radiation dosimetry of 18F-CP-18, a potential apoptosis imaging agent, as determined from PET/CT scans in healthy volunteers.

scientific article

Biodistribution and radiation dosimetry of the carbonic anhydrase IX imaging agent [(18) F]VM4-037 determined from PET/CT scans in healthy volunteers.

scientific article published in October 2014

Biodistribution and radiation dosimetry of the integrin marker 18F-RGD-K5 determined from whole-body PET/CT in monkeys and humans

scientific article published on 12 April 2012

Catalytic Asymmetric Dihydroxylation

Chemistry of insect antifeedants from Azadirachta indica (Part 10): synthesis of a highly functionalised decalin fragment of azadirachtin

article

Chemistry of insect antifeedants from Azadirachta indica(part 12): use of silicon as a control element in the synthesis of a highly functionalized decalin fragment of azadirachtin

Chemistry of insect antifeedants from Azadirachta indica(part 13): on the use of the intramolecular Diels–Alder reaction for the construction of trans-fused hydrobenzofuran fragments for azadirachtin synthesis

Click Chemistry: Diverse Chemical Function from a Few Good Reactions

scientific article (publication date: June 2001)

Click-Chemie: diverse chemische Funktionalität mit einer Handvoll guter Reaktionen

scientific article from 2001

Design and optimization of coin-shaped microreactor chips for PET radiopharmaceutical synthesis

scientific article

Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807.

scientific article published in January 2013

Early clinical PET imaging results with the novel PHF-tau radioligand [F18]-T808.

scientific article

Evaluation of [(18)F]-CP18 as a PET imaging tracer for apoptosis

scientific article published on December 2013

Flow optimization study of a batch microfluidics PET tracer synthesizing device.

scientific article published on February 2011

Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation

scientific article

From in situ to in vivo: an in situ click-chemistry-derived carbonic anhydrase II imaging agent for positron emission tomography

scientific article published on 3 December 2012

In situ click chemistry: enzyme inhibitors made to their own specifications

scientific article published in October 2004

In situ click chemistry: enzyme-generated inhibitors of carbonic anhydrase II.

scientific article published in December 2004

In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitors

scientific article published in May 2005

In vitro and in vivo evaluation of the caspase-3 substrate-based radiotracer [(18)F]-CP18 for PET imaging of apoptosis in tumors

scientific article published on December 2013

Inhibitors of HIV-1 protease by using in situ click chemistry

scientific article published on 01 February 2006

Integrated microfluidics for parallel screening of an in situ click chemistry library

scientific article

Inverse 1,2,3-triazole-1-yl-ethyl substituted hydroxamates as highly potent matrix metalloproteinase inhibitors: (radio)synthesis, in vitro and first in vivo evaluation

scientific article published on 16 August 2013

Microfluidic single vessel production of hypoxia tracer 1H-1-(3-[18F]-fluoro-2-hydroxy-propyl)-2-nitro-imidazole ([18F]-FMISO).

scientific article published on 7 June 2012

Molecular basis of interactions of cholinesterases with tight binding inhibitors.

scientific article published on 11 November 2005

Multistep synthesis of a radiolabeled imaging probe using integrated microfluidics

scientific article published in December 2005

Noninvasive molecular imaging of apoptosis in a mouse model of anthracycline-induced cardiotoxicity

scientific article

PET Imaging of the P2X7 Ion Channel with a Novel Tracer [18F]JNJ-64413739 in a Rat Model of Neuroinflammation

scientific article published on 01 October 2019

PET imaging of hypoxia using [18F]HX4: a phase I trial

scientific article

Pre-clinical evaluation of a 3-nitro-1,2,4-triazole analogue of [18F]FMISO as hypoxia-selective tracer for PET.

scientific article published on 6 May 2010

Preclinical Evaluation and Nonhuman Primate Receptor Occupancy Study of 18F-JNJ-64413739, a PET Radioligand for P2X7 Receptors

scientific article published on 07 February 2019

Preclinical evaluation and validation of [18F]HX4, a promising hypoxia marker for PET imaging

scientific article

Radiolabeled hydroxamate-based matrix metalloproteinase inhibitors: How chemical modifications affect pharmacokinetics and metabolic stability.

scientific article published on 17 March 2016

Repeatability of hypoxia PET imaging using [¹⁸F]HX4 in lung and head and neck cancer patients: a prospective multicenter trial

scientific article

Structural insights into conformational flexibility at the peripheral site and within the active center gorge of AChE.

scientific article published on 2 November 2005

Synthesis of a C16–C28 spiroacetal fragment of avermectin B1a and reassignment of some 1H and 13C resonances of avermectin B1a

Synthesis, radiosynthesis, in vitro and first in vivo evaluation of a new matrix metalloproteinase inhibitor based on γ-fluorinated α-sulfonylaminohydroxamic acid

scientific article published on 27 July 2018

The clinical importance of assessing tumor hypoxia: relationship of tumor hypoxia to prognosis and therapeutic opportunities

scientific article

The growing impact of click chemistry on drug discovery

scientific article

The synthesis of azadirachtin: a potent insect antifeedant.

scientific article published in January 2008

Total synthesis of the anthelmintic macrolide avermectin B1a

article

Toward an Understanding of the High Enantioselectivity in the Osmium-Catalyzed Asymmetric Dihydroxylation (AD). 1. Kinetics

scholarly article by Hartmuth C. Kolb et al published February 1994 in Journal of the American Chemical Society

Toward an Understanding of the High Enantioselectivity in the Osmium-Catalyzed Asymmetric Dihydroxylation. 4. Electronic Effects in Amine-Accelerated Osmylations

scholarly article by Derek W. Nelson et al published February 1997 in Journal of the American Chemical Society

[(18)F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease

scientific article published on 12 February 2013

¹⁸F-HX4 hypoxia imaging with PET/CT in head and neck cancer: a comparison with ¹⁸F-FMISO

scientific article published on 01 October 2012

List of works by Hartmuth C. Kolb

"On water": unique reactivity of organic compounds in aqueous suspension

A highly selective and specific PET tracer for imaging of tau pathologies

A new class of highly potent matrix metalloproteinase inhibitors based on triazole-substituted hydroxamates: (radio)synthesis and in vitro and first in vivo evaluation.

An integrated microfluidic device for large-scale in situ click chemistry screening

Atherosclerotic plaque uptake of a novel integrin tracer ¹⁸F-Flotegatide in a mouse model of atherosclerosis

Batch-reactor microfluidic device: first human use of a microfluidically produced PET radiotracer

Biodistribution and radiation dosimetry of 18F-CP-18, a potential apoptosis imaging agent, as determined from PET/CT scans in healthy volunteers.

Biodistribution and radiation dosimetry of the carbonic anhydrase IX imaging agent [(18) F]VM4-037 determined from PET/CT scans in healthy volunteers.

Biodistribution and radiation dosimetry of the integrin marker 18F-RGD-K5 determined from whole-body PET/CT in monkeys and humans

Catalytic Asymmetric Dihydroxylation

Chemistry of insect antifeedants from Azadirachta indica (Part 10): synthesis of a highly functionalised decalin fragment of azadirachtin

Chemistry of insect antifeedants from Azadirachta indica(part 12): use of silicon as a control element in the synthesis of a highly functionalized decalin fragment of azadirachtin

Chemistry of insect antifeedants from Azadirachta indica(part 13): on the use of the intramolecular Diels–Alder reaction for the construction of trans-fused hydrobenzofuran fragments for azadirachtin synthesis

Click Chemistry: Diverse Chemical Function from a Few Good Reactions

Click-Chemie: diverse chemische Funktionalität mit einer Handvoll guter Reaktionen

Design and optimization of coin-shaped microreactor chips for PET radiopharmaceutical synthesis

Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807.

Early clinical PET imaging results with the novel PHF-tau radioligand [F18]-T808.

Evaluation of [(18)F]-CP18 as a PET imaging tracer for apoptosis

Flow optimization study of a batch microfluidics PET tracer synthesizing device.

Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation

From in situ to in vivo: an in situ click-chemistry-derived carbonic anhydrase II imaging agent for positron emission tomography

In situ click chemistry: enzyme inhibitors made to their own specifications

In situ click chemistry: enzyme-generated inhibitors of carbonic anhydrase II.

In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitors

In vitro and in vivo evaluation of the caspase-3 substrate-based radiotracer [(18)F]-CP18 for PET imaging of apoptosis in tumors

Inhibitors of HIV-1 protease by using in situ click chemistry

Integrated microfluidics for parallel screening of an in situ click chemistry library

Inverse 1,2,3-triazole-1-yl-ethyl substituted hydroxamates as highly potent matrix metalloproteinase inhibitors: (radio)synthesis, in vitro and first in vivo evaluation

Microfluidic single vessel production of hypoxia tracer 1H-1-(3-[18F]-fluoro-2-hydroxy-propyl)-2-nitro-imidazole ([18F]-FMISO).

Molecular basis of interactions of cholinesterases with tight binding inhibitors.

Multistep synthesis of a radiolabeled imaging probe using integrated microfluidics

Noninvasive molecular imaging of apoptosis in a mouse model of anthracycline-induced cardiotoxicity

PET Imaging of the P2X7 Ion Channel with a Novel Tracer [18F]JNJ-64413739 in a Rat Model of Neuroinflammation

PET imaging of hypoxia using [18F]HX4: a phase I trial

Pre-clinical evaluation of a 3-nitro-1,2,4-triazole analogue of [18F]FMISO as hypoxia-selective tracer for PET.

Preclinical Evaluation and Nonhuman Primate Receptor Occupancy Study of 18F-JNJ-64413739, a PET Radioligand for P2X7 Receptors

Preclinical evaluation and validation of [18F]HX4, a promising hypoxia marker for PET imaging

Radiolabeled hydroxamate-based matrix metalloproteinase inhibitors: How chemical modifications affect pharmacokinetics and metabolic stability.

Repeatability of hypoxia PET imaging using [¹⁸F]HX4 in lung and head and neck cancer patients: a prospective multicenter trial

Structural insights into conformational flexibility at the peripheral site and within the active center gorge of AChE.

Synthesis of a C16–C28 spiroacetal fragment of avermectin B1a and reassignment of some 1H and 13C resonances of avermectin B1a

Synthesis, radiosynthesis, in vitro and first in vivo evaluation of a new matrix metalloproteinase inhibitor based on γ-fluorinated α-sulfonylaminohydroxamic acid

The clinical importance of assessing tumor hypoxia: relationship of tumor hypoxia to prognosis and therapeutic opportunities

The growing impact of click chemistry on drug discovery

The synthesis of azadirachtin: a potent insect antifeedant.

Total synthesis of the anthelmintic macrolide avermectin B1a

Toward an Understanding of the High Enantioselectivity in the Osmium-Catalyzed Asymmetric Dihydroxylation (AD). 1. Kinetics

Toward an Understanding of the High Enantioselectivity in the Osmium-Catalyzed Asymmetric Dihydroxylation. 4. Electronic Effects in Amine-Accelerated Osmylations

[(18)F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease

¹⁸F-HX4 hypoxia imaging with PET/CT in head and neck cancer: a comparison with ¹⁸F-FMISO