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List of works by Aziz Sancar

A cryptochrome/photolyase class of enzymes with single-stranded DNA-specific photolyase activity

scientific article

A mathematical model for human nucleotide excision repair: damage recognition by random order assembly and kinetic proofreading

scientific article

A role for cryptochromes in sleep regulation

scientific article

ATR Kinase Inhibition Protects Non-cycling Cells from the Lethal Effects of DNA Damage and Transcription Stress

scientific article published on 3 March 2016

An Integrated Approach for Analysis of the DNA Damage Response in Mammalian Cells: NUCLEOTIDE EXCISION REPAIR, DNA DAMAGE CHECKPOINT, AND APOPTOSIS

scientific article

An alternative form of replication protein a expressed in normal human tissues supports DNA repair

scientific article

Analysis of Ribonucleotide Removal from DNA by Human Nucleotide Excision Repair

scientific article

Analysis of autophosphorylating kinase activities of Arabidopsis and human cryptochromes

scientific article published on November 2006

Analysis of the role of intraprotein electron transfer in photoreactivation by DNA photolyase in vivo

scientific article published in December 2004

Bifurcating electron-transfer pathways in DNA photolyases determine the repair quantum yield

scientific article published in October 2016

Biochemical analysis of the canonical model for the mammalian circadian clock

scientific article

Biography

scientific article published in January 2017

Blue-light-receptive cryptochrome is expressed in a sponge eye lacking neurons and opsin

scientific article (publication date: 15 April 2012)

Cdc7-Dbf4 and the human S checkpoint response to UVC

scientific article

Characterization of transcription-repair coupling factors in E. coli and humans

scientific article published in January 2003

Circadian clock control of the cellular response to DNA damage

scientific article

Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis ⬇️

scientific article published on May 31, 2011

Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase

scientific article

Circadian oscillation of nucleotide excision repair in mammalian brain

scientific article

Circadian photoreception in humans and mice

scientific article published on December 2002

Circadian regulation of DNA excision repair: implications for chrono-chemotherapy

scientific article

Cisplatin DNA damage and repair maps of the human genome at single-nucleotide resolution

scientific article published on 29 September 2016

Claud S. Rupert (1919-2017): The Father of DNA Repair.

scientific article

Cockayne syndrome group B protein enhances elongation by RNA polymerase II ⬇️

scientific article published on October 14, 1997

Comparative photochemistry of animal type 1 and type 4 cryptochromes

scientific article

Control of skin cancer by the circadian rhythm ⬇️

scientific article published on October 24, 2011

Cooperative activation of the ATR checkpoint kinase by TopBP1 and damaged DNA.

scientific article published on 12 January 2009

Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system

scientific article published on 08 January 2014

Coupling of human circadian and cell cycles by the timeless protein

scientific article

Cryptochrome, circadian cycle, cell cycle checkpoints, and cancer

scientific article published in August 2005

Cryptochromes and circadian photoreception in animals

scientific article published in January 2005

Cryptochromes and inner retinal non-visual irradiance detection

scientific article

Crystal Structure of DNA Photolyase from Escherichia coli ⬇️

scientific article published on June 30, 1995

DDB accumulates at DNA damage sites immediately after UV irradiation and directly stimulates nucleotide excision repair

scientific article

DNA damage-specific control of cell death by cryptochrome in p53-mutant ras-transformed cells

scientific article published on 13 November 2012

DNA distress: just ring 9-1-1.

scientific article

DNA excision repair: where do all the dimers go?

scientific article

DNA repair synthesis and ligation affect the processing of excised oligonucleotides generated by human nucleotide excision repair

scientific article

Determining complete electron flow in the cofactor photoreduction of oxidized photolyase

scientific article published on 23 July 2013

Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2

scientific article

Direct determination of resonance energy transfer in photolyase: structural alignment for the functional state

scientific article

Direct observation of thymine dimer repair in DNA by photolyase

scientific article

Direct role for the replication protein treslin (Ticrr) in the ATR kinase-mediated checkpoint response

scientific article published on 21 May 2013

Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock

scientific article

Dynamic determination of the functional state in photolyase and the implication for cryptochrome

scientific article published on 23 July 2013

Dynamic maps of UV damage formation and repair for the human genome

scientific article

Dynamics and mechanism of cyclobutane pyrimidine dimer repair by DNA photolyase ⬇️

scientific article published on July 29, 2011

Dynamics and mechanism of repair of ultraviolet-induced (6-4) photoproduct by photolyase

scientific article

ERCC4 (XPF) encodes a human nucleotide excision repair protein with eukaryotic recombination homologs

scientific article

Effect of circadian clock mutations on DNA damage response in mammalian cells ⬇️

scientific article published on August 23, 2012

Effect of damage type on stimulation of human excision nuclease by SWI/SNF chromatin remodeling factor

scientific article

Effect of vitamin A depletion on nonvisual phototransduction pathways in cryptochromeless mice

scientific article published in December 2004

Electrically monitoring DNA repair by photolyase

scientific article

Electron Tunneling Pathways and Role of Adenine in Repair of Cyclobutane Pyrimidine Dimer by DNA Photolyase ⬇️

scientific article published on May 4, 2012

Expression of the Blue-Light Receptor Cryptochrome in the Human Retina ⬇️

scientific article published on October 1, 2003

Femtochemistry in enzyme catalysis: DNA photolyase

scientific article published on January 2007

Femtosecond dynamics of flavin cofactor in DNA photolyase: radical reduction, local solvation, and charge recombination.

scientific article published in February 2005

Formation and function of flavin anion radical in cryptochrome 1 blue-light photoreceptor of monarch butterfly

scientific article

Formation of Arabidopsis Cryptochrome 2 photobodies in mammalian nuclei: application as an optogenetic DNA damage checkpoint switch

scientific article published on 05 July 2013

Formation of a ternary complex by human XPA, ERCC1, and ERCC4(XPF) excision repair proteins

scientific article

Functional redundancy of cryptochromes and classical photoreceptors for nonvisual ocular photoreception in mice

scientific article

Further evidence for the role of cryptochromes in retinohypothalamic photoreception/phototransduction

scientific article published on March 2004

Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression

scientific article published on 21 February 2014

Genome-wide analysis of human global and transcription-coupled excision repair of UV damage at single-nucleotide resolution

scientific article published on May 2015

Genome-wide excision repair in Arabidopsis is coupled to transcription and reflects circadian gene expression patterns.

scientific article published on 17 April 2018

Genome-wide kinetics of DNA excision repair in relation to chromatin state and mutagenesis

scientific article published on 28 March 2016

Genome-wide transcription-coupled repair in Escherichia coli is mediated by the Mfd translocase

scientific article published on 06 February 2017

Guidelines for Genome-Scale Analysis of Biological Rhythms

scientific article published on November 2017

Highly specific and sensitive method for measuring nucleotide excision repair kinetics of ultraviolet photoproducts in human cells

scientific article

Human Blue‐light Photoreceptor hCRY2 Specifically Interacts with Protein Serine/Threonine Phosphatase 5 and Modulates Its Activity ⬇️

scientific article published on November 1, 1997

Human DNA damage checkpoint protein hRAD9 is a 3' to 5' exonuclease

scientific article

Human DNA repair excision nuclease. Analysis of the roles of the subunits involved in dual incisions by using anti-XPG and anti-ERCC1 antibodies

scientific article

Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures

scientific article

Human genome-wide repair map of DNA damage caused by the cigarette smoke carcinogen benzo[a]pyrene

scientific article

Human transcription-repair coupling factor CSB/ERCC6 is a DNA-stimulated ATPase but is not a helicase and does not disrupt the ternary transcription complex of stalled RNA polymerase II

scientific article

Identification and characterization of human MUS81-MMS4 structure-specific endonuclease

scientific article

In vitro analysis of the role of replication protein A (RPA) and RPA phosphorylation in ATR-mediated checkpoint signaling

scientific article

In vitro repair of oxidative DNA damage by human nucleotide excision repair system: Possible explanation for neurodegeneration in Xeroderma pigmentosum patients ⬇️

scientific article published on August 19, 1997

Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway

scientific article

Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH

scientific article

It Is Chemistry but Not Your Grandfather's Chemistry

scientific article published in January 2017

Light induction of a vertebrate clock gene involves signaling through blue-light receptors and MAP kinases

scientific article

Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro

scientific article

Long patch base excision repair proceeds via coordinated stimulation of the multienzyme DNA repair complex

scientific article

Loss of cryptochrome reduces cancer risk in p53 mutant mice

scholarly article

Mammalian Period represses and de-represses transcription by displacing CLOCK-BMAL1 from promoters in a Cryptochrome-dependent manner

scientific article published on 29 September 2016

Mechanism of Release and Fate of Excised Oligonucleotides during Nucleotide Excision Repair ⬇️

scientific article published on May 9, 2012

Mechanism of photosignaling by Drosophila cryptochrome: role of the redox status of the flavin chromophore

scientific article published on 30 December 2013

Mechanism of stimulation of human DNA ligase I by the Rad9-rad1-Hus1 checkpoint complex.

scientific article

Mechanisms of DNA Repair by Photolyase and Excision Nuclease (Nobel Lecture).

scientific article published on 23 June 2016

Melanoma and DNA damage from a distance (farstander effect) ⬇️

scientific article published on February 1, 2011

Mfd translocase is necessary and sufficient for transcription-coupled repair in Escherichia coli

scientific article

Molecular anatomy of the human excision nuclease assembled at sites of DNA damage

scientific article

Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus

scientific article

Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

scientific article

Multiple ATR-Chk1 Pathway Proteins Preferentially Associate with Checkpoint-Inducing DNA Substrates ⬇️

scientific article published on July 29, 2011

Nucleotide Excision Repair in Eukaryotes

Nucleotide excision repair

scientific article

Nucleotide excision repair from site-specifically platinum-modified nucleosomes

scientific article published in June 2003

Nucleotide excision repair in E. coli and man.

scientific article

Nucleotide excision repair in human cells: fate of the excised oligonucleotide carrying DNA damage in vivo

scientific article published on 08 June 2013

Oliver Smithies (1925-2017).

scientific article published in February 2017

Photochemistry and photobiology of cryptochrome blue-light photopigments: the search for a photocycle

scientific article

Photolyase and cryptochrome blue-light photoreceptors

scientific article

Photolyase/cryptochrome blue-light photoreceptors use photon energy to repair DNA and reset the circadian clock

scientific article

Pleiotropic effects of cryptochromes 1 and 2 on free-running and light-entrained murine circadian rhythms

scientific article published in July 2002

Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5.

scholarly article

Preferential binding of ATR protein to UV-damaged DNA.

scientific article

Purification and characterization of DNA photolyases

scientific article published in January 2006

Purification and characterization of Escherichia coli and human nucleotide excision repair enzyme systems

scientific article

Purification and characterization of a type III photolyase from Caulobacter crescentus

scientific article published on 5 September 2008

Purification and characterization of human DNA damage checkpoint Rad complexes

scientific article

Purification and characterization of the XPF-ERCC1 complex of human DNA repair excision nuclease

scientific article

Purification and characterization of three members of the photolyase/cryptochrome family blue-light photoreceptors from Vibrio cholerae

scientific article published on 22 July 2003

Purification and properties of human blue-light photoreceptor cryptochrome 2

scientific article

Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins

scientific article

Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities

scientific journal article

RHINO forms a stoichiometric complex with the 9-1-1 checkpoint clamp and mediates ATR-Chk1 signaling

scientific article published on January 2015

RNA polymerase II is released from the DNA template during transcription-coupled repair in mammalian cells

scientific article published on 27 December 2017

RNA polymerase: the most specific damage recognition protein in cellular responses to DNA damage?

scholarly article

Reaction mechanism of Drosophila cryptochrome

scientific article

Recognition and repair of the cyclobutane thymine dimer, a major cause of skin cancers, by the human excision nuclease ⬇️

scientific article published on October 15, 2003

Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling

scientific article

Reconstitution of a human ATR-mediated checkpoint response to damaged DNA.

scholarly article

Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase

scientific article published on 14 October 2009

Reconstitution of human excision nuclease with recombinant XPF-ERCC1 complex

scientific article

Recruitment of DNA damage checkpoint proteins to damage in transcribed and nontranscribed sequences

scientific article published in January 2006

Regulation of apoptosis by the circadian clock through NF-kappaB signaling

scientific article

Regulation of nucleotide excision repair activity by transcriptional and post-transcriptional control of the XPA protein

scientific article

Regulation of the mammalian circadian clock by cryptochrome

scientific article published on 27 April 2004

Repair of DNA-polypeptide crosslinks by human excision nuclease

scientific article

Repair of DNA-protein cross-links in mammalian cells.

scientific article

Reply to Brettel and Byrdin: On the efficiency of DNA repair by photolyase.

scientific article published on 8 May 2012

Resonance Raman spectroscopic investigation of the light-harvesting chromophore in escherichia coli photolyase and Vibrio cholerae cryptochrome-1.

scientific article published on 23 February 2007

Role of structural plasticity in signal transduction by the cryptochrome blue-light photoreceptor

scientific journal article

SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding

scientific article published on 14 July 2016

Similar nucleotide excision repair capacity in melanocytes and melanoma cells

scientific article

Sleep deprivation effects on circadian clock gene expression in the cerebral cortex parallel electroencephalographic differences among mouse strains

scientific article published on July 2008

Structure and function of DNA photolyase and cryptochrome blue-light photoreceptors

scientific article (publication date: June 2003)

Structure and function of photolyase and in vivo enzymology: 50th anniversary

scientific article published on 04 August 2008

Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy

scientific article (publication date: 3 May 2002)

Tethering DNA Damage Checkpoint Mediator Proteins Topoisomerase IIβ-binding Protein 1 (TopBP1) and Claspin to DNA Activates Ataxia-Telangiectasia Mutated and RAD3-related (ATR) Phosphorylation of Checkpoint Kinase 1 (Chk1) ⬇️

scientific article published on April 18, 2011

The 2015 Nobel Prize in Chemistry The Discovery of Essential Mechanisms that Repair DNA Damage

scientific article published in January 2016

The DNA Damage Response Kinases DNA-dependent Protein Kinase (DNA-PK) and Ataxia Telangiectasia Mutated (ATM) Are Stimulated by Bulky Adduct-containing DNA ⬇️

scientific article published on April 12, 2011

The SWI/SNF chromatin-remodeling factor stimulates repair by human excision nuclease in the mononucleosome core particle

scientific article

The Second Chromophore in Drosophila Photolyase/Cryptochrome Family Photoreceptors ⬇️

scientific article published on December 27, 2011

The circadian clock controls sunburn apoptosis and erythema in mouse skin

scientific article published on 28 November 2014

The human ATR-mediated DNA damage checkpoint in a reconstituted system

scientific article published on 24 February 2009

The human Rad9 checkpoint protein stimulates the carbamoyl phosphate synthetase activity of the multifunctional protein CAD

scientific article

The human Rad9-Rad1-Hus1 checkpoint complex stimulates flap endonuclease 1.

scholarly article

The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement

scientific article

The influence of repair pathways on the cytotoxicity and mutagenicity induced by the pyridyloxobutylation pathway of tobacco-specific nitrosamines

scientific article published on August 2009

The molecular origin of high DNA-repair efficiency by photolyase.

scientific article

Thermodynamic cooperativity and kinetic proofreading in DNA damage recognition and repair

scientific article (publication date: February 2004)

Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress

scientific article

UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1)

scientific article published on 19 March 2015

Ultrafast dynamics of flavins in five redox states

scientific article published on 04 September 2008

Ultrafast dynamics of resonance energy transfer in cryptochrome

scientific article published in June 2005

Ultrafast solvation dynamics at binding and active sites of photolyases

scientific article

Vitamin B 2 -based blue-light photoreceptors in the retinohypothalamic tract as the photoactive pigments for setting the circadian clock in mammals ⬇️

scientific article published on May 26, 1998

Wildtype epidermal growth factor receptor (Egfr) is not required for daily locomotor or masking behavior in mice

scientific article

Xeroderma pigmentosum complementation group E protein (XPE/DDB2): purification of various complexes of XPE and analyses of their damaged DNA binding and putative DNA repair properties

scientific article published in November 2005

cis -Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects

scientific article

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