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List of works by Mizushima Noboru

A Dual Binding Receptor for ER-phagy

scientific article published in January 2018

A brief history of autophagy from cell biology to physiology and disease

scientific article published on 23 April 2018

A comprehensive glossary of autophagy-related molecules and processes

scientific article published on 16 May 2010

A comprehensive glossary of autophagy-related molecules and processes (2nd edition)

scientific article

A critical role for the autophagy gene Atg5 in T cell survival and proliferation

scientific article

A critical role of VMP1 in lipoprotein secretion

scientific article published on 17 September 2019

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

scientific article (publication date: 13 November 2008)

A new probe to measure autophagic flux in vitro and in vivo.

scientific article

A receptor for eating mitochondria

scientific article published on 01 July 2009

A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery

scientific article

A(beta) generation in autophagic vacuoles

scientific article

ALIS are stress-induced protein storage compartments for substrates of the proteasome and autophagy

scientific article

ATG conjugation-dependent degradation of the inner autophagosomal membrane is a key step for autophagosome maturation

scientific article

ATG8 localization in apicomplexan parasites: apicoplast and more?

scientific article

Accumulation of undegraded autophagosomes by expression of dominant-negative STX17 (syntaxin 17) mutants.

scientific article

Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes

scientific article

An Autophagic Flux Probe that Releases an Internal Control

scientific article

Analysis of the role of autophagy in replication of herpes simplex virus in cell culture

scientific article

At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy.

scientific article published on 24 December 2013

Atg101, a novel mammalian autophagy protein interacting with Atg13

scientific article

Atg101: Not Just an Accessory Subunit in the Autophagy-initiation Complex

scientific article

Atg13 Is Essential for Autophagy and Cardiac Development in Mice

scientific article published on 07 December 2015

Atg14 and UVRAG: mutually exclusive subunits of mammalian Beclin 1-PI3K complexes

scientific article published on 2 May 2009

Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal type 3-deficient mice

scientific article published in August 2005

Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17.

scientific article published on 22 May 2018

Autophagosome formation in mammalian cells

scientific article

Autophagosome formation is initiated at phosphatidylinositol synthase-enriched ER subdomains

scientific article

Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens

scientific article

Autophagosomes in GFP-LC3 Transgenic Mice

scientific article published in January 2008

Autophagy

scientific article published on 23 February 2010

Autophagy and human diseases

scientific article published on 10 December 2013

Autophagy fights disease through cellular self-digestion

scientific article (publication date: 28 February 2008)

Autophagy in Human Diseases

scientific article published on 01 October 2020

Autophagy in Protein and Organelle Turnover ⬇️

scientific article published on 03 August 2011

Autophagy in differentiation and development

scientific article

Autophagy in immunity and inflammation

scientific article

Autophagy in the lens.

scientific article published on 21 August 2015

Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance

scientific article published in Nature

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

scientific article

Autophagy is essential for hearing in mice

scientific article published on 11 May 2017

Autophagy is essential for preimplantation development of mouse embryos

scientific article published in July 2008

Autophagy machinery in the context of mammalian mitophagy.

scientific article

Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury

scientific article

Autophagy regulates lipid metabolism through selective turnover of NCoR1

scientific article published on 05 April 2019

Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations

scientific article published on 01 January 2018

Autophagy-deficient mice develop multiple liver tumors

scientific article published on April 2011

Autophagy-monitoring and autophagy-deficient mice

scientific article published on 18 August 2017

Autophagy-related Atg8 localizes to the apicoplast of the human malaria parasite Plasmodium falciparum

scientific article (publication date: 2012)

Autophagy: Renovation of Cells and Tissues ⬇️

scientific article (publication date: 11 November 2011)

Autophagy: a strategy for neogenesis

scientific article published in May 2005

Autophagy: process and function

scientific article (publication date: 15 November 2007)

Autophagy: resetting glutamine-dependent metabolism and oxygen consumption.

scientific article published on 21 August 2012

Basal autophagy is required for the efficient catabolism of sialyloligosaccharides

scientific article published on 23 July 2013

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

scientific article (publication date: 23 September 2005)

Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG

scientific article (publication date: December 2008)

Beth Levine 1960-2020

scientific article published on 17 July 2020

Cellular autophagy machinery is not required for vaccinia virus replication and maturation

scientific article published on 23 April 2006

Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy

scientific article

Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins

scientific article

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

scientific article (publication date: July 2005)

Chromosomal mapping of the GFP-LC3 transgene in GFP-LC3 mice

scientific article published on 7 August 2007

Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo

scientific article published on 15 December 2009

Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy

scientific article published on 12 March 2008

Coronavirus replication complex formation utilizes components of cellular autophagy

scientific article published on 29 December 2003

Correction: Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide

scientific article published on 21 March 2016

Correction: Methamphetamine Inhibits Antigen Processing, Presentation, and Phagocytosis.

scientific article published on 13 March 2008

Crohn disease: a current perspective on genetics, autophagy and immunity

scientific article

Crystallization and preliminary X-ray analysis of LC3-I.

scientific article

Crystallization and preliminary crystallographic analysis of human Atg4B-LC3 complex

scientific article published on 17 January 2007

Cycloheximide inhibits starvation-induced autophagy through mTORC1 activation

scientific article published on 10 February 2014

DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death.

scientific article published on 19 September 2008

De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood

scientific article

Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation

scientific article published on 11 March 2013

Differential contribution of insulin and amino acids to the mTORC1-autophagy pathway in the liver and muscle

scientific article published on 6 June 2013

Differential requirement for ATG2A domains for localization to autophagic membranes and lipid droplets.

scientific article published on 7 November 2017

Distinct mechanisms of ferritin delivery to lysosomes in iron-depleted and iron-replete cells

scientific article

Dynamic association of the ULK1 complex with omegasomes during autophagy induction

scientific article

Dynamic involvement of ATG5 in cellular stress responses.

scientific article

Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development

scientific article published on 27 October 2014

Dynein- and activity-dependent retrograde transport of autophagosomes in neuronal axons

scientific article published on 20 April 2010

Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide

scientific article published on February 2016

Escape of intracellular Shigella from autophagy

scientific article

Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death

scientific article (publication date: 27 May 2005)

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

scientific article

Evolution from covalent conjugation to non-covalent interaction in the ubiquitin-like ATG12 system

scientific article published on 25 March 2019

Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells

scientific article published on 25 July 2015

Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids

scientific article published on 3 January 2014

FIP200 regulates targeting of Atg16L1 to the isolation membrane

scientific article

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

scientific article

Featuring...Dr. Noboru Mizushima Winner of the 2007 FEBS Letters Young Scientist Award. Interview by Daniela Ruffell

scientific article published on 23 April 2007

Fertilization-induced autophagy in mouse embryos is independent of mTORC1.

scientific article published on 22 May 2014

Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology

scientific article

Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast

scientific article

Fusion and scission of membranes: Ubiquitous topological transformations in cells

scientific article

GFP-like proteins stably accumulate in lysosomes

scientific article published on 6 February 2008

Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size

scientific article published on 29 May 2007

Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size

scientific article published on 21 April 2006

Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy

scientific article published on 07 January 2017

Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation

scientific article published on 09 August 2018

Genome-wide CRISPR screening reveals nucleotide synthesis negatively regulates autophagy

scientific article published on 01 January 2021

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

scientific article

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

scientific article

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

scientific journal article

In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

scientific article

In vivo requirement for Atg5 in antigen presentation by dendritic cells

scientific article

Induction of autophagy in axonal dystrophy and degeneration

scientific journal article

Intracellular inclusions containing mutant alpha1-antitrypsin Z are propagated in the absence of autophagic activity

scientific article published on 19 December 2005

Intracellular quality control by autophagy: how does autophagy prevent neurodegeneration?

scientific article

Intrinsically Disordered Protein TEX264 Mediates ER-phagy

scientific article published on 18 April 2019

Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells

scientific article published on June 2008

Isolation of hyperactive mutants of mammalian target of rapamycin

scientific article published on 23 September 2008

LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation

scientific article

LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localization

scientific article published on 12 July 2007

LC3- and p62-based biochemical methods for the analysis of autophagy progression in mammalian cells

scientific article

Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid droplets

scientific article (publication date: 19 September 2003)

Loss of autophagy impairs physiological steatosis by accumulation of NCoR1

scientific article published on 26 December 2019

Lysosome biology in autophagy

scientific article published on 11 February 2020

Macroautophagy, endogenous MHC II loading and T cell selection: the benefits of breaking the rules

scientific article published on 24 February 2009

Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets.

scientific article published on 4 January 2012

Methamphetamine inhibits antigen processing, presentation, and phagocytosis

scientific article

Methods for monitoring autophagy

scientific article published in December 2004

Methods for monitoring autophagy using GFP-LC3 transgenic mice

scientific article published in January 2009

Methods for monitoring macroautophagy

scientific article

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

scientific article published on 6 October 2012

Mitochondrial fission factor Drp1 maintains oocyte quality via dynamic rearrangement of multiple organelles

scientific article published on 25 September 2014

Molecular definitions of autophagy and related processes.

scientific article published on 08 June 2017

Molecular mechanism of autophagy: the role of the Apg12 conjugation system

scientific article published in July 2002

Monitoring and Measuring Autophagy

scientific article

Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method

scientific article (publication date: 18 December 2002)

Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate

scientific article (publication date: May 2003)

NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA

scientific article published on 02 June 2021

Nbr1, a Receptor for ESCRT-Dependent Endosomal Microautophagy in Fission Yeast

scientific article published on 01 September 2015

Noboru Mizushima: All about autophagy. Interview by Caitlin Sedwick

scientific article published on 13 September 2010

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

scientific article

Open and closed HORMAs regulate autophagy initiation.

scientific article

Organelle degradation during the lens and erythroid differentiation is independent of autophagy

scientific article

Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane

scientific article published on 18 March 2011

Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease).

scientific article

Physiological functions of autophagy

scientific article published on January 2009

Physiological role in constitutive autophagy

scientific article

Physiological role of autophagy as an intracellular recycling system: with an emphasis on nutrient metabolism

scientific article published on 17 March 2010

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

scientific article

Proteasome-dependent activation of mammalian target of rapamycin complex 1 (mTORC1) is essential for autophagy suppression and muscle remodeling following denervation

scientific article published on 3 December 2012

Proteasome-dependent activation of mammalian target of rapamycin complex 1 (mTORC1) is essential for autophagy suppression and muscle remodeling following denervation.

scientific article published in May 2013

Protein turnover via autophagy: implications for metabolism

scientific article published on January 2007

Rapamycin inhibits polyglutamine aggregation independently of autophagy by reducing protein synthesis

scientific article

Reevaluation of neurodegeneration in lurcher mice: constitutive ion fluxes cause cell death with, not by, autophagy

scientific article published in February 2010

Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1

scientific article

Regulators of mammalian cellular autophagy

scientific article

Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes

scientific article (publication date: December 2004)

Role of ULK-FIP200 complex in mammalian autophagy: FIP200, a counterpart of yeast Atg17?

scientific article

Role of the Apg12 conjugation system in mammalian autophagy

scientific article

Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle

scientific article

SKD1 AAA ATPase-dependent endosomal transport is involved in autolysosome formation

scientific article (publication date: February 2002)

Simple method of zygosity identification in transgenic mice by real-time quantitative PCR.

scientific article

Stearoyl-CoA desaturase 1 activity is required for autophagosome formation

scientific article

Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy

scientific article

Structure of the Atg101-Atg13 complex reveals essential roles of Atg101 in autophagy initiation

scientific article

Structure, lipid scrambling activity and role in autophagosome formation of ATG9A

scientific article published on 26 October 2020

Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy

scientific article

Sugar modification inhibits autophagosome-lysosome fusion

scientific article

Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease

scientific article published on 09 September 2008

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

scientific article (publication date: 15 June 2006)

Survival of effector CD8+ T cells during influenza infection is dependent on autophagy

scientific article published on April 2015

Syntaxin 17: the autophagosomal SNARE.

scientific article published on 6 March 2013

Systematic analysis of ATG13 domain requirements for autophagy induction.

scientific article published on 26 November 2017

Systemic Analysis of Atg5-Null Mice Rescued from Neonatal Lethality by Transgenic ATG5 Expression in Neurons.

scientific article published on 28 September 2016

TMEM41B functions with VMP1 in autophagosome formation

scientific article published on 26 February 2019

Temporal analysis of recruitment of mammalian ATG proteins to the autophagosome formation site.

scientific article

The ATG conjugation systems are important for degradation of the inner autophagosomal membrane.

scientific article

The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice

scientific article

The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17

scientific article

The Role of Atg Proteins in Autophagosome Formation ⬇️

scientific article published on July 18, 2011

The ULK complex initiates autophagosome formation at phosphatidylinositol synthase-enriched ER subdomains

scientific article published on 17 August 2017

The autophagy gene Wdr45/Wipi4 regulates learning and memory function and axonal homeostasis

scientific article published in June 2015

The crystal structure of microtubule-associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8.

scientific article

The dynamics of autophagy visualized in live cells: from autophagosome formation to fusion with endo/lysosomes

scientific article published on 21 April 2005

The exponential growth of autophagy-related research: from the humble yeast to the Nobel Prize

scientific article published on 10 February 2017

The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes

scientific article

The pleiotropic role of autophagy: from protein metabolism to bactericide.

scientific article

The role of autophagy during the oocyte-to-embryo transition

scientific article published on 22 November 2008

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

scientific journal article

The role of mammalian autophagy in protein metabolism ⬇️

scientific article published on March 1, 2007

The role of the Atg1/ULK1 complex in autophagy regulation

scientific article (publication date: April 2010)

The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy

scientific article

The ubiquitin E2 enzyme UBE2QL1 mediates lysophagy

scientific article published on 15 September 2019

Tissue-specific Autophagy Alterations and Increased Tumorigenesis in Mice Deficient in Atg4C/Autophagin-3

scientific article published in Journal of Biological Chemistry

Transcriptomic and proteomic analysis of a 14-3-3 gene-deficient yeast

scientific article

Transgenic rescue of Atg5-null mice from neonatal lethality with neuron-specific expression of ATG5: Systemic analysis of adult Atg5-deficient mice

scientific article published on 22 February 2017

Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly

scientific article

Two ubiquitin-like conjugation systems essential for autophagy

scientific article published on April 2004

Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection

scientific article

Ubiquitin-like proteins and autophagy at a glance

scientific article published on 01 May 2012

Ultrastructural analysis of autophagosome organization using mammalian autophagy-deficient cells

scientific article published on 22 July 2014

Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy

scientific article

When more is less: excess and deficiency of autophagy coexist in skeletal muscle in Pompe disease

scientific article published on 30 January 2009

Withdrawal: Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3

scientific article published in Journal of Biological Chemistry

YKT6 as a second SNARE protein of mammalian autophagosomes

scientific article published on 13 October 2018

p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding

scientific journal article

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