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List of works by Austin Smith

'No' to ban on stem-cell patents ⬇️

scientific article published on April 28, 2011

A Method to Identify and Analyze Biological Programs through Automated Reasoning

scientific article published on July 2016

A PiggyBac-Based Recessive Screening Method to Identify Pluripotency Regulators ⬇️

scientific article published on April 18, 2011

A Schwann cell mitogen accompanying regeneration of motor neurons

scientific article published in Nature

A common molecular logic determines embryonic stem cell self-renewal and reprogramming

scientific article published on 27 November 2018

A conceptual and computational framework for modelling and understanding the non-equilibrium gene regulatory networks of mouse embryonic stem cells.

scientific article published on September 2017

A genome-wide RNAi screen reveals MAP kinase phosphatases as key ERK pathway regulators during embryonic stem cell differentiation.

scientific article

A genome-wide screen in EpiSCs identifies Nr5a nuclear receptors as potent inducers of ground state pluripotency.

scientific article

A high-content small molecule screen identifies sensitivity of glioblastoma stem cells to inhibition of polo-like kinase 1

scientific article (publication date: 2013)

A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation

scientific article published on 18 August 2017

A model-based analysis of culture-dependent phenotypes of mESCs.

scientific article

An unpaired mouse centromere passes consistently through male meiosis and does not significantly compromise spermatogenesis.

scientific article published on 8 November 2003

Automated large-scale culture and medium-throughput chemical screen for modulators of proliferation and viability of human induced pluripotent stem cell-derived neuroepithelial-like stem cells.

scientific article

CD133 (Prominin) negative human neural stem cells are clonogenic and tripotent

scientific article

Capacitation of human naïve pluripotent stem cells for multi-lineage differentiation

scientific article published on 03 April 2019

Capture of authentic embryonic stem cells from rat blastocysts

scientific article

Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons

scientific article

Characterization of the uterine phenotype during the peri-implantation period for LIF-null, MF1 strain mice.

scientific article published in May 2005

Convergence of cMyc and β-catenin on Tcf7l1 enables endoderm specification

scientific article published on 16 December 2015

Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture

scientific article (publication date: February 2003)

Culture parameters for stable expansion, genetic modification and germline transmission of rat pluripotent stem cells

scientific article

Defined conditions for propagation and manipulation of mouse embryonic stem cells

scientific article published on 26 March 2019

Defining an essential transcription factor program for naïve pluripotency

scientific article published in June 2014

Differentiation and gene regulation Programming, reprogramming and regeneration

article

Differentiation of human induced pluripotent stem cells into brown and white adipocytes: role of Pax3.

scientific article published in June 2014

Disabling de novo DNA methylation in embryonic stem cells allows an illegitimate fate trajectory

scientific article published on 01 September 2021

Dynamics of gene silencing during X inactivation using allele-specific RNA-seq.

scientific article

Embryonic germ cells from mice and rats exhibit properties consistent with a generic pluripotent ground state.

scientific article

Engineering the mouse genome with bacterial artificial chromosomes to create multipurpose alleles.

scientific article published on 10 March 2003

Epigenetic resetting of human pluripotency.

scientific article

Esrrb Complementation Rescues Development of Nanog-Null Germ Cells

scientific article published in January 2018

Esrrb is a pivotal target of the Gsk3/Tcf3 axis regulating embryonic stem cell self-renewal

scientific journal article

Essential alterations of heparan sulfate during the differentiation of embryonic stem cells to Sox1-enhanced green fluorescent protein-expressing neural progenitor cells

scientific article published on 26 April 2007

Exit from Pluripotency Is Gated by Intracellular Redistribution of the bHLH Transcription Factor Tfe3 ⬇️

scientific article published on April 11, 2013

Exploitation of adherent neural stem cells in basic and applied neurobiology.

scientific article published in January 2006

FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment

scientific article published in August 2007

Fibroblast growth factor induces a neural stem cell phenotype in foetal forebrain progenitors and during embryonic stem cell differentiation

scientific article

Formative pluripotency: the executive phase in a developmental continuum

scientific article published on February 2017

Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation

scientific article published on 25 November 2002

Fusion brings down barriers

scientific article published in Nature

Gene Editing in Rat Embryonic Stem Cells to Produce In Vitro Models and In Vivo Reporters.

scientific article published on October 2017

Genesis of embryonic stem cells ⬇️

scientific article published on August 29, 2003

Genetic exploration of the exit from self-renewal using haploid embryonic stem cells

scientific journal article

Germline potential of parthenogenetic haploid mouse embryonic stem cells.

scientific article

Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens

scientific article published in June 2009

Human hypoblast formation is not dependent on FGF signalling.

scientific article

Identification of the missing pluripotency mediator downstream of leukaemia inhibitory factor ⬇️

scientific article published on August 13, 2013

Imaging, quantification and visualization of spatio-temporal patterning in mESC colonies under different culture conditions.

scientific article published on September 2012

Imaging-based chemical screens using normal and glioma-derived neural stem cells

scientific article

In Vitro Recapitulation of Developmental Transitions in Human Neural Stem Cells

scientific article published on 24 August 2019

Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation.

scientific article published on 19 June 2011

Integrated analysis of single-cell embryo data yields a unified transcriptome signature for the human preimplantation epiblast

scientific article

Interplay between FGF2 and BMP controls the self-renewal, dormancy and differentiation of rat neural stem cells

scientific article

Interplay of cell-cell contacts and RhoA/MRTF-A signaling regulates cardiomyocyte identity.

scientific article

Introduction: Mammalian stem cell systems

Isolation and propagation of enteric neural crest progenitor cells from mouse embryonic stem cells and embryos

scientific article

JAK/STAT3 signalling is sufficient and dominant over antagonistic cues for the establishment of naive pluripotency ⬇️

scientific article published on May 8, 2012

Klf4 reverts developmentally programmed restriction of ground state pluripotency

scientific article

Knock-in of nuclear localised beta-galactosidase reveals that the tyrosine phosphatase Ptprv is specifically expressed in cells of the bone collar.

scientific article published in April 2004

Lineage-Specific Profiling Delineates the Emergence and Progression of Naive Pluripotency in Mammalian Embryogenesis

scientific article

Long-term tripotent differentiation capacity of human neural stem (NS) cells in adherent culture

scientific article

Looking inwards: opening a window onto human development

scientific article published in January 2015

Mapping the route from naive pluripotency to lineage specification.

scientific article

Microfluidic platform for 3D cell culture with live imaging and clone retrieval

scientific article published on 23 June 2020

Mouse and human induced pluripotent stem cells as a source for multipotent Isl1+ cardiovascular progenitors

scientific article published on 22 October 2009

Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause

scientific article published on February 2016

NODAL Secures Pluripotency upon Embryonic Stem Cell Progression from the Ground State.

scientific article published on 28 June 2017

Naive Pluripotent Stem Cells Derived Directly from Isolated Cells of the Human Inner Cell Mass

scientific article published on 27 February 2016

Naive pluripotency is associated with global DNA hypomethylation

scientific article published on 17 February 2013

Nanog heterogeneity: tilting at windmills?

scientific article published on July 2013

Nanog is the gateway to the pluripotent ground state.

scientific article

Nanog overcomes reprogramming barriers and induces pluripotency in minimal conditions

scientific article published on 30 December 2010

Nanog promotes transfer of pluripotency after cell fusion

scientific article

Nanog safeguards pluripotency and mediates germline development

scientific article (publication date: 20 December 2007)

Negative feedback via RSK modulates Erk-dependent progression from naïve pluripotency

scientific article published on 12 June 2018

Neural stem cells engrafted in the adult brain fuse with endogenous neurons

scientific article published on 20 November 2012

Neuroepithelial cells supply an initial transient wave of MSC differentiation

scientific article published in June 2007

Niche-independent symmetrical self-renewal of a mammalian tissue stem cell

scientific article

Normal timing of oligodendrocyte development from genetically engineered, lineage-selectable mouse ES cells

scientific article published in September 2002

Notch promotes neural lineage entry by pluripotent embryonic stem cells

scientific article

Oct4 and LIF/Stat3 additively induce Krüppel factors to sustain embryonic stem cell self-renewal

scientific article published in December 2009

Osteogenic and chondrogenic differentiation of embryonic stem cells in response to specific growth factors

scientific article published on 24 March 2005

Otx2 and Oct4 drive early enhancer activation during embryonic stem cell transition from naive pluripotency

scientific article

Parameters influencing derivation of embryonic stem cells from murine embryos

scientific article published on 01 December 2008

Pluripotency Deconstructed.

scientific article

Pluripotency in the embryo and in culture

scientific article

Pluripotent stem cells: private obsession and public expectation

scientific article published on April 2010

Rapid loss of Oct-4 and pluripotency in cultured rodent blastocysts and derivative cell lines

scientific article published on January 2003

Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus

scientific article

Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human

scientific article published on 16 July 2015

Resetting transcription factor control circuitry toward ground-state pluripotency in human

scientific article

Screening for mammalian neural genes via fluorescence-activated cell sorter purification of neural precursors from Sox1-gfp knock-in mice.

scientific article

Self-organizing circuitry and emergent computation in mouse embryonic stem cells.

scientific article

Self-renewal of teratocarcinoma and embryonic stem cells.

scientific article published in September 2004

Single cell transcriptome analysis of human, marmoset and mouse embryos reveals common and divergent features of preimplantation development

article

Single-cell transcriptome analysis of human, marmoset and mouse embryos reveals common and divergent features of preimplantation development

article

Sox2 and Pax6 maintain the proliferative and developmental potential of gliogenic neural stem cells In vitro

scientific article published on 15 July 2011

SoxB transcription factors specify neuroectodermal lineage choice in ES cells

scientific article

Stat3 activation is limiting for reprogramming to ground state pluripotency.

scientific article

Stat3 promotes mitochondrial transcription and oxidative respiration during maintenance and induction of naive pluripotency.

scientific article published on 22 February 2016

Stem Cells in the Nervous System: Functional and Clinical Implications

Stem cells and regeneration: a special issue

scientific article

Stem cells expanded from the human embryonic hindbrain stably retain regional specification and high neurogenic potency

scientific article published on July 2013

Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo.

scientific article published on 26 August 2009

The Art of Capturing Pluripotency: Creating the Right Culture.

scientific article published on June 2017

The Battlefield of Pluripotency

scientific article published on 01 December 2005

The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification

scientific article (publication date: June 2014)

The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity

scientific article

The ground state of pluripotency.

scientific article published on August 2010

The liberation of embryonic stem cells

scientific article

The mammalian germline as a pluripotency cycle.

scientific article

The nature of embryonic stem cells

scientific article

The origin and identity of embryonic stem cells

scientific article published in January 2011

The transcriptional and epigenomic foundations of ground state pluripotency.

scientific article

Towards consistent generation of pancreatic lineage progenitors from human pluripotent stem cells

scientific article published on October 2015

Tracking the embryonic stem cell transition from ground state pluripotency

scientific article

Treatment of a mouse model of spinal cord injury by transplantation of human induced pluripotent stem cell-derived long-term self-renewing neuroepithelial-like stem cells

scientific article published in June 2012

Tripotential differentiation of adherently expandable neural stem (NS) cells

scientific article

Unequal segregation of parental chromosomes in embryonic stem cell hybrids

scientific article published in July 2005

Validated germline-competent embryonic stem cell lines from nonobese diabetic mice

scientific article

Zfp281 orchestrates interconversion of pluripotent states by engaging Ehmt1 and Zic2

scientific article published on 29 November 2019

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