List of works - Christoph Handschin

A Link between cholesterol levels and phenobarbital induction of cytochromes P450.

scientific article published in February 2002

A conserved nuclear receptor consensus sequence (DR-4) mediates transcriptional activation of the chicken CYP2H1 gene by phenobarbital in a hepatoma cell line.

scientific article

A functional motor unit in the culture dish: co-culture of spinal cord explants and muscle cells.

scientific article

A fundamental system of cellular energy homeostasis regulated by PGC-1alpha

scholarly article

A high-mobility, low-cost phenotype defines human effector-memory CD8+ T cells.

scientific article

ApoE-/- PGC-1α-/- mice display reduced IL-18 levels and do not develop enhanced atherosclerosis

scientific article

BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle

scientific article published on 18 July 2019

CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR)

scientific article published on September 2000

Caloric restriction and exercise "mimetics'': Ready for prime time?

scientific article

Complex Coordination of Cell Plasticity by a PGC-1α-controlled Transcriptional Network in Skeletal Muscle

scientific article

Coordinated balancing of muscle oxidative metabolism through PGC-1α increases metabolic flexibility and preserves insulin sensitivity

scientific article published on 8 April 2011

Coregulator-mediated control of skeletal muscle plasticity - A mini-review

scientific article published on 2 January 2017

Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy.

scientific article published on 6 March 2013

Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle

scientific article published on 19 April 2022

Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice

scientific article published on 11 December 2013

Electric pulse stimulation of cultured murine muscle cells reproduces gene expression changes of trained mouse muscle

scientific article

Endocrine Crosstalk Between Skeletal Muscle and the Brain

scientific article published on 24 August 2018

Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle

scientific article

Exercise-linked improvement in age-associated loss of balance is associated with increased vestibular input to motor neurons

scientific article published on 11 November 2020

Exploring the Role of PGC-1α in Defining Nuclear Organisation in Skeletal Muscle Fibres

scientific article published on 7 November 2016

External physical and biochemical stimulation to enhance skeletal muscle bioengineering

scientific article

For a pragmatic approach to exercise studies

article by Christoph Handschin et al published 1 January 2010 in Journal of Applied Physiology

Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology.

scientific article

How Epigenetic Modifications Drive the Expression and Mediate the Action of PGC-1α in the Regulation of Metabolism ⬇️

scientific article published on 31 October 2019

Human Muscle Precursor Cells Overexpressing PGC-1α Enhance Early Skeletal Muscle Tissue Formation

scientific article

Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.

scientific article

In silico approaches, and in vitro and in vivo experiments to predict induction of drug metabolism.

scientific article published on September 2003

Induction of drug metabolism: the role of nuclear receptors.

scientific article published on December 2003

Injected Human Muscle Precursor Cells Overexpressing PGC-1α Enhance Functional Muscle Regeneration after Trauma.

scientific article published on 21 January 2018

LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver

scientific article published in June 2005

Loss of Renal Tubular PGC-1α Exacerbates Diet-Induced Renal Steatosis and Age-Related Urinary Sodium Excretion in Mice

scientific article

Magnetic stimulation supports muscle and nerve regeneration after trauma in mice

scientific article published on 22 July 2015

MicroRNAs emerge as modulators of NAD+-dependent energy metabolism in skeletal muscle

scientific article published on 01 May 2014

Moderate Modulation of Cardiac PGC-1α Expression Partially Affects Age-Associated Transcriptional Remodeling of the Heart.

scientific article published on 21 March 2018

Modulation of PGC-1α activity as a treatment for metabolic and muscle-related diseases.

scientific article published on 12 March 2014

Molecular cloning and characterization of chicken orphan nuclear receptor cTR2.

scientific article published in July 2003

Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1α

scientific article published on April 2014

Multiple enhancer units mediate drug induction of CYP2H1 by xenobiotic-sensing orphan nuclear receptor chicken xenobiotic receptor

scientific article published in October 2001

Muscle PGC-1α is required for long-term systemic and local adaptations to a ketogenic diet in mice

scientific article

Muscle PGC-1α modulates satellite cell number and proliferation by remodeling the stem cell niche.

scientific article published on 02 December 2016

Muscle Wasting Diseases: Novel Targets and Treatments

scientific article published on 27 August 2018

Myoblasts inhibit prostate cancer growth by paracrine secretion of tumor necrosis factor-α.

scientific article published on 30 October 2012

Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function

scientific article

NUBIScan, an in silico approach for prediction of nuclear receptor response elements

scientific article published in June 2002

Noninvasive PET Imaging and Tracking of Engineered Human Muscle Precursor Cells for Skeletal Muscle Tissue Engineering

scientific article published on 19 May 2016

Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha

scientific article published in August 2005

Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in skeletal muscle activates mTORC2, enhances glucose metabolism and muscle performance

scientific article published on 12 January 2018

PDE2 activity differs in right and left rat ventricular myocardium and differentially regulates β2 adrenoceptor-mediated effects.

scientific article published on 27 November 2014

PGC-1 coactivators and the regulation of skeletal muscle fiber-type determination

scientific article published on 01 April 2011

PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy.

scientific article published on April 2007

PGC-1α affects aging-related changes in muscle and motor function by modulating specific exercise-mediated changes in old mice

scientific article published on 25 October 2017

PGC-1α and exercise in the control of body weight.

scientific article

PGC-1α and myokines in the aging muscle - a mini-review.

scientific article published on 04 February 2010

PGC-1α determines light damage susceptibility of the murine retina

scientific article

PGC-1α expression in murine AgRP neurons regulates food intake and energy balance.

scientific article published on 18 May 2016

PGC-1α improves glucose homeostasis in skeletal muscle in an activity-dependent manner.

scientific article

PGC-1α modulates necrosis, inflammatory response, and fibrotic tissue formation in injured skeletal muscle

scientific article

Paracrine cross-talk between skeletal muscle and macrophages in exercise by PGC-1α-controlled BNP

scientific article published on 16 January 2017

Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism

scientific article published on 29 March 2006

Peroxisome proliferator-activated receptor {gamma} coactivator 1{alpha} (PGC-1{alpha}) promotes skeletal muscle lipid refueling in vivo by activating de novo lipogenesis and the pentose phosphate pathway.

scientific article

Peroxisome proliferator-activated receptor γ coactivator 1α regulates mitochondrial calcium homeostasis, sarcoplasmic reticulum stress, and cell death to mitigate skeletal muscle aging

scientific article published on 10 July 2019

Peroxisome proliferator-activated receptor γ coactivator 1β (PGC-1β) improves skeletal muscle mitochondrial function and insulin sensitivity ⬇️

scientific article published on April 2, 2011

Pharmacological targeting of age-related changes in skeletal muscle tissue

scientific article published on 04 March 2019

Pharmacological targeting of exercise adaptations in skeletal muscle: Benefits and pitfalls

scientific article published on 20 October 2017

Plasticity of the Muscle Stem Cell Microenvironment

scientific article published in January 2017

RANTES (regulated on activation, normal T cell expressed and secreted), inflammation, obesity, and the metabolic syndrome

scientific article published on 01 February 2007

Regulation of skeletal muscle cell plasticity by the peroxisome proliferator-activated receptor γ coactivator 1α.

scientific article published on 24 February 2010

Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.

scientific article

Relation of nNOS isoforms to mitochondrial density and PGC-1alpha expression in striated muscles of mice.

scientific article published on 17 April 2018

Remodeling of calcium handling in skeletal muscle through PGC-1α: impact on force, fatigability, and fiber type

scientific article (publication date: 2012)

Resveratrol and SRT1720 Elicit Differential Effects in Metabolic Organs and Modulate Systemic Parameters Independently of Skeletal Muscle Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α)

scientific article published on 18 May 2015

Role of Nuclear Receptors in Exercise-Induced Muscle Adaptations.

scientific article

Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A

scientific article

Skeletal muscle PGC-1α modulates systemic ketone body homeostasis and ameliorates diabetic hyperketonemia in mice

scientific article published on 05 February 2016

Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance

scientific article published on 24 June 2019

Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise

scientific article

Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals

scientific article published on 16 August 2007

Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids.

scientific article published in February 2005

Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK

scientific article

Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

scientific article (publication date: 20 October 2006)

The Genomic Context and Corecruitment of SP1 Affect ERRα Coactivation by PGC-1α in Muscle Cells.

scientific article published on 16 May 2016

The PGC-1 coactivators promote an anti-inflammatory environment in skeletal muscle in vivo

scientific article

The Peroxisome Proliferator-activated Receptor γ Coactivator 1α/β (PGC-1) Coactivators Repress the Transcriptional Activity of NF-κB in Skeletal Muscle Cells ⬇️

scientific article published on December 8, 2012

The coactivator PGC-1α regulates skeletal muscle oxidative metabolism independently of the nuclear receptor PPARβ/δ in sedentary mice fed a regular chow diet

scientific article

The corepressor NCoR1 antagonizes PGC-1α and estrogen-related receptor α in the regulation of skeletal muscle function and oxidative metabolism

scientific article

The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia

scientific article published on 09 September 2020

The peroxisome proliferator-activated receptor γ coactivator 1α/β (PGC-1) coactivators repress the transcriptional activity of NF-κB in skeletal muscle cells.

scientific article published in March 2013

The transcriptional coactivator PGC-1α is dispensable for chronic overload-induced skeletal muscle hypertrophy and metabolic remodeling

scientific article

Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle

scientific article

Transcriptional network analysis in muscle reveals AP-1 as a partner of PGC-1α in the regulation of the hypoxic gene program

scientific article

mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue

scientific article published on 15 January 2016

List of works by Christoph Handschin

A Link between cholesterol levels and phenobarbital induction of cytochromes P450.

A conserved nuclear receptor consensus sequence (DR-4) mediates transcriptional activation of the chicken CYP2H1 gene by phenobarbital in a hepatoma cell line.

A functional motor unit in the culture dish: co-culture of spinal cord explants and muscle cells.

A fundamental system of cellular energy homeostasis regulated by PGC-1alpha

A high-mobility, low-cost phenotype defines human effector-memory CD8+ T cells.

ApoE-/- PGC-1α-/- mice display reduced IL-18 levels and do not develop enhanced atherosclerosis

BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle

CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR)

Caloric restriction and exercise "mimetics'': Ready for prime time?

Complex Coordination of Cell Plasticity by a PGC-1α-controlled Transcriptional Network in Skeletal Muscle

Coordinated balancing of muscle oxidative metabolism through PGC-1α increases metabolic flexibility and preserves insulin sensitivity

Coregulator-mediated control of skeletal muscle plasticity - A mini-review

Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy.

Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle

Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice

Electric pulse stimulation of cultured murine muscle cells reproduces gene expression changes of trained mouse muscle

Endocrine Crosstalk Between Skeletal Muscle and the Brain

Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle

Exercise-linked improvement in age-associated loss of balance is associated with increased vestibular input to motor neurons

Exploring the Role of PGC-1α in Defining Nuclear Organisation in Skeletal Muscle Fibres

External physical and biochemical stimulation to enhance skeletal muscle bioengineering

For a pragmatic approach to exercise studies

Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology.

How Epigenetic Modifications Drive the Expression and Mediate the Action of PGC-1α in the Regulation of Metabolism ⬇️

Human Muscle Precursor Cells Overexpressing PGC-1α Enhance Early Skeletal Muscle Tissue Formation

Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.

In silico approaches, and in vitro and in vivo experiments to predict induction of drug metabolism.

Induction of drug metabolism: the role of nuclear receptors.

Injected Human Muscle Precursor Cells Overexpressing PGC-1α Enhance Functional Muscle Regeneration after Trauma.

LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver

Loss of Renal Tubular PGC-1α Exacerbates Diet-Induced Renal Steatosis and Age-Related Urinary Sodium Excretion in Mice

Magnetic stimulation supports muscle and nerve regeneration after trauma in mice

MicroRNAs emerge as modulators of NAD+-dependent energy metabolism in skeletal muscle

Moderate Modulation of Cardiac PGC-1α Expression Partially Affects Age-Associated Transcriptional Remodeling of the Heart.

Modulation of PGC-1α activity as a treatment for metabolic and muscle-related diseases.

Molecular cloning and characterization of chicken orphan nuclear receptor cTR2.

Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1α

Multiple enhancer units mediate drug induction of CYP2H1 by xenobiotic-sensing orphan nuclear receptor chicken xenobiotic receptor

Muscle PGC-1α is required for long-term systemic and local adaptations to a ketogenic diet in mice

Muscle PGC-1α modulates satellite cell number and proliferation by remodeling the stem cell niche.

Muscle Wasting Diseases: Novel Targets and Treatments

Myoblasts inhibit prostate cancer growth by paracrine secretion of tumor necrosis factor-α.

Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function

NUBIScan, an in silico approach for prediction of nuclear receptor response elements

Noninvasive PET Imaging and Tracking of Engineered Human Muscle Precursor Cells for Skeletal Muscle Tissue Engineering

Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha

Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in skeletal muscle activates mTORC2, enhances glucose metabolism and muscle performance

PDE2 activity differs in right and left rat ventricular myocardium and differentially regulates β2 adrenoceptor-mediated effects.

PGC-1 coactivators and the regulation of skeletal muscle fiber-type determination

PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy.

PGC-1α affects aging-related changes in muscle and motor function by modulating specific exercise-mediated changes in old mice

PGC-1α and exercise in the control of body weight.

PGC-1α and myokines in the aging muscle - a mini-review.

PGC-1α determines light damage susceptibility of the murine retina

PGC-1α expression in murine AgRP neurons regulates food intake and energy balance.

PGC-1α improves glucose homeostasis in skeletal muscle in an activity-dependent manner.

PGC-1α modulates necrosis, inflammatory response, and fibrotic tissue formation in injured skeletal muscle

Paracrine cross-talk between skeletal muscle and macrophages in exercise by PGC-1α-controlled BNP

Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism

Peroxisome proliferator-activated receptor {gamma} coactivator 1{alpha} (PGC-1{alpha}) promotes skeletal muscle lipid refueling in vivo by activating de novo lipogenesis and the pentose phosphate pathway.

Peroxisome proliferator-activated receptor γ coactivator 1α regulates mitochondrial calcium homeostasis, sarcoplasmic reticulum stress, and cell death to mitigate skeletal muscle aging

Peroxisome proliferator-activated receptor γ coactivator 1β (PGC-1β) improves skeletal muscle mitochondrial function and insulin sensitivity ⬇️

Pharmacological targeting of age-related changes in skeletal muscle tissue

Pharmacological targeting of exercise adaptations in skeletal muscle: Benefits and pitfalls

Plasticity of the Muscle Stem Cell Microenvironment

RANTES (regulated on activation, normal T cell expressed and secreted), inflammation, obesity, and the metabolic syndrome

Regulation of skeletal muscle cell plasticity by the peroxisome proliferator-activated receptor γ coactivator 1α.

Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.

Relation of nNOS isoforms to mitochondrial density and PGC-1alpha expression in striated muscles of mice.

Remodeling of calcium handling in skeletal muscle through PGC-1α: impact on force, fatigability, and fiber type

Resveratrol and SRT1720 Elicit Differential Effects in Metabolic Organs and Modulate Systemic Parameters Independently of Skeletal Muscle Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α)

Role of Nuclear Receptors in Exercise-Induced Muscle Adaptations.

Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A

Skeletal muscle PGC-1α modulates systemic ketone body homeostasis and ameliorates diabetic hyperketonemia in mice

Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance

Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise

Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals

Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids.

Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK