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List of works by Michael Karin

A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery

scientific article

A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma

A NIK-IKKα Module Expands ErbB2-Induced Tumor-Initiating Cells by Stimulating Nuclear Export of p27/Kip1 ⬇️

scientific article published on April 18, 2013

A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide

scientific journal article

A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse

scientific article published on 11 December 2013

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis

scientific article published in June 2015

A conserved C-terminal sequence that is deleted in v-ErbA is essential for the biological activities of c-ErbA (the thyroid hormone receptor).

scientific article published on June 1993

A cytokine-mediated link between innate immunity, inflammation, and cancer

scientific article

A dual role for Ikk alpha in tooth development

scientific journal article

A gp130-Src-YAP module links inflammation to epithelial regeneration

scientific article

A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches

scientific article

A lymphotoxin-driven pathway to hepatocellular carcinoma

scientific article published on October 2009

A new group of conserved coactivators that increase the specificity of AP-1 transcription factors

scientific article

A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging

scientific article published on 23 January 2017

A shift in the ligand responsiveness of thyroid hormone receptor alpha induced by heterodimerization with retinoid X receptor alpha

scientific article published on January 1996

AU binding proteins recruit the exosome to degrade ARE-containing mRNAs

scientific article

Activation of IKK by thymosin alpha1 requires the TRAF6 signalling pathway

scientific article

Activation of IKK by thymosin α1 requires the TRAF6 signalling pathway

Activation of IKK by thymosin α1 requires the TRAF6 signalling pathway.

scientific article published in October 2006

Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers

scientific article

Activation of a heterologous promoter in response to dexamethasone and cadmium by metallothionein gene 5'-flanking DNA

scientific article published on 01 February 1984

Activation of cAMP and mitogen responsive genes relies on a common nuclear factor

scientific article

Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis

scientific article

Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change

scholarly article

Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

scientific article published on November 2012

Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium

scientific article

Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease

scientific article published in September 2006

Amino-terminal phosphorylation of c-Jun regulates apoptosis in the retinal ganglion cells by optic nerve transection

scientific article published in May 2002

An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis

scientific article published on 01 February 2020

An HNF4α-miRNA Inflammatory Feedback Circuit Regulates Hepatocellular Oncogenesis ⬇️

scientific article published on December 9, 2011

An IKKα-E2F1-BMI1 cascade activated by infiltrating B cells controls prostate regeneration and tumor recurrence

scientific article published on 24 June 2013

An antiinflammatory role for IKKbeta through the inhibition of "classical" macrophage activation

scientific article published on 19 May 2008

Analysis of NF-κB activation in mouse intestinal epithelial cells

scientific article published in January 2015

Analysis of nondegradative protein ubiquitylation with a monoclonal antibody specific for lysine-63-linked polyubiquitin

scholarly article

Analysis of the IKKbeta/NF-kappaB signaling pathway during embryonic angiogenesis

scientific article

Anthrax lethal factor and edema factor act on conserved targets in Drosophila

scholarly article

Anthrax toxin induces macrophage death by p38 MAPK inhibition but leads to inflammasome activation via ATP leakage

scientific article published on 16 June 2011

Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists

scientific article

Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: Advantages of targeting upstream kinases MKK‐3 or MKK‐6 ⬇️

scientific article published on September 1, 2012

Antitumor promotion by phenolic antioxidants: inhibition of AP-1 activity through induction of Fra expression

scientific article

Author Correction: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

scientific article published in Nature

Autocrine IL-6 signaling: a key event in tumorigenesis?

scientific article

Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment

scientific article

B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia ⬇️

scientific article published on October 18, 2010

B-cell-derived lymphotoxin promotes castration-resistant prostate cancer

scientific article

BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway

scientific article

Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress ⬇️

scientific article

Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice

scientific article published on 13 February 2020

CK2 Is a C-Terminal IκB Kinase Responsible for NF-κB Activation during the UV Response ⬇️

scientific article published on October 1, 2003

CYLD and HCC: when being too sensitive to your dirty neighbors results in self-destruction

scientific article published on June 2012

Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes

scientific article

Cancer and inflammation: promise for biologic therapy.

scientific article

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

scientific article

Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation

scientific article

Cell-selective inhibition of NF-κB signaling improves therapeutic index in a melanoma chemotherapy model

scientific article published on November 2011

Chemotherapy, immunity and microbiota--a new triumvirate?

scientific article published on February 2014

Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production

scientific article published on 11 April 2019

Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation ⬇️

scientific article published on August 14, 2012

Chronic lymphocytic leukemia of Emu-TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression

scientific article published on 15 September 2009

Common flora and intestine: A carcinogenic marriage

scientific article published on January 2013

Conditional ablation of Ikkb inhibits melanoma tumor development in mice

scientific article

Conditional deletion of IkappaB-kinase-beta accelerates helicobacter-dependent gastric apoptosis, proliferation, and preneoplasia

scientific article

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

scientific article published on 01 March 2020

Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation

scientific article

Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation

scholarly article by Monica Guma et al published 1 September 2012 in Journal of Experimental Medicine

Construction and expression of a monomeric c-Jun protein that binds and activates transcription of AP-1-responsive genes ⬇️

scientific article published on September 15, 1992

Control of osteoclast activity and bone loss by IKK subunits: new targets for therapy.

scientific article

Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation

scientific article

Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes

scientific article published in January 1998

Correction: Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma

scientific article published on 01 November 2019

Corrigendum: PI3Kγ is a molecular switch that controls immune suppression

scientific article published on 14 December 2016

Corrigendum: Sestrin2 inhibits mTORC1 through modulation of GATOR complexes

scientific article published on 21 September 2015

Crystal structure of inhibitor of κB kinase β ⬇️

scientific article published on March 20, 2011

Cutting Edge: IL-10–Mediated Tristetraprolin Induction Is Part of a Feedback Loop That Controls Macrophage STAT3 Activation and Cytokine Production ⬇️

scientific article published on August 3, 2012

DNA methylation markers for diagnosis and prognosis of common cancers.

scientific article

Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer

scientific article

Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation

scientific article published on 9 July 2008

Design and Characterization of a Potent and Selective Dual ATP- and Substrate-Competitive Subnanomolar Bidentate c-Jun N-Terminal Kinase (JNK) Inhibitor ⬇️

scientific article published on August 23, 2011

Developing diversity

scientific article published in Nature

Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas

scientific article

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

scientific article

Different requirements for formation of Jun: Jun and Jun: Fos complexes

scientific article published on 01 December 1989

Differential regulation of hepatic transporters in the absence of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and nuclear factor-kappaB in two models of cholestasis

scientific article published on 6 December 2006

Differential splicing of the GHF1 primary transcript gives rise to two functionally distinct homeodomain proteins

scientific article published in June 1992

Disruption of JNK2 decreases the cytokine response to Plasmodium falciparum glycosylphosphatidylinositol in vitro and confers protection in a cerebral malaria model

scientific article published on November 2006

Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation

scientific article published on September 2004

Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis

scientific article

ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P

scientific article published on 13 September 2018

ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development

scientific article published on 14 August 2014

ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation

scientific article published on 17 May 2016

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma

scientific article

Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death

scientific article published on 12 September 2018

Emerging roles of Lys63-linked polyubiquitylation in immune responses

scientific article published on July 2015

Epithelial Control of Gut-Associated Lymphoid Tissue Formation through p38α-Dependent Restraint of NF-κB Signaling.

scientific article published on 20 January 2016

Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury

scientific article

Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis

scientific article published in Nature

Erratum: B-cell-derived lymphotoxin promotes castration-resistant prostate cancer

scientific article published in Nature

Erratum: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

scientific article published on 22 November 2017

Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex

scientific article

Essential role of p38 mitogen-activated protein kinase in contact hypersensitivity

scientific article

Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death

scientific article published on July 2004

Evidence that reactive oxygen species do not mediate NF-kappaB activation

scientific article

Expanding TRAF function: TRAF3 as a tri-faced immune regulator ⬇️

scientific article published on June 10, 2011

Fatty Acid-Induced T Cell Loss Greases Liver Carcinogenesis

scientific article published in May 2016

Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver

scientific article

From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importance

scientific article

From death receptor to reactive oxygen species and c-Jun N-terminal protein kinase: the receptor-interacting protein 1 odyssey

scientific article

Fructose stimulated de novo lipogenesis is promoted by inflammation

scientific article published on 24 August 2020

Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance

scholarly article

GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer

scientific article

GHF-1-promoter-targeted immortalization of a somatotropic progenitor cell results in dwarfism in transgenic mice

scientific article published on April 1993

Gender difference in NASH susceptibility: Roles of hepatocyte Ikkβ and Sult1e1.

scientific article published on 10 August 2017

Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression

scientific article

Genetic dissection of antigen receptor induced-NF-kappaB activation

scientific article published in July 2004

Glucocorticoid receptor binding and activation of a heterologous promoter by dexamethasone by the first intron of the human growth hormone gene

scientific article published on November 1985

Hepatic expression of HCV RNA-dependent RNA polymerase triggers innate immune signaling and cytokine production

scientific article

Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation

scientific article

Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis

scientific article published on August 2008

Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis

scientific article

Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer

scientific article

Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity

scientific article published on October 2008

I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection

scientific article published on 19 February 2013

I kappa B kinase complex alpha kinase activity controls chemokine and high endothelial venule gene expression in lymph nodes and nasal-associated lymphoid tissue

scientific article published in November 2004

IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy

scientific article

IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation

scholarly article

IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias

scientific article

IKKalpha, a critical regulator of epidermal differentiation and a suppressor of skin cancer

scientific article

IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis

scientific article published in July 2005

IKKα activation of NOTCH links tumorigenesis via FOXA2 suppression

scientific article published on 22 December 2011

IKKα inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways

scientific article published on 8 January 2018

IKKα-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis ⬇️

scientific article published on April 27, 2012

IKKβ Is Required for Prevention of Apoptosis Mediated by Cell-Bound but Not by Circulating TNFα ⬇️

scientific article published on 01 November 2003

IKKβ inhibition prevents fat-induced beta cell dysfunction in vitro and in vivo in rodents

scientific article published on 20 July 2017

IKKβ regulates essential functions of the vascular endothelium through kinase-dependent and -independent pathways ⬇️

scientific article published on January 1, 2011

IKK‐β‐mediated myeloid cell activation exacerbates inflammation and inhibits recovery after spinal cord injury ⬇️

scientific article published on April 14, 2011

IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease

scientific article published on 31 December 2019

IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ

scientific article published on 19 December 2010

IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

scientific article (publication date: 3 February 2009)

IL-6 and related cytokines as the critical lynchpins between inflammation and cancer

scientific article published on 16 February 2014

Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling

scientific article

Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2

scientific article

Identification of a new JNK inhibitor targeting the JNK-JIP interaction site

scholarly article

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

scientific article (publication date: November 1993)

Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling

scientific article

Ikappa B kinasebeta/nuclear factor-kappaB activation controls the development of liver metastasis by way of interleukin-6 expression

scientific article published on December 2009

IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells

scholarly article

IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis

scientific article published on April 2004

IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium

scholarly article

Immune Infiltration and Prostate Cancer

scientific article (publication date: 2015)

Immunity by ubiquitylation: a reversible process of modification

scientific article

Immunity, Inflammation, and Cancer

scientific article (publication date: 19 March 2010)

Immunity, inflammation, and cancer: an eternal fight between good and evil

scientific article

Immunoregulatory genes and immunosuppression by glucocorticoids.

scientific article published in January 1997

Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis

scientific article

Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy

scientific article published on 29 April 2015

Implications of anti-cytokine therapy in colorectal cancer and autoimmune diseases ⬇️

scientific article published on December 19, 2012

In vitro activation of the HIV-1 enhancer in extracts from cells treated with a phorbol ester tumor promoter.

scientific article

Inactivation of I kappaB-kinase-beta dependent genes in airway epithelium reduces tobacco smoke induced acute airway inflammation

scientific article

Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation.

scientific article published on December 1995

Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells

scientific article

Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction

scientific article published on November 2016

Inflammation and colon cancer

scientific article published on June 2010

Inflammation and liver tumorigenesis ⬇️

scientific article published on May 17, 2013

Inflammation and oncogenesis: a vicious connection

scientific article

Inflammation, Autophagy, and Obesity: Common Features in the Pathogenesis of Pancreatitis and Pancreatic Cancer ⬇️

scientific article published on June 1, 2013

Inflammation-activated protein kinases as targets for drug development

scientific article

Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

scientific article

Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage ⬇️

scientific article published on March 1, 2011

Inhibition of IkappaB kinase by a new class of retinoid-related anticancer agents that induce apoptosis

scientific article

Inhibition of JNK activation through NF-κB target genes ⬇️

scientific article published on November 15, 2001

Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression

scientific article published on September 2004

Inhibitor kappaB kinase beta binding by inhibitor kappaB kinase gamma

scientific article published on 9 October 2007

Inhibitor of nuclear factor kB kinase deficiency enhances oxidative stress and prolongs c-Jun NH2-terminal kinase activation induced by arsenic ⬇️

journal article published in 2003

Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer

scientific article

Integrative genomic analysis of mouse and human hepatocellular carcinoma

article published in the Proceedings of the National Academy of Sciences of the United States of America

Interleukin-1 costimulatory activity on the interleukin-2 promoter via AP-1

scientific article published on 01 October 1989

Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis.

scientific article

Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy

scientific article published on 22 March 2007

Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia

scientific article published on 6 February 2017

Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11).

scientific article

Intracellular pattern recognition receptors in the host response

scientific article published on July 2006

Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls

scientific article

Is NF-kappaB2/p100 a direct activator of programmed cell death?

scientific article

I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss

scientific article

IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1.

scientific article published on 11 July 2016

JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration.

scientific article

JNK is involved in signal integration during costimulation of T lymphocytes.

scientific article published on June 1994

JNK-1 deficiency limits macrophage-mediated antigen-induced arthritis ⬇️

scientific article published on June 1, 2011

JNK1 Is Required for Maintenance of Neuronal Microtubules and Controls Phosphorylation of Microtubule-Associated Proteins ⬇️

scientific article (publication date: April 2003)

JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction

scientific article published on 06 April 2010

JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis

scientific article

JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity

scientific article

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

scientific article

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation

scientific article (publication date: 15 December 1994)

JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension

scientific article

Joint damage and inflammation in c-Jun N-terminal kinase 2 knockout mice with passive murine collagen-induced arthritis

scientific article published in March 2002

Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch

scientific article

Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production

scientific article published on 3 December 2006

Lasting N-Terminal Phosphorylation of c-Jun and Activation of c-Jun N-Terminal Kinases after Neuronal Injury ⬇️

scientific article published on July 15, 1998

Limiting inflammation-the negative regulation of NF-κB and the NLRP3 inflammasome

scientific article

Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling

scientific article published on 01 June 2018

Liver carcinogenesis: from naughty chemicals to soothing fat and the surprising role of NRF2.

scientific article published on 04 May 2016

Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition

scientific article published on 5 June 2014

Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice ⬇️

scientific article published on April 8, 2013

Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation

scholarly article

Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis

scientific article published on 06 January 2014

Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia

scientific article published on June 2011

Lymphotoxin signaling is initiated by the viral polymerase in HCV-linked tumorigenesis

scientific article (publication date: March 2013)

MEK kinase 1 is a negative regulator of virus-specific CD8(+) T cells

scientific article published on August 2006

MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration.

scientific article published on May 2000

MEKK1 binds HECT E3 ligase Itch by its amino-terminal RING motif to regulate Th2 cytokine gene expression.

scientific article

Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression ⬇️

scientific article published on September 14, 2010

Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition

scientific article published on 29 August 2002

Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3

scientific journal article

Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation

scientific article

Matrix Metalloproteinase-1-mediated Up-regulation of Vascular Endothelial Growth Factor-2 in Endothelial Cells ⬇️

scientific article published on November 15, 2012

Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase

scientific article

Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes

scientific article

Metallothionein mRNA induction in HeLa cells in response to zinc or dexamethasone is a primary induction response

scientific article published in Nature

Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation

MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer

scientific article published on April 2014

Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase

scientific article

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Multicellular Stalk-Like Structures in Saccharomyces cerevisiae ⬇️

scientific article published on August 1, 1998

Mutations in the conserved C-terminal sequence in thyroid hormone receptor dissociate hormone-dependent activation from interference with AP-1 activity.

scientific article published on August 1997

Myeloid IKKβ promotes antitumor immunity by modulating CCL11 and the innate immune response

scientific article published on 21 October 2014

NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice

scientific article published on 13 November 2018

NCOA5, IL-6, type 2 diabetes, and HCC: The deadly quartet

scientific article published on January 2014

NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation

scientific article

NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice

scholarly article

NF-kappaB activation in hypothalamic pro-opiomelanocortin neurons is essential in illness- and leptin-induced anorexia

scientific article

NF-kappaB and cancer-identifying targets and mechanisms

scientific article published on February 2008

NF-kappaB and cancer: mechanisms and targets

scientific article published in June 2006

NF-kappaB as a critical link between inflammation and cancer

scientific article

NF-kappaB in cancer: a marked target

scientific article

NF-kappaB in mammary gland development and breast cancer

scientific article published on April 2003

NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta

scientific article

NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha

scientific article published on 23 April 2008

NF-kappaB: linking inflammation and immunity to cancer development and progression

scientific article (publication date: October 2005)

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

scientific article published on February 2016

NF-κB and STAT3 – key players in liver inflammation and cancer ⬇️

scientific article published on December 28, 2010

NF-κB, inflammation, immunity and cancer: coming of age.

scientific article

NF-κB-p62-NRF2 survival signaling is associated with high ROR1 expression in chronic lymphocytic leukemia

scientific article published on 28 January 2020

NF‐κB and the link between inflammation and cancer ⬇️

scientific article published on March 1, 2012

NOD2 and Crohn's disease: loss or gain of function?

scientific article

NOD2 contributes to cutaneous defense against Staphylococcus aureus through alpha-toxin-dependent innate immune activation

scientific article published on 16 June 2009

NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly

scientific article published on 24 February 2020

Neuronal I kappa B kinase beta protects mice from autoimmune encephalomyelitis by mediating neuroprotective and immunosuppressive effects in the central nervous system

scientific article

Neutrophil-Derived IL-1β Impairs the Efficacy of NF-κB Inhibitors against Lung Cancer

scientific article published on 15 June 2016

New Approaches for Studying Alcoholic Liver Disease

scientific article published on 14 September 2014

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

scientific article published in Nature

Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice

scientific article

Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing

scientific article published in February 2005

Noninvasive detection of fetal subchromosomal abnormalities by semiconductor sequencing of maternal plasma DNA

scientific article

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling

scientific article published on 9 November 2008

Nuclear IKKβ Is an Adaptor Protein for IκBα Ubiquitination and Degradation in UV-Induced NF-κB Activation ⬇️

scientific article published on August 27, 2010

Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin

scientific article

Nuclear export of NF90 is required for interleukin-2 mRNA stabilization

scientific article published in December 2002

Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation

scientific article

Obesity and Cancer: The Oil that Feeds the Flame

scientific article

Obesity, autophagy and the pathogenesis of liver and pancreatic cancers ⬇️

scientific article published on March 1, 2012

Obesity, inflammation, and liver cancer ⬇️

scientific article published on November 25, 2011

Oncogene at last--c-Jun promotes liver cancer in mice

scientific article

Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases

scientific article published on June 1994

Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73 ⬇️

scientific article published on August 1, 1992

Opposing functions of IKKbeta during acute and chronic intestinal inflammation

scholarly article

PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression

scientific article published on 09 June 2020

Pas de Deux: Control of Anti-tumor Immunity by Cancer-Associated Inflammation

scientific article published on 01 July 2019

Peering into the aftermath: JAKi rips STAT3 in cancer

scientific article

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

scientific article (publication date: 2000)

Potentiation of estrogen receptor activation function 1 (AF-1) by Src/JNK through a serine 118-independent pathway

scientific article

Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

scientific article published on 15 November 2018

Protein phosphatase 2A potentiates activity of promoters containing AP-1-binding elements

scientific article published on April 1993

Proteotyping of Mammary Tissue from Transgenic and Gene Knockout Mice with Immunohistochemical Markers: a Tool To Define Developmental Lesions ⬇️

scientific article published on May 1, 2003

Publisher Correction: The gut-liver axis and the intersection with the microbiome

scientific article published on 01 December 2018

RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB Activation

scientific article published on 10 October 2019

Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases

scientific article (publication date: 11 March 2005)

Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma

scientific article published on 01 September 2019

Reduced Expression of UGT1A1 in Intestines of Humanized UGT1 Mice via Inactivation of NF-κB Leads to Hyperbilirubinemia ⬇️

scientific article published on October 6, 2011

Redundant pathways for negative feedback regulation of bile acid production

scientific article

Regulating the regulators: control of protein ubiquitination and ubiquitin-like modifications by extracellular stimuli

scientific article

Regulation and function of IKK and IKK-related kinases

scientific article

Regulation of late B cell differentiation by intrinsic IKKalpha-dependent signals

scholarly article

Reparative inflammation takes charge of tissue regeneration

scientific article published in January 2016

Retraction: DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA

scientific article published on 01 February 2009

Role for IKK2 in muscle: waste not, want not.

scientific article

Role of TLR2‐dependent inflammation in metastatic progression ⬇️

scientific article published on January 1, 2011

Role of microglial IKKbeta in kainic acid-induced hippocampal neuronal cell death

scientific article published on 26 September 2008

Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation

scientific article published on September 2011

Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates

scholarly article

Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies

scientific article

Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals

scientific article published on 13 January 2020

Sestrin regulation of TORC1: Is Sestrin a leucine sensor?

scientific article published on 07 June 2016

Sestrin2 inhibits mTORC1 through modulation of GATOR complexes

scientific article published on 30 March 2015

Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart

scientific article

Sestrins are evolutionarily conserved mediators of exercise benefits

scientific article published on 13 January 2020

Sestrins at the crossroad between stress and aging

scientific article

Sestrins inhibit mTORC1 kinase activation through the GATOR complex

scientific journal article

Sestrins orchestrate cellular metabolism to attenuate aging

scientific article

Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic β-Catenin, PIK3CA and MET.

scientific article published on 2 March 2018

Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators

scientific article

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

scientific journal article

Sphingolipids: The Oil on the TRAFire That Promotes Inflammation ⬇️

scientific article published on September 28, 2010

Stabilization of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway.

scientific article

Streptolysin O promotes group A Streptococcus immune evasion by accelerated macrophage apoptosis

scientific article

Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas

scientific article published on 7 November 2017

Stressin' Sestrins take an aging fight

scientific article published on October 2010

Supreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response

scientific article published on February 2008

Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation

scientific article

TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis

scientific article

TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2.

scientific article published on 27 December 2011

TNFR signaling: ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes

scientific article published on March 2009

Targeted deletion of hepatocyte Ikkbeta confers growth advantages

scientific article published on 24 January 2009

Targeting Inflammation in Cancer Prevention and Therapy

scientific article published on 10 November 2016

Targeting of TAK1 by the NF-kappa B protein Relish regulates the JNK-mediated immune response in Drosophila

scientific article published on March 2004

The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover

scientific journal article

The HECT family of E3 ubiquitin ligases: multiple players in cancer development

scientific article published on July 2008

The IKK NF-kappa B system: a treasure trove for drug development

scientific article published on January 2004

The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer

scientific article published on April 2004

The IKK/NF-kappaB pathway.

scientific article published in January 2002

The IKK/NF-κB pathway ⬇️

scientific article published on January 1, 2002

The IL-23 to IL-17 cascade inflammation-related cancers.

scientific article published on 12 October 2015

The IkappaB kinase - a bridge between inflammation and cancer

scientific article

The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines

scientific article

The Ras-JNK pathway is involved in shear-induced gene expression

scientific article published on November 1996

The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation

scientific article published on October 2013

The Unholy Trinity: Inflammation, Cytokines, and STAT3 Shape The Cancer Microenvironment ⬇️

scientific article published on April 12, 2011

The anti-death machinery in IKK/NF-kappaB signaling

scientific article

The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes

scientific article

The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation

scientific article

The chemokine CXCL16 and its receptor, CXCR6, as markers and promoters of inflammation-associated cancers

scientific article

The commonly used antimicrobial additive triclosan is a liver tumor promoter

scientific article

The control of cell motility and epithelial morphogenesis by Jun kinases

scientific article published on February 2004

The control of mRNA stability in response to extracellular stimuli.

scientific article

The gut-liver axis and the intersection with the microbiome

scientific article published on 01 July 2018

The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice

scientific article published on 22 March 2004

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

scientific article

The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways

scientific article published on October 2002

The mammalian ultraviolet response is triggered by activation of src tyrosine kinases

scientific article published on 01 December 1992

The pore-forming toxin β hemolysin/cytolysin triggers p38 MAPK-dependent IL-10 production in macrophages and inhibits innate immunity

scientific article

The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4.

scientific article published on March 2004

The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease

scientific article published on 19 February 2016

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation ⬇️

scientific article (publication date: December 1991)

The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis.

scientific article published on 12 March 2003

The therapeutic value of targeting inflammation in gastrointestinal cancers

scientific article

The transactivating domain of the c-Jun proto-oncoprotein is required for cotransformation of rat embryo cells

scientific article published on December 1991

The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase

scientific article

The two faces of IKK and NF-κB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion

scientific article published on 07 April 2003

The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production

scholarly article

The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer

scientific article published on 07 February 2008

The yeast and mammalian Ras pathways control transcription of heat shock genes independently of heat shock transcription factor

scientific article published on July 1994

Three distinct signalling responses by murine fibroblasts to genotoxic stress

scientific article published on November 1996

Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts

scientific article

Tissue-specific influences affect glucocorticoid regulatory element actions on the human growth hormone gene promotor

scientific article published on 01 January 1985

Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation

scientific article

Tracking the road from inflammation to cancer: the critical role of IkappaB kinase (IKK).

scientific article published on January 2006

Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction.

scientific article published on September 1990

Transcriptional regulation of the Th17 immune response by IKKα ⬇️

scientific article published on March 14, 2011

Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growth

scientific article published on 12 October 2015

Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-kappaB.

scientific article published in September 2011

Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease

scientific article published on 23 November 2020

Tumor Promotion via Injury- and Death-Induced Inflammation ⬇️

scientific article published on October 28, 2011

Tumor infiltrating B-cells are increased in prostate cancer tissue

scientific article published on 30 January 2014

Tumor-Elicited Inflammation and Colorectal Cancer

scientific article published on 28 May 2015

Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling ⬇️

scientific article published on February 16, 2011

Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade

scientific article

Whipping NF-κB to Submission via GADD45 and MKK7.

scientific article published in October 2014

YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis

scientific article published on 27 January 2017

c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases

scientific article published on October 1994

c-Jun NH2-terminal kinase 1 is a critical regulator for the development of gastric cancer in mice

scientific article published in July 2008

c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions

scientific article

p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps

scientific article

p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts

scientific journal article

p38α inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species

scientific article published on 27 December 2012

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

scientific journal article

p62 in Cancer: Signaling Adaptor Beyond Autophagy

scientific article published in October 2016

p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells

scientific article

p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer

scientific journal article

p62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer

scientific article

p63 induces key target genes required for epidermal morphogenesis

scholarly article

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