List of works - Wolfgang Hillen

Transcriptional activation by tetracyclines in mammalian cells

scientific article

Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity

scientific article

Mechanisms underlying expression of Tn10 encoded tetracycline resistance

scientific article published on January 1994

Structural basis of gene regulation by the tetracycline inducible Tet repressor-operator system

scientific article

Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance

scientific article

Regulation of carbon catabolism in Bacillus species.

scientific article

In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice

scientific journal article

Gene regulation by tetracyclines. Constraints of resistance regulation in bacteria shape TetR for application in eukaryotes

scientific article

Quantitative analysis of gene expression with an improved green fluorescent protein

article

Tetracyclines: antibiotic action, uptake, and resistance mechanisms

scientific article published on June 1996

A theophylline responsive riboswitch based on helix slipping controls gene expression in vivo

scientific article

Structural basis for allosteric control of the transcription regulator CcpA by the phosphoprotein HPr-Ser46-P.

scientific article

Stringent doxycycline-dependent control of gene activities using an episomal one-vector system

scientific article

The complex formed between Tet repressor and tetracycline-Mg2+ reveals mechanism of antibiotic resistance

scientific article

A chimeric transactivator allows tetracycline-responsive gene expression in whole plants

scientific article published in April 1994

Nucleotide sequence of the Tn10 encoded tetracycline resistance gene

scientific article published on January 25, 1983

Conditional gene expression by controlling translation with tetracycline-binding aptamers

scientific article

Silencing Mycobacterium smegmatis by using tetracycline repressors

scientific article published on 4 May 2007

Control of expression of the Tn10-encoded tetracycline resistance operon II. Interaction of RNA polymerase and TET repressor with the tet operon regulatory region

scientific article published on January 15, 1984

Nomenclature for new tetracycline resistance determinants

scientific article

Control of expression of the Tn10-encoded tetracycline resistance genes. Equilibrium and kinetic investigation of the regulatory reactions

scientific article

Tetracycline-inducible systems for Drosophila

scientific article

Nomenclature for tetracycline resistance determinants

scientific article

Comparison of tetracycline and tigecycline binding to ribosomes mapped by dimethylsulphate and drug-directed Fe2+ cleavage of 16S rRNA.

scientific article published on 25 February 2004

Conformational changes of the Tet repressor induced by tetracycline trapping

scientific article

Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes

scientific article

Tetracycline-inducible expression systems with reduced basal activity in mammalian cells

scientific article published on January 1999

Structural requirements of tetracycline-Tet repressor interaction: determination of equilibrium binding constants for tetracycline analogs with the Tet repressor

scientific article published on August 1991

Interference of components of the phosphoenolpyruvate phosphotransferase system with the central virulence gene regulator PrfA of Listeria monocytogenes

scientific article

Doxycycline-regulated lentiviral vector system with a novel reverse transactivator rtTA2S-M2 shows a tight control of gene expression in vitro and in vivo

scientific article published in March 2003

Expression, inducer spectrum, domain structure, and function of MopR, the regulator of phenol degradation in Acinetobacter calcoaceticus NCIB8250.

scientific article published on February 1997

Genetic organization, nucleotide sequence and regulation of expression of genes encoding phenol hydroxylase and catechol 1,2-dioxygenase in Acinetobacter calcoaceticus NCIB8250.

scientific article published on October 1995

The Tetracycline Repressor-A Paradigm for a Biological Switch

scientific article published in June 2000

Two mutations in the tetracycline repressor change the inducer anhydrotetracycline to a corepressor

scientific article published on 4 February 2004

Kinetic and equilibrium characterization of the Tet repressor-tetracycline complex by fluorescence measurements. Evidence for divalent metal ion requirement and energy transfer

scientific article published on 01 February 1986

Structural mechanism for the fine-tuning of CcpA function by the small molecule effectors glucose 6-phosphate and fructose 1,6-bisphosphate

scientific article

Tight control of gene expression by a helper-dependent adenovirus vector carrying the rtTA2(s)-M2 tetracycline transactivator and repressor system.

scientific article published in November 2002

Activity reversal of Tet repressor caused by single amino acid exchanges

scientific article published in August 2004

Reproducible doxycycline-inducible transgene expression at specific loci generated by Cre-recombinase mediated cassette exchange

scientific article

Teaching TetR to recognize a new inducer

scientific article

Coupling physiology and gene regulation in bacteria: the phosphotransferase sugar uptake system delivers the signals

scientific article published on 01 December 1998

Quantitative interdependence of coeffectors, CcpA and cre in carbon catabolite regulation of Bacillus subtilis

scientific article published in May 2005

Heterologous repressor-operator recognition among four classes of tetracycline resistance determinants

scientific article

Inducible DNA-loop formation blocks transcriptional activation by an SV40 enhancer

scientific article

Ligand-modulated binding of a gene regulatory protein to DNA. Quantitative analysis of cyclic-AMP induced binding of CRP from Escherichia coli to non-specific and specific DNA targets

scientific article published on 01 June 1989

Differential regulation of the Tn10-encoded tetracycline resistance genes tetA and tetR by the tandem tet operators O1 and O2.

scientific article published on February 1988

Expression of alkane hydroxylase from Acinetobacter sp. Strain ADP1 is induced by a broad range of n-alkanes and requires the transcriptional activator AlkR.

scientific article published on November 1998

Nucleotide sequence of the repressor gene of the RA1 tetracycline resistance determinant: structural and functional comparison with three related Tet repressor genes

scientific article published on October 25, 1984

Noninducible Tet repressor mutations map from the operator binding motif to the C terminus

scientific article

Dynamics of repressor-operator recognition: the Tn10-encoded tetracycline resistance control

scientific article published in February 1988

List of works by Wolfgang Hillen

Transcriptional activation by tetracyclines in mammalian cells

Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity

Mechanisms underlying expression of Tn10 encoded tetracycline resistance

Structural basis of gene regulation by the tetracycline inducible Tet repressor-operator system

Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance

Regulation of carbon catabolism in Bacillus species.

In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice

Gene regulation by tetracyclines. Constraints of resistance regulation in bacteria shape TetR for application in eukaryotes

Quantitative analysis of gene expression with an improved green fluorescent protein

Tetracyclines: antibiotic action, uptake, and resistance mechanisms

A theophylline responsive riboswitch based on helix slipping controls gene expression in vivo

Structural basis for allosteric control of the transcription regulator CcpA by the phosphoprotein HPr-Ser46-P.

Stringent doxycycline-dependent control of gene activities using an episomal one-vector system

The complex formed between Tet repressor and tetracycline-Mg2+ reveals mechanism of antibiotic resistance

A chimeric transactivator allows tetracycline-responsive gene expression in whole plants

Nucleotide sequence of the Tn10 encoded tetracycline resistance gene

Conditional gene expression by controlling translation with tetracycline-binding aptamers

Silencing Mycobacterium smegmatis by using tetracycline repressors

Control of expression of the Tn10-encoded tetracycline resistance operon II. Interaction of RNA polymerase and TET repressor with the tet operon regulatory region

Nomenclature for new tetracycline resistance determinants

Control of expression of the Tn10-encoded tetracycline resistance genes. Equilibrium and kinetic investigation of the regulatory reactions

Tetracycline-inducible systems for Drosophila

Nomenclature for tetracycline resistance determinants

Comparison of tetracycline and tigecycline binding to ribosomes mapped by dimethylsulphate and drug-directed Fe2+ cleavage of 16S rRNA.

Conformational changes of the Tet repressor induced by tetracycline trapping

Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes

Tetracycline-inducible expression systems with reduced basal activity in mammalian cells

Structural requirements of tetracycline-Tet repressor interaction: determination of equilibrium binding constants for tetracycline analogs with the Tet repressor

Interference of components of the phosphoenolpyruvate phosphotransferase system with the central virulence gene regulator PrfA of Listeria monocytogenes

Doxycycline-regulated lentiviral vector system with a novel reverse transactivator rtTA2S-M2 shows a tight control of gene expression in vitro and in vivo

Expression, inducer spectrum, domain structure, and function of MopR, the regulator of phenol degradation in Acinetobacter calcoaceticus NCIB8250.

Genetic organization, nucleotide sequence and regulation of expression of genes encoding phenol hydroxylase and catechol 1,2-dioxygenase in Acinetobacter calcoaceticus NCIB8250.

The Tetracycline Repressor-A Paradigm for a Biological Switch

Two mutations in the tetracycline repressor change the inducer anhydrotetracycline to a corepressor

Kinetic and equilibrium characterization of the Tet repressor-tetracycline complex by fluorescence measurements. Evidence for divalent metal ion requirement and energy transfer

Structural mechanism for the fine-tuning of CcpA function by the small molecule effectors glucose 6-phosphate and fructose 1,6-bisphosphate

Tight control of gene expression by a helper-dependent adenovirus vector carrying the rtTA2(s)-M2 tetracycline transactivator and repressor system.

Activity reversal of Tet repressor caused by single amino acid exchanges

Reproducible doxycycline-inducible transgene expression at specific loci generated by Cre-recombinase mediated cassette exchange

Teaching TetR to recognize a new inducer

Coupling physiology and gene regulation in bacteria: the phosphotransferase sugar uptake system delivers the signals

Quantitative interdependence of coeffectors, CcpA and cre in carbon catabolite regulation of Bacillus subtilis

Heterologous repressor-operator recognition among four classes of tetracycline resistance determinants

Inducible DNA-loop formation blocks transcriptional activation by an SV40 enhancer

Ligand-modulated binding of a gene regulatory protein to DNA. Quantitative analysis of cyclic-AMP induced binding of CRP from Escherichia coli to non-specific and specific DNA targets

Differential regulation of the Tn10-encoded tetracycline resistance genes tetA and tetR by the tandem tet operators O1 and O2.

Expression of alkane hydroxylase from Acinetobacter sp. Strain ADP1 is induced by a broad range of n-alkanes and requires the transcriptional activator AlkR.

Nucleotide sequence of the repressor gene of the RA1 tetracycline resistance determinant: structural and functional comparison with three related Tet repressor genes

Noninducible Tet repressor mutations map from the operator binding motif to the C terminus

Dynamics of repressor-operator recognition: the Tn10-encoded tetracycline resistance control