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List of works by Gunther Hartmann

5' Triphosphorylated small interfering RNAs control replication of hepatitis B virus and induce an interferon response in human liver cells and mice

scientific article published on 13 May 2011

5'-Triphosphate RNA is the ligand for RIG-I

scientific article (publication date: 10 November 2006)

5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma

scientific article

A Message from the Oligonucleotide Therapeutics Society ⬇️

scientific article published on 01 February 2012

A human in vitro whole blood assay to predict the systemic cytokine response to therapeutic oligonucleotides including siRNA

scientific article

A mammalian microRNA expression atlas based on small RNA library sequencing

scientific article

AChE and RACK1 promote the anti-inflammatory properties of fluoxetine.

scientific article

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING

scientific article published on 25 September 2018

ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.

scientific article published on 26 November 2015

Abstract B44: Selective stimulation of RIG-I with a novel synthetic RNA induces strong anti-tumor immunity in mouse tumor models

Accessing the therapeutic potential of immunostimulatory nucleic acids

scientific article published on 30 July 2008

Activation of Endothelial Toll-Like Receptor 3 Impairs Endothelial Function

Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells.

scientific article

Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression

scientific article

Analysis of integrated clinical trial protocols in early phases of medicinal product development

scientific article published on 18 September 2017

Analysis of plasmacytoid and myeloid dendritic cells in nasal epithelium

scientific article

Antisense therapy in oncology: new hope for an old idea?

scientific article

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates

scientific article

Approaching the RNA ligand for RIG-I?

scientific article published on January 2009

Basic principles, planning and implementation of non-commercial clinical trials

scientific article published on January 2011

Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA.

scientific article

Calponin-h2: a potential serum marker for the early detection of human breast cancer?

scientific article published on 07 August 2014

Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes

scientific article published on 20 October 2014

Clinical Performance of CEA, CA19-9, CA15-3, CA125 and AFP in Gastrointestinal Cancer Using LOCI™-based Assays

scientific article published on January 2017

Clinical performance of LOCI™-based tumor marker assays for tumor markers CA 15-3, CA 125, CEA, CA 19-9 and AFP in gynecological cancers

scientific article

CpG ODN enhance antigen-specific NKT cell activation via plasmacytoid dendritic cells

scientific article published in August 2005

CpG oligonucleotides elicit antitumor responses in a human melanoma NOD/SCID xenotransplantation model

scientific article published in February 2004

CpG oligonucleotides induce strong humoral but only weak CD4+ T cell responses to protein antigens in rhesus macaques in vivo

article

CpG-A Oligonucleotides Induce a Monocyte-Derived Dendritic Cell-Like Phenotype That Preferentially Activates CD8 T Cells

scientific article published on 01 April 2003

Cutting Edge: The RIG-I Ligand 3pRNA Potently Improves CTL Cross-Priming and Facilitates Antiviral Vaccination.

scientific article published on 27 January 2016

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

scientific article

Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS.

scientific article published on 4 December 2011

Deficiency in coatomer complex I causes aberrant activation of STING signalling

scientific article published on 28 April 2022

Delivery by Cationic Gelatin Nanoparticles Strongly Increases the Immunostimulatory Effects of CpG Oligonucleotides

article

Delivery with polycations extends the immunostimulant Ribomunyl® into a potent antiviral Toll-like receptor 7/8 agonist

article published in 2011

Dendritic cell vaccination in human melanoma: relationships between clinical effects and vaccine parameters

scientific article published on 27 July 2010

Diagnostic Performance of a Novel Multiplex Immunoassay in Colorectal Cancer

scientific article published in May 2017

Diagnostic relevance of a novel multiplex immunoassay panel in breast cancer

scientific article published in June 2017

Direct RIG-I activation in human NK cells induces TRAIL-dependent cytotoxicity toward autologous melanoma cells

scientific article published on 09 January 2019

Discriminating self from non-self in nucleic acid sensing

scientific article

Effects of an active immunization on the immune response of laying Japanese quail (Coturnix coturnix japonica) fed with or without genetically modified Bacillus thuringiensis-maize

scientific article published on June 2010

Efficient solid-phase synthesis of pppRNA by using product-specific labeling

scientific article

Endothelial RIG-I activation impairs endothelial function

scientific article published in 2012

Enhanced Dendritic Cell Maturation by TNF- or Cytidine-Phosphate-Guanosine DNA Drives T Cell Activation In Vitro and Therapeutic Anti-Tumor Immune Responses In Vivo

article

Enzymatic synthesis and purification of a defined RIG-I ligand

scientific article published on January 2014

Exosomes as nucleic acid nanocarriers

scientific article published on 28 June 2012

Free-Circulating Methylated DNA in Blood for Diagnosis, Staging, Prognosis, and Monitoring of Head and Neck Squamous Cell Carcinoma Patients: An Observational Prospective Cohort Study

scientific article published on 17 May 2017

Funktion von extrazellulären Vesikeln und Bedeutung für die labormedizinische Diagnostik

G-rich DNA-induced stress response blocks type-I-IFN but not CXCL10 secretion in monocytes

scientific article published on 12 December 2016

Higher activation of TLR9 in plasmacytoid dendritic cells by microbial DNA compared with self-DNA based on CpG-specific recognition of phosphodiester DNA.

scientific article published on 20 July 2009

Human TLR8 Senses RNA From -Infected Red Blood Cells Which Is Uniquely Required for the IFN-γ Response in NK Cells

Human plasmacytoid dendritic cells support Th17 cell effector function in response to TLR7 ligation

scientific article

IL-12p70-dependent Th1 induction by human B cells requires combined activation with CD40 ligand and CpG DNA.

scientific article published on January 2004

Identification of specific nuclear structural protein alterations in human breast cancer

scientific article published on November 2011

Immunogenic cell death of human ovarian cancer cells induced by cytosolic poly(I:C) leads to myeloid cell maturation and activates NK cells.

scientific article

Immunohistological analysis of in-transit metastasis in a patient with advanced melanoma treated with combination therapy of cytosine guanine dinucleotide oligodeoxynucleotide, dacarbazine and beta-interferon: A case report

scientific article published on 06 March 2012

Immunostimulatory RNA Blocks Suppression by Regulatory T Cells

scientific article published on 04 December 2009

Immunostimulatory RNA oligonucleotides induce an effective antitumoral NK cell response through the TLR7.

scientific article

Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T-cell and IgG2a response

scientific article published in April 2007

Immunotherapy with dendritic cells and CpG oligonucleotides can be combined with chemotherapy without loss of efficacy in a mouse model of colon cancer

scientific article published in June 2006

Improved sensitivity for detection of breast cancer by combination of miR-34a and tumor markers CA 15-3 or CEA.

scientific article

In vivo synthesis of tumor necrosis factor-alpha in healthy humans after live yellow fever vaccination.

scientific article published on March 1998

Infection fatality rate of SARS-CoV2 in a super-spreading event in Germany

scientific article published on 17 November 2020

Inflammasome-Dependent Induction of Adaptive NK Cell Memory

scientific article published on 6 June 2016

Inhibition of toll-like receptor 7- and 9-mediated alpha/beta interferon production in human plasmacytoid dendritic cells by respiratory syncytial virus and measles virus

scientific article published on May 2005

Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy

scientific article published on 11 November 2021

Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome

scientific article published on June 2010

MDA-5 activation by cytoplasmic double-stranded RNA impairs endothelial function and aggravates atherosclerosis

scientific article

Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration

scientific article published on 11 August 2021

Mitf silencing cooperates with IL-12 gene transfer to inhibit melanoma in mice

scientific article published on 13 January 2010

Monocyte-Mediated Inhibition of TLR9-Dependent IFN- Induction in Plasmacytoid Dendritic Cells Questions Bacterial DNA as the Active Ingredient of Bacterial Lysates

scientific article published on 05 November 2010

No indication for a defect in toll-like receptor signaling in patients with hyper-IgE syndrome

scientific article published in July 2005

Nucleic Acid Immunity

scientific article published on 15 December 2016

Nucleic acid adjuvants: toward an educated vaccine

scientific article published on January 2012

Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing

scientific article published on 29 August 2013

Peritumoral CpG DNA elicits a coordinated response of CD8 T cells and innate effectors to cure established tumors in a murine colon carcinoma model

scientific article published in October 2002

Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN.

scientific article

Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help

scientific article

Preferential expression and function of Toll-like receptor 3 in human astrocytes

scientific article published on 11 November 2004

Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells.

scientific article

Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides

scientific article

RIG-I Activation Protects and Rescues from Lethal Influenza Virus Infection and Bacterial Superinfection

scientific article

RIG-I Resists Hypoxia-Induced Immunosuppression and Dedifferentiation

scientific article

RIG-I activation induces the release of extracellular vesicles with antitumor activity

scientific article published on 19 August 2016

RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids

scientific article published on 12 October 2012

RIG-I detects triphosphorylated RNA of Listeria monocytogenes during infection in non-immune cells

scientific article

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

scientific article

RNA recognition via TLR7 and TLR8.

scientific article published on January 2008

Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-alpha induction in plasmacytoid dendritic cells

scientific article

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus

scientific article

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production

scientific article

Regulation and function of the cytosolic viral RNA sensor RIG-I in pancreatic beta cells.

scientific article

Replication-dependent potent IFN-alpha induction in human plasmacytoid dendritic cells by a single-stranded RNA virus

scientific article published on November 2004

Role of adenosine receptors in regulating chemotaxis and cytokine production of plasmacytoid dendritic cells

scientific article published on 9 October 2003

Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytes.

scientific article

Selective and direct activation of human neutrophils but not eosinophils by Toll-like receptor 8.

scientific article published on 10 April 2009

Self-priming determines high type I IFN production by plasmacytoid dendritic cells

scientific article published on 16 January 2014

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA

scientific article

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

scientific article

Shock waves: a novel method for cytoplasmic delivery of antisense oligonucleotides.

scientific article

SiRNA delivery with exosome nanoparticles

scientific article published in April 2011

Sorafenib in combination with carboplatin and paclitaxel as neoadjuvant chemotherapy in patients with advanced ovarian cancer.

scientific article published on 5 March 2010

Specific expression of k63-linked ubiquitination of calmodulin-like protein 5 in breast cancer of premenopausal patients

scientific article

Spontaneous Formation of Nucleic Acid-based Nanoparticles Is Responsible for High Interferon-α Induction by CpG-A in Plasmacytoid Dendritic Cells

scientific article published in Journal of Biological Chemistry

Staphylococcus aureus Protein A Triggers T Cell-Independent B Cell Proliferation by Sensitizing B Cells for TLR2 Ligands

scientific article published on 01 March 2007

Stimulation of TLR7 prior to polymicrobial sepsis improves the immune control of the inflammatory response in adult mice

scientific article published on 17 October 2010

Structural alterations of MET trigger response to MET kinase inhibition in lung adenocarcinoma patients

scientific article published on 28 December 2017

Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I

scientific article

Structural studies of oligonucleotides containing G-quadruplex motifs using AFM.

scientific article published on January 2004

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

scientific article

Suppression of tumor necrosis factor-α production by interleukin-10 is enhanced by cAMP-elevating agents

scientific article published on 01 February 1997

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

scientific article

T cell-independent, TLR-induced IL-12p70 production in primary human monocytes

scientific article published on June 2006

TLR8-driven IL-12-dependent reciprocal and synergistic activation of NK cells and monocytes by immunostimulatory RNA.

scientific article

TRADD Protein Is an Essential Component of the RIG-like Helicase Antiviral Pathway

Targeted activation of RNA helicase retinoic acid-inducible gene-I induces proimmunogenic apoptosis of human ovarian cancer cells

scientific article published on 15 June 2010

Targeting the cytosolic innate immune receptors RIG-I and MDA5 effectively counteracts cancer cell heterogeneity in glioblastoma

scientific article published on June 2013

The chase for the RIG-I ligand--recent advances

scientific article published on 11 May 2010

Therapeutic efficacy of bifunctional siRNA combining TGF-β1 silencing with RIG-I activation in pancreatic cancer

scientific article published on 21 January 2013

Therapeutic tissue regeneration by a macrophage colony-stimulating factor Fc conjugate

scientific article published on September 2014

Tumour-derived prostaglandin E and transforming growth factor-beta synergize to inhibit plasmacytoid dendritic cell-derived interferon-alpha

scientific article

Turning tumors into vaccines: co-opting the innate immune system

scientific article published on July 2013

VKORC1-dependent pharmacokinetics of intravenous and oral phylloquinone (vitamin K1) mixed micelles formulation

scientific article published on 5 August 2012

Virally Infected Mouse Liver Endothelial Cells Trigger CD8+ T-Cell Immunity

Where Failure Is Not an Option -Personalized Medicine in Astronauts

scientific article

Yeast virus-derived stimulator of the innate immune system augments the efficacy of virus vector-based immunotherapy.

scientific article published on 26 February 2014

siRNA and isRNA: two edges of one sword

scientific article published on 31 July 2006

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